KEGG   PATHWAY: mgp04150
Entry
mgp04150                    Pathway                                
Name
mTOR signaling pathway - Meleagris gallopavo (turkey)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
mgp04150  mTOR signaling pathway
mgp04150

Organism
Meleagris gallopavo (turkey) [GN:mgp]
Gene
104913072  large neutral amino acids transporter small subunit 1-like [KO:K13780]
100550163  SLC38A9; sodium-coupled neutral amino acid transporter 9 [KO:K14995]
100542050  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
100540888  LOW QUALITY PROTEIN: V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
100544578  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
100551354  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
100548796  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
100541148  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
100545200  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
100538546  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
100546359  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
104916803  V-type proton ATPase subunit G 1-like [KO:K02152]
100547163  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
100543959  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
104916916  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
100546552  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
104916344  LAMTOR4; ragulator complex protein LAMTOR4 [KO:K20399]
100539685  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
100541833  FLCN; folliculin [KO:K09594]
104913320  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
100548743  FNIP2; LOW QUALITY PROTEIN: folliculin-interacting protein 2 [KO:K20401]
100545434  ras-related GTP-binding protein A [KO:K16185]
100538914  RRAGC; ras-related GTP-binding protein C [KO:K16186]
100548680  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 [KO:K23080]
100539418  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
100542585  MIOS; GATOR complex protein MIOS [KO:K20407]
100545518  SEH1L; nucleoporin SEH1 [KO:K14299]
100545185  WDR24; GATOR complex protein WDR24 isoform X1 [KO:K20408]
100545126  WDR59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
100544923  SEC13; protein SEC13 homolog [KO:K14004]
100547493  DEPDC5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
100542704  NPRL2; GATOR complex protein NPRL2 [KO:K20405]
100538854  NPRL3; GATOR complex protein NPRL3 [KO:K20406]
100542923  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
100546701  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
100549898  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
100547037  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100548925  DEP domain-containing mTOR-interacting protein-like [KO:K20402]
100543973  DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402]
100550866  MLST8; LOW QUALITY PROTEIN: target of rapamycin complex subunit LST8 [KO:K08266]
100551328  TELO2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
100547136  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
100546210  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
100542734  GRB10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
100551046  LPIN2; LOW QUALITY PROTEIN: phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
104909978  phosphatidate phosphatase LPIN1-like [KO:K15728] [EC:3.1.3.4]
100548157  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
100538803  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
100546275  EIF4EBP1; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100539467  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
100545934  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
100540237  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X3 [KO:K03259]
100551178  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
100548374  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
100547767  eukaryotic translation initiation factor 4B-like [KO:K03258]
100540046  RPS6; 40S ribosomal protein S6 [KO:K02991]
100542875  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
100550340  STRADB; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
100539688  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
100548710  CAB39; calcium-binding protein 39 [KO:K08272]
780945  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
100034740  PRKAA1; protein kinase, AMP-activated, alpha 1 catalytic subunit [KO:K07198] [EC:2.7.11.31]
104916235  5'-AMP-activated protein kinase catalytic subunit alpha-1-like [KO:K07198] [EC:2.7.11.31]
100539473  TSC1; hamartin isoform X1 [KO:K07206]
100542960  TSC2; tuberin isoform X3 [KO:K07207]
100551099  TBC1 domain family member 7 [KO:K20396]
100545017  RHEB; LOW QUALITY PROTEIN: GTP-binding protein Rheb [KO:K07208]
104916364  protein Wnt-1 [KO:K03209]
100545665  WNT2; LOW QUALITY PROTEIN: protein Wnt-2 [KO:K00182]
100551435  WNT2B; protein Wnt-2b [KO:K00182]
100549905  WNT3; protein Wnt-3b [KO:K00312]
100547574  WNT3A; protein Wnt-3a [KO:K00312]
100547391  WNT4; protein Wnt-4 [KO:K00408]
100544120  WNT5B; protein Wnt-5b [KO:K00444]
100546517  WNT5A; protein Wnt-5a [KO:K00444]
100540128  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
100542958  WNT7A; protein Wnt-7a [KO:K00572]
100542203  WNT7B; protein Wnt-7b [KO:K00572]
100545216  WNT8B; protein Wnt-8b [KO:K00714]
100539004  WNT8A; LOW QUALITY PROTEIN: protein Wnt-8a [KO:K00714]
100549597  WNT9B; protein Wnt-9b [KO:K01064]
100540276  WNT9A; protein Wnt-9a [KO:K01064]
100539047  WNT10A; protein Wnt-10a [KO:K01357]
100544486  WNT11; protein Wnt-11 [KO:K01384]
100538380  protein Wnt-11b-like isoform X1 [KO:K01384]
100544116  WNT16; protein Wnt-16 [KO:K01558]
104911467  FZD1; frizzled-1 [KO:K02432]
104916481  frizzled-1-like [KO:K02432]
100550955  FZD7; frizzled-7 [KO:K02432]
100550954  frizzled-2 [KO:K02235]
100539241  FZD3; LOW QUALITY PROTEIN: frizzled-3 [KO:K02329]
100551449  FZD4; frizzled-4 [KO:K02354]
100538891  FZD5; frizzled-5 [KO:K02375]
100550240  FZD8; frizzled-8 [KO:K02375]
100548950  FZD6; frizzled-6 [KO:K02376]
100549231  FZD10; frizzled-10 [KO:K02842]
100547034  FZD9; frizzled-9 [KO:K02842]
100548748  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
100544535  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
100542715  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
100542700  DVL3; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
100545864  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100544064  tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
100542558  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100540225  INS; insulin [KO:K04526]
104911603  insulin-like growth factor I [KO:K05459]
678666  insulin-like growth factor I precursor [KO:K05459]
100550007  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
100539720  IGF1R; LOW QUALITY PROTEIN: insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100541322  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100542624  son of sevenless homolog 1 [KO:K03099]
100540230  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100546858  HRAS; GTPase HRas [KO:K02833]
100151750  KRAS; GTPase KRas [KO:K07827]
104914532  NRAS; GTPase NRas [KO:K07828]
100550268  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100541264  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100543421  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
100551337  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X2 [KO:K04369] [EC:2.7.12.2]
100543845  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100548475  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
100547002  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
100540546  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
100541690  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
100539255  IRS1; insulin receptor substrate 1 [KO:K16172]
100549888  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100549239  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100548237  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100543492  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100546867  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100541251  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100541724  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X2 [KO:K06276] [EC:2.7.11.1]
100545672  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100539659  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100542478  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
100549384  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
100545395  RICTOR; LOW QUALITY PROTEIN: rapamycin-insensitive companion of mTOR [KO:K08267]
100540360  PRR5; proline-rich protein 5 isoform X1 [KO:K20411]
100542474  PRR5L; proline-rich protein 5-like [KO:K20411]
100547488  RHOA; transforming protein RhoA [KO:K04513]
100541727  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100538953  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
100541500  SGK1; serine/threonine-protein kinase Sgk1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
mgp00561  Glycerolipid metabolism
mgp04010  MAPK signaling pathway
mgp04140  Autophagy - animal
mgp04810  Regulation of actin cytoskeleton
mgp04910  Insulin signaling pathway
KO pathway
ko04150   
LinkDB

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