KEGG   PATHWAY: mleu00260
Entry
mleu00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Mandrillus leucophaeus (drill)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
mleu00260  Glycine, serine and threonine metabolism
mleu00260

Module
mleu_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:mleu00260]
mleu_M00047  Creatine pathway [PATH:mleu00260]
mleu_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:mleu00260]
mleu_M00555  Betaine biosynthesis, choline => betaine [PATH:mleu00260]
mleu_M00621  Glycine cleavage system [PATH:mleu00260]
mleu_M00974  Betaine metabolism, animals, betaine => glycine [PATH:mleu00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Mandrillus leucophaeus (drill) [GN:mleu]
Gene
105545564  SHMT2; serine hydroxymethyltransferase, mitochondrial isoform X1 [KO:K00600] [EC:2.1.2.1]
105536039  SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
105551227  AGXT; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
105532047  GRHPR; LOW QUALITY PROTEIN: glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
105544011  GLYCTK; glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]
105554091  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
105534833  phosphoglycerate mutase 1-like isoform X1 [KO:K01834] [EC:5.4.2.11]
105541938  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
105548120  LOW QUALITY PROTEIN: phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
105530911  LOW QUALITY PROTEIN: phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
105533670  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
105537328  PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
105542496  PSAT1; phosphoserine aminotransferase isoform X1 [KO:K00831] [EC:2.6.1.52]
105532191  phosphoserine phosphatase-like [KO:K01079] [EC:3.1.3.3]
105530985  PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
105539029  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
105532582  L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
105548114  ALAS2; LOW QUALITY PROTEIN: 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
105544016  ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
105554947  MAOB; amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
105554948  MAOA; amine oxidase [flavin-containing] A isoform X1 [KO:K00274] [EC:1.4.3.4]
105552934  membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
105552935  membrane primary amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
105552937  AOC2; retina-specific copper amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
105531881  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
105540347  AMT; aminomethyltransferase, mitochondrial isoform X1 [KO:K00605] [EC:2.1.2.10]
105544089  DLD; dihydrolipoyl dehydrogenase, mitochondrial isoform X1 [KO:K00382] [EC:1.8.1.4]
105532556  LOW QUALITY PROTEIN: glycine cleavage system H protein, mitochondrial-like [KO:K02437]
105543030  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
105536253  DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
105531239  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
105548194  GATM; glycine amidinotransferase, mitochondrial isoform X1 [KO:K00613] [EC:2.1.4.1]
105551990  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
105543977  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
105540550  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
105548271  BHMT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
105548269  DMGDH; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
105547001  PIPOX; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
105547817  SARDH; sarcosine dehydrogenase, mitochondrial isoform X1 [KO:K00314] [EC:1.5.8.3]
105544315  GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
105555593  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
105532533  CTH; cystathionine gamma-lyase isoform X1 [KO:K01758] [EC:4.4.1.1]
105552292  SDS; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
105552293  SDSL; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
105544690  SRR; serine racemase [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
mleu00010  Glycolysis / Gluconeogenesis
mleu00020  Citrate cycle (TCA cycle)
mleu00230  Purine metabolism
mleu00250  Alanine, aspartate and glutamate metabolism
mleu00270  Cysteine and methionine metabolism
mleu00290  Valine, leucine and isoleucine biosynthesis
mleu00330  Arginine and proline metabolism
mleu00470  D-Amino acid metabolism
mleu00564  Glycerophospholipid metabolism
mleu00600  Sphingolipid metabolism
mleu00620  Pyruvate metabolism
mleu00630  Glyoxylate and dicarboxylate metabolism
mleu00640  Propanoate metabolism
mleu00860  Porphyrin metabolism
mleu00920  Sulfur metabolism
KO pathway
ko00260   
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