KEGG   PATHWAY: lpic00600
Entry
lpic00600                   Pathway                                
Name
Sphingolipid metabolism - Lytechinus pictus (painted urchin)
Class
Metabolism; Lipid metabolism
Pathway map
lpic00600  Sphingolipid metabolism
lpic00600

Module
lpic_M00066  Lactosylceramide biosynthesis [PATH:lpic00600]
lpic_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:lpic00600]
lpic_M00100  Sphingosine degradation [PATH:lpic00600]
Other DBs
GO: 0006665
Organism
Lytechinus pictus (painted urchin) [GN:lpic]
Gene
129264288  serine palmitoyltransferase 2-like isoform X1 [KO:K00654] [EC:2.3.1.50]
129271079  LOW QUALITY PROTEIN: serine palmitoyltransferase 1-like [KO:K00654] [EC:2.3.1.50]
129255359  ceramide synthase 1-like [KO:K04710] [EC:2.3.1.299]
129260098  acid ceramidase-like [KO:K12348] [EC:3.5.1.23]
129262054  acid ceramidase-like [KO:K12348] [EC:3.5.1.23]
129282054  putative neutral ceramidase C [KO:K12349] [EC:3.5.1.23]
129282175  uncharacterized protein LOC129282175 [KO:K12349] [EC:3.5.1.23]
129282245  uncharacterized protein LOC129282245 [KO:K12349] [EC:3.5.1.23]
129262341  alkaline ceramidase 2-like [KO:K01441] [EC:3.5.1.23]
129279638  alkaline ceramidase 3-like [KO:K04711] [EC:3.5.1.-]
129264452  sphingolipid delta(4)-desaturase DES1-like [KO:K04712] [EC:1.14.19.17 1.14.18.5]
129256290  LOW QUALITY PROTEIN: sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]
129282421  putative neutral sphingomyelinase isoform X1 [KO:K12351] [EC:3.1.4.12]
129282597  putative neutral sphingomyelinase [KO:K12351] [EC:3.1.4.12]
129270780  sphingomyelin phosphodiesterase 5-like [KO:K12352] [EC:3.1.4.12]
129254386  sphingomyelin phosphodiesterase 4-like isoform X1 [KO:K12353] [EC:3.1.4.12]
129280227  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
129280230  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
129280809  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
129255976  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
129253540  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
129282982  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
129273538  sphingosine-1-phosphate phosphatase 2-like [KO:K04717] [EC:3.1.3.-]
129269183  LOW QUALITY PROTEIN: sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
129269184  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
129281171  sphingosine-1-phosphate lyase 1-like [KO:K01634] [EC:4.1.2.27]
129281215  sphingosine-1-phosphate lyase 1-like [KO:K01634] [EC:4.1.2.27]
129281216  sphingosine-1-phosphate lyase 1-like [KO:K01634] [EC:4.1.2.27]
129271183  ceramide glucosyltransferase-B-like [KO:K00720] [EC:2.4.1.80]
129262261  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
129262262  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
129260305  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
129260977  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
129260978  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
129261578  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
129262433  non-lysosomal glucosylceramidase-like [KO:K17108] [EC:3.2.1.45]
129278705  beta-1,4-galactosyltransferase 6-like [KO:K07553] [EC:2.4.1.274]
129275084  beta-1,4-galactosyltransferase 5-like isoform X1 [KO:K09905] [EC:2.4.1.274 2.4.1.-]
129268268  beta-1,4-galactosyltransferase 5-like isoform X1 [KO:K09905] [EC:2.4.1.274 2.4.1.-]
129272964  beta-1,4-galactosyltransferase 5-like [KO:K09905] [EC:2.4.1.274 2.4.1.-]
129275196  LOW QUALITY PROTEIN: beta-galactosidase-like [KO:K12309] [EC:3.2.1.23]
129274234  beta-galactosidase-like [KO:K12309] [EC:3.2.1.23]
129274651  UDP-glucuronosyltransferase 2C1-like [KO:K04628] [EC:2.4.1.47]
129273666  galactocerebrosidase-like isoform X1 [KO:K01202] [EC:3.2.1.46]
129262993  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
129263095  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
129276157  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
129266224  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
129278523  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
129255019  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
129266437  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
129266544  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
129266873  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
129266877  LOW QUALITY PROTEIN: galactose-3-O-sulfotransferase 2-like [KO:K01019] [EC:2.8.2.11]
129267013  LOW QUALITY PROTEIN: galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
129279356  galactosylceramide sulfotransferase-like isoform X1 [KO:K01019] [EC:2.8.2.11]
129255832  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
129255980  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
129281203  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
129281292  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
129258500  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
129282383  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
129282471  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
129282870  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
129259104  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
129262210  arylsulfatase-like [KO:K01134] [EC:3.1.6.8]
129254127  arylsulfatase A-like [KO:K01134] [EC:3.1.6.8]
129254715  arylsulfatase A-like [KO:K01134] [EC:3.1.6.8]
129257413  arylsulfatase A-like [KO:K01134] [EC:3.1.6.8]
129257414  arylsulfatase A-like [KO:K01134] [EC:3.1.6.8]
129271238  arylsulfatase A-like [KO:K01134] [EC:3.1.6.8]
129260532  arylsulfatase-like [KO:K01134] [EC:3.1.6.8]
129261152  arylsulfatase-like [KO:K01134] [EC:3.1.6.8]
129262073  arylsulfatase-like [KO:K01134] [EC:3.1.6.8]
129262077  arylsulfatase-like isoform X1 [KO:K01134] [EC:3.1.6.8]
129278282  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
129278561  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
129279355  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
129279611  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
129279655  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
129279692  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
129283258  sialidase-4-like [KO:K12357] [EC:3.2.1.18]
129262378  beta-hexosaminidase subunit alpha-like isoform X1 [KO:K12373] [EC:3.2.1.52]
129262383  LOW QUALITY PROTEIN: beta-hexosaminidase subunit alpha-like [KO:K12373] [EC:3.2.1.52]
129282407  uncharacterized protein LOC129282407 [KO:K12383]
129261073  ganglioside GM2 activator-like [KO:K12383]
129282117  prosaposin-like [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
lpic00260  Glycine, serine and threonine metabolism
lpic00601  Glycosphingolipid biosynthesis - lacto and neolacto series
lpic00603  Glycosphingolipid biosynthesis - globo and isoglobo series
lpic00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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