KEGG   PATHWAY: mcc04814
Entry
mcc04814                    Pathway                                
Name
Motor proteins - Macaca mulatta (rhesus monkey)
Class
Cellular Processes; Cell motility
Pathway map
mcc04814  Motor proteins
mcc04814

Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
718989  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
704215  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
574351  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 [KO:K10415]
695696  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 [KO:K10415]
694204  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
704654  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
716480  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 isoform X2 [KO:K10417]
702360  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
100423738  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
713503  DYNLRB2; dynein light chain roadblock-type 2 [KO:K10419]
100428465  DYNLRB1; dynein light chain roadblock-type 1 isoform X1 [KO:K10419]
696789  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
106998065  DYNLT1; dynein light chain Tctex-type 1 isoform X1 [KO:K10420]
114677428  TCTE3; tctex1 domain-containing protein 3 [KO:K25419]
704192  TCTEX1D4; tctex1 domain-containing protein 4 [KO:K25420]
699673  TCTEX1D1; tctex1 domain-containing protein 1 [KO:K25421]
697401  DNAH1; dynein heavy chain 1, axonemal [KO:K10408]
697227  DNAH3; dynein heavy chain 3, axonemal isoform X1 [KO:K10408]
721901  DNAH2; dynein heavy chain 2, axonemal isoform X1 [KO:K10408]
695393  DNAH7; dynein heavy chain 7, axonemal isoform X1 [KO:K10408]
717339  DNAH5; dynein heavy chain 5, axonemal [KO:K10408]
694115  DNAH6; dynein heavy chain 6, axonemal isoform X1 [KO:K10408]
712022  DNAH11; LOW QUALITY PROTEIN: dynein heavy chain 11, axonemal [KO:K10408]
703670  DNAH12; dynein heavy chain 12, axonemal isoform X1 [KO:K10408]
719528  DNAH8; dynein heavy chain 8, axonemal isoform X1 [KO:K10408]
715774  DNAH17; LOW QUALITY PROTEIN: dynein heavy chain 17, axonemal [KO:K10408]
722104  DNAH9; dynein heavy chain 9, axonemal isoform X1 [KO:K10408]
710343  DNAH10; dynein heavy chain 10, axonemal [KO:K10408]
703819  DNAH14; dynein heavy chain 14, axonemal isoform X4 [KO:K10408]
701307  DNAI1; dynein intermediate chain 1, axonemal isoform X1 [KO:K10409]
696977  DNAI2; dynein intermediate chain 2, axonemal [KO:K11143]
711075  WDR63; WD repeat-containing protein 63 isoform X1 [KO:K24722]
699921  WDR78; LOW QUALITY PROTEIN: WD repeat-containing protein 78 [KO:K24723]
713912  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
697410  DNAL1; dynein light chain 1, axonemal [KO:K10411]
702019  DNAL4; dynein light chain 4, axonemal [KO:K10412]
708290  DCTN1; dynactin subunit 1 isoform X6 [KO:K04648]
714948  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
700703  DCTN3; dynactin subunit 3 [KO:K10425]
712783  DCTN4; dynactin subunit 4 [KO:K10426]
698277  DCTN5; dynactin subunit 5 [KO:K10427]
694273  DCTN6; dynactin subunit 6 [KO:K10428]
713513  ACTR1A; alpha-centractin [KO:K16575]
707328  ACTR1B; beta-centractin [KO:K16575]
700125  ACTR10; actin-related protein 10 isoform X1 [KO:K16576]
704662  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
705653  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
703410  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
100429776  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
700092  BICDL2; BICD family-like cargo adapter 2 [KO:K16756]
698147  BICDL1; BICD family-like cargo adapter 1 isoform X1 [KO:K16756]
706093  HOOK3; protein Hook homolog 3 isoform X1 [KO:K16536]
574194  TUBA1A; tubulin alpha-1A chain [KO:K07374]
702583  TUBA4A; tubulin alpha-4A chain isoform X1 [KO:K07374]
707215  tubulin alpha-3 chain [KO:K07374]
710378  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
718034  TUBA3E; tubulin alpha-3E chain [KO:K07374]
722506  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
709643  TUBA1B; tubulin alpha-1B chain [KO:K07374]
710110  tubulin alpha-1C chain isoform X1 [KO:K07374]
574113  TUBB; tubulin beta chain [KO:K07375]
693889  TUBB1; tubulin beta-1 chain [KO:K07375]
708415  TUBB2B; tubulin beta-2B chain [KO:K07375]
709331  TUBB8; tubulin beta-8 chain [KO:K07375]
712533  tubulin beta-8 chain-like [KO:K07375]
722929  tubulin beta-2A chain [KO:K07375]
100425863  TUBB4B; tubulin beta-4B chain [KO:K07375]
699231  uncharacterized protein LOC699231 [KO:K07375]
703019  TUBB4A; tubulin beta-4A chain [KO:K07375]
114673745  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
722862  tubulin beta-8 chain [KO:K07375]
720677  tubulin beta-8 chain-like isoform X1 [KO:K07375]
708952  tubulin beta-8 chain-like [KO:K07375]
106996033  tubulin beta-8 chain-like [KO:K07375]
710756  TUBG1; tubulin gamma-1 chain [KO:K10389]
100429346  tubulin gamma-2 chain isoform X1 [KO:K10389]
711819  TUBD1; tubulin delta chain isoform X4 [KO:K10390]
696810  TUBE1; tubulin epsilon chain isoform X4 [KO:K10391]
693340  KIF5C; kinesin heavy chain [KO:K10396]
696652  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
711936  KIF5A; kinesin heavy chain [KO:K10396]
698356  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
714331  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
714643  KLC2; kinesin light chain 2 [KO:K10407]
695677  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
574270  KIF3A; kinesin-like protein KIF3A isoform X3 [KO:K10394]
711883  KIF3B; kinesin-like protein KIF3B [KO:K20196]
677714  KIFAP3; kinesin-associated protein 3 isoform X1 [KO:K25388]
695287  KIF3C; kinesin-like protein KIF3C [KO:K20197]
717482  KIF17; kinesin-like protein KIF17 isoform X1 [KO:K20198]
721601  KIF1C; kinesin-like protein KIF1C [KO:K10392]
716855  KIF1A; kinesin-like protein KIF1A isoform X1 [KO:K10392]
722674  KIF1B; kinesin-like protein KIF1B isoform X3 [KO:K10392]
100429368  KIF13B; kinesin-like protein KIF13B isoform X1 [KO:K17914]
704126  KIF13A; kinesin-like protein KIF13A isoform X1 [KO:K17914]
709293  KIF14; kinesin-like protein KIF14 [KO:K17915]
695167  KIF16B; kinesin-like protein KIF16B isoform X5 [KO:K17916]
708953  STARD9; stAR-related lipid transfer protein 9 isoform X1 [KO:K16491]
695574  KIF4A; chromosome-associated kinesin KIF4A [KO:K10395]
715082  KIF4B; chromosome-associated kinesin KIF4B [KO:K10395]
706132  KIF7; kinesin-like protein KIF7 isoform X1 [KO:K18806]
710792  KIF21B; kinesin-like protein KIF21B isoform X3 [KO:K24185]
699150  KIF21A; kinesin-like protein KIF21A isoform X1 [KO:K24185]
713779  KIF27; kinesin-like protein KIF27 isoform X1 [KO:K24186]
699174  KIF11; kinesin-like protein KIF11 [KO:K10398]
716533  KIF20A; kinesin-like protein KIF20A [KO:K10402]
696152  KIF20B; kinesin-like protein KIF20B isoform X1 [KO:K10402]
695229  KIF23; kinesin-like protein KIF23 isoform X2 [KO:K17387]
711186  CENPE; centromere-associated protein E isoform X1 [KO:K11498]
698453  KIF18A; kinesin-like protein KIF18A [KO:K10401]
713072  KIF18B; kinesin-like protein KIF18B isoform X1 [KO:K26156]
697090  KIF19; kinesin-like protein KIF19 [KO:K26157]
711742  KIF9; kinesin-like protein KIF9 isoform X1 [KO:K10397]
719593  KIF6; kinesin-like protein KIF6 isoform X1 [KO:K10397]
706401  KIF22; kinesin-like protein KIF22 isoform X2 [KO:K10403]
702237  KIF26A; kinesin-like protein KIF26A isoform X1 [KO:K10404]
712374  KIF26B; kinesin-like protein KIF26B isoform X1 [KO:K10404]
704313  KIF12; kinesin-like protein KIF12 isoform X1 [KO:K10399]
714704  KIF15; kinesin-like protein KIF15 isoform X1 [KO:K10400]
696561  KIF2A; kinesin-like protein KIF2A [KO:K10393]
705683  KIF2B; kinesin-like protein KIF2B [KO:K10393]
701030  KIF24; kinesin-like protein KIF24 isoform X1 [KO:K10393]
705381  KIF2C; kinesin-like protein KIF2C isoform X3 [KO:K10393]
717800  KIFC1; kinesin-like protein KIFC1 isoform X1 [KO:K10405]
705951  KIFC3; kinesin-like protein KIFC3 isoform X5 [KO:K10406]
702650  KIFC2; LOW QUALITY PROTEIN: kinesin-like protein KIFC2 [KO:K10406]
697170  KIF25; kinesin-like protein KIF25 isoform X1 [KO:K18627]
721217  MYO1C; unconventional myosin-Ic isoform X1 [KO:K10356]
714033  MYO1A; unconventional myosin-Ia [KO:K10356]
718097  MYO1D; unconventional myosin-Id [KO:K10356]
712101  MYO1F; unconventional myosin-If isoform X1 [KO:K10356]
708772  MYO1H; unconventional myosin-Ih isoform X2 [KO:K10356]
100429961  MYO1E; unconventional myosin-Ie [KO:K10356]
694510  MYO1B; unconventional myosin-Ib [KO:K10356]
698101  MYO1G; unconventional myosin-Ig [KO:K10356]
693391  MYO3B; myosin-IIIb isoform X1 [KO:K08834] [EC:2.7.11.1]
707165  MYO3A; myosin-IIIa [KO:K08834] [EC:2.7.11.1]
574273  MYO5A; unconventional myosin-Va isoform X1 [KO:K10357]
699592  MYO5B; unconventional myosin-Vb isoform X1 [KO:K10357]
695333  MYO5C; unconventional myosin-Vc isoform X1 [KO:K10357]
716634  MYO6; unconventional myosin-VI [KO:K10358]
699411  MYO7A; unconventional myosin-VIIa isoform X3 [KO:K10359]
714563  MYO7B; unconventional myosin-VIIb [KO:K21868]
701520  MYO9A; unconventional myosin-IXa isoform X2 [KO:K10360]
719690  LOW QUALITY PROTEIN: unconventional myosin-IXb [KO:K10360]
114669840  MYO9B; LOW QUALITY PROTEIN: unconventional myosin-IXb [KO:K10360]
718002  MYO10; unconventional myosin-X isoform X1 [KO:K12559]
700077  MYO15A; unconventional myosin-XV isoform X1 [KO:K10361]
707287  MYO15B; myosin XVB isoform X1 [KO:K10361]
696674  MYO16; unconventional myosin-XVI isoform X1 [KO:K17481]
711171  MYO18A; unconventional myosin-XVIIIa isoform X7 [KO:K10362]
714823  MYO18B; unconventional myosin-XVIIIb isoform X3 [KO:K10362]
713496  MYO19; LOW QUALITY PROTEIN: unconventional myosin-XIX [KO:K25838]
717888  MYH4; myosin-4 isoform X1 [KO:K24220]
717865  myosin-8 [KO:K24220]
717912  MYH2; myosin, heavy chain 2, skeletal muscle, adult [KO:K24220]
717943  MYH3; myosin-3 [KO:K24220]
712230  MYH7B; myosin-7B isoform X2 [KO:K24220]
707408  MYH15; LOW QUALITY PROTEIN: myosin-15 [KO:K24220]
717848  MYH13; myosin-13 [KO:K24220]
100500731  MYH1; myosin-1 [KO:K24220]
713471  MYH6; myosin-6 [KO:K17751]
100428939  myosin-7 [KO:K17751]
695017  MYH9; myosin-9 isoform X1 [KO:K10352]
713882  MYH11; myosin-11 isoform X1 [KO:K10352]
719560  MYH14; myosin-14 isoform X1 [KO:K10352]
721979  MYH10; myosin-10 isoform X4 [KO:K10352]
711561  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
712209  MYL3; myosin light chain 3 isoform X1 [KO:K12749]
717354  MYL4; myosin light chain 4 isoform X1 [KO:K12750]
711889  MYL6; myosin light polypeptide 6 [KO:K12751]
710137  myosin light polypeptide 6 [KO:K12751]
106992272  MYL6B; myosin light chain 6B isoform X1 [KO:K12751]
703865  myosin light polypeptide 6-like [KO:K12751]
694835  myosin light polypeptide 6-like [KO:K12751]
697761  myosin light polypeptide 6-like [KO:K12751]
711937  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
697765  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
707293  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
709784  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
106997584  MYL10; myosin regulatory light chain 10 isoform X3 [KO:K12756]
694957  MYL12B; myosin regulatory light chain 12B [KO:K12757]
695077  MYL12A; myosin, light chain 12A, regulatory, non-sarcomeric isoform X1 [KO:K12757]
711778  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
100426612  ACTA1; actin, alpha skeletal muscle [KO:K10354]
100427024  ACTA2; actin, aortic smooth muscle [KO:K12313]
697367  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
707447  ACTG2; actin, gamma-enteric smooth muscle [KO:K12315]
713687  ACTG1; actin, cytoplasmic 2 [KO:K05692]
574285  ACTB; actin, cytoplasmic 1 [KO:K05692]
705671  actin, cytoplasmic 2-like [KO:K05692]
697047  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
707860  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
698339  TNNT1; troponin T, slow skeletal muscle isoform X1 [KO:K10372]
717270  TNNC2; troponin C, skeletal muscle [KO:K12042]
721041  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
704095  TNNT3; troponin T, fast skeletal muscle isoform X14 [KO:K12046]
698470  TNNI3; troponin I, cardiac muscle isoform X2 [KO:K12044]
709882  TNNT2; troponin T, cardiac muscle [KO:K12045]
705236  TPM1; tropomyosin alpha-1 chain isoform X8 [KO:K10373]
696604  TPM2; tropomyosin beta chain isoform X1 [KO:K10374]
716336  TPM3; tropomyosin alpha-3 chain [KO:K09290]
719428  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
Reference
PMID:21092854
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
PMID:29662141
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
PMID:20428469
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
PMID:21314430
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
PMID:33912943
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
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