KEGG   PATHWAY: mlx00350
Entry
mlx00350                    Pathway                                
Name
Tyrosine metabolism - Mirounga leonina (Southern elephant seal)
Class
Metabolism; Amino acid metabolism
Pathway map
mlx00350  Tyrosine metabolism
mlx00350

Module
mlx_M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline [PATH:mlx00350]
mlx_M00043  Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine [PATH:mlx00350]
mlx_M00044  Tyrosine degradation, tyrosine => homogentisate [PATH:mlx00350]
Other DBs
GO: 0006570
Organism
Mirounga leonina (Southern elephant seal) [GN:mlx]
Gene
118024778  GOT1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
118009968  GOT1L1; putative aspartate aminotransferase, cytoplasmic 2 [KO:K14454] [EC:2.6.1.1]
118023718  GOT2; aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
118023597  TAT; tyrosine aminotransferase [KO:K00815] [EC:2.6.1.5]
118019531  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
117998280  IL4I1; L-amino-acid oxidase [KO:K03334] [EC:1.4.3.2]
118018433  HPD; 4-hydroxyphenylpyruvate dioxygenase [KO:K00457] [EC:1.13.11.27]
118007052  HGD; homogentisate 1,2-dioxygenase [KO:K00451] [EC:1.13.11.5]
118002494  GSTZ1; maleylacetoacetate isomerase isoform X1 [KO:K01800] [EC:5.2.1.2]
118014783  maleylacetoacetate isomerase-like [KO:K01800] [EC:5.2.1.2]
118023127  FAH; fumarylacetoacetase isoform X1 [KO:K01555] [EC:3.7.1.2]
118013459  TYR; tyrosinase [KO:K00505] [EC:1.14.18.1]
118015655  TH; tyrosine 3-monooxygenase isoform X1 [KO:K00501] [EC:1.14.16.2]
118009126  DCT; L-dopachrome tautomerase isoform X1 [KO:K01827] [EC:5.3.3.12]
117998999  TYRP1; 5,6-dihydroxyindole-2-carboxylic acid oxidase isoform X1 [KO:K00506] [EC:1.14.18.-]
118024528  DDC; aromatic-L-amino-acid decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
118018100  DBH; dopamine beta-hydroxylase [KO:K00503] [EC:1.14.17.1]
118025065  PNMT; phenylethanolamine N-methyltransferase [KO:K00553] [EC:2.1.1.28]
118003895  transmembrane O-methyltransferase [KO:K00545] [EC:2.1.1.6]
117999784  COMT; catechol O-methyltransferase isoform X1 [KO:K00545] [EC:2.1.1.6]
118009417  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
118009422  MAOB; amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
118024938  retina-specific copper amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
118018299  LOW QUALITY PROTEIN: membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
118014690  LOW QUALITY PROTEIN: membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
118015647  LOW QUALITY PROTEIN: aldehyde dehydrogenase family 3 member B2-like [KO:K00129] [EC:1.2.1.5]
118016145  ALDH3B1; aldehyde dehydrogenase family 3 member B1 isoform X1 [KO:K00129] [EC:1.2.1.5]
117999878  ALDH3A1; aldehyde dehydrogenase, dimeric NADP-preferring isoform X1 [KO:K00129] [EC:1.2.1.5]
118010307  alcohol dehydrogenase E chain isoform X1 [KO:K13951] [EC:1.1.1.1]
118010827  ADH4; all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
118010308  ADH5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
118010824  LOW QUALITY PROTEIN: alcohol dehydrogenase 6-like [KO:K13952] [EC:1.1.1.1]
118007270  LOW QUALITY PROTEIN: thyroid peroxidase-like [KO:K00431] [EC:1.11.1.8]
118007322  LOW QUALITY PROTEIN: thyroid peroxidase-like [KO:K00431] [EC:1.11.1.8]
118012164  aldehyde oxidase 4-like [KO:K00157] [EC:1.2.3.1]
118012656  LOW QUALITY PROTEIN: aldehyde oxidase 2-like [KO:K00157] [EC:1.2.3.1]
118012657  aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
118021707  FAHD1; acylpyruvase FAHD1, mitochondrial [KO:K01557] [EC:3.7.1.5]
117999748  MIF; macrophage migration inhibitory factor [KO:K07253] [EC:5.3.2.1]
Compound
C00022  Pyruvate
C00042  Succinate
C00082  L-Tyrosine
C00122  Fumarate
C00146  Phenol
C00164  Acetoacetate
C00232  Succinate semialdehyde
C00355  3,4-Dihydroxy-L-phenylalanine
C00483  Tyramine
C00530  Hydroquinone
C00544  Homogentisate
C00547  L-Noradrenaline
C00628  2,5-Dihydroxybenzoate
C00642  4-Hydroxyphenylacetate
C00788  L-Adrenaline
C00811  4-Coumarate
C00822  Dopaquinone
C01036  4-Maleylacetoacetate
C01060  3,5-Diiodo-L-tyrosine
C01061  4-Fumarylacetoacetate
C01161  3,4-Dihydroxyphenylacetate
C01179  3-(4-Hydroxyphenyl)pyruvate
C01384  Maleic acid
C01693  L-Dopachrome
C01829  Thyroxine
C01850  Rosmarinate
C02167  Maleylpyruvate
C02442  N-Methyltyramine
C02465  Triiodothyronine
C02514  3-Fumarylpyruvate
C02515  3-Iodo-L-tyrosine
C03063  2-Oxohept-3-enedioate
C03077  4-Chlorophenylacetate
C03758  Dopamine
C03765  4-Hydroxyphenylacetaldehyde
C03964  (R)-3-(4-Hydroxyphenyl)lactate
C04043  3,4-Dihydroxyphenylacetaldehyde
C04045  3-(3,4-Dihydroxyphenyl)pyruvate
C04052  5-Carboxy-2-oxohept-3-enedioate
C04185  5,6-Dihydroxyindole-2-carboxylate
C04186  5-Carboxymethyl-2-hydroxymuconate
C04368  3-Amino-3-(4-hydroxyphenyl)propanoate
C04642  2-Hydroxy-5-carboxymethylmuconate semialdehyde
C04796  4-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C04797  5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C05338  4-Hydroxyphenylacetyl-CoA
C05350  2-Hydroxy-3-(4-hydroxyphenyl)propenoate
C05576  3,4-Dihydroxyphenylethyleneglycol
C05577  3,4-Dihydroxymandelaldehyde
C05578  5,6-Dihydroxyindole
C05579  Indole-5,6-quinone
C05580  3,4-Dihydroxymandelate
C05581  3-Methoxy-4-hydroxyphenylacetaldehyde
C05582  Homovanillate
C05583  3-Methoxy-4-hydroxyphenylglycolaldehyde
C05584  3-Methoxy-4-hydroxymandelate
C05585  Gentisate aldehyde
C05587  3-Methoxytyramine
C05588  L-Metanephrine
C05589  L-Normetanephrine
C05593  3-Hydroxyphenylacetate
C05594  3-Methoxy-4-hydroxyphenylethyleneglycol
C05595  4-Hydroxyphenylacetylglutamic acid
C05596  p-Hydroxyphenylacetylglycine
C05600  2-Hydroxyhepta-2,4-dienedioate
C05604  2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
C06044  4-Hydroxyphenylethanol
C06046  Salidroside
C06047  Stizolobate
C06048  Stizolobinate
C06199  Hordenine
C06201  2,4-Dihydroxyhept-2-enedioate
C10447  3,4-Dihydroxyphenylpropanoate
C17935  Cysteinyldopa
C17936  Phaeomelanin
C17937  Eumelanin
C17938  5,6-Indolequinone-2-carboxylic acid
C22038  (R)-3-(3,4-Dihydroxyphenyl)lactate
Reference
PMID:8550403
  Authors
Prieto MA, Diaz E, Garcia JL.
  Title
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
  Journal
J Bacteriol 178:111-20 (1996)
DOI:10.1128/JB.178.1.111-120.1996
Reference
PMID:1194238
  Authors
Sparnins VL, Dagley S.
  Title
Alternative routes of aromatic catabolism in Pseudomonas acidovorans and Pseudomonas putida: gallic acid as a substrate and inhibitor of dioxygenases.
  Journal
J Bacteriol 124:1374-81 (1975)
DOI:10.1128/JB.124.3.1374-1381.1975
Reference
PMID:18435614
  Authors
Ito S, Wakamatsu K
  Title
Chemistry of mixed melanogenesis--pivotal roles of dopaquinone.
  Journal
Photochem Photobiol 84:582-92 (2008)
DOI:10.1111/j.1751-1097.2007.00238.x
Reference
PMID:11171088
  Authors
Olivares C, Jimenez-Cervantes C, Lozano JA, Solano F, Garcia-Borron JC
  Title
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase.
  Journal
Biochem J 354:131-9 (2001)
DOI:10.1042/bj3540131
Related
pathway
mlx00020  Citrate cycle (TCA cycle)
mlx00360  Phenylalanine metabolism
mlx00400  Phenylalanine, tyrosine and tryptophan biosynthesis
mlx00620  Pyruvate metabolism
mlx00650  Butanoate metabolism
KO pathway
ko00350   
LinkDB

DBGET integrated database retrieval system