KEGG   PATHWAY: mbez04727
Entry
mbez04727                   Pathway                                
Name
GABAergic synapse - Moschus berezovskii (Chinese forest musk deer)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
Pathway map
mbez04727  GABAergic synapse
mbez04727

Other DBs
GO: 0051932
Organism
Moschus berezovskii (Chinese forest musk deer) [GN:mbez]
Gene
129535819  SLC38A1; sodium-coupled neutral amino acid symporter 1 [KO:K14990]
129536253  SLC38A2; sodium-coupled neutral amino acid symporter 2 isoform X1 [KO:K14207]
129536838  GLS2; glutaminase liver isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
129538630  GLS; glutaminase kidney isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
129549609  glutamate decarboxylase 1-like [KO:K01580] [EC:4.1.1.15]
129538278  GAD1; glutamate decarboxylase 1 [KO:K01580] [EC:4.1.1.15]
129555292  GAD2; glutamate decarboxylase 2 [KO:K01580] [EC:4.1.1.15]
129563496  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
129545359  ABAT; 4-aminobutyrate aminotransferase, mitochondrial [KO:K13524] [EC:2.6.1.19 2.6.1.22]
129550013  GABRA5; gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175]
129564463  GABRA3; gamma-aminobutyric acid receptor subunit alpha-3 [KO:K05175]
129558513  GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 [KO:K05175]
129558593  GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 [KO:K05175]
129561676  GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 [KO:K05175]
129562030  GABRA4; gamma-aminobutyric acid receptor subunit alpha-4 [KO:K05175]
129550205  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 [KO:K05181]
129558722  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 [KO:K05181]
129561769  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
129550206  GABRG3; gamma-aminobutyric acid receptor subunit gamma-3 [KO:K05186]
129558456  GABRG2; gamma-aminobutyric acid receptor subunit gamma-2 [KO:K05186]
129561822  GABRG1; gamma-aminobutyric acid receptor subunit gamma-1 [KO:K05186]
129551444  GABRD; gamma-aminobutyric acid receptor subunit delta [KO:K05184]
129564576  GABRE; gamma-aminobutyric acid receptor subunit epsilon [KO:K05185]
129535187  GABRQ; gamma-aminobutyric acid receptor subunit theta [KO:K05192]
129553139  GABRP; gamma-aminobutyric acid receptor subunit pi isoform X1 [KO:K05189]
129558401  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
129540637  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
129563285  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
129544793  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
129545462  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
129546400  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
129544400  HAP1; LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K04647]
129535768  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 isoform X1 [KO:K08341]
129542675  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
129547253  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
129544518  NSF; vesicle-fusing ATPase isoform X1 [KO:K06027] [EC:3.6.4.6]
129537579  TRAK2; trafficking kinesin-binding protein 2 [KO:K15374]
129537930  PLCL1; inactive phospholipase C-like protein 1 isoform X1 [KO:K15375]
129562719  GPHN; gephyrin isoform X1 [KO:K15376] [EC:2.10.1.1 2.7.7.75]
129555992  SLC12A5; solute carrier family 12 member 5 [KO:K23967]
129550339  GABRR3; gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190]
129560907  GABRR2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190]
129561049  GABRR1; gamma-aminobutyric acid receptor subunit rho-1 [KO:K05190]
129559399  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
129539723  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
129535727  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
129547932  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
129564275  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
129551192  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
129556852  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 isoform X1 [KO:K04615]
129543401  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615]
129552346  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
129547858  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
129541702  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
129547086  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
129551433  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
129545675  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
129536555  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
129562435  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
129548858  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
129555099  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
129558470  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
129552025  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
129552085  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
129553378  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
129539229  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
129562463  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
129536585  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
129535859  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
129547117  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
129560440  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
129545325  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
129552267  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
129547732  SLC6A1; sodium- and chloride-dependent GABA transporter 1 isoform X1 [KO:K05034]
129536968  SLC6A13; sodium- and chloride-dependent GABA transporter 2 [KO:K05046]
129547575  SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
129536175  SLC6A12; sodium- and chloride-dependent betaine transporter [KO:K05045]
129551310  GLUL; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
129559100  LOW QUALITY PROTEIN: glutamine synthetase-like [KO:K01915] [EC:6.3.1.2]
129547857  SLC38A3; sodium-coupled neutral amino acid transporter 3 [KO:K13576]
129564379  SLC38A5; sodium-coupled neutral amino acid transporter 5 isoform X1 [KO:K14992]
Compound
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00042  Succinate
C00064  L-Glutamine
C00076  Calcium cation
C00238  Potassium cation
C00334  4-Aminobutanoate
C00575  3',5'-Cyclic AMP
C00698  Cl-
Reference
  Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
  Title
Neuropsychopharmacology: The fifth generation of progress
  Journal
Lippincott Williams & Wikins (2002)
DOI:10.1002/hup.431
Reference
PMID:17499109
  Authors
Farrant M, Kaila K
  Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
  Journal
Prog Brain Res 160:59-87 (2007)
DOI:10.1016/S0079-6123(06)60005-8
Reference
PMID:9364667
  Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
  Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
  Journal
Trends Neurosci 20:523-9 (1997)
DOI:10.1016/S0166-2236(97)01147-8
Reference
PMID:20655485
  Authors
Pinard A, Seddik R, Bettler B
  Title
GABAB receptors: physiological functions and mechanisms of diversity.
  Journal
Adv Pharmacol 58:231-55 (2010)
DOI:10.1016/S1054-3589(10)58010-4
Reference
PMID:21376567
  Authors
Chalifoux JR, Carter AG
  Title
GABAB receptor modulation of synaptic function.
  Journal
Curr Opin Neurobiol 21:339-44 (2011)
DOI:10.1016/j.conb.2011.02.004
Reference
PMID:20655481
  Authors
Padgett CL, Slesinger PA
  Title
GABAB receptor coupling to G-proteins and ion channels.
  Journal
Adv Pharmacol 58:123-47 (2010)
DOI:10.1016/S1054-3589(10)58006-2
Reference
PMID:17499108
  Authors
Emson PC
  Title
GABA(B) receptors: structure and function.
  Journal
Prog Brain Res 160:43-57 (2007)
DOI:10.1016/S0079-6123(06)60004-6
Reference
PMID:16932937
  Authors
Kornau HC
  Title
GABA(B) receptors and synaptic modulation.
  Journal
Cell Tissue Res 326:517-33 (2006)
DOI:10.1007/s00441-006-0264-7
Reference
PMID:18382465
  Authors
Jacob TC, Moss SJ, Jurd R
  Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
  Journal
Nat Rev Neurosci 9:331-43 (2008)
DOI:10.1038/nrn2370
Reference
PMID:12086709
  Authors
Kneussel M
  Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
  Journal
Brain Res Brain Res Rev 39:74-83 (2002)
DOI:10.1016/S0165-0173(02)00159-5
Reference
PMID:21555068
  Authors
Luscher B, Fuchs T, Kilpatrick CL
  Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
  Journal
Neuron 70:385-409 (2011)
DOI:10.1016/j.neuron.2011.03.024
Reference
PMID:19374920
  Authors
Arancibia-Carcamo IL, Kittler JT
  Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
  Journal
Pharmacol Ther 123:17-31 (2009)
DOI:10.1016/j.pharmthera.2009.03.012
Reference
PMID:16787421
  Authors
Bak LK, Schousboe A, Waagepetersen HS
  Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
  Journal
J Neurochem 98:641-53 (2006)
DOI:10.1111/j.1471-4159.2006.03913.x
Reference
PMID:15210304
  Authors
Conti F, Minelli A, Melone M
  Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
  Journal
Brain Res Brain Res Rev 45:196-212 (2004)
DOI:10.1016/j.brainresrev.2004.03.003
Reference
PMID:12888801
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
Reference
PMID:10780899
  Authors
Chebib M, Johnston GA
  Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
  Journal
J Med Chem 43:1427-47 (2000)
DOI:10.1021/jm9904349
Related
pathway
mbez00020  Citrate cycle (TCA cycle)
mbez00250  Alanine, aspartate and glutamate metabolism
mbez04144  Endocytosis
mbez04721  Synaptic vesicle cycle
KO pathway
ko04727   
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