Entry
Name
Cytokine-cytokine receptor interaction - Dasypus novemcinctus (nine-banded armadillo)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
dnm04060 Cytokine-cytokine receptor interaction
Organism
Dasypus novemcinctus (nine-banded armadillo) [GN:
dnm ]
Gene
101410629 TNFSF9; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
101411052 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
101411097 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
101411496 TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
101412713 IL20RA; interleukin-20 receptor subunit alpha isoform X2 [KO:K05136 ]
101413233 FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390 ]
101414325 TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
101414757 TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
101416625 EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X2 [KO:K05162 ]
101416908 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B isoform X2 [KO:K05150 ]
101416909 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147 ]
101417353 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
101419016 TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152 ]
101420120 RELT; tumor necrosis factor receptor superfamily member 19L isoform X2 [KO:K05156 ]
101420558 TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145 ]
101423062 IL23A; LOW QUALITY PROTEIN: interleukin-23 subunit alpha [KO:K05426 ]
101423246 TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160 ]
101423597 IL18RAP; LOW QUALITY PROTEIN: interleukin-18 receptor accessory protein [KO:K05174 ]
101424295 IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056 ]
101424799 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
101425226 IL12A; LOW QUALITY PROTEIN: interleukin-12 subunit alpha [KO:K05406 ]
101426145 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
101427378 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
101427698 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
101427791 IL5RA; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067 ]
101428873 IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135 ]
101429635 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
101429977 LTBR; tumor necrosis factor receptor superfamily member 3 [KO:K03159 ]
101430481 CNTFR; LOW QUALITY PROTEIN: ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
101431862 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
101432032 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151 ]
101433349 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
101434825 IL17RE; LOW QUALITY PROTEIN: interleukin-17 receptor E [KO:K05168 ]
101435481 TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721 ]
101435971 BMP3; LOW QUALITY PROTEIN: bone morphogenetic protein 3 [KO:K05496 ]
101436253 TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155 ]
101437298 IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070 ]
101437378 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
101438083 TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722 ]
101440382 CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160 ]
101440631 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141 ]
101442055 TNFSF8; tumor necrosis factor ligand superfamily member 8 isoform X1 [KO:K05471 ]
101442775 IL1RAP; interleukin-1 receptor accessory protein isoform X3 [KO:K04723 ]
101443015 IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072 ]
101443386 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
101445402 TNFSF12; tumor necrosis factor ligand superfamily member 12 isoform X2 [KO:K05474 ]
101446228 IL31RA; LOW QUALITY PROTEIN: interleukin-31 receptor subunit alpha [KO:K22630 ]
101447393 IL27RA; LOW QUALITY PROTEIN: interleukin-27 receptor subunit alpha [KO:K19598 ]
101447903 OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
105744144 TNFSF13; tumor necrosis factor ligand superfamily member 13 [KO:K05475 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway