KEGG   PATHWAY: ldi04115
Entry
ldi04115                    Pathway                                
Name
p53 signaling pathway - Leptosomus discolor (cuckoo roller)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
ldi04115  p53 signaling pathway
ldi04115

Organism
Leptosomus discolor (cuckoo roller) [GN:ldi]
Gene
104348694  LOW QUALITY PROTEIN: serine-protein kinase ATM-like [KO:K04728] [EC:2.7.11.1]
104339794  CHEK2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
104355056  ATR; LOW QUALITY PROTEIN: serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
104351417  GORAB; RAB6-interacting golgin [KO:K19748]
104344817  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
104350272  MDM4; LOW QUALITY PROTEIN: protein Mdm4 [KO:K10127]
104351310  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
104351847  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
104341693  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
104341678  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
104352406  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
104350804  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
104341086  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
104352699  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
104341257  SFN; 14-3-3 protein sigma [KO:K06644]
104340052  RPRM; protein reprimo [KO:K10128]
104351726  G2/mitotic-specific cyclin-B1-like [KO:K05868]
104339792  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
104347429  CDK1; cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
104343232  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
104343790  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
104341043  GTSE1; G2 and S phase-expressed protein 1 [KO:K10129]
104348736  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
104340089  p53-induced death domain-containing protein 1-like [KO:K10130]
104346345  caspase-8-like [KO:K04398] [EC:3.4.22.61]
104342577  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
104342311  BID; BH3-interacting domain death agonist [KO:K04726]
104353448  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
104354129  SIVA1; apoptosis regulatory protein Siva [KO:K22744]
104350966  BCL2L1; bcl-2-like protein 1 [KO:K04570]
104348269  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
104347643  TP53I3; quinone oxidoreductase PIG3 [KO:K10133] [EC:1.-.-.-]
104342188  SHISA5; LOW QUALITY PROTEIN: protein shisa-5 [KO:K10135]
104344454  PERP; p53 apoptosis effector related to PMP-22 [KO:K10136]
104340861  ZMAT3; zinc finger matrin-type protein 3 [KO:K10137]
104347383  SIAH1; E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:2.3.2.27]
104343575  cytochrome c, somatic-like [KO:K08738]
104343718  cytochrome c [KO:K08738]
104352978  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
104353970  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
104353695  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
104353491  AIFM2; LOW QUALITY PROTEIN: apoptosis-inducing factor 2 [KO:K22745]
104345759  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
104352212  IGF1; insulin-like growth factor I [KO:K05459]
104354286  CD82; CD82 antigen [KO:K06509]
104347809  THBS1; thrombospondin-1 [KO:K16857]
104346850  SERPINB5; serpin B5 [KO:K10139]
104341105  DNA damage-binding protein 2 [KO:K10140]
104340873  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
104343208  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
104353254  SESN3; sestrin-3 [KO:K10141]
104341581  sestrin-3-like [KO:K10141]
104345454  SESN1; sestrin-1 [KO:K10141]
104342262  SESN2; LOW QUALITY PROTEIN: sestrin-2 [KO:K20394]
104352410  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
104352218  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
104340871  STEAP3; metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
104348683  RFWD2; E3 ubiquitin-protein ligase RFWD2 [KO:K10143] [EC:2.3.2.27]
104354453  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
104340981  CCNG1; cyclin-G1 [KO:K10145]
104347784  CCNG2; cyclin-G2 [KO:K10146]
104341176  PPM1D; protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
104343844  TP73; LOW QUALITY PROTEIN: tumor protein p73 [KO:K10148]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
ldi04110  Cell cycle
ldi04210  Apoptosis
ldi04218  Cellular senescence
KO pathway
ko04115   
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