KEGG   PATHWAY: dord00983
Entry
dord00983                   Pathway                                
Name
Drug metabolism - other enzymes - Dipodomys ordii (Ord's kangaroo rat)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
dord00983  Drug metabolism - other enzymes
dord00983

Organism
Dipodomys ordii (Ord's kangaroo rat) [GN:dord]
Gene
105986958  Hprt1; hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
105988415  Impdh1; inosine-5'-monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
105994605  Impdh2; inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
105985627  Gmps; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
105996366  Tpmt; thiopurine S-methyltransferase isoform X1 [KO:K00569] [EC:2.1.1.67]
105988652  thiopurine S-methyltransferase-like [KO:K00569] [EC:2.1.1.67]
105983773  Xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
105981672  Itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
105994407  carboxylesterase 1D-like [KO:K01044] [EC:3.1.1.1]
105994451  carboxylesterase 1E-like [KO:K01044] [EC:3.1.1.1]
105983009  pyrethroid hydrolase Ces2e-like isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
105982928  pyrethroid hydrolase Ces2e-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
105983010  pyrethroid hydrolase Ces2e-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
105983013  acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
105983014  pyrethroid hydrolase Ces2e-like isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
105980109  UDP-glucuronosyltransferase 1-2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105980125  UDP-glucuronosyltransferase 1-9-like [KO:K00699] [EC:2.4.1.17]
105980211  UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
105980274  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105980275  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105980276  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105988433  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
105988435  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
105988436  Ugt2a1; UDP-glucuronosyltransferase 2A1 [KO:K00699] [EC:2.4.1.17]
105988494  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
105988496  UDP-glucuronosyltransferase 2B15-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105988497  UDP-glucuronosyltransferase 2B15-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105988499  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105988500  UDP-glucuronosyltransferase 2B15-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105988501  UDP-glucuronosyltransferase 2B15-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105988504  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
106002475  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
106002724  UDP-glucuronosyltransferase 1-7-like [KO:K00699] [EC:2.4.1.17]
106002380  UDP-glucuronosyltransferase 1-7-like [KO:K00699] [EC:2.4.1.17]
105998493  Gusb; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
106002566  LOW QUALITY PROTEIN: cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
105997994  Cda; cytidine deaminase [KO:K01489] [EC:3.5.4.5]
105992717  Tymp; thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
106000801  Dpyd; dihydropyrimidine dehydrogenase [NADP(+)] isoform X1 [KO:K00207] [EC:1.3.1.2]
105982867  Dpys; LOW QUALITY PROTEIN: dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
105984348  Upb1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
105996493  Upp2; uridine phosphorylase 2 isoform X1 [KO:K00757] [EC:2.4.2.3]
105996323  Uckl1; uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
105989407  Uck1; uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
105989669  Uck2; uridine-cytidine kinase 2 [KO:K00876] [EC:2.7.1.48]
105982919  Tk2; thymidine kinase 2, mitochondrial [KO:K00857] [EC:2.7.1.21]
106000826  Tk1; thymidine kinase, cytosolic isoform X1 [KO:K00857] [EC:2.7.1.21]
105987970  Umps; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
105986189  Cmpk1; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
105984066  Rrm1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
105982864  Rrm2b; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
105983759  Rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
105985207  Nme7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
105981912  Nme3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
105994541  Nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
106003147  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
106003148  nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
105981206  Dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 [KO:K01520] [EC:3.6.1.23]
105999461  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
105983334  Mpo; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
105991867  arylamine N-acetyltransferase 2 [KO:K00622] [EC:2.3.1.5]
105992221  arylamine N-acetyltransferase 2-like [KO:K00622] [EC:2.3.1.5]
105992232  arylamine N-acetyltransferase 2-like [KO:K00622] [EC:2.3.1.5]
105998603  cytochrome P450 2E1-like isoform X1 [KO:K07415] [EC:1.14.14.-]
106000254  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
106001755  LOW QUALITY PROTEIN: cytochrome P450 2E1-like [KO:K07415] [EC:1.14.14.-]
105995680  Mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
105986657  Gsto2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
105986770  Gsto1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
105992227  Mgst1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
105987712  Gsta4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
105987713  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
105987814  glutathione S-transferase A3-like [KO:K00799] [EC:2.5.1.18]
105987815  glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
105989689  Mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
105984148  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
105984357  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
105984364  glutathione S-transferase theta-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
105997418  glutathione S-transferase Mu 2-like [KO:K00799] [EC:2.5.1.18]
105997419  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
105997436  glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
105997437  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
105997438  glutathione S-transferase Mu 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
105997439  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
105997442  glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
105997443  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
105997484  Gstm3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
105989131  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
105989276  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
LinkDB

DBGET integrated database retrieval system