KEGG   PATHWAY: hsyr00900
Entry
hsyr00900                   Pathway                                
Name
Terpenoid backbone biosynthesis - Hibiscus syriacus (Rose-of-Sharon)
Description
Terpenoids, also known as isoprenoids, are a large class of natural products consisting of isoprene (C5) units. There are two biosynthetic pathways, the mevalonate pathway [MD:M00095] and the non-mevalonate pathway or the MEP/DOXP pathway [MD:M00096], for the terpenoid building blocks: isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). The action of prenyltransferases then generates higher-order building blocks: geranyl diphosphate (GPP), farsenyl diphosphate (FPP), and geranylgeranyl diphosphate (GGPP), which are the precursors of monoterpenoids (C10), sesquiterpenoids (C15), and diterpenoids (C20), respectively. Condensation of these building blocks gives rise to the precursors of sterols (C30) and carotenoids (C40). The MEP/DOXP pathway is absent in higher animals and fungi, but in green plants the MEP/DOXP and mevalonate pathways co-exist in separate cellular compartments. The MEP/DOXP pathway, operating in the plastids, is responsible for the formation of essential oil monoterpenes and linalyl acetate, some sesquiterpenes, diterpenes, and carotenoids and phytol. The mevalonate pathway, operating in the cytosol, gives rise to triterpenes, sterols, and most sesquiterpenes.
Class
Metabolism; Metabolism of terpenoids and polyketides
Pathway map
hsyr00900  Terpenoid backbone biosynthesis
hsyr00900

Module
hsyr_M00095  C5 isoprenoid biosynthesis, mevalonate pathway [PATH:hsyr00900]
hsyr_M00096  C5 isoprenoid biosynthesis, non-mevalonate pathway [PATH:hsyr00900]
hsyr_M00366  C10-C20 isoprenoid biosynthesis, plants [PATH:hsyr00900]
Other DBs
GO: 0009240 0016091
Organism
Hibiscus syriacus (Rose-of-Sharon) [GN:hsyr]
Gene
120148853  probable 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic [KO:K01662] [EC:2.2.1.7]
120116502  probable 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic isoform X1 [KO:K01662] [EC:2.2.1.7]
120201867  probable 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic [KO:K01662] [EC:2.2.1.7]
120138093  probable 1-deoxy-D-xylulose-5-phosphate synthase 2, chloroplastic [KO:K01662] [EC:2.2.1.7]
120154736  probable 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic [KO:K01662] [EC:2.2.1.7]
120172560  probable 1-deoxy-D-xylulose-5-phosphate synthase 2, chloroplastic isoform X1 [KO:K01662] [EC:2.2.1.7]
120189678  probable 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic [KO:K01662] [EC:2.2.1.7]
120125535  probable 1-deoxy-D-xylulose-5-phosphate synthase 2, chloroplastic [KO:K01662] [EC:2.2.1.7]
120126706  probable 1-deoxy-D-xylulose-5-phosphate synthase 2, chloroplastic [KO:K01662] [EC:2.2.1.7]
120212031  probable 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic [KO:K01662] [EC:2.2.1.7]
120214032  1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic-like [KO:K00099] [EC:1.1.1.267]
120204581  1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic-like [KO:K00099] [EC:1.1.1.267]
120191883  1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic-like [KO:K00099] [EC:1.1.1.267]
120203939  2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic [KO:K00991] [EC:2.7.7.60]
120116426  4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, chloroplastic-like [KO:K00919] [EC:2.7.1.148]
120214323  2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, chloroplastic-like isoform X1 [KO:K01770] [EC:4.6.1.12]
120139944  2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, chloroplastic-like [KO:K01770] [EC:4.6.1.12]
120180682  4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic [KO:K03526] [EC:1.17.7.1 1.17.7.3]
120115355  4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic-like [KO:K03526] [EC:1.17.7.1 1.17.7.3]
120135008  4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic-like [KO:K03526] [EC:1.17.7.1 1.17.7.3]
120214925  4-hydroxy-3-methylbut-2-enyl diphosphate reductase, chloroplastic-like [KO:K03527] [EC:1.17.7.4]
120134722  4-hydroxy-3-methylbut-2-enyl diphosphate reductase, chloroplastic-like isoform X1 [KO:K03527] [EC:1.17.7.4]
120175571  4-hydroxy-3-methylbut-2-enyl diphosphate reductase, chloroplastic-like [KO:K03527] [EC:1.17.7.4]
120146929  acetyl-CoA acetyltransferase, cytosolic 1-like isoform X1 [KO:K00626] [EC:2.3.1.9]
120195848  probable acetyl-CoA acetyltransferase, cytosolic 2 [KO:K00626] [EC:2.3.1.9]
120133180  acetyl-CoA acetyltransferase, cytosolic 1-like isoform X1 [KO:K00626] [EC:2.3.1.9]
120166114  acetyl-CoA acetyltransferase, cytosolic 1 isoform X1 [KO:K00626] [EC:2.3.1.9]
120177154  acetyl-CoA acetyltransferase, cytosolic 1-like [KO:K00626] [EC:2.3.1.9]
120166888  hydroxymethylglutaryl-CoA synthase-like [KO:K01641] [EC:2.3.3.10]
120158534  hydroxymethylglutaryl-CoA synthase-like [KO:K01641] [EC:2.3.3.10]
120214975  3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like isoform X1 [KO:K00021] [EC:1.1.1.34]
120149648  3-hydroxy-3-methylglutaryl-coenzyme A reductase 2 [KO:K00021] [EC:1.1.1.34]
120133880  3-hydroxy-3-methylglutaryl-coenzyme A reductase 2-like [KO:K00021] [EC:1.1.1.34]
120151081  3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like [KO:K00021] [EC:1.1.1.34]
120153680  3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like [KO:K00021] [EC:1.1.1.34]
120171390  3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like [KO:K00021] [EC:1.1.1.34]
120171763  3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like [KO:K00021] [EC:1.1.1.34]
120188478  3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like [KO:K00021] [EC:1.1.1.34]
120123805  3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 [KO:K00021] [EC:1.1.1.34]
120175361  3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like [KO:K00021] [EC:1.1.1.34]
120128061  3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like [KO:K00021] [EC:1.1.1.34]
120160409  3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like isoform X1 [KO:K00021] [EC:1.1.1.34]
120161963  3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like [KO:K00021] [EC:1.1.1.34]
120178064  3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like [KO:K00021] [EC:1.1.1.34]
120178707  3-hydroxy-3-methylglutaryl-coenzyme A reductase 2-like [KO:K00021] [EC:1.1.1.34]
120115762  mevalonate kinase-like [KO:K00869] [EC:2.7.1.36]
120178740  mevalonate kinase-like [KO:K00869] [EC:2.7.1.36]
120215715  phosphomevalonate kinase, peroxisomal-like [KO:K00938] [EC:2.7.4.2]
120187189  phosphomevalonate kinase, peroxisomal-like isoform X1 [KO:K00938] [EC:2.7.4.2]
120174339  phosphomevalonate kinase, peroxisomal-like isoform X1 [KO:K00938] [EC:2.7.4.2]
120141965  phosphomevalonate kinase, peroxisomal-like isoform X1 [KO:K00938] [EC:2.7.4.2]
120123436  diphosphomevalonate decarboxylase MVD2, peroxisomal-like [KO:K01597] [EC:4.1.1.33]
120161786  diphosphomevalonate decarboxylase MVD2, peroxisomal-like [KO:K01597] [EC:4.1.1.33]
120118198  isopentenyl phosphate kinase-like [KO:K06981] [EC:2.7.4.26]
120170909  isopentenyl phosphate kinase-like [KO:K06981] [EC:2.7.4.26]
120116104  isopentenyl-diphosphate Delta-isomerase I-like [KO:K01823] [EC:5.3.3.2]
120174120  isopentenyl-diphosphate Delta-isomerase II-like [KO:K01823] [EC:5.3.3.2]
120177595  isopentenyl-diphosphate Delta-isomerase I-like [KO:K01823] [EC:5.3.3.2]
120129513  farnesyl pyrophosphate synthase 1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
120114650  farnesyl pyrophosphate synthase 1-like [KO:K00787] [EC:2.5.1.1 2.5.1.10]
120197799  farnesyl pyrophosphate synthase [KO:K00787] [EC:2.5.1.1 2.5.1.10]
120157826  farnesyl pyrophosphate synthase-like isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
120190617  farnesyl pyrophosphate synthase 1-like isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
120129638  solanesyl-diphosphate synthase 1, mitochondrial-like [KO:K14066] [EC:2.5.1.1]
120114060  solanesyl diphosphate synthase 3, chloroplastic/mitochondrial-like [KO:K14066] [EC:2.5.1.1]
120217302  LOW QUALITY PROTEIN: solanesyl diphosphate synthase 3, chloroplastic/mitochondrial-like [KO:K14066] [EC:2.5.1.1]
120151244  solanesyl diphosphate synthase 3, chloroplastic/mitochondrial-like isoform X1 [KO:K14066] [EC:2.5.1.1]
120169985  solanesyl diphosphate synthase 3, chloroplastic/mitochondrial-like isoform X1 [KO:K14066] [EC:2.5.1.1]
120137581  solanesyl diphosphate synthase 3, chloroplastic/mitochondrial-like [KO:K14066] [EC:2.5.1.1]
120144954  solanesyl-diphosphate synthase 1, mitochondrial-like isoform X1 [KO:K14066] [EC:2.5.1.1]
120196579  geranylgeranyl pyrophosphate synthase, chloroplastic-like [KO:K13789] [EC:2.5.1.1 2.5.1.10 2.5.1.29]
120181334  geranylgeranyl pyrophosphate synthase, chloroplastic-like [KO:K13789] [EC:2.5.1.1 2.5.1.10 2.5.1.29]
120200256  geranylgeranyl pyrophosphate synthase, chloroplastic-like [KO:K13789] [EC:2.5.1.1 2.5.1.10 2.5.1.29]
120134600  heterodimeric geranylgeranyl pyrophosphate synthase small subunit, chloroplastic-like [KO:K13789] [EC:2.5.1.1 2.5.1.10 2.5.1.29]
120202434  heterodimeric geranylgeranyl pyrophosphate synthase small subunit, chloroplastic-like [KO:K13789] [EC:2.5.1.1 2.5.1.10 2.5.1.29]
120169633  geranylgeranyl pyrophosphate synthase, chloroplastic-like [KO:K13789] [EC:2.5.1.1 2.5.1.10 2.5.1.29]
120137893  geranylgeranyl pyrophosphate synthase, chloroplastic-like [KO:K13789] [EC:2.5.1.1 2.5.1.10 2.5.1.29]
120140772  geranylgeranyl pyrophosphate synthase, chloroplastic-like [KO:K13789] [EC:2.5.1.1 2.5.1.10 2.5.1.29]
120159642  geranylgeranyl pyrophosphate synthase, chloroplastic-like [KO:K13789] [EC:2.5.1.1 2.5.1.10 2.5.1.29]
120145156  heterodimeric geranylgeranyl pyrophosphate synthase small subunit, chloroplastic-like [KO:K13789] [EC:2.5.1.1 2.5.1.10 2.5.1.29]
120162503  solanesyl diphosphate synthase 1, chloroplastic-like [KO:K05356] [EC:2.5.1.84 2.5.1.85]
120164653  solanesyl diphosphate synthase 1, chloroplastic-like [KO:K05356] [EC:2.5.1.84 2.5.1.85]
120123256  solanesyl diphosphate synthase 1, chloroplastic-like [KO:K05356] [EC:2.5.1.84 2.5.1.85]
120131052  LOW QUALITY PROTEIN: dehydrodolichyl diphosphate synthase CPT3-like [KO:K11778] [EC:2.5.1.87]
120149655  dehydrodolichyl diphosphate synthase complex subunit nus1-like [KO:K11778] [EC:2.5.1.87]
120134451  uncharacterized protein LOC120134451 isoform X1 [KO:K11778] [EC:2.5.1.87]
120200226  dehydrodolichyl diphosphate synthase CPT3-like [KO:K11778] [EC:2.5.1.87]
120135596  cis-prenyltransferase 4, chloroplastic-like [KO:K11778] [EC:2.5.1.87]
120167969  dehydrodolichyl diphosphate synthase 2-like [KO:K11778] [EC:2.5.1.87]
120120577  dehydrodolichyl diphosphate synthase complex subunit NUS1-like isoform X1 [KO:K11778] [EC:2.5.1.87]
120142043  dehydrodolichyl diphosphate synthase 2-like [KO:K11778] [EC:2.5.1.87]
120142858  dehydrodolichyl diphosphate synthase CPT3-like [KO:K11778] [EC:2.5.1.87]
120208816  dehydrodolichyl diphosphate synthase CPT3-like [KO:K11778] [EC:2.5.1.87]
120209672  dehydrodolichyl diphosphate synthase CPT3-like [KO:K11778] [EC:2.5.1.87]
120144052  LOW QUALITY PROTEIN: dehydrodolichyl diphosphate synthase 2-like [KO:K11778] [EC:2.5.1.87]
120144493  dehydrodolichyl diphosphate synthase complex subunit NUS1-like [KO:K11778] [EC:2.5.1.87]
120129302  dehydrodolichyl diphosphate synthase CPT3-like [KO:K11778] [EC:2.5.1.87]
120168859  geranylgeranyl diphosphate reductase, chloroplastic-like [KO:K10960] [EC:1.3.1.83 1.3.1.111]
120142800  geranylgeranyl diphosphate reductase, chloroplastic-like [KO:K10960] [EC:1.3.1.83 1.3.1.111]
120158728  geranylgeranyl diphosphate reductase, chloroplastic-like [KO:K10960] [EC:1.3.1.83 1.3.1.111]
120150919  probable terpene synthase 12 [KO:K12742] [EC:4.2.3.27]
120150921  probable terpene synthase 12 [KO:K12742] [EC:4.2.3.27]
120137220  probable terpene synthase 12 [KO:K12742] [EC:4.2.3.27]
120142667  probable terpene synthase 12 [KO:K12742] [EC:4.2.3.27]
120180767  protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha-like [KO:K05955] [EC:2.5.1.58 2.5.1.59]
120219104  protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha-like [KO:K05955] [EC:2.5.1.58 2.5.1.59]
120157720  protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha-like [KO:K05955] [EC:2.5.1.58 2.5.1.59]
120157728  protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha-like [KO:K05955] [EC:2.5.1.58 2.5.1.59]
120207977  LOW QUALITY PROTEIN: protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha-like [KO:K05955] [EC:2.5.1.58 2.5.1.59]
120212900  protein farnesyltransferase subunit beta-like [KO:K05954] [EC:2.5.1.58]
120123643  protein farnesyltransferase subunit beta-like [KO:K05954] [EC:2.5.1.58]
120180864  CAAX prenyl protease 2-like [KO:K08658] [EC:3.4.26.1]
120181051  CAAX prenyl protease 2-like [KO:K08658] [EC:3.4.26.1]
120188080  CAAX prenyl protease 2-like [KO:K08658] [EC:3.4.26.1]
120142986  CAAX prenyl protease 2-like [KO:K08658] [EC:3.4.26.1]
120132907  CAAX prenyl protease 1 homolog [KO:K06013] [EC:3.4.24.84]
120136329  CAAX prenyl protease 1 homolog [KO:K06013] [EC:3.4.24.84]
120141084  CAAX prenyl protease 1 homolog [KO:K06013] [EC:3.4.24.84]
120208085  CAAX prenyl protease 1 homolog [KO:K06013] [EC:3.4.24.84]
120212430  protein-S-isoprenylcysteine O-methyltransferase A-like [KO:K00587] [EC:2.1.1.100]
120199694  protein-S-isoprenylcysteine O-methyltransferase B-like isoform X1 [KO:K00587] [EC:2.1.1.100]
120186796  protein-S-isoprenylcysteine O-methyltransferase A-like [KO:K00587] [EC:2.1.1.100]
120143878  protein-S-isoprenylcysteine O-methyltransferase A-like [KO:K00587] [EC:2.1.1.100]
120203360  probable isoprenylcysteine alpha-carbonyl methylesterase ICMEL1 [KO:K15889] [EC:3.1.1.-]
120120953  probable isoprenylcysteine alpha-carbonyl methylesterase ICMEL2 isoform X1 [KO:K15889] [EC:3.1.1.-]
120171079  probable isoprenylcysteine alpha-carbonyl methylesterase ICMEL2 isoform X1 [KO:K15889] [EC:3.1.1.-]
120161315  isoprenylcysteine alpha-carbonyl methylesterase ICME-like isoform X1 [KO:K15889] [EC:3.1.1.-]
120147469  farnesylcysteine lyase-like [KO:K05906] [EC:1.8.3.5 1.8.3.6]
120144865  farnesylcysteine lyase [KO:K05906] [EC:1.8.3.5 1.8.3.6]
120190845  putative dihydroflavonol 4-reductase [KO:K15891] [EC:1.1.1.354]
120148215  probable phytol kinase 3, chloroplastic [KO:K15892] [EC:2.7.1.216]
120185589  probable phytol kinase 3, chloroplastic [KO:K15892] [EC:2.7.1.216]
120161781  probable phytol kinase 3, chloroplastic isoform X1 [KO:K15892] [EC:2.7.1.216]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00118  D-Glyceraldehyde 3-phosphate
C00129  Isopentenyl diphosphate
C00235  Dimethylallyl diphosphate
C00332  Acetoacetyl-CoA
C00341  Geranyl diphosphate
C00353  Geranylgeranyl diphosphate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00418  (R)-Mevalonate
C00448  trans,trans-Farnesyl diphosphate
C01107  (R)-5-Phosphomevalonate
C01126  (2E,6E)-Farnesol
C01143  (R)-5-Diphosphomevalonate
C01230  all-trans-Hexaprenyl diphosphate
C02321  cis-1,4-Polyisoprene
C03461  2-trans,6-trans-Farnesal
C04145  all-trans-Nonaprenyl diphosphate
C04146  all-trans-Octaprenyl diphosphate
C04216  all-trans-Heptaprenyl diphosphate
C04506  Protein C-terminal S-farnesyl-L-cysteine
C04574  di-trans,poly-cis-Undecaprenyl diphosphate
C04748  Protein C-terminal S-farnesyl-L-cysteine methyl ester
C05427  Phytyl diphosphate
C05859  ditrans,polycis-Polyprenyl diphosphate
C06081  Polyprenol
C11434  2-C-Methyl-D-erythritol 4-phosphate
C11435  4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol
C11436  2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
C11437  1-Deoxy-D-xylulose 5-phosphate
C11453  2-C-Methyl-D-erythritol 2,4-cyclodiphosphate
C11811  1-Hydroxy-2-methyl-2-butenyl 4-diphosphate
C16521  Isoprene
C16826  2-cis,6-trans-Farnesyl diphosphate
C17432  all-trans-Decaprenyl diphosphate
C18321  trans,octacis-Decaprenyl diphosphate
C19691  Farnesylcysteine
C19760  2-cis,6-cis-Farnesyl diphosphate
C19852  tritrans,heptacis-Undecaprenyl diphosphate
C19853  trans,polycis-Polyprenyl diphosphate
C20120  S-Farnesyl protein
C20121  trans,trans-Farnesyl phosphate
C20345  Isopentenyl phosphate
C20847  (R)-Mevalonate 3-phosphate
C20848  (R)-Mevalonate 3,5-bisphosphate
C22453  trans-Anhydromevalonate 5-phosphate
Reference
PMID:12777052
  Authors
Lange BM, Ghassemian M.
  Title
Genome organization in Arabidopsis thaliana: a survey for genes involved in isoprenoid and chlorophyll metabolism.
  Journal
Plant Mol Biol 51:925-48 (2003)
DOI:10.1023/A:1023005504702
Reference
PMID:16262699
  Authors
Saiki R, Nagata A, Kainou T, Matsuda H, Kawamukai M
  Title
Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans.
  Journal
FEBS J 272:5606-22 (2005)
DOI:10.1111/j.1742-4658.2005.04956.x
Reference
PMID:9858571
  Authors
Sato M, Sato K, Nishikawa S, Hirata A, Kato J, Nakano A
  Title
The yeast RER2 gene, identified by endoplasmic reticulum protein localization mutations, encodes cis-prenyltransferase, a key enzyme in dolichol synthesis.
  Journal
Mol Cell Biol 19:471-83 (1999)
DOI:10.1128/MCB.19.1.471
Reference
PMID:24375100
  Authors
Vannice JC, Skaff DA, Keightley A, Addo JK, Wyckoff GJ, Miziorko HM
  Title
Identification in Haloferax volcanii of phosphomevalonate decarboxylase and isopentenyl phosphate kinase as catalysts of the terminal enzyme reactions in an  archaeal alternate mevalonate pathway.
  Journal
J Bacteriol 196:1055-63 (2014)
DOI:10.1128/JB.01230-13
Related
pathway
hsyr00010  Glycolysis / Gluconeogenesis
hsyr00100  Steroid biosynthesis
hsyr00130  Ubiquinone and other terpenoid-quinone biosynthesis
hsyr00270  Cysteine and methionine metabolism
hsyr00510  N-Glycan biosynthesis
hsyr00902  Monoterpenoid biosynthesis
hsyr00904  Diterpenoid biosynthesis
hsyr00906  Carotenoid biosynthesis
hsyr00908  Zeatin biosynthesis
hsyr00909  Sesquiterpenoid and triterpenoid biosynthesis
KO pathway
ko00900   
LinkDB

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