KEGG   PATHWAY: ecad00270
Entry
ecad00270                   Pathway                                
Name
Cysteine and methionine metabolism - Erigeron canadensis (horseweed)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
ecad00270  Cysteine and methionine metabolism
ecad00270

Module
ecad_M00021  Cysteine biosynthesis, serine => cysteine [PATH:ecad00270]
ecad_M00034  Methionine salvage pathway [PATH:ecad00270]
ecad_M00368  Ethylene biosynthesis, methionine => ethylene [PATH:ecad00270]
Other DBs
GO: 0006534 0006555
Organism
Erigeron canadensis (horseweed) [GN:ecad]
Gene
122578717  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
122603651  serine acetyltransferase 2-like [KO:K00640] [EC:2.3.1.30]
122592505  serine acetyltransferase 1, chloroplastic [KO:K00640] [EC:2.3.1.30]
122596244  serine acetyltransferase 5 [KO:K00640] [EC:2.3.1.30]
122586832  serine acetyltransferase 5-like [KO:K00640] [EC:2.3.1.30]
122599732  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
122589714  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
122579042  cysteine synthase 2 [KO:K01738] [EC:2.5.1.47]
122596088  cysteine synthase [KO:K01738] [EC:2.5.1.47]
122598182  cysteine synthase-like isoform X1 [KO:K01738] [EC:2.5.1.47]
122586503  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
122591207  bifunctional L-3-cyanoalanine synthase/cysteine synthase 1, mitochondrial [KO:K13034] [EC:2.5.1.47 4.4.1.9]
122593674  cystathionine beta-lyase, chloroplastic-like isoform X1 [KO:K01760] [EC:4.4.1.13]
122582932  cystathionine beta-lyase, chloroplastic-like [KO:K01760] [EC:4.4.1.13]
122607043  homocysteine S-methyltransferase 2-like [KO:K00547] [EC:2.1.1.10]
122581696  homocysteine S-methyltransferase 2-like [KO:K00547] [EC:2.1.1.10]
122596164  homocysteine S-methyltransferase 1 [KO:K00547] [EC:2.1.1.10]
122606099  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase-like [KO:K00549] [EC:2.1.1.14]
122606330  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]
122602749  S-adenosylmethionine synthase 2 [KO:K00789] [EC:2.5.1.6]
122578533  S-adenosylmethionine synthase 5 [KO:K00789] [EC:2.5.1.6]
122604750  S-adenosylmethionine synthase 3-like [KO:K00789] [EC:2.5.1.6]
122581009  S-adenosylmethionine synthase 3 [KO:K00789] [EC:2.5.1.6]
122610094  S-adenosylmethionine synthase 2 [KO:K00789] [EC:2.5.1.6]
122605796  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
122584836  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
122585188  S-adenosylmethionine decarboxylase proenzyme 4 [KO:K01611] [EC:4.1.1.50]
122611343  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
122610246  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
122589437  spermine synthase-like [KO:K00797] [EC:2.5.1.16]
122604883  spermidine synthase [KO:K00797] [EC:2.5.1.16]
122608317  spermine synthase [KO:K00797] [EC:2.5.1.16]
122584470  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
122593477  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
122594208  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
122596364  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
122581794  5'-methylthioadenosine nucleosidase-like [KO:K01244] [EC:3.2.2.16]
122598189  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase-like [KO:K01244] [EC:3.2.2.16]
122596618  methylthioribose kinase [KO:K00899] [EC:2.7.1.100]
122587748  methylthioribose kinase-like isoform X1 [KO:K00899] [EC:2.7.1.100]
122597901  methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
122593512  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
122599664  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
122582183  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
122582533  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 3-like [KO:K08967] [EC:1.13.11.53 1.13.11.54]
122596501  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
122586844  probable N-succinyldiaminopimelate aminotransferase DapC [KO:K23977] [EC:2.6.1.117]
122594339  nicotianamine aminotransferase 1-like [KO:K00815] [EC:2.6.1.5]
122581868  tyrosine aminotransferase-like [KO:K00815] [EC:2.6.1.5]
122595461  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
122584673  tyrosine aminotransferase-like isoform X1 [KO:K00815] [EC:2.6.1.5]
122584674  tyrosine aminotransferase-like isoform X1 [KO:K00815] [EC:2.6.1.5]
122610911  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
122598211  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
122599611  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
122588475  aromatic aminotransferase ISS1 [KO:K00837] [EC:2.6.1.-]
122609968  methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]
122578248  DNA (cytosine-5)-methyltransferase CMT3-like [KO:K00558] [EC:2.1.1.37]
122579368  DNA (cytosine-5)-methyltransferase 1-like isoform X1 [KO:K00558] [EC:2.1.1.37]
122594112  DNA (cytosine-5)-methyltransferase 1B-like isoform X1 [KO:K00558] [EC:2.1.1.37]
122607143  DNA (cytosine-5)-methyltransferase 1-like [KO:K00558] [EC:2.1.1.37]
122609857  LOW QUALITY PROTEIN: DNA (cytosine-5)-methyltransferase CMT3-like [KO:K00558] [EC:2.1.1.37]
122611193  DNA (cytosine-5)-methyltransferase CMT2-like isoform X1 [KO:K00558] [EC:2.1.1.37]
122601960  DNA (cytosine-5)-methyltransferase CMT2-like [KO:K00558] [EC:2.1.1.37]
122584228  uncharacterized protein LOC122584228 [KO:K17398] [EC:2.1.1.37]
122603154  adenosylhomocysteinase 1 [KO:K01251] [EC:3.13.2.1]
122583978  adenosylhomocysteinase-like [KO:K01251] [EC:3.13.2.1]
122599427  adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
122602635  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
122579855  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
122596038  1-aminocyclopropane-1-carboxylate synthase [KO:K20772] [EC:4.4.1.14]
122603513  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
122578887  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
122593791  1-aminocyclopropane-1-carboxylate synthase 7-like [KO:K01762] [EC:4.4.1.14]
122597705  1-aminocyclopropane-1-carboxylate synthase 7-like [KO:K01762] [EC:4.4.1.14]
122589291  1-aminocyclopropane-1-carboxylate synthase 9-like [KO:K01762] [EC:4.4.1.14]
122602130  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
122578935  1-aminocyclopropane-1-carboxylate oxidase 5-like isoform X1 [KO:K05933] [EC:1.14.17.4]
122578936  1-aminocyclopropane-1-carboxylate oxidase 5-like [KO:K05933] [EC:1.14.17.4]
122596311  1-aminocyclopropane-1-carboxylate oxidase 3-like [KO:K05933] [EC:1.14.17.4]
122609861  1-aminocyclopropane-1-carboxylate oxidase 5-like [KO:K05933] [EC:1.14.17.4]
122600660  1-aminocyclopropane-1-carboxylate oxidase 1-like [KO:K05933] [EC:1.14.17.4]
122578049  aspartokinase 2, chloroplastic-like isoform X1 [KO:K00928] [EC:2.7.2.4]
122603751  aspartokinase 2, chloroplastic-like [KO:K00928] [EC:2.7.2.4]
122586829  bifunctional aspartokinase/homoserine dehydrogenase, chloroplastic-like [KO:K12524] [EC:2.7.2.4 1.1.1.3]
122603081  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
122586603  cystathionine gamma-synthase 1, chloroplastic [KO:K01739] [EC:2.5.1.48]
122607720  branched-chain-amino-acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
122607778  branched-chain-amino-acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
122609158  branched-chain amino acid aminotransferase 1, mitochondrial-like [KO:K00826] [EC:2.6.1.42]
122601485  branched-chain-amino-acid aminotransferase 5, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
122603434  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
122592627  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial-like isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
122593836  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
122606897  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
122610067  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
122603479  glutathione synthetase, chloroplastic-like isoform X1 [KO:K21456] [EC:6.3.2.3]
122605652  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
122578409  aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
122595732  aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
122595458  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
122604142  aspartate aminotransferase, chloroplastic [KO:K00811] [EC:2.6.1.1]
122592819  thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
122609981  L-lactate dehydrogenase A [KO:K00016] [EC:1.1.1.27]
122585488  D-cysteine desulfhydrase 2, mitochondrial [KO:K05396] [EC:4.4.1.15]
122587179  putative D-cysteine desulfhydrase 1, mitochondrial [KO:K05396] [EC:4.4.1.15]
122606783  L-cysteine desulfhydrase [KO:K22207] [EC:4.4.1.28]
122594530  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
122597992  malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
122600426  malate dehydrogenase [KO:K00025] [EC:1.1.1.37]
122579908  malate dehydrogenase, glyoxysomal-like [KO:K00026] [EC:1.1.1.37]
122595213  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
122607443  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
122586743  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
122599168  malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
122600536  malate dehydrogenase 1, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
122592994  D-3-phosphoglycerate dehydrogenase 3, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
122595435  D-3-phosphoglycerate dehydrogenase 1, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
122585623  phosphoserine aminotransferase 2, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
ecad00010  Glycolysis / Gluconeogenesis
ecad00250  Alanine, aspartate and glutamate metabolism
ecad00260  Glycine, serine and threonine metabolism
ecad00290  Valine, leucine and isoleucine biosynthesis
ecad00430  Taurine and hypotaurine metabolism
ecad00480  Glutathione metabolism
ecad00620  Pyruvate metabolism
ecad00640  Propanoate metabolism
ecad00770  Pantothenate and CoA biosynthesis
ecad00900  Terpenoid backbone biosynthesis
ecad00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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