KEGG   PATHWAY: dpz04141
Entry
dpz04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Daphnia pulicaria
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
dpz04141  Protein processing in endoplasmic reticulum
dpz04141

Other DBs
GO: 0030433 0034976
Organism
Daphnia pulicaria [GN:dpz]
Gene
124315300  protein transport protein Sec61 subunit alpha [KO:K10956]
124311533  protein transport protein Sec61 subunit beta-like [KO:K09481]
124352647  translocation protein SEC62-like [KO:K12275]
124336926  translocation protein SEC63 homolog [KO:K09540]
124325970  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1-like [KO:K12666]
124320677  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2-like [KO:K12667]
124338167  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1-like [KO:K12668]
124342717  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit-like isoform X1 [KO:K12670]
124320267  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B-like [KO:K07151] [EC:2.4.99.18]
124338458  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A-like [KO:K07151] [EC:2.4.99.18]
124336829  tumor suppressor candidate 3-like [KO:K19478]
124315654  oligosaccharyltransferase complex subunit ostc-B-like [KO:K26501]
124337589  LOW QUALITY PROTEIN: mannosyl-oligosaccharide glucosidase-like [KO:K01228] [EC:3.2.1.106]
124315295  nucleotide exchange factor SIL1-like [KO:K14001]
124328723  endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
124342692  dnaJ homolog subfamily C member 1-like [KO:K09521]
124327582  dnaJ homolog subfamily C member 3-like [KO:K09523]
124342249  dnaJ homolog subfamily C member 10-like isoform X1 [KO:K09530] [EC:1.8.4.-]
124344116  endoplasmin-like isoform X1 [KO:K09487]
124327014  neutral alpha-glucosidase AB-like isoform X1 [KO:K05546] [EC:3.2.1.207]
124349619  glucosidase 2 subunit beta-like [KO:K08288]
124338663  calnexin-like isoform X1 [KO:K08054]
124346984  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
124336260  calreticulin-like [KO:K08057]
124315191  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
124321727  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
124349682  mannosyl-oligosaccharide alpha-1,2-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
124349546  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
124349882  vesicular integral-membrane protein VIP36-like [KO:K10082]
124328926  protein ERGIC-53-like [KO:K10080]
124348555  uncharacterized protein LOC124348555 [KO:K07953] [EC:3.6.5.-]
124350803  GTP-binding protein SAR1-like [KO:K07953] [EC:3.6.5.-]
124337175  GTP-binding protein SAR1B-like isoform X1 [KO:K07953] [EC:3.6.5.-]
124312591  GTP-binding protein SAR1-like [KO:K07953] [EC:3.6.5.-]
124337113  protein SEC13 homolog [KO:K14004]
124337690  protein SEC13 homolog [KO:K14004]
124340896  protein transport protein Sec23A-like isoform X1 [KO:K14006]
124312623  protein transport protein Sec24C-like isoform X1 [KO:K14007]
124340711  protein transport protein Sec24A-like [KO:K14007]
124315099  UDP-glucose:glycoprotein glucosyltransferase 1-like isoform X1 [KO:K11718] [EC:2.4.1.-]
124343208  ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
124338223  ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
124313981  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
124329088  protein disulfide-isomerase-like isoform X1 [KO:K09580] [EC:5.3.4.1]
124312560  probable protein disulfide-isomerase A4 [KO:K09582] [EC:5.3.4.1]
124349004  protein disulfide-isomerase A6 homolog [KO:K09584] [EC:5.3.4.1]
124336418  endoplasmic reticulum resident protein 29-like [KO:K09586]
124349014  thioredoxin domain-containing protein 5 homolog [KO:K13984] [EC:5.3.4.1]
124341448  ero1-like protein [KO:K10950] [EC:1.8.4.-]
124311111  endoplasmic reticulum lectin 1-like [KO:K14008]
124312439  translocon-associated protein subunit alpha-like [KO:K13249]
124314828  translocon-associated protein subunit beta-like [KO:K13250]
124349099  translocon-associated protein subunit gamma-like [KO:K13251]
124316561  translocon-associated protein subunit delta-like [KO:K04571]
124314235  B-cell receptor-associated protein 31-like [KO:K14009]
124313176  translocating chain-associated membrane protein 1-like [KO:K14010]
124343321  derlin-1-like [KO:K11519]
124313308  derlin-2-like [KO:K13989]
124336337  UBX domain-containing protein 1-B-like [KO:K24348]
124343464  UBX domain-containing protein 4-like [KO:K24348]
124327587  UBX domain-containing protein 6-like [KO:K14011]
124349022  NSFL1 cofactor p47-like [KO:K14012]
124314656  transitional endoplasmic reticulum ATPase [KO:K13525]
124325976  nuclear protein localization protein 4 homolog [KO:K14015]
124320644  ubiquitin recognition factor in ER-associated degradation protein 1-like isoform X1 [KO:K14016]
124349254  heat shock 70 kDa protein cognate 4 [KO:K03283]
124312088  heat shock 70 kDa protein cognate 4-like [KO:K03283]
124338213  heat shock 70 kDa protein II-like [KO:K03283]
124312606  dnaJ homolog subfamily A member 1-like [KO:K09502]
124338614  dnaJ homolog subfamily A member 2-like [KO:K09503]
124312694  dnaJ protein homolog 1-like [KO:K09507]
124336292  dnaJ homolog subfamily B member 12-like isoform X1 [KO:K09518]
124344486  dnaJ homolog subfamily C member 5-like isoform X1 [KO:K09525]
124316176  heat shock protein 83 [KO:K04079]
124315152  heat shock 70 kDa protein 4L-like [KO:K09485]
124311429  uncharacterized protein LOC124311429 [KO:K09555]
124326244  BAG family molecular chaperone regulator 2-like [KO:K09556]
124316448  hsp70-binding protein 1-like [KO:K09562]
124341228  ubiquitin thioesterase OTU1-like [KO:K13719] [EC:3.1.2.-]
124310961  phospholipase A-2-activating protein-like [KO:K14018]
124343280  UV excision repair protein RAD23 homolog B-like [KO:K10839]
124313261  ubiquilin-1-like [KO:K04523]
124329564  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase-like [KO:K01456] [EC:3.5.1.52]
124326374  ataxin-3-like [KO:K11863] [EC:3.4.22.-]
124329002  ubiquitin conjugation factor E4 B-like [KO:K10597] [EC:2.3.2.27]
124350999  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
124343156  wolframin-like [KO:K14020]
124328705  membrane-bound transcription factor site-1 protease-like isoform X1 [KO:K08653] [EC:3.4.21.112]
124341424  membrane-bound transcription factor site-2 protease-like isoform X1 [KO:K07765] [EC:3.4.24.85]
124329555  serine/threonine-protein kinase/endoribonuclease IRE2-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
124340078  mitogen-activated protein kinase kinase kinase 15-like isoform X1 [KO:K04426] [EC:2.7.11.25]
124315156  dual specificity mitogen-activated protein kinase kinase 7-like [KO:K04431] [EC:2.7.12.2]
124349759  stress-activated protein kinase JNK-like [KO:K04440] [EC:2.7.11.24]
124349803  stress-activated protein kinase JNK-like [KO:K04440] [EC:2.7.11.24]
124337887  E3 ubiquitin-protein ligase MARCHF6-like isoform X1 [KO:K10661] [EC:2.3.2.27]
124348936  ubiquitin-conjugating enzyme E2 J1-like [KO:K10578] [EC:2.3.2.23]
124312171  ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:2.3.2.23]
124313428  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
124311463  ubiquitin-conjugating enzyme E2 G2-like [KO:K04555] [EC:2.3.2.23]
124329346  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase synoviolin B-like [KO:K10601] [EC:2.3.2.27]
124329207  E3 ubiquitin-protein ligase RNF185-like [KO:K10666] [EC:2.3.2.27]
124312664  selenoprotein S-like [KO:K14025]
124312887  protein sel-1 homolog 1-like [KO:K14026]
124343604  protein sel-1 homolog 1-like [KO:K14026]
124329492  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
124336426  E3 ubiquitin-protein ligase CHIP-like isoform X1 [KO:K09561] [EC:2.3.2.27]
124338598  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
124337026  E3 ubiquitin-protein ligase parkin-like [KO:K04556] [EC:2.3.2.31]
124349781  RING-box protein 1A [KO:K03868] [EC:2.3.2.32]
124349791  RING-box protein 1A-like [KO:K03868] [EC:2.3.2.32]
124310889  cullin-1-like [KO:K03347]
124315686  cullin-1-like [KO:K03347]
124326098  S-phase kinase-associated protein 1 [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
dpz00510  N-Glycan biosynthesis
dpz03050  Proteasome
dpz03060  Protein export
KO pathway
ko04141   
LinkDB

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