Entry
Name
Cell adhesion molecules - Myotis lucifugus (little brown bat)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Myotis lucifugus (little brown bat) [GN:
mlf ]
Gene
102431808 CD58; lymphocyte function-associated antigen 3 isoform X5 [KO:K06492 ]
102424295 VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation [KO:K23268 ]
102423993 IGSF11; LOW QUALITY PROTEIN: immunoglobulin superfamily member 11 [KO:K06791 ]
102417504 CD80; T-lymphocyte activation antigen CD80 isoform X1 [KO:K05412 ]
102436777 CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413 ]
102433442 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
111822996 HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752 ]
111823581 HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752 ]
102424361 HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752 ]
102424046 boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752 ]
102426046 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
102417581 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
102417899 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
102418225 HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752 ]
102416953 SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752 ]
102421254 HLA class II histocompatibility antigen, DM beta chain [KO:K06752 ]
102423761 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
102441293 SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752 ]
102418131 HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752 ]
102434058 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
102434372 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
111824054 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
102443188 HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752 ]
102431574 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
102431885 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
102417382 SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752 ]
102431149 HLA class II histocompatibility antigen, DRB1-9 beta chain-like [KO:K06752 ]
102417268 HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752 ]
102439327 SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752 ]
106694679 SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752 ]
102426241 HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752 ]
102423747 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
102433751 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
106695222 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
102422459 HLA class II histocompatibility antigen, DM alpha chain [KO:K06752 ]
102419180 SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752 ]
102441506 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
102428157 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
102431769 HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752 ]
102418553 SLA class II histocompatibility antigen, DQ haplotype C beta chain-like [KO:K06752 ]
102419081 RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752 ]
102423684 HLA class II histocompatibility antigen, DP beta 1 chain-like isoform X1 [KO:K06752 ]
102429593 H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752 ]
102423144 SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like isoform X2 [KO:K06752 ]
102423440 boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752 ]
102423734 SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752 ]
102425725 HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752 ]
102426355 SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752 ]
102424057 DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X1 [KO:K06752 ]
102424373 HLA class II histocompatibility antigen, DR beta 5 chain-like [KO:K06752 ]
102440675 HLA class I histocompatibility antigen, B-46 alpha chain-like isoform X10 [KO:K06751 ]
102442541 HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751 ]
102433344 HLA class I histocompatibility antigen, B-67 alpha chain-like isoform X2 [KO:K06751 ]
102438185 patr class I histocompatibility antigen, A-126 alpha chain-like isoform X2 [KO:K06751 ]
102435002 HLA class I histocompatibility antigen, B-67 alpha chain-like isoform X3 [KO:K06751 ]
102429481 HLA class I histocompatibility antigen, B-67 alpha chain-like isoform X12 [KO:K06751 ]
111822980 patr class I histocompatibility antigen, A-126 alpha chain-like isoform X3 [KO:K06751 ]
111822961 HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751 ]
102432715 patr class I histocompatibility antigen, B-2 alpha chain-like isoform X6 [KO:K06751 ]
102429581 saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751 ]
102417058 HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751 ]
102435927 HLA class I histocompatibility antigen, B-67 alpha chain-like isoform X1 [KO:K06751 ]
102431662 HLA class I histocompatibility antigen, B-18 alpha chain-like isoform X1 [KO:K06751 ]
102428684 HLA class I histocompatibility antigen, B-57 alpha chain-like [KO:K06751 ]
102418243 class I histocompatibility antigen, Gogo-B*0103 alpha chain-like isoform X1 [KO:K06751 ]
102424088 H-2 class I histocompatibility antigen, alpha chain-like isoform X1 [KO:K06751 ]
102440606 HLA class I histocompatibility antigen, B-54 alpha chain-like isoform X1 [KO:K06751 ]
102416963 patr class I histocompatibility antigen, B-1 alpha chain-like [KO:K06751 ]
111823006 saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751 ]
102431053 HLA class I histocompatibility antigen, B-82 alpha chain-like [KO:K06751 ]
102442224 HLA class I histocompatibility antigen, B-14 alpha chain-like [KO:K06751 ]
102438496 patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751 ]
102441816 patr class I histocompatibility antigen, A-108 alpha chain-like isoform X1 [KO:K06751 ]
102418018 class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751 ]
102422972 HLA class I histocompatibility antigen, B-57 alpha chain-like [KO:K06751 ]
102424815 HLA class I histocompatibility antigen, B-45 alpha chain-like isoform X3 [KO:K06751 ]
102422085 class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751 ]
102424768 HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751 ]
102417991 BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751 ]
102421589 PDCD1LG2; programmed cell death 1 ligand 2 isoform X1 [KO:K06708 ]
102425787 VTCN1; V-set domain-containing T-cell activation inhibitor 1 [KO:K06747 ]
102439545 CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160 ]
102437788 LOW QUALITY PROTEIN: T-cell differentiation antigen CD6-like [KO:K06456 ]
102418061 TIGIT; T-cell immunoreceptor with Ig and ITIM domains [KO:K16350 ]
102434456 ICAM3; LOW QUALITY PROTEIN: intercellular adhesion molecule 3 [KO:K06486 ]
102430335 JAM2; LOW QUALITY PROTEIN: junctional adhesion molecule B [KO:K06735 ]
102418361 PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471 ]
102420992 CD34; hematopoietic progenitor cell antigen CD34 isoform X2 [KO:K06474 ]
102433895 NCAM1; LOW QUALITY PROTEIN: neural cell adhesion molecule 1 [KO:K06491 ]
102426986 SLITRK5; LOW QUALITY PROTEIN: SLIT and NTRK-like protein 5 [KO:K25836 ]
102429691 SLITRK3; LOW QUALITY PROTEIN: SLIT and NTRK-like protein 3 [KO:K25834 ]
102423997 CNTNAP1; LOW QUALITY PROTEIN: contactin-associated protein 1 [KO:K07379 ]
Reference
Authors
Barclay AN.
Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
Journal
Reference
Authors
Sharpe AH, Freeman GJ.
Title
The B7-CD28 superfamily.
Journal
Reference
Authors
Grewal IS, Flavell RA.
Title
CD40 and CD154 in cell-mediated immunity.
Journal
Reference
Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
Journal
Reference
Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
Title
Cell adhesion and polarity during immune interactions.
Journal
Reference
Authors
Dejana E.
Title
Endothelial cell-cell junctions: happy together.
Journal
Reference
Authors
Bazzoni G.
Title
The JAM family of junctional adhesion molecules.
Journal
Reference
Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
Title
Endothelial function and hemostasis.
Journal
Reference
Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
Title
Cell adhesion molecules--update.
Journal
Reference
Authors
Muller WA.
Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
Journal
Reference
Authors
Yamagata M, Sanes JR, Weiner JA.
Title
Synaptic adhesion molecules.
Journal
Reference
Authors
Ethell IM, Pasquale EB.
Title
Molecular mechanisms of dendritic spine development and remodeling.
Journal
Reference
Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
Journal
Reference
Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
Journal
Reference
Authors
Dunican DJ, Doherty P.
Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
Journal
Reference
Authors
Girault JA, Peles E.
Title
Development of nodes of Ranvier.
Journal
Reference
Authors
Arroyo EJ, Scherer SS.
Title
On the molecular architecture of myelinated fibers.
Journal
Reference
Authors
Salzer JL.
Title
Polarized domains of myelinated axons.
Journal
Reference
Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
Title
Roles and modes of action of nectins in cell-cell adhesion.
Journal
Reference
Authors
Nakanishi H, Takai Y.
Title
Roles of nectins in cell adhesion, migration and polarization.
Journal
Reference
Authors
Siu MK, Cheng CY.
Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
Journal
Reference
Authors
Lee NP, Cheng CY.
Title
Adaptors, junction dynamics, and spermatogenesis.
Journal
Reference
Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
Journal
Reference
Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
Title
Cadherin-based cell adhesion in neuromuscular development.
Journal
Reference
Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
Journal
Related pathway
mlf04610 Complement and coagulation cascades
mlf04660 T cell receptor signaling pathway
mlf04670 Leukocyte transendothelial migration
KO pathway
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