KEGG   PATHWAY: lruf00270
Entry
lruf00270                   Pathway                                
Name
Cysteine and methionine metabolism - Lynx rufus (bobcat)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
lruf00270  Cysteine and methionine metabolism
lruf00270

Module
lruf_M00034  Methionine salvage pathway [PATH:lruf00270]
lruf_M00035  Methionine degradation [PATH:lruf00270]
lruf_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:lruf00270]
Other DBs
GO: 0006534 0006555
Organism
Lynx rufus (bobcat) [GN:lruf]
Gene
124515354  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
124504917  kynurenine--oxoglutarate transaminase 1 isoform X1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
124515192  kynurenine--oxoglutarate transaminase 3 isoform X1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
124526607  cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]
124504614  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
124504513  S-methylmethionine--homocysteine S-methyltransferase BHMT2 [KO:K00547] [EC:2.1.1.10]
124518627  methionine synthase isoform X1 [KO:K00548] [EC:2.1.1.13]
124520486  methionine adenosyltransferase 2 subunit beta isoform X1 [KO:K00789] [EC:2.5.1.6]
124506813  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
124503020  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
124528242  S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
124515768  LOW QUALITY PROTEIN: S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
124516173  spermidine synthase [KO:K00797] [EC:2.5.1.16]
124509410  spermine synthase [KO:K00802] [EC:2.5.1.22]
124501059  S-methyl-5'-thioadenosine phosphorylase isoform X1 [KO:K00772] [EC:2.4.2.28]
124512522  purine nucleoside phosphorylase LACC1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
124524513  methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
124506280  methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]
124520131  enolase-phosphatase E1 [KO:K09880] [EC:3.1.3.77]
124503802  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]
124511945  tyrosine aminotransferase [KO:K00815] [EC:2.6.1.5]
124510891  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
124514368  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
124528630  glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
124523703  DNA (cytosine-5)-methyltransferase 1 isoform X1 [KO:K00558] [EC:2.1.1.37]
124503063  DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
124504049  DNA (cytosine-5)-methyltransferase 3B [KO:K17399] [EC:2.1.1.37]
124503748  adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
124515331  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
124523232  adenosylhomocysteinase 3 isoform X1 [KO:K01251] [EC:3.13.2.1]
124510934  branched-chain-amino-acid aminotransferase, mitochondrial-like [KO:K00826] [EC:2.6.1.42]
124501664  branched-chain-amino-acid aminotransferase, cytosolic isoform X1 [KO:K00826] [EC:2.6.1.42]
124510283  alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
124528633  glutamate--cysteine ligase catalytic subunit isoform X1 [KO:K11204] [EC:6.3.2.2]
124515390  glutamate--cysteine ligase regulatory subunit [KO:K11205]
124504338  glutathione synthetase [KO:K21456] [EC:6.3.2.3]
124521674  cysteine dioxygenase type 1 [KO:K00456] [EC:1.13.11.20]
124520023  putative aspartate aminotransferase, cytoplasmic 2 [KO:K14454] [EC:2.6.1.1]
124507047  aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
124511357  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
124502023  3-mercaptopyruvate sulfurtransferase isoform X1 [KO:K01011] [EC:2.8.1.1 2.8.1.2]
124502454  thiosulfate sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]
124505110  L-lactate dehydrogenase A chain [KO:K00016] [EC:1.1.1.27]
124505180  L-lactate dehydrogenase B chain-like isoform X1 [KO:K00016] [EC:1.1.1.27]
124506216  L-lactate dehydrogenase C chain [KO:K00016] [EC:1.1.1.27]
124528295  L-lactate dehydrogenase B chain [KO:K00016] [EC:1.1.1.27]
124507753  LOW QUALITY PROTEIN: L-lactate dehydrogenase A-like 6A [KO:K00016] [EC:1.1.1.27]
124529375  L-lactate dehydrogenase A-like 6A [KO:K00016] [EC:1.1.1.27]
124502309  L-lactate dehydrogenase B chain [KO:K00016] [EC:1.1.1.27]
124509583  L-lactate dehydrogenase A chain-like [KO:K00016] [EC:1.1.1.27]
124503709  malate dehydrogenase, cytoplasmic [KO:K00025] [EC:1.1.1.37]
124519253  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
124518446  serine dehydratase-like isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
124518447  L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
124515175  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
124528731  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
lruf00010  Glycolysis / Gluconeogenesis
lruf00250  Alanine, aspartate and glutamate metabolism
lruf00260  Glycine, serine and threonine metabolism
lruf00290  Valine, leucine and isoleucine biosynthesis
lruf00430  Taurine and hypotaurine metabolism
lruf00480  Glutathione metabolism
lruf00620  Pyruvate metabolism
lruf00640  Propanoate metabolism
lruf00770  Pantothenate and CoA biosynthesis
lruf00900  Terpenoid backbone biosynthesis
lruf00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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