KEGG   PATHWAY: hrj00600
Entry
hrj00600                    Pathway                                
Name
Sphingolipid metabolism - Haliotis rubra (blacklip abalone)
Class
Metabolism; Lipid metabolism
Pathway map
hrj00600  Sphingolipid metabolism
hrj00600

Module
hrj_M00066  Lactosylceramide biosynthesis [PATH:hrj00600]
hrj_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:hrj00600]
hrj_M00094  Ceramide biosynthesis [PATH:hrj00600]
hrj_M00099  Sphingosine biosynthesis [PATH:hrj00600]
hrj_M00100  Sphingosine degradation [PATH:hrj00600]
Other DBs
GO: 0006665
Organism
Haliotis rubra (blacklip abalone) [GN:hrj]
Gene
124272816  serine palmitoyltransferase 1-like [KO:K00654] [EC:2.3.1.50]
124284458  serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]
124284459  serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]
124262202  3-ketodihydrosphingosine reductase-like [KO:K04708] [EC:1.1.1.102]
124276679  ceramide synthase 5-like [KO:K23727] [EC:2.3.1.291]
124276681  ceramide synthase 2-like [KO:K23727] [EC:2.3.1.291]
124273151  ceramide synthase 5-like [KO:K23727] [EC:2.3.1.291]
124272697  acid ceramidase-like [KO:K12348] [EC:3.5.1.23]
124272735  LOW QUALITY PROTEIN: acid ceramidase-like [KO:K12348] [EC:3.5.1.23]
124277903  neutral ceramidase-like [KO:K12349] [EC:3.5.1.23]
124283321  alkaline ceramidase 3-like [KO:K04711] [EC:3.5.1.-]
124279420  sphingolipid delta(4)-desaturase DES1-like [KO:K04712] [EC:1.14.19.17 1.14.18.5]
124258333  sphingolipid delta(4)-desaturase DES1-like [KO:K04712] [EC:1.14.19.17 1.14.18.5]
124277088  sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]
124277089  LOW QUALITY PROTEIN: sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]
124277090  LOW QUALITY PROTEIN: sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]
124282696  sphingomyelin phosphodiesterase A-like [KO:K12350] [EC:3.1.4.12]
124272200  sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]
124260941  LOW QUALITY PROTEIN: putative neutral sphingomyelinase [KO:K12351] [EC:3.1.4.12]
124268441  sphingomyelin phosphodiesterase 5-like [KO:K12352] [EC:3.1.4.12]
124253750  sphingomyelin phosphodiesterase 4-like isoform X1 [KO:K12353] [EC:3.1.4.12]
124277348  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
124277365  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
124254841  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
124254852  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
124255069  ceramide kinase-like isoform X1 [KO:K04715] [EC:2.7.1.138]
124269656  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
124269657  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
124269658  ceramide kinase-like isoform X1 [KO:K04715] [EC:2.7.1.138]
124272807  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
124272808  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
124256183  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
124256184  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
124281800  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
124281802  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
124281803  phospholipid phosphatase 3-like isoform X1 [KO:K01080] [EC:3.1.3.4]
124292513  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
124259585  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
124260105  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
124276789  sphingosine-1-phosphate phosphatase 2-like [KO:K04716] [EC:3.1.3.-]
124267147  sphingosine-1-phosphate phosphatase 1-like [KO:K04716] [EC:3.1.3.-]
124272727  ceramide phosphoethanolamine synthase-like [KO:K26283] [EC:2.7.8.48]
124274695  ceramide phosphoethanolamine synthase-like isoform X1 [KO:K26283] [EC:2.7.8.48]
124282272  LOW QUALITY PROTEIN: sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
124261393  sphingosine-1-phosphate lyase 1-like [KO:K01634] [EC:4.1.2.27]
124274207  LOW QUALITY PROTEIN: sphingosine-1-phosphate lyase-like [KO:K01634] [EC:4.1.2.27]
124289638  LOW QUALITY PROTEIN: ceramide glucosyltransferase-like [KO:K00720] [EC:2.4.1.80]
124256637  ceramide glucosyltransferase-like [KO:K00720] [EC:2.4.1.80]
124260052  ceramide glucosyltransferase-like [KO:K00720] [EC:2.4.1.80]
124255819  lysosomal acid glucosylceramidase-like isoform X1 [KO:K01201] [EC:3.2.1.45]
124271541  non-lysosomal glucosylceramidase-like [KO:K17108] [EC:3.2.1.45]
124286114  beta-N-acetyl-D-glucosaminide beta-1,4-N-acetylglucosaminyl-transferase-like [KO:K07553] [EC:2.4.1.274]
124252644  beta-N-acetyl-D-glucosaminide beta-1,4-N-acetylglucosaminyl-transferase-like [KO:K09905] [EC:2.4.1.274 2.4.1.-]
124278146  beta-galactosidase-like [KO:K12309] [EC:3.2.1.23]
124273131  beta-galactosidase-like [KO:K12309] [EC:3.2.1.23]
124273148  beta-galactosidase-like [KO:K12309] [EC:3.2.1.23]
124272888  UDP-glucuronosyltransferase 1A1-like [KO:K04628] [EC:2.4.1.47]
124267383  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
124280395  galactocerebrosidase-like isoform X1 [KO:K01202] [EC:3.2.1.46]
124258272  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
124258274  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
124258275  uncharacterized protein LOC124258275 [KO:K01202] [EC:3.2.1.46]
124258283  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
124258336  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
124258340  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
124258341  galactocerebrosidase-like isoform X1 [KO:K01202] [EC:3.2.1.46]
124258342  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
124258343  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
124258348  galactocerebrosidase-like isoform X1 [KO:K01202] [EC:3.2.1.46]
124258351  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
124258352  galactocerebrosidase-like isoform X1 [KO:K01202] [EC:3.2.1.46]
124258367  galactocerebrosidase-like isoform X1 [KO:K01202] [EC:3.2.1.46]
124258369  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
124258370  galactocerebrosidase-like isoform X1 [KO:K01202] [EC:3.2.1.46]
124258372  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
124258373  LOW QUALITY PROTEIN: galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
124264250  galactose-3-O-sulfotransferase 2-like [KO:K01019] [EC:2.8.2.11]
124276504  galactose-3-O-sulfotransferase 2-like [KO:K01019] [EC:2.8.2.11]
124276505  galactose-3-O-sulfotransferase 2-like [KO:K01019] [EC:2.8.2.11]
124276506  galactose-3-O-sulfotransferase 2-like [KO:K01019] [EC:2.8.2.11]
124277391  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
124267072  galactose-3-O-sulfotransferase 2-like [KO:K01019] [EC:2.8.2.11]
124279613  galactose-3-O-sulfotransferase 2-like [KO:K01019] [EC:2.8.2.11]
124290370  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
124270340  galactose-3-O-sulfotransferase 2-like [KO:K01019] [EC:2.8.2.11]
124261145  galactose-3-O-sulfotransferase 2-like [KO:K01019] [EC:2.8.2.11]
124274324  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
124252701  uncharacterized protein LOC124252701 [KO:K12373] [EC:3.2.1.52]
124253196  LOW QUALITY PROTEIN: beta-hexosaminidase subunit alpha-like [KO:K12373] [EC:3.2.1.52]
124255404  LOW QUALITY PROTEIN: beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
124267395  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
124267697  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
124268054  LOW QUALITY PROTEIN: chitobiase-like [KO:K12373] [EC:3.2.1.52]
124280272  LOW QUALITY PROTEIN: beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
124259963  uncharacterized protein LOC124259963 [KO:K12373] [EC:3.2.1.52]
124264264  ganglioside GM2 activator-like [KO:K12383]
124277600  ganglioside GM2 activator-like [KO:K12383]
124267462  ganglioside GM2 activator-like [KO:K12383]
124268026  ganglioside GM2 activator-like isoform X1 [KO:K12383]
124256465  ganglioside GM2 activator-like [KO:K12383]
124256528  uncharacterized protein LOC124256528 [KO:K12383]
124281260  ganglioside GM2 activator-like [KO:K12383]
124281261  ganglioside GM2 activator-like isoform X1 [KO:K12383]
124281296  ganglioside GM2 activator-like [KO:K12383]
124281623  ganglioside GM2 activator-like [KO:K12383]
124281634  ganglioside GM2 activator-like [KO:K12383]
124272244  ganglioside GM2 activator-like [KO:K12383]
124260094  ganglioside GM2 activator-like [KO:K12383]
124260119  ganglioside GM2 activator-like [KO:K12383]
124260624  ganglioside GM2 activator-like [KO:K12383]
124277160  uncharacterized protein LOC124277160 isoform X1 [KO:K12382]
124278435  prosaposin-like [KO:K12382]
124278437  prosaposin-like [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
hrj00260  Glycine, serine and threonine metabolism
hrj00601  Glycosphingolipid biosynthesis - lacto and neolacto series
hrj00603  Glycosphingolipid biosynthesis - globo and isoglobo series
hrj00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

DBGET integrated database retrieval system