Entry Name Bacterial invasion of epithelial cells - Miniopterus natalensis (Natal long-fingered bat)
Description Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-phagocytic host cells (e.g. epithelial cells) using two mechanisms referred to as zipper model and trigger model. Listeria, Staphylococcus, Streptococcus, and Yersinia are examples of bacteria that enter using the zipper model. These bacteria express proteins on their surfaces that interact with cellular receptors, initiating signalling cascades that result in close apposition of the cellular membrane around the entering bacteria. Shigella and Salmonella are the examples of bacteria entering cells using the trigger model. These bacteria use type III secretion systems to inject protein effectors that interact with the actin cytoskeleton.
Class Human Diseases; Infectious disease: bacterialBRITE hierarchy
Pathway map mna05100 Bacterial invasion of epithelial cells
Ortholog table Organism Miniopterus natalensis (Natal long-fingered bat) [GN:
mna ]
Gene 107526728 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
107529317 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
107535325 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
107532628 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
107538463 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
107541106 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
107538414 CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
107537599 RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392 ]
107540702 WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753 ]
107540073 WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748 ]
107540948 ARPC1A; actin-related protein 2/3 complex subunit 1A isoform X1 [KO:K05757 ]
107524752 ARPC2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758 ]
107535481 ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754 ]
107535558 SHC4; LOW QUALITY PROTEIN: SHC-transforming protein 4 [KO:K17449 ]
107524660 BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726 ]
107540988 MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728 ]
107530890 ELMO2; engulfment and cell motility protein 2 isoform X1 [KO:K18985 ]
Reference Authors Mostowy S, Cossart P
Title Cytoskeleton rearrangements during Listeria infection: clathrin and septins as new players in the game.
Journal Reference Authors Hauck CR, Ohlsen K
Title Sticky connections: extracellular matrix protein recognition and integrin-mediated cellular invasion by Staphylococcus aureus.
Journal Reference Authors Wang B, Li S, Dedhar S, Cleary PP
Title Paxillin phosphorylation: bifurcation point downstream of integrin-linked kinase (ILK) in streptococcal invasion.
Journal Reference Authors Matsumoto H, Young GM
Title Translocated effectors of Yersinia.
Journal Reference Authors McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
Title Salmonella takes control: effector-driven manipulation of the host.
Journal Reference Authors Iwai H, Kim M, Yoshikawa Y, Ashida H, Ogawa M, Fujita Y, Muller D, Kirikae T, Jackson PK, Kotani S, Sasakawa C
Title A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling.
Journal Related mna04810 Regulation of actin cytoskeleton
KO pathway LinkDB All DBs
