KEGG   PATHWAY: lsv00270
Entry
lsv00270                    Pathway                                
Name
Cysteine and methionine metabolism - Lactuca sativa (garden lettuce)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
lsv00270  Cysteine and methionine metabolism
lsv00270

Module
lsv_M00021  Cysteine biosynthesis, serine => cysteine [PATH:lsv00270]
lsv_M00034  Methionine salvage pathway [PATH:lsv00270]
lsv_M00368  Ethylene biosynthesis, methionine => ethylene [PATH:lsv00270]
Other DBs
GO: 0006534 0006555
Organism
Lactuca sativa (garden lettuce) [GN:lsv]
Gene
111888140  serine acetyltransferase 1, chloroplastic [KO:K00640] [EC:2.3.1.30]
111898706  serine acetyltransferase 1, chloroplastic [KO:K00640] [EC:2.3.1.30]
111892647  serine acetyltransferase 5 [KO:K00640] [EC:2.3.1.30]
111902248  serine acetyltransferase 1, chloroplastic [KO:K00640] [EC:2.3.1.30]
111902547  serine acetyltransferase 2 [KO:K00640] [EC:2.3.1.30]
111906855  serine acetyltransferase 5 [KO:K00640] [EC:2.3.1.30]
111890748  cysteine synthase [KO:K01738] [EC:2.5.1.47]
111902253  cysteine synthase 2 [KO:K01738] [EC:2.5.1.47]
111916528  cysteine synthase isoform X1 [KO:K01738] [EC:2.5.1.47]
111881600  cysteine synthase [KO:K01738] [EC:2.5.1.47]
111902665  bifunctional L-3-cyanoalanine synthase/cysteine synthase 1, mitochondrial [KO:K13034] [EC:2.5.1.47 4.4.1.9]
111889251  cystathionine beta-lyase, chloroplastic [KO:K01760] [EC:4.4.1.13]
111899138  homocysteine S-methyltransferase 2 isoform X1 [KO:K00547] [EC:2.1.1.10]
111894472  homocysteine S-methyltransferase 1 [KO:K00547] [EC:2.1.1.10]
111921674  homocysteine S-methyltransferase 2 [KO:K00547] [EC:2.1.1.10]
111899781  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]
111899782  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]
111916594  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]
111887445  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase isoform X1 [KO:K00549] [EC:2.1.1.14]
111893008  S-adenosylmethionine synthase 2 [KO:K00789] [EC:2.5.1.6]
111894057  S-adenosylmethionine synthase 2 [KO:K00789] [EC:2.5.1.6]
111916361  S-adenosylmethionine synthase 2 [KO:K00789] [EC:2.5.1.6]
111914201  S-adenosylmethionine synthase 5 [KO:K00789] [EC:2.5.1.6]
111880479  S-adenosylmethionine synthase 5 [KO:K00789] [EC:2.5.1.6]
111910454  S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
111914047  S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
111876661  S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
111885081  S-adenosylmethionine decarboxylase proenzyme 4 [KO:K01611] [EC:4.1.1.50]
111885104  S-adenosylmethionine decarboxylase proenzyme 4 [KO:K01611] [EC:4.1.1.50]
111888877  spermine synthase [KO:K00797] [EC:2.5.1.16]
111918009  spermine synthase [KO:K00797] [EC:2.5.1.16]
111913711  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
111903682  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
111876315  spermine synthase [KO:K00797] [EC:2.5.1.16]
111878037  nicotianamine synthase [KO:K05953] [EC:2.5.1.43]
111878402  nicotianamine synthase [KO:K05953] [EC:2.5.1.43]
111878404  nicotianamine synthase [KO:K05953] [EC:2.5.1.43]
111878908  LOW QUALITY PROTEIN: nicotianamine synthase [KO:K05953] [EC:2.5.1.43]
111884303  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase [KO:K01244] [EC:3.2.2.16]
111886116  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase [KO:K01244] [EC:3.2.2.16]
111877025  methylthioribose kinase [KO:K00899] [EC:2.7.1.100]
111877034  methylthioribose kinase [KO:K00899] [EC:2.7.1.100]
111892610  methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
111893438  methylthioribose-1-phosphate isomerase-like isoform X1 [KO:K08963] [EC:5.3.1.23]
111910625  methylthioribose-1-phosphate isomerase isoform X1 [KO:K08963] [EC:5.3.1.23]
111879539  methylthioribose-1-phosphate isomerase-like isoform X1 [KO:K08963] [EC:5.3.1.23]
111897967  LOW QUALITY PROTEIN: methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
111902555  LOW QUALITY PROTEIN: methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
111879582  methylthioribose-1-phosphate isomerase isoform X2 [KO:K08963] [EC:5.3.1.23]
111905674  uncharacterized protein LOC111905674 isoform X1 [KO:K08963] [EC:5.3.1.23]
111898422  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
111916909  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
111908740  acireductone dioxygenase 1 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
111909375  acireductone dioxygenase 3 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
111877416  uncharacterized protein LOC111877416 [KO:K23977] [EC:2.6.1.117]
111919969  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
111906702  nicotianamine aminotransferase 1 isoform X1 [KO:K00815] [EC:2.6.1.5]
111906715  nicotianamine aminotransferase 1 [KO:K00815] [EC:2.6.1.5]
111906716  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
111906717  tyrosine aminotransferase isoform X1 [KO:K00815] [EC:2.6.1.5]
111916900  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
111884400  nicotianamine aminotransferase 1 [KO:K00815] [EC:2.6.1.5]
111877162  aromatic aminotransferase ISS1 [KO:K00837] [EC:2.6.1.-]
111919006  methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]
111919214  methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]
111919222  methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]
111891835  DNA (cytosine-5)-methyltransferase CMT2 [KO:K00558] [EC:2.1.1.37]
111905319  putative DNA (cytosine-5)-methyltransferase CMT1 [KO:K00558] [EC:2.1.1.37]
111876994  DNA (cytosine-5)-methyltransferase CMT2 isoform X1 [KO:K00558] [EC:2.1.1.37]
111878393  DNA (cytosine-5)-methyltransferase 1B isoform X1 [KO:K00558] [EC:2.1.1.37]
111887753  DNA (cytosine-5)-methyltransferase CMT3 [KO:K00558] [EC:2.1.1.37]
111884521  PWWP domain-containing protein 1 [KO:K17398] [EC:2.1.1.37]
111896942  adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
111912064  adenosylhomocysteinase 1 [KO:K01251] [EC:3.13.2.1]
111905147  adenosylhomocysteinase 1 [KO:K01251] [EC:3.13.2.1]
111900984  1-aminocyclopropane-1-carboxylate synthase [KO:K20772] [EC:4.4.1.14]
111878569  1-aminocyclopropane-1-carboxylate synthase [KO:K20772] [EC:4.4.1.14]
111886468  1-aminocyclopropane-1-carboxylate synthase [KO:K20772] [EC:4.4.1.14]
111894665  1-aminocyclopropane-1-carboxylate synthase 7 [KO:K01762] [EC:4.4.1.14]
111892562  1-aminocyclopropane-1-carboxylate synthase 7 [KO:K01762] [EC:4.4.1.14]
111910693  1-aminocyclopropane-1-carboxylate synthase 3 [KO:K01762] [EC:4.4.1.14]
111900308  1-aminocyclopropane-1-carboxylate synthase 3 [KO:K01762] [EC:4.4.1.14]
111912966  LOW QUALITY PROTEIN: 1-aminocyclopropane-1-carboxylate synthase 3 [KO:K01762] [EC:4.4.1.14]
111890969  1-aminocyclopropane-1-carboxylate oxidase 3 [KO:K05933] [EC:1.14.17.4]
111921123  1-aminocyclopropane-1-carboxylate oxidase 3 [KO:K05933] [EC:1.14.17.4]
111904962  1-aminocyclopropane-1-carboxylate oxidase 3 [KO:K05933] [EC:1.14.17.4]
111905714  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
111878839  1-aminocyclopropane-1-carboxylate oxidase 3 [KO:K05933] [EC:1.14.17.4]
111879600  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
111879601  1-aminocyclopropane-1-carboxylate oxidase 5 [KO:K05933] [EC:1.14.17.4]
111879602  1-aminocyclopropane-1-carboxylate oxidase 5 [KO:K05933] [EC:1.14.17.4]
111888682  aspartokinase 2, chloroplastic [KO:K00928] [EC:2.7.2.4]
111917006  aspartokinase 2, chloroplastic isoform X1 [KO:K00928] [EC:2.7.2.4]
111877761  bifunctional aspartokinase/homoserine dehydrogenase, chloroplastic [KO:K12524] [EC:2.7.2.4 1.1.1.3]
111904375  uncharacterized protein LOC111904375 [KO:K00133] [EC:1.2.1.11]
111899676  homoserine kinase [KO:K00872] [EC:2.7.1.39]
111910590  homoserine kinase [KO:K00872] [EC:2.7.1.39]
111893968  cystathionine gamma-synthase 1, chloroplastic [KO:K27857] [EC:2.5.1.160]
111894747  branched-chain-amino-acid aminotransferase 2, chloroplastic [KO:K00826] [EC:2.6.1.42]
111913043  branched-chain amino acid aminotransferase 2, chloroplastic isoform X1 [KO:K00826] [EC:2.6.1.42]
111911663  branched-chain amino acid aminotransferase 2, chloroplastic [KO:K00826] [EC:2.6.1.42]
111896211  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
111920617  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
111918915  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
111909725  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
111909669  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
111918610  aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
111885869  aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
111914645  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
111895160  aspartate aminotransferase, chloroplastic [KO:K00811] [EC:2.6.1.1]
111884958  thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial isoform X1 [KO:K01011] [EC:2.8.1.1 2.8.1.2]
111886876  L-lactate dehydrogenase A [KO:K00016] [EC:1.1.1.27]
111892866  L-lactate dehydrogenase B [KO:K00016] [EC:1.1.1.27]
111903024  putative D-cysteine desulfhydrase 1, mitochondrial [KO:K05396] [EC:4.4.1.15]
111877541  D-cysteine desulfhydrase 2, mitochondrial [KO:K05396] [EC:4.4.1.15]
111915341  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
111908772  L-cysteine desulfhydrase [KO:K22207] [EC:4.4.1.28]
111896027  malate dehydrogenase, cytoplasmic isoform X1 [KO:K00025] [EC:1.1.1.37]
111883301  malate dehydrogenase [KO:K00025] [EC:1.1.1.37]
111921241  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
111919992  malate dehydrogenase 1, mitochondrial [KO:K00026] [EC:1.1.1.37]
111877758  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
111881009  malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
111885116  malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
111913909  D-3-phosphoglycerate dehydrogenase 3, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
111877306  D-3-phosphoglycerate dehydrogenase 1, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
111911123  phosphoserine aminotransferase 2, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01102  O-Phospho-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
lsv00010  Glycolysis / Gluconeogenesis
lsv00250  Alanine, aspartate and glutamate metabolism
lsv00260  Glycine, serine and threonine metabolism
lsv00290  Valine, leucine and isoleucine biosynthesis
lsv00430  Taurine and hypotaurine metabolism
lsv00480  Glutathione metabolism
lsv00620  Pyruvate metabolism
lsv00640  Propanoate metabolism
lsv00770  Pantothenate and CoA biosynthesis
lsv00900  Terpenoid backbone biosynthesis
lsv00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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