KEGG   PATHWAY: kmr00260
Entry
kmr00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Kryptolebias marmoratus (mangrove rivulus)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
kmr00260  Glycine, serine and threonine metabolism
kmr00260

Module
kmr_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:kmr00260]
kmr_M00047  Creatine pathway [PATH:kmr00260]
kmr_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:kmr00260]
kmr_M00555  Betaine biosynthesis, choline => betaine [PATH:kmr00260]
kmr_M00621  Glycine cleavage system [PATH:kmr00260]
kmr_M00974  Betaine metabolism, animals, betaine => glycine [PATH:kmr00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Kryptolebias marmoratus (mangrove rivulus) [GN:kmr]
Gene
108247518  tha1; threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
108231703  shmt2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
108236695  serine hydroxymethyltransferase, mitochondrial-like [KO:K00600] [EC:2.1.2.1]
108236091  serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
108236240  serine hydroxymethyltransferase, cytosolic-like isoform X2 [KO:K00600] [EC:2.1.2.1]
108241174  agxta; alanine--glyoxylate and serine--pyruvate aminotransferase a [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
108239569  agxtb; alanine--glyoxylate and serine--pyruvate aminotransferase b [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
108231960  grhprb; glyoxylate reductase/hydroxypyruvate reductase b [KO:K00049] [EC:1.1.1.79 1.1.1.81]
108242403  grhpra; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
108231114  glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]
108242709  phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
108232557  pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
108247963  pgam1b; phosphoglycerate mutase 1b [KO:K01834] [EC:5.4.2.11]
108229885  bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
108240723  phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
108233654  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
108246047  psph; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
108236093  gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial isoform X1 [KO:K00639] [EC:2.3.1.29]
108233578  tdh2; L-threonine dehydrogenase 2 [KO:K15789] [EC:1.1.1.103]
108242421  tdh; L-threonine dehydrogenase [KO:K15789] [EC:1.1.1.103]
108231470  alas1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
108236847  alas2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
108241385  si:ch211-127i16.2; probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
108243545  mao; amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
108245363  aoc2; retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
108233712  gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
108233041  amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
108250022  dldh; dihydrolipoyl dehydrogenase, mitochondrial isoform X1 [KO:K00382] [EC:1.8.1.4]
108250842  gcshb; glycine cleavage system protein H (aminomethyl carrier), b [KO:K02437]
108230145  glycine cleavage system H protein, mitochondrial [KO:K02437]
108234641  D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
108231105  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
108251614  gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
108234267  gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
108236777  chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
108230647  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
108233717  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
108233718  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
108251296  bhmt; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
108251297  dmgdh; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
108245341  pipox; peroxisomal sarcosine oxidase isoform X2 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
108232690  sardh; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
108246999  gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
108244998  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
108232423  cbsb; cystathionine beta-synthase b [KO:K01697] [EC:4.2.1.22]
108234240  cth; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
108251486  L-threo-3-hydroxyaspartate ammonia-lyase [KO:K01754] [EC:4.3.1.19]
108247004  sdsl; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
108236463  L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
108238630  zgc:162816; D-threo-3-hydroxyaspartate dehydratase [KO:K20498] [EC:4.3.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
kmr00010  Glycolysis / Gluconeogenesis
kmr00020  Citrate cycle (TCA cycle)
kmr00230  Purine metabolism
kmr00250  Alanine, aspartate and glutamate metabolism
kmr00270  Cysteine and methionine metabolism
kmr00290  Valine, leucine and isoleucine biosynthesis
kmr00330  Arginine and proline metabolism
kmr00470  D-Amino acid metabolism
kmr00564  Glycerophospholipid metabolism
kmr00600  Sphingolipid metabolism
kmr00620  Pyruvate metabolism
kmr00630  Glyoxylate and dicarboxylate metabolism
kmr00640  Propanoate metabolism
kmr00860  Porphyrin metabolism
kmr00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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