KEGG   PATHWAY: mna04810
Entry
mna04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Miniopterus natalensis (Natal long-fingered bat)
Class
Cellular Processes; Cell motility
Pathway map
mna04810  Regulation of actin cytoskeleton
mna04810

Other DBs
GO: 0030036
Organism
Miniopterus natalensis (Natal long-fingered bat) [GN:mna]
Gene
107523936  ITGB6; integrin beta-6 [KO:K06589]
107524118  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
107524124  MYL5; LOW QUALITY PROTEIN: myosin light chain 5 [KO:K12753]
107524357  MYH11; myosin-11 [KO:K10352]
107524443  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
107524660  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
107524668  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
107524720  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
107524737  FN1; fibronectin isoform X1 [KO:K05717]
107524752  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
107524922  ACTR3B; actin-related protein 3B [KO:K18584]
107525072  [KO:K05764]
107525073  ITGB1; integrin beta-1 [KO:K05719]
107525258  KRAS; GTPase KRas [KO:K07827]
107525631  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
107525695  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
107525716  VAV1; proto-oncogene vav [KO:K05730]
107525841  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
107525851  SOS2; son of sevenless homolog 2 [KO:K03099]
107525908  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
107525996  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
107526171  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
107526261  FGF10; fibroblast growth factor 10 [KO:K04358]
107526271  [KO:K06480]
107526542  LIMK1; LOW QUALITY PROTEIN: LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
107526566  MYL10; LOW QUALITY PROTEIN: myosin regulatory light chain 10 [KO:K12756]
107526728  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
107526828  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
107526917  ACTR3; actin-related protein 3 [KO:K18584]
107526945  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
107527140  ITGA2; integrin alpha-2 [KO:K06481]
107527275  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
107527296  CYFIP1; cytoplasmic FMR1-interacting protein 1 [KO:K05749]
107527350  ITGB5; integrin beta-5 [KO:K06588]
107527424  KNG1; kininogen-1 isoform X1 [KO:K03898]
107527538  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
107527759  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
107527976  ITGAE; integrin alpha-E [KO:K06524]
107528063  PFN1; profilin-1 [KO:K05759]
107528072  BDKRB1; B1 bradykinin receptor [KO:K03915]
107528081  BDKRB2; B2 bradykinin receptor [KO:K03916]
107528299  ITGB7; integrin beta-7 [KO:K06590]
107528331  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107528505  PXN; paxillin isoform X1 [KO:K05760]
107528798  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
107528800  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
107528854  ITGA2B; integrin alpha-IIb [KO:K06476]
107529021  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
107529098  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
107529317  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107529450  RHOA; transforming protein RhoA [KO:K04513]
107529564  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
107529566  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
107529597  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
107529752  PFN3; profilin-3 [KO:K05759]
107529769  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
107529795  FGF2; fibroblast growth factor 2 [KO:K18497]
107529991  RDX; radixin [KO:K05762]
107530252  ITGA8; integrin alpha-8 [KO:K06584]
107530288  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
107530315  F2; prothrombin isoform X1 [KO:K01313] [EC:3.4.21.5]
107530390  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
107530451  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107530545  CRKL; crk-like protein [KO:K04438]
107530646  C8A; complement component C8 alpha chain [KO:K03997]
107530647  C8B; complement component C8 beta chain [KO:K03998]
107530883  ITGB3; integrin beta-3 [KO:K06493]
107530895  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
107531103  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
107531145  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
107531201  F2R; proteinase-activated receptor 1 [KO:K03914]
107531210  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
107531241  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
107531488  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
107531500  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
107531785  MYH14; myosin-14 [KO:K10352]
107531795  RRAS; ras-related protein R-Ras [KO:K07829]
107531851  FGF21; fibroblast growth factor 21 [KO:K22429]
107532028  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 [KO:K05627]
107532204  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
107532411  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
107532553  CXCL12; stromal cell-derived factor 1 [KO:K10031]
107532623  MRAS; ras-related protein M-Ras [KO:K07831]
107532628  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
107532684  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
107532710  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
107532758  FGF16; fibroblast growth factor 16 [KO:K04358]
107533084  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
107533158  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
107533206  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
107533406  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
107533494  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
107533556  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
107533619  CFL1; cofilin-1 [KO:K05765]
107533801  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107533875  SSH1; LOW QUALITY PROTEIN: protein phosphatase Slingshot homolog 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
107533957  [KO:K06269] [EC:3.1.3.16]
107533962  ABI2; abl interactor 2 isoform X1 [KO:K05751]
107534016  FGD3; LOW QUALITY PROTEIN: FYVE, RhoGEF and PH domain-containing protein 3 [KO:K05722]
107534042  FGF20; fibroblast growth factor 20 [KO:K04358]
107534199  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107534237  ARHGEF1; rho guanine nucleotide exchange factor 1 [KO:K12330]
107534373  EGF; pro-epidermal growth factor [KO:K04357]
107534437  CYFIP2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
107534581  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
107534692  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
107534729  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
107534745  BRK1; protein BRICK1 [KO:K05752]
107534754  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
107534875  FGF7; fibroblast growth factor 7 [KO:K04358]
107534899  MSN; moesin [KO:K05763]
107535065  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
107535162  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
107535230  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
107535325  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
107535357  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
107535481  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
107535608  CRK; adapter molecule crk isoform X1 [KO:K04438]
107535858  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
107535889  [KO:K12757]
107535890  [KO:K12757]
107535907  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
107536013  PPP1R12B; protein phosphatase 1 regulatory subunit 12B [KO:K12329]
107536182  C8G; complement component C8 gamma chain isoform X1 [KO:K03999]
107536314  NCKAP1; nck-associated protein 1 [KO:K05750]
107536364  PAK7; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
107536630  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
107536679  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
107536980  FGF9; fibroblast growth factor 9 [KO:K04358]
107537102  FGF5; fibroblast growth factor 5 [KO:K04358]
107537179  [KO:K05730]
107537244  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
107537350  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
107537599  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
107537600  ACTB; actin, cytoplasmic 1 [KO:K05692]
107537619  C5; complement C5 [KO:K03994]
107537650  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
107537672  GSN; gelsolin isoform X1 [KO:K05768]
107538124  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
107538226  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
107538305  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
107538414  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
107538463  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
107538572  FGF22; fibroblast growth factor 22 [KO:K04358]
107538841  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 isoform X1 [KO:K05720]
107538868  FGF23; fibroblast growth factor 23 [KO:K22428]
107538886  FGF6; fibroblast growth factor 6 [KO:K04358]
107539040  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
107539076  ACTG1; actin, cytoplasmic 2 [KO:K05692]
107539122  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
107539175  ITGA3; integrin alpha-3 [KO:K06482]
107539316  ARHGEF4; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 4 [KO:K05769]
107539533  FAM49B; protein FAM49B isoform X1 [KO:K27976]
107539778  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
107539942  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
107540015  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
107540055  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
107540073  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
107540140  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
107540309  ITGB8; integrin beta-8 [KO:K06591]
107540349  FGF18; fibroblast growth factor 18 [KO:K04358]
107540385  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
107540702  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
107540803  [KO:K06462]
107540806  ITGAD; integrin alpha-D [KO:K06594]
107540812  ITGAM; integrin alpha-M [KO:K06461]
107540891  [KO:K04393]
107540907  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
107540948  ARPC1A; actin-related protein 2/3 complex subunit 1A isoform X1 [KO:K05757]
107541059  NCKAP1L; nck-associated protein 1-like [KO:K05750]
107541067  ITGA5; integrin alpha-5 [KO:K06484]
107541106  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107541162  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
107541170  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
107541310  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
107541381  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
107541481  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
107541504  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
107541527  [KO:K04347]
107541636  SCIN; adseverin [KO:K05768]
107541780  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
107541791  PFN4; profilin-4 [KO:K05759]
107541875  EZR; ezrin [KO:K08007]
107541988  ITGAL; integrin alpha-L [KO:K05718]
107542067  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
107542143  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
107542167  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
107542168  [KO:K04358]
107542172  FGF19; fibroblast growth factor 19 [KO:K22603]
107542256  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
107542351  HRAS; GTPase HRas isoform X1 [KO:K02833]
107542383  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107542396  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
107542477  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
107542543  FGF8; fibroblast growth factor 8 [KO:K04358]
107542803  CFL2; cofilin-2 [KO:K05765]
107543032  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
107543141  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
107543550  FGF17; fibroblast growth factor 17 [KO:K04358]
107543606  ENAH; protein enabled homolog [KO:K05746]
107543669  ITGB2; integrin beta-2 [KO:K06464]
107543865  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
107543896  PFN2; profilin-2 [KO:K05759]
107543909  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
107544026  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
107544330  [KO:K12755]
107544471  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
107544520  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
107544543  MYH10; myosin-10 [KO:K10352]
107544784  MYH9; myosin-9 [KO:K10352]
107545203  DIAPH3; protein diaphanous homolog 3 [KO:K05745]
107545262  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
107545303  NRAS; GTPase NRas [KO:K07828]
107545649  C7; complement component C7 isoform X1 [KO:K03996]
107545692  C9; complement component C9 [KO:K04000]
107545701  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
107545822  VCL; vinculin isoform X1 [KO:K05700]
107545944  C6; complement component C6 [KO:K03995]
107545978  ACTR2; actin-related protein 2 [KO:K17260]
107546228  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
107546303  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
107546348  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
107546393  FAM49A; protein FAM49A [KO:K27976]
107546454  SPATA13; spermatogenesis-associated protein 13 [KO:K05769]
107546495  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
107546708  ITGA4; integrin alpha-4 [KO:K06483]
107546716  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
mna04010  MAPK signaling pathway
mna04510  Focal adhesion
mna04520  Adherens junction
KO pathway
ko04810   

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