KEGG   PATHWAY: hhv03040
Entry
hhv03040                    Pathway                                
Name
Spliceosome - Hyaena hyaena (striped hyena)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
hhv03040  Spliceosome
hhv03040

Other DBs
GO: 0005681
Organism
Hyaena hyaena (striped hyena) [GN:hhv]
Gene
120220725  U1 spliceosomal RNA [KO:K14276]
120241946  U1 spliceosomal RNA [KO:K14276]
120221330  U1 spliceosomal RNA [KO:K14276]
120221759  U1 spliceosomal RNA [KO:K14276]
120241951  U1 spliceosomal RNA [KO:K14276]
120223176  U1 spliceosomal RNA [KO:K14276]
120222907  U2 spliceosomal RNA [KO:K14277]
120249222  U2 spliceosomal RNA [KO:K14277]
120225114  U2 spliceosomal RNA [KO:K14277]
120226092  U2 spliceosomal RNA [KO:K14277]
120227783  U2 spliceosomal RNA [KO:K14277]
120229730  U2 spliceosomal RNA [KO:K14277]
120225220  U2 spliceosomal RNA [KO:K14277]
120246796  U2 spliceosomal RNA [KO:K14277]
120227814  U2 spliceosomal RNA [KO:K14277]
120223934  U4 spliceosomal RNA [KO:K14278]
120223869  U4 spliceosomal RNA [KO:K14278]
120235885  U4 spliceosomal RNA [KO:K14278]
120239350  U4 spliceosomal RNA [KO:K14278]
120235286  U4 spliceosomal RNA [KO:K14278]
120233584  U4 spliceosomal RNA [KO:K14278]
120238484  U4 spliceosomal RNA [KO:K14278]
120248306  U4 spliceosomal RNA [KO:K14278]
120238397  U4 spliceosomal RNA [KO:K14278]
120236114  U5 spliceosomal RNA [KO:K14279]
120236113  U5 spliceosomal RNA [KO:K14279]
120226659  U5 spliceosomal RNA [KO:K14279]
120230544  U5 spliceosomal RNA [KO:K14279]
120222588  U5 spliceosomal RNA [KO:K14279]
120220521  U6 spliceosomal RNA [KO:K14280]
120220384  U6 spliceosomal RNA [KO:K14280]
120226179  U6 spliceosomal RNA [KO:K14280]
120220385  U6 spliceosomal RNA [KO:K14280]
120230050  U6 spliceosomal RNA [KO:K14280]
120229732  U6 spliceosomal RNA [KO:K14280]
120235050  U6 spliceosomal RNA [KO:K14280]
120233171  U6 spliceosomal RNA [KO:K14280]
120222418  U6 spliceosomal RNA [KO:K14280]
120243631  U6 spliceosomal RNA [KO:K14280]
120225661  U6 spliceosomal RNA [KO:K14280]
120234228  U6 spliceosomal RNA [KO:K14280]
120237516  U6 spliceosomal RNA [KO:K14280]
120243141  U6 spliceosomal RNA [KO:K14280]
120226145  U6 spliceosomal RNA [KO:K14280]
120220598  U6 spliceosomal RNA [KO:K14280]
120228377  U6 spliceosomal RNA [KO:K14280]
120245697  U6 spliceosomal RNA [KO:K14280]
120222189  U6 spliceosomal RNA [KO:K14280]
120246278  U6 spliceosomal RNA [KO:K14280]
120236387  U6 spliceosomal RNA [KO:K14280]
120222516  U6 spliceosomal RNA [KO:K14280]
120230221  U6 spliceosomal RNA [KO:K14280]
120238613  U6 spliceosomal RNA [KO:K14280]
120221163  U6 spliceosomal RNA [KO:K14280]
120246606  U6 spliceosomal RNA [KO:K14280]
120247976  U6 spliceosomal RNA [KO:K14280]
120231742  U6 spliceosomal RNA [KO:K14280]
120232526  U6 spliceosomal RNA [KO:K14280]
120238223  U6 spliceosomal RNA [KO:K14280]
120244333  U6 spliceosomal RNA [KO:K14280]
120220571  U6 spliceosomal RNA [KO:K14280]
120222166  U6 spliceosomal RNA [KO:K14280]
120242929  U6 spliceosomal RNA [KO:K14280]
120244489  U6 spliceosomal RNA [KO:K14280]
120240637  U6 spliceosomal RNA [KO:K14280]
120221760  U6 spliceosomal RNA [KO:K14280]
120237596  U6 spliceosomal RNA [KO:K14280]
120219853  U6 spliceosomal RNA [KO:K14280]
120244014  U6 spliceosomal RNA [KO:K14280]
120224896  U6 spliceosomal RNA [KO:K14280]
120219753  U6 spliceosomal RNA [KO:K14280]
120235242  U6 spliceosomal RNA [KO:K14280]
120224885  U6 spliceosomal RNA [KO:K14280]
120226009  U6 spliceosomal RNA [KO:K14280]
120248322  U6 spliceosomal RNA [KO:K14280]
120227125  U6 spliceosomal RNA [KO:K14280]
120221116  U6 spliceosomal RNA [KO:K14280]
120223909  U6 spliceosomal RNA [KO:K14280]
120227622  U6 spliceosomal RNA [KO:K14280]
120230545  U6 spliceosomal RNA [KO:K14280]
120227195  U6 spliceosomal RNA [KO:K14280]
120245561  U6 spliceosomal RNA [KO:K14280]
120239102  U6 spliceosomal RNA [KO:K14280]
120233300  U6 spliceosomal RNA [KO:K14280]
120224006  U6 spliceosomal RNA [KO:K14280]
120248139  U6 spliceosomal RNA [KO:K14280]
120243632  U6 spliceosomal RNA [KO:K14280]
120247099  U6 spliceosomal RNA [KO:K14280]
120230353  U6 spliceosomal RNA [KO:K14280]
120230358  U6 spliceosomal RNA [KO:K14280]
120223197  U6 spliceosomal RNA [KO:K14280]
120220896  U6 spliceosomal RNA [KO:K14280]
120240847  U6 spliceosomal RNA [KO:K14280]
120224496  U6 spliceosomal RNA [KO:K14280]
120238499  DDX46; probable ATP-dependent RNA helicase DDX46 [KO:K12811] [EC:5.6.2.7]
120221910  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
120222644  DHX16; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1 [KO:K12813] [EC:5.6.2.6]
120223625  DHX38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
120225786  CDC40; pre-mRNA-processing factor 17 [KO:K12816]
120236940  PRPF18; pre-mRNA-splicing factor 18 isoform X1 [KO:K12817]
120222892  DHX8; ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
120240586  SLU7; pre-mRNA-splicing factor SLU7 [KO:K12819]
120234703  DHX15; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [KO:K12820] [EC:5.6.2.6]
120220100  LOW QUALITY PROTEIN: small nuclear ribonucleoprotein-associated protein B-like [KO:K11086]
120235463  SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' [KO:K11086]
120220538  SNRPD1; small nuclear ribonucleoprotein Sm D1 isoform X1 [KO:K11087]
120241224  SNRPD2; small nuclear ribonucleoprotein Sm D2 [KO:K11096]
120225654  SNRPD3; small nuclear ribonucleoprotein Sm D3 [KO:K11088]
120234012  LOW QUALITY PROTEIN: small nuclear ribonucleoprotein Sm D3-like [KO:K11088]
120220481  small nuclear ribonucleoprotein E-like [KO:K11097]
120228848  SNRPE; small nuclear ribonucleoprotein E [KO:K11097]
120234639  SNRPF; small nuclear ribonucleoprotein F [KO:K11098]
120224492  small nuclear ribonucleoprotein G-like [KO:K11099]
120232058  small nuclear ribonucleoprotein G-like [KO:K11099]
120243620  small nuclear ribonucleoprotein G-like [KO:K11099]
120219606  small nuclear ribonucleoprotein G-like [KO:K11099]
120219651  small nuclear ribonucleoprotein G-like [KO:K11099]
120236636  SNRPG; small nuclear ribonucleoprotein G [KO:K11099]
120245466  LOW QUALITY PROTEIN: small nuclear ribonucleoprotein G-like [KO:K11099]
120248675  small nuclear ribonucleoprotein G-like [KO:K11099]
120240941  SNRNP70; U1 small nuclear ribonucleoprotein 70 kDa isoform X1 [KO:K11093]
120240124  SNRPA; U1 small nuclear ribonucleoprotein A [KO:K11091]
120231980  U1 small nuclear ribonucleoprotein C-like [KO:K11095]
120238220  SNRPC; U1 small nuclear ribonucleoprotein C [KO:K11095]
120237900  PRPF40B; pre-mRNA-processing factor 40 homolog B isoform X1 [KO:K12821]
120221824  PRPF40A; pre-mRNA-processing factor 40 homolog A isoform X1 [KO:K12821]
120222214  RBM25; RNA-binding protein 25 [KO:K12822]
120234203  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
120248354  TCERG1; transcription elongation regulator 1 isoform X1 [KO:K12824]
120242218  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
120233693  SNRPA1; U2 small nuclear ribonucleoprotein A' [KO:K11092]
120236007  U2 small nuclear ribonucleoprotein B''-like [KO:K11094]
120245183  U2 small nuclear ribonucleoprotein B'' [KO:K11094]
120227612  SF3A1; splicing factor 3A subunit 1 isoform X1 [KO:K12825]
120242321  SF3A2; splicing factor 3A subunit 2 [KO:K12826]
120239919  SF3A3; splicing factor 3A subunit 3 [KO:K12827]
120222073  SF3B1; splicing factor 3B subunit 1 isoform X1 [KO:K12828]
120240160  SF3B2; splicing factor 3B subunit 2 isoform X1 [KO:K12829]
120224299  SF3B3; splicing factor 3B subunit 3 [KO:K12830]
120241305  SF3B4; splicing factor 3B subunit 4 [KO:K12831]
120231027  SF3B5; splicing factor 3B subunit 5 [KO:K12832]
120235840  SF3B6; splicing factor 3B subunit 6 [KO:K12833]
120233613  PHF5A; PHD finger-like domain-containing protein 5A [KO:K12834]
120234185  DDX42; ATP-dependent RNA helicase DDX42 [KO:K12835] [EC:5.6.2.7]
120243489  U2AF1L4; splicing factor U2AF 26 kDa subunit isoform X1 [KO:K12836]
120240662  U2AF1; splicing factor U2AF 35 kDa subunit isoform X1 [KO:K12836]
120239644  U2AF2; splicing factor U2AF 65 kDa subunit isoform X1 [KO:K12837]
120246523  PUF60; poly(U)-binding-splicing factor PUF60 isoform X1 [KO:K12838]
120244304  SMNDC1; survival of motor neuron-related-splicing factor 30 isoform X1 [KO:K12839]
120237191  RBM17; splicing factor 45 isoform X1 [KO:K12840]
120239246  calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841]
120221749  U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
120244561  retinitis pigmentosa 9 protein-like isoform X1 [KO:K19604]
120244564  RP9; retinitis pigmentosa 9 protein [KO:K19604]
120221889  LSM2; U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
120234728  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
120242844  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
120247150  LSM3; U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
120239218  LSM4; U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
120244556  LSM5; U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
120244816  U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
120246679  LSM6; U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
120242327  LSM7; U6 snRNA-associated Sm-like protein LSm7 isoform X1 [KO:K12626]
120222913  LSM8; LSM8 homolog, U6 small nuclear RNA associated [KO:K12627]
120241279  PRPF3; U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843]
120237253  PRPF4; U4/U6 small nuclear ribonucleoprotein Prp4 isoform X1 [KO:K12662]
120236101  PPIH; peptidyl-prolyl cis-trans isomerase H isoform X1 [KO:K09567] [EC:5.2.1.8]
120239727  PRPF31; U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
120233043  NHP2-like protein 1 [KO:K12845]
120235122  SNU13; NHP2-like protein 1 isoform X1 [KO:K12845]
120236633  SNRNP27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein isoform X1 [KO:K12846]
120220503  USP39; U4/U6.U5 tri-snRNP-associated protein 2 isoform X1 [KO:K12847]
120240203  SART1; U4/U6.U5 tri-snRNP-associated protein 1 isoform X1 [KO:K11984]
120245628  ZMAT2; zinc finger matrin-type protein 2 [KO:K12848]
120235949  PRPF38A; pre-mRNA-splicing factor 38A [KO:K12849]
120247170  PRPF38B; pre-mRNA-splicing factor 38B [KO:K12850]
120222274  EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component isoform X1 [KO:K12852]
120231570  SNRNP200; U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
120234919  PRPF6; pre-mRNA-processing factor 6 isoform X1 [KO:K12855]
120245888  PRPF8; pre-mRNA-processing-splicing factor 8 [KO:K12856]
120232087  SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
120223018  DDX23; probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
120240949  TXNL4A; thioredoxin-like protein 4A isoform X1 [KO:K12859]
120246197  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
120231224  CDC5L; cell division cycle 5-like protein [KO:K12860]
120243080  BCAS2; pre-mRNA-splicing factor SPF27 [KO:K12861]
120221630  PLRG1; pleiotropic regulator 1 isoform X1 [KO:K12862]
120228613  spliceosome-associated protein CWC15 homolog [KO:K12863]
120247193  CWC15; spliceosome-associated protein CWC15 homolog [KO:K12863]
120248014  spliceosome-associated protein CWC15 homolog [KO:K12863]
120228586  CTNNBL1; beta-catenin-like protein 1 [KO:K12864]
120227766  heat shock 70 kDa protein 1 [KO:K03283]
120220580  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
120240081  heat shock cognate 71 kDa protein-like [KO:K03283]
120221892  heat shock 70 kDa protein 1-like [KO:K03283]
120221893  heat shock 70 kDa protein 1 [KO:K03283]
120221952  heat shock cognate 71 kDa protein-like [KO:K03283]
120241045  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
120249032  heat shock cognate 71 kDa protein-like [KO:K03283]
120221022  PQBP1; polyglutamine-binding protein 1 [KO:K12865]
120236881  WBP11; WW domain-binding protein 11 [KO:K12866]
120231947  SNW1; SNW domain-containing protein 1 isoform X1 [KO:K06063]
120244884  XAB2; pre-mRNA-splicing factor SYF1 [KO:K12867]
120232646  SYF2; pre-mRNA-splicing factor SYF2 [KO:K12868]
120232669  pre-mRNA-splicing factor SYF2-like isoform X1 [KO:K12868]
120219751  CRNKL1; crooked neck-like protein 1 [KO:K12869]
120242697  ISY1; pre-mRNA-splicing factor ISY1 homolog isoform X1 [KO:K12870]
120233848  PPIL1; peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
120226390  PPIE; peptidyl-prolyl cis-trans isomerase E [KO:K09564] [EC:5.2.1.8]
120229378  CCDC12; coiled-coil domain-containing protein 12 isoform X1 [KO:K12871]
120236602  RBM22; pre-mRNA-splicing factor RBM22 [KO:K12872]
120227947  BUD31; protein BUD31 homolog [KO:K12873]
120241878  AQR; RNA helicase aquarius [KO:K12874]
120240438  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
120228203  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
120220714  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
120239131  protein mago nashi homolog [KO:K12877]
120235498  MAGOH; protein mago nashi homolog [KO:K12877]
120223859  MAGOHB; protein mago nashi homolog 2 [KO:K12877]
120220562  THOC1; THO complex subunit 1 [KO:K12878]
120236165  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
120236749  THOC3; THO complex subunit 3 [KO:K12880]
120228204  ALYREF; THO complex subunit 4 [KO:K12881]
120233492  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
120232659  NCBP2L; nuclear cap-binding protein subunit 2-like isoform X1 [KO:K12883]
120244358  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
120224441  heterogeneous nuclear ribonucleoprotein A3-like [KO:K12741]
120225229  heterogeneous nuclear ribonucleoprotein A1-like isoform X1 [KO:K12741]
120232949  heterogeneous nuclear ribonucleoprotein A3-like [KO:K12741]
120226848  heterogeneous nuclear ribonucleoprotein A1 [KO:K12741]
120228779  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
120241467  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
120222600  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 [KO:K12741]
120230823  heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741]
120230983  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
120236539  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
120231528  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
120236704  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
120246058  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
120240406  HNRNPC; heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1 [KO:K12884]
120220135  RBMX; RNA-binding motif protein, X chromosome isoform X1 [KO:K12885]
120244064  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
120244886  HNRNPM; heterogeneous nuclear ribonucleoprotein M isoform X1 [KO:K12887]
120235269  HNRNPU; heterogeneous nuclear ribonucleoprotein U isoform X1 [KO:K12888]
120236659  PCBP1; poly(rC)-binding protein 1 [KO:K12889]
120237759  SRSF1; serine/arginine-rich splicing factor 1 isoform X1 [KO:K12890]
120228091  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
120233808  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
120237416  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
120231214  SRSF4; serine/arginine-rich splicing factor 4 [KO:K12893]
120242597  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
120244625  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
120243519  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
120224786  TRA2A; transformer-2 protein homolog alpha [KO:K12897]
120238089  TRA2B; transformer-2 protein homolog beta [KO:K12897]
120233126  SRSF10; serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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