KEGG   PATHWAY: mbez04144
Entry
mbez04144                   Pathway                                
Name
Endocytosis - Moschus berezovskii (Chinese forest musk deer)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
mbez04144  Endocytosis
mbez04144

Other DBs
GO: 0006897
Organism
Moschus berezovskii (Chinese forest musk deer) [GN:mbez]
Gene
129562494  ARF6; ADP-ribosylation factor 6 [KO:K07941]
129557632  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
129558539  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
129541834  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
129539589  PIP5KL1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
129542392  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
129551706  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
129550979  dynamin-3-like [KO:K01528] [EC:3.6.5.5]
129539058  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
129559547  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
129556821  CLTA; clathrin light chain A isoform X1 [KO:K04644]
129558423  CLTB; clathrin light chain B [KO:K04645]
129539313  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
129546528  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
129548612  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
129539881  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
129545261  AP2M1; AP-2 complex subunit mu [KO:K11826]
129546626  AP2S1; AP-2 complex subunit sigma [KO:K11827]
129546612  EHD2; EH domain-containing protein 2 [KO:K12469]
129556858  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
129548192  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
129558058  ZFYVE16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
129540331  ZFYVE9; zinc finger FYVE domain-containing protein 9 [KO:K04679]
129550473  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
129549831  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
129562707  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
129540337  TFRC; transferrin receptor protein 1 [KO:K06503]
129548207  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
129562088  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
129555293  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
129561939  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
129559284  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
129550230  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
129554414  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
129550267  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
129546690  CBLC; E3 ubiquitin-protein ligase CBL-C [KO:K22518] [EC:2.3.2.27]
129564323  SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
129556845  endophilin-A2-like [KO:K11247]
129550046  SH3GL3; endophilin-A3 [KO:K11247]
129557561  SH3GL2; endophilin-A1 isoform X1 [KO:K11247]
129557980  SH3GL1; endophilin-A2 [KO:K11247]
129541810  SH3GLB1; endophilin-B1 [KO:K11248]
129539093  SH3GLB2; endophilin-B2 isoform X1 [KO:K21269]
129537595  BIN1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
129551959  AMPH; amphiphysin [KO:K12562]
129544203  EPN2; epsin-2 isoform X1 [KO:K12471]
129544257  EPN3; epsin-3 [KO:K12471]
129545975  EPN1; epsin-1 isoform X1 [KO:K12471]
129559562  EPS15L1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
129540328  EPS15; epidermal growth factor receptor substrate 15 [KO:K12472]
129556326  SPART; spartin [KO:K19366]
129562471  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
129549878  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
129535751  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
129554762  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
129535908  RNF41; E3 ubiquitin-protein ligase NRDP1 isoform X1 [KO:K11981] [EC:2.3.2.27]
129562587  ITCH; E3 ubiquitin-protein ligase Itchy homolog [KO:K05632] [EC:2.3.2.26]
129544554  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
129545732  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
129559950  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
129558071  LDLR; low-density lipoprotein receptor isoform X1 [KO:K12473]
129537774  LDLRAP1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
129550044  LOW QUALITY PROTEIN: disabled homolog 2-like [KO:K12475]
129553302  DAB2; disabled homolog 2 isoform X1 [KO:K12475]
129547764  C-C chemokine receptor type 5 [KO:K04180]
129538412  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
129538314  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
129538394  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
129556649  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
129551250  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
129542379  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
129548707  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
129558306  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
129561756  GRK4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
129555304  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
129535020  G protein-coupled receptor kinase 4-like [KO:K08291] [EC:2.7.11.16]
129542477  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
129554677  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
129552611  WASL; actin nucleation-promoting factor WASL [KO:K23612]
129539256  ACTR2; actin-related protein 2 [KO:K17260]
129537514  ACTR3; actin-related protein 3 [KO:K18584]
129552806  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
129555368  actin-related protein 3-like [KO:K18584]
129542356  LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
129545724  ARPC1B; actin-related protein 2/3 complex subunit 1B isoform X1 [KO:K05757]
129545729  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
129537783  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
129542567  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
129558855  actin-related protein 2/3 complex subunit 4-like [KO:K05755]
129548062  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
129551300  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
129539125  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein isoform X1 [KO:K05754]
129537537  WIPF1; WAS/WASL-interacting protein family member 1 [KO:K19475]
129544374  WIPF2; WAS/WASL-interacting protein family member 2 [KO:K19475]
129552492  WIPF3; WAS/WASL-interacting protein family member 3 isoform X1 [KO:K19475]
129543099  heat shock 70 kDa protein 1-like [KO:K03283]
129543100  heat shock 70 kDa protein 1B [KO:K03283]
129556947  heat shock cognate 71 kDa protein-like [KO:K03283]
129540977  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
129554454  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
129541422  DNAJC6; putative tyrosine-protein phosphatase auxilin [KO:K09526]
129536766  WASHC4; WASH complex subunit 4 [KO:K18465]
129557835  LOW QUALITY PROTEIN: WASH complex subunit 5-like [KO:K18464]
129557843  LOW QUALITY PROTEIN: WASH complex subunit 5-like [KO:K18464]
129555616  WASH complex subunit 2-like isoform X1 [KO:K18462]
129536372  WASHC1; WASH complex subunit 1 [KO:K18461]
129537186  WASHC3; WASH complex subunit 3 isoform X1 [KO:K18463]
129537139  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
129552421  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
129540552  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
129538451  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
129542513  VPS29; vacuolar protein sorting-associated protein 29 [KO:K18467]
129553362  vacuolar protein sorting-associated protein 29-like [KO:K18467]
129554892  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
129555771  VPS26A; vacuolar protein sorting-associated protein 26A [KO:K18466]
129547135  VPS35; vacuolar protein sorting-associated protein 35 isoform X1 [KO:K18468]
129564384  SNX12; sorting nexin-12 isoform X1 [KO:K17918]
129560921  SNX3; sorting nexin-3 [KO:K17918]
129563606  USP8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
129539321  STAMBP; STAM-binding protein isoform X1 [KO:K11866] [EC:3.4.19.12]
129547679  RAB7A; ras-related protein Rab-7a [KO:K07897]
129544607  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
129537765  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
129558366  STAM; signal transducing adapter molecule 1 [KO:K04705]
129549004  TSG101; tumor susceptibility gene 101 protein [KO:K12183]
129560652  tumor susceptibility gene 101 protein-like [KO:K12183]
129559405  MVB12A; multivesicular body subunit 12A [KO:K12186]
129539877  MVB12B; multivesicular body subunit 12B isoform X1 [KO:K12186]
129560250  VPS28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
129548907  VPS37C; vacuolar protein sorting-associated protein 37C [KO:K12185]
129549345  VPS37A; vacuolar protein sorting-associated protein 37A [KO:K12185]
129545625  VPS37D; vacuolar protein sorting-associated protein 37D [KO:K12185]
129542236  VPS37B; vacuolar protein sorting-associated protein 37B [KO:K12185]
129549250  vacuolar-sorting protein SNF8-like [KO:K12188]
129544286  SNF8; vacuolar-sorting protein SNF8 [KO:K12188]
129556304  VPS36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
129544443  VPS25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
129544630  CHMP6; charged multivesicular body protein 6 [KO:K12195]
129563586  CHMP4A; charged multivesicular body protein 4a [KO:K12194]
129562538  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
129559832  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
129539296  CHMP3; charged multivesicular body protein 3 [KO:K12193]
129546357  CHMP2A; charged multivesicular body protein 2a [KO:K12191]
129555796  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
129556897  CHMP7; charged multivesicular body protein 7 [KO:K15053]
129535940  vacuolar protein sorting-associated protein 4B-like [KO:K12196]
129549905  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
129546956  VPS4A; vacuolar protein sorting-associated protein 4A [KO:K12196]
129561140  VTA1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
129549796  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
129547156  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
129556934  CHMP5; charged multivesicular body protein 5 [KO:K12198]
129546938  IST1; IST1 homolog isoform X1 [KO:K19476]
129548162  PDCD6IP; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
129562951  SPG21; maspardin isoform X1 [KO:K19367]
129560720  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
129558550  SNX2; sorting nexin-2 [KO:K17917]
129562597  SNX1; sorting nexin-1 isoform X1 [KO:K17917]
129550506  SNX6; sorting nexin-6 [KO:K17920]
129558888  SNX5; sorting nexin-5 isoform X1 [KO:K17920]
129559380  LOW QUALITY PROTEIN: sorting nexin-6-like [KO:K17920]
129548758  SNX32; LOW QUALITY PROTEIN: sorting nexin-32 [KO:K17920]
129563285  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
129548597  HRAS; GTPase HRas isoform X1 [KO:K02833]
129556783  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
129536097  interleukin-2 receptor subunit beta-like [KO:K05069]
129537055  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
129564419  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
129539448  transforming protein RhoA-like [KO:K04513]
129547838  RHOA; transforming protein RhoA [KO:K04513]
129543112  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
129543113  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
129543114  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
129543175  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
129543498  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
129558890  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
129554628  FOLR3; folate receptor gamma [KO:K13649]
129554630  folate receptor beta-like [KO:K13649]
129554631  FOLR1; folate receptor alpha [KO:K13649]
129552427  CAV1; caveolin-1 isoform X1 [KO:K06278]
129552428  CAV2; caveolin-2 [KO:K12958]
129548045  CAV3; caveolin-3 [KO:K12959]
129539710  EHD3; EH domain-containing protein 3 [KO:K12476]
129562528  EHD4; EH domain-containing protein 4 [KO:K12477]
129537096  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
129549747  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
129536190  RAB5B; ras-related protein Rab-5B [KO:K07888]
129544418  RAB5C; ras-related protein Rab-5C [KO:K07889]
129542167  RABEP1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
129547710  RBSN; rabenosyn-5 [KO:K12481]
129559455  RUFY1; RUN and FYVE domain-containing protein 1 [KO:K12482]
129555782  RUFY2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
129548799  EHD1; EH domain-containing protein 1 [KO:K12483]
129540678  VPS45; vacuolar protein sorting-associated protein 45 isoform X1 [KO:K12479]
129538145  SNX4; sorting nexin-4 [KO:K17919]
129549789  RAB31; ras-related protein Rab-31 isoform X1 [KO:K07891]
129564613  ras-related protein Rab-22A-like [KO:K07891]
129561592  RAB22A; ras-related protein Rab-22A isoform X1 [KO:K07891]
129539106  RAB10; ras-related protein Rab-10 [KO:K07903]
129559033  RAB8A; ras-related protein Rab-8A [KO:K07901]
129542829  RAB35; ras-related protein Rab-35 [KO:K07876]
129562529  RAB11A; ras-related protein Rab-11A [KO:K07904]
129558337  RAB11B; ras-related protein Rab-11B [KO:K07905]
129549396  RAB11FIP1; rab11 family-interacting protein 1 [KO:K12484]
129539604  RAB11FIP5; rab11 family-interacting protein 5 [KO:K12484]
129555315  RAB11FIP2; rab11 family-interacting protein 2 [KO:K12484]
129555475  ZFYVE27; protrudin isoform X1 [KO:K19368]
129535944  KIF5A; kinesin heavy chain [KO:K10396]
129558468  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
129538351  KIF5C; kinesin heavy chain [KO:K10396]
129545188  RAB11FIP3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
129540428  RAB11FIP4; rab11 family-interacting protein 4 isoform X1 [KO:K12485]
129557434  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
129549547  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
129547002  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
129535038  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
129551440  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
129545616  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
129544365  CDC42; cell division control protein 42 homolog [KO:K04393]
129540651  SMAP2; stromal membrane-associated protein 2 [KO:K12486]
129561117  SMAP1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
129540948  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
129542161  GIT2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
129537697  ASAP3; LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
129559888  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
129539916  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
129542735  ACAP1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12489]
129544204  ACAP2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
129551408  ACAP3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
129554638  ARAP1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
129561498  ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
129558724  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
129552789  AGAP3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
129540638  AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
129536500  AGAP2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 [KO:K17848]
129561105  ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 [KO:K12492]
129535890  ARFGAP3; ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
129554806  ARFGAP2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
129549449  PSD3; PH and SEC7 domain-containing protein 3 isoform X1 [KO:K12494]
129558407  PSD2; PH and SEC7 domain-containing protein 2 [KO:K12494]
129539904  PSD4; PH and SEC7 domain-containing protein 4 isoform X1 [KO:K12494]
129555403  PSD; PH and SEC7 domain-containing protein 1 [KO:K12494]
129536478  IQSEC3; IQ motif and SEC7 domain-containing protein 3 [KO:K12495]
129564551  IQSEC2; IQ motif and SEC7 domain-containing protein 2 isoform X1 [KO:K12495]
129547691  IQSEC1; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
129536530  CYTH4; cytohesin-4 isoform X1 [KO:K18441]
129544659  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
129545756  CYTH3; cytohesin-3 isoform X1 [KO:K18441]
129546586  CYTH2; cytohesin-2 isoform X1 [KO:K18441]
129564589  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
129559881  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
129555408  GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
129558048  ARF1; ADP-ribosylation factor 1 [KO:K07937]
129544519  ADP-ribosylation factor 2 [KO:K07937]
129538298  ADP-ribosylation factor 2-like [KO:K07937]
129536425  ARF3; ADP-ribosylation factor 3 [KO:K07938]
129547955  ARF4; ADP-ribosylation factor 4 [KO:K07939]
129552100  ARF5; ADP-ribosylation factor 5 [KO:K07940]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
mbez04060  Cytokine-cytokine receptor interaction
mbez04070  Phosphatidylinositol signaling system
mbez04130  SNARE interactions in vesicular transport
mbez04142  Lysosome
mbez04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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