KEGG   PATHWAY: mnb04010
Entry
mnb04010                    Pathway                                
Name
MAPK signaling pathway - Merops nubicus (carmine bee-eater)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
mnb04010  MAPK signaling pathway
mnb04010

Other DBs
GO: 0000165
Organism
Merops nubicus (carmine bee-eater) [GN:mnb]
Gene
103767931  ARTN; artemin [KO:K25415]
103768083  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
103768183  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
103768224  [KO:K04412]
103768234  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
103768314  [KO:K04348] [EC:3.1.3.16]
103768398  MRAS; ras-related protein M-Ras [KO:K07831]
103768524  INS; insulin [KO:K04526]
103768655  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
103768821  [KO:K04358]
103768936  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
103768947  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
103768986  [KO:K04388] [EC:2.7.11.30]
103768990  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103769043  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103769053  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
103769106  [KO:K02833]
103769123  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
103769215  [KO:K04456] [EC:2.7.11.1]
103769292  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
103769299  [KO:K04432] [EC:2.7.12.2]
103769301  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
103769347  [KO:K04456] [EC:2.7.11.1]
103769462  [KO:K04854]
103769579  [KO:K04345] [EC:2.7.11.11]
103769745  [KO:K16342] [EC:3.1.1.4]
103769846  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103769870  SRF; serum response factor [KO:K04378]
103769876  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
103769935  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
103769937  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
103769942  FGF8; fibroblast growth factor 8 [KO:K04358]
103770113  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
103770115  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
103770117  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
103770308  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
103770423  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103770485  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103770510  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103770589  [KO:K05121] [EC:2.7.10.1]
103770767  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
103770961  [KO:K05096] [EC:2.7.10.1]
103771091  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
103771145  [KO:K16342] [EC:3.1.1.4]
103771241  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
103771334  EREG; proepiregulin [KO:K09784]
103771344  [KO:K07861]
103771381  [KO:K16342] [EC:3.1.1.4]
103771382  [KO:K16342] [EC:3.1.1.4]
103771446  FIGF; vascular endothelial growth factor D [KO:K05449]
103771640  [KO:K04372] [EC:2.7.11.1]
103771812  [KO:K04429] [EC:2.7.11.1]
103771848  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
103771881  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
103771889  [KO:K04358]
103772180  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103772210  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
103772482  TRAF2; LOW QUALITY PROTEIN: TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
103772591  RAP1A; ras-related protein Rap-1A [KO:K04353]
103772628  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
103772629  [KO:K05096] [EC:2.7.10.1]
103772670  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
103772703  FGF18; fibroblast growth factor 18 [KO:K04358]
103772710  STMN1; stathmin [KO:K04381]
103772713  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
103772736  [KO:K16342] [EC:3.1.1.4]
103772787  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
103772808  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
103772841  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
103772861  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
103772985  FGF6; fibroblast growth factor 6 [KO:K04358]
103773004  [KO:K04386]
103773038  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103773052  [KO:K04417] [EC:2.7.11.25]
103773184  [KO:K04380]
103773368  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
103773410  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103773415  KITLG; kit ligand [KO:K05461]
103773496  [KO:K04407] [EC:2.7.11.1]
103773517  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
103773590  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
103773603  HGF; hepatocyte growth factor [KO:K05460]
103773783  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
103773796  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103773811  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103773865  [KO:K04519]
103773940  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
103773950  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103774185  FGF19; fibroblast growth factor 19 [KO:K22603]
103774238  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
103774564  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
103774619  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
103774719  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
103774727  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
103774779  RAP1B; ras-related protein Rap-1b [KO:K07836]
103774876  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
103774921  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
103774940  [KO:K04433] [EC:2.7.12.2]
103775054  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
103775087  PGF; placenta growth factor [KO:K16859]
103775096  NTF3; neurotrophin-3 [KO:K04356]
103775121  [KO:K04440] [EC:2.7.11.24]
103775202  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
103775251  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103775293  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
103775667  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103775669  VEGFA; vascular endothelial growth factor A [KO:K05448]
103775687  CRKL; crk-like protein [KO:K04438]
103775715  TGFA; protransforming growth factor alpha [KO:K08774]
103775759  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863]
103775826  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
103775967  [KO:K04386]
103775970  FGF16; fibroblast growth factor 16 [KO:K04358]
103776072  ELK4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
103776203  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
103776247  GNA12; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
103776266  [KO:K22428]
103776282  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
103776410  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
103776418  [KO:K02833]
103776479  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103776486  [KO:K04439]
103776523  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103776675  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
103776764  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
103776769  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
103776815  [KO:K17534] [EC:2.7.11.25]
103776857  [KO:K04861]
103776961  RRAS2; ras-related protein R-Ras2 [KO:K07830]
103777038  CRK; adapter molecule crk [KO:K04438]
103777114  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
103777136  SOS2; son of sevenless homolog 2 [KO:K03099]
103777156  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
103777188  PDGFD; platelet-derived growth factor D [KO:K05450]
103777222  [KO:K04421] [EC:2.7.11.25]
103777499  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
103777528  FGF7; fibroblast growth factor 7 [KO:K04358]
103777549  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
103777588  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
103777601  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
103777924  [KO:K04856]
103777931  FGF3; fibroblast growth factor 3 [KO:K04358]
103777981  NGF; beta-nerve growth factor [KO:K02582]
103778013  IGF1; insulin-like growth factor I [KO:K05459]
103778180  [KO:K19662] [EC:2.7.11.13]
103778241  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
103778339  [KO:K16342] [EC:3.1.1.4]
103778425  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
103778453  RASA1; ras GTPase-activating protein 1 [KO:K04352]
103778492  BDNF; brain-derived neurotrophic factor [KO:K04355]
103778523  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
103778600  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
103778610  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103778701  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
103778704  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
103778827  IGF2; insulin-like growth factor II [KO:K13769]
103778842  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
103778880  STK4; serine/threonine-protein kinase 4 [KO:K04411]
103778913  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103778941  CDC42; cell division control protein 42 homolog [KO:K04393]
103778948  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
103778981  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
103778990  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
103779056  FGF9; fibroblast growth factor 9 [KO:K04358]
103779079  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
103779101  TGFB3; transforming growth factor beta-3 [KO:K13377]
103779122  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
103779183  [KO:K04373] [EC:2.7.11.1]
103779189  SOS1; son of sevenless homolog 1 [KO:K03099]
103779350  [KO:K02677] [EC:2.7.11.13]
103779397  NRTN; neurturin [KO:K25414]
103779398  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
103779507  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
103779642  MAPK9; LOW QUALITY PROTEIN: mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
103779660  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
103779675  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
103779754  [KO:K04458] [EC:3.1.3.48]
103780040  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
103780302  MEF2C; myocyte-specific enhancer factor 2C [KO:K04454]
103780502  [KO:K05126] [EC:2.7.10.1]
103780751  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
103780839  [KO:K04358]
103780878  TAB2; LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
103780889  [KO:K04424] [EC:2.7.11.25]
103780897  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
103780956  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
103780961  [KO:K04358]
103780984  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
103781003  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
103781178  RASA2; ras GTPase-activating protein 2 [KO:K08053]
103781238  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
103781283  ANGPT1; angiopoietin-1 [KO:K05465]
103781319  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103781380  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
103781482  [KO:K05121] [EC:2.7.10.1]
103781603  AREG; amphiregulin [KO:K09782]
103781606  NRAS; GTPase NRas [KO:K07828]
103781766  EFNA5; ephrin-A5 [KO:K05462]
103781888  [KO:K04443] [EC:2.7.11.1]
103782038  PDGFC; platelet-derived growth factor C [KO:K05450]
103782192  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
103782210  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
103782384  JUN; transcription factor AP-1 [KO:K04448]
103782388  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
103782490  KRAS; GTPase KRas isoform X1 [KO:K07827]
103782515  VEGFC; vascular endothelial growth factor C [KO:K05449]
103782598  NF1; LOW QUALITY PROTEIN: neurofibromin [KO:K08052]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
mnb04070  Phosphatidylinositol signaling system
mnb04110  Cell cycle
mnb04115  p53 signaling pathway
mnb04210  Apoptosis
mnb04310  Wnt signaling pathway
KO pathway
ko04010   

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