Entry
Name
p53 signaling pathway
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
BRITE hierarchy
Pathway map
Ortholog table
Orthology
K19748 RAB6-interacting golgin
K06621 cyclin-dependent kinase inhibitor 2A
K27356 RelA-associated inhibitor
K06625 cyclin-dependent kinase inhibitor 1A
K04503 G1/S-specific cyclin-D1
K10151 G1/S-specific cyclin-D2
K10152 G1/S-specific cyclin-D3
K06626 G1/S-specific cyclin-E1
K10128 reprimo, TP53-dependent G2 arrest mediator candidate
K05868 G2/mitotic-specific cyclin-B1
K21770 G2/mitotic-specific cyclin-B2
K04402 growth arrest and DNA-damage-inducible protein
K10129 G-2 and S-phase expressed protein 1
K26543 zinc finger protein 385A
K04390 tumor necrosis factor receptor superfamily member 6
K10130 leucine-rich repeats and death domain-containing protein
K04722 tumor necrosis factor receptor superfamily member 10A/B
K04726 BH3 interacting domain death agonist
K02159 apoptosis regulator BAX
K10131 phorbol-12-myristate-13-acetate-induced protein 1
K10132 Bcl-2-binding component 3
K13773 p53-regulated apoptosis-inducing protein 1
K22744 apoptosis regulatory protein Siva
K04570 Bcl-2-like 1 (apoptosis regulator Bcl-X)
K02161 apoptosis regulator Bcl-2
K10133 tumor protein p53-inducible protein 3 [EC:1.-.-.-]
K10134 etoposide-induced 2.4 mRNA
K10136 TP53 apoptosis effector
K10137 zinc finger, matrin type 3
K02084 apoptotic protease-activating factor
K22745 apoptosis-inducing factor 2
K10138 insulin-like growth factor-binding protein 3
K05459 insulin-like growth factor 1
K03982 plasminogen activator inhibitor 1
K04596 adhesion G protein-coupled receptor B1
K10140 DNA damage-binding protein 2
K10142 metalloreductase STEAP3 [EC:1.16.1.-]
K10144 RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27 ]
Reference
Authors
Levine AJ, Hu W, Feng Z.
Title
The P53 pathway: what questions remain to be explored?
Journal
Reference
Authors
Harris SL, Levine AJ.
Title
The p53 pathway: positive and negative feedback loops.
Journal
Reference
Authors
Balint E E, Vousden KH.
Title
Activation and activities of the p53 tumour suppressor protein.
Journal
Reference
Authors
Taylor WR, Stark GR.
Title
Regulation of the G2/M transition by p53.
Journal
Reference
Authors
Hofseth LJ, Hussain SP, Harris CC.
Title
p53: 25 years after its discovery.
Journal
Reference
Authors
Pietenpol JA, Stewart ZA.
Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
Journal
Reference
Authors
Tokino T, Nakamura Y.
Title
The role of p53-target genes in human cancer.
Journal
Reference
Authors
Hermeking H, Benzinger A.
Title
14-3-3 proteins in cell cycle regulation.
Journal
Reference
Authors
Sherr CJ.
Title
Divorcing ARF and p53: an unsettled case.
Journal
Reference
Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
Journal
Reference
Authors
Resnick-Silverman L, Manfredi JJ
Title
Two Faces of SIVA.
Journal
Reference
Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
Journal
Reference
Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
Journal
Reference
Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
Journal
Reference
Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
Journal
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