KEGG   PATHWAY: mnb04150
Entry
mnb04150                    Pathway                                
Name
mTOR signaling pathway - Merops nubicus (carmine bee-eater)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
mnb04150  mTOR signaling pathway
mnb04150

Organism
Merops nubicus (carmine bee-eater) [GN:mnb]
Gene
103771033  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
103774054  SLC38A9; LOW QUALITY PROTEIN: putative sodium-coupled neutral amino acid transporter 9 [KO:K14995]
103776409  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
103774935  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
103768955  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
103770060  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
103768221  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
103777671  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
103774993  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
103773090  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
103772460  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
103778981  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
103778484  FLCN; folliculin [KO:K09594]
103775997  FNIP1; LOW QUALITY PROTEIN: folliculin-interacting protein 1 [KO:K20400]
103769373  FNIP2; folliculin-interacting protein 2 [KO:K20401]
103771293  RRAGA; ras-related GTP-binding protein A [KO:K16185]
103773232  RRAGD; ras-related GTP-binding protein D [KO:K16186]
103768225  RRAGC; ras-related GTP-binding protein C [KO:K16186]
103768825  GATSL2; GATS-like protein 2 [KO:K23081]
103775773  MIOS; WD repeat-containing protein mio [KO:K20407]
103778328  SEH1L; nucleoporin SEH1 [KO:K14299]
103769506  WDR24; WD repeat-containing protein 24 [KO:K20408]
103779049  WDR59; WD repeat-containing protein 59 [KO:K20409]
103773583  SEC13; protein SEC13 homolog [KO:K14004]
103780689  DEPDC5; LOW QUALITY PROTEIN: DEP domain-containing protein 5 [KO:K20404]
103779782  NPRL2; nitrogen permease regulator 2-like protein [KO:K20405]
103769516  NPRL3; nitrogen permease regulator 3-like protein isoform X1 [KO:K20406]
103776949  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
103780080  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
103774214  DEP domain-containing mTOR-interacting protein-like [KO:K20402]
103781381  DEP domain-containing mTOR-interacting protein [KO:K20402]
103767907  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
103780972  TELO2; telomere length regulation protein TEL2 homolog [KO:K11137]
103771502  CLIP1; CAP-Gly domain-containing linker protein 1 [KO:K10421]
103772104  GRB10; growth factor receptor-bound protein 10 [KO:K20064]
103781329  phosphatidate phosphatase LPIN3-like [KO:K15728] [EC:3.1.3.4]
103775858  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
103776863  LPIN2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
103781619  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
103779970  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
103779524  eukaryotic translation initiation factor 4E [KO:K03259]
103781061  EIF4E2; eukaryotic translation initiation factor 4E type 2 [KO:K03259]
103772882  eukaryotic translation initiation factor 4E-like [KO:K03259]
103774235  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
103776253  RPS6; 40S ribosomal protein S6 [KO:K02991]
103779875  STRADA; STE20-related kinase adapter protein alpha [KO:K08271]
103769205  STRADB; STE20-related kinase adapter protein beta [KO:K17532]
103774112  CAB39; calcium-binding protein 39 [KO:K08272]
103774324  CAB39L; calcium-binding protein 39-like [KO:K08272]
103768405  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
103781006  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
103774360  TSC1; hamartin isoform X1 [KO:K07206]
103768547  TSC2; tuberin [KO:K07207]
103779908  TBC1D7; TBC1 domain family member 7 isoform X1 [KO:K20396]
103778076  RHEB; GTP-binding protein Rheb [KO:K07208]
103780532  WNT2; protein Wnt-2 [KO:K00182]
103769895  proto-oncogene Wnt-3 [KO:K00312]
103778181  WNT4; protein Wnt-4 [KO:K00408]
103773360  WNT5A; protein Wnt-5a [KO:K00444]
103772917  WNT5B; protein Wnt-5b [KO:K00444]
103776401  WNT7A; protein Wnt-7a [KO:K00572]
103771117  WNT8B; protein Wnt-8b [KO:K00714]
103771152  protein Wnt-8c [KO:K00714]
103770161  WNT9B; protein Wnt-9b [KO:K01064]
103777423  WNT9A; protein Wnt-9a [KO:K01064]
103776228  WNT11; protein Wnt-11 [KO:K01384]
103769214  FZD7; LOW QUALITY PROTEIN: frizzled-7 [KO:K02432]
103775330  LOW QUALITY PROTEIN: frizzled-1-like [KO:K02432]
103777827  frizzled-2 [KO:K02235]
103780361  FZD3; frizzled-3 [KO:K02329]
103768107  FZD4; frizzled-4 [KO:K02354]
103776595  FZD5; frizzled-5 [KO:K02375]
103767979  FZD6; LOW QUALITY PROTEIN: frizzled-6 [KO:K02376]
103774603  frizzled-9 [KO:K02842]
103782359  FZD10; frizzled-10 [KO:K02842]
103776265  low-density lipoprotein receptor-related protein 6 [KO:K03068]
103778772  low-density lipoprotein receptor-related protein 5 [KO:K03068]
103779406  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
103770681  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
103770115  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
103775251  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103768524  INS; insulin [KO:K04526]
103778013  IGF1; insulin-like growth factor I [KO:K05459]
103769292  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
103776523  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103772841  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
103779189  SOS1; son of sevenless homolog 1 [KO:K03099]
103777136  SOS2; son of sevenless homolog 2 [KO:K03099]
103769106  LOW QUALITY PROTEIN: GTPase HRas-like [KO:K02833]
103776418  GTPase HRas [KO:K02833]
103782490  KRAS; GTPase KRas isoform X1 [KO:K07827]
103781606  NRAS; GTPase NRas [KO:K07828]
103769301  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
103770485  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103778610  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103769043  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103773038  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103779183  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
103773368  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
103772861  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
103779079  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
103773776  IRS1; insulin receptor substrate 1 [KO:K16172]
103768794  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103776111  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103780557  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103781787  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103778679  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103782078  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103779323  PDPK1; LOW QUALITY PROTEIN: 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
103769215  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103769347  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103769846  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103778058  RICTOR; rapamycin-insensitive companion of mTOR [KO:K08267]
103778088  PRR5; proline-rich protein 5 [KO:K20411]
103772644  PRR5L; LOW QUALITY PROTEIN: proline-rich protein 5-like [KO:K20411]
103773600  rho-related GTP-binding protein RhoC-like [KO:K04513]
103776231  RHOA; transforming protein RhoA [KO:K04513]
103779350  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
103778180  LOW QUALITY PROTEIN: protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
103772288  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
mnb00561  Glycerolipid metabolism
mnb04010  MAPK signaling pathway
mnb04140  Autophagy - animal
mnb04810  Regulation of actin cytoskeleton
mnb04910  Insulin signaling pathway
KO pathway
ko04150   
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