KEGG   PATHWAY: mpuf04727
Entry
mpuf04727                   Pathway                                
Name
GABAergic synapse - Mustela putorius furo (domestic ferret)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
Pathway map
mpuf04727  GABAergic synapse
mpuf04727

Other DBs
GO: 0051932
Organism
Mustela putorius furo (domestic ferret) [GN:mpuf]
Gene
101676755  SLC38A1; sodium-coupled neutral amino acid transporter 1 [KO:K14990]
101677243  SLC38A2; sodium-coupled neutral amino acid transporter 2 isoform X1 [KO:K14207]
101692330  GLS2; glutaminase liver isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
101686127  GLS; glutaminase kidney isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
101676657  GAD1; glutamate decarboxylase 1 isoform X1 [KO:K01580] [EC:4.1.1.15]
101670399  LOW QUALITY PROTEIN: glutamate decarboxylase 1-like [KO:K01580] [EC:4.1.1.15]
101690464  GAD2; glutamate decarboxylase 2 [KO:K01580] [EC:4.1.1.15]
101688041  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
101676585  ABAT; 4-aminobutyrate aminotransferase, mitochondrial [KO:K13524] [EC:2.6.1.19 2.6.1.22]
101691707  GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 [KO:K05175]
101692962  GABRA4; gamma-aminobutyric acid receptor subunit alpha-4 [KO:K05175]
101694403  GABRA5; gamma-aminobutyric acid receptor subunit alpha-5 isoform X1 [KO:K05175]
101676892  GABRA3; gamma-aminobutyric acid receptor subunit alpha-3 isoform X1 [KO:K05175]
101691066  GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 [KO:K05175]
101691269  GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 isoform X1 [KO:K05175]
101692177  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181]
101693608  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 isoform X1 [KO:K05181]
101693761  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181]
106003318  gamma-aminobutyric acid receptor subunit gamma-3-like [KO:K05181]
101690381  GABRG2; gamma-aminobutyric acid receptor subunit gamma-2 isoform X1 [KO:K05186]
101671235  GABRG3; gamma-aminobutyric acid receptor subunit gamma-3 [KO:K05186]
101690601  GABRG1; gamma-aminobutyric acid receptor subunit gamma-1 isoform X1 [KO:K05186]
101688618  GABRD; gamma-aminobutyric acid receptor subunit delta [KO:K05184]
101676597  GABRE; gamma-aminobutyric acid receptor subunit epsilon [KO:K05185]
101677756  GABRQ; gamma-aminobutyric acid receptor subunit theta [KO:K05192]
101673788  GABRP; gamma-aminobutyric acid receptor subunit pi [KO:K05189]
101692436  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101681986  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
106003305  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101679339  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101680372  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101671536  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101687210  LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K04647]
101687795  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
101675535  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
101689809  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
101683543  NSF; vesicle-fusing ATPase [KO:K06027] [EC:3.6.4.6]
101685332  TRAK2; trafficking kinesin-binding protein 2 [KO:K15374]
101686823  PLCL1; inactive phospholipase C-like protein 1 isoform X1 [KO:K15375]
101689332  GPHN; gephyrin isoform X1 [KO:K15376] [EC:2.10.1.1 2.7.7.75]
101673738  SLC12A5; solute carrier family 12 member 5 [KO:K23967]
101681034  GABRR3; gamma-aminobutyric acid receptor subunit rho-3 isoform X1 [KO:K05190]
101688993  GABRR2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190]
101689270  GABRR1; gamma-aminobutyric acid receptor subunit rho-1 [KO:K05190]
101674676  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
101673094  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X2 [KO:K04849]
101679746  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X10 [KO:K04850]
101669870  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101689134  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
101688476  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
101685811  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615]
101690704  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
101691741  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
101674354  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
101687914  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
101677157  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
101690759  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101678181  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101682835  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101685801  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101680687  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
101688079  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
101687979  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
101677959  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X2 [KO:K04543]
101691468  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101676486  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101691734  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
101676834  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
101674868  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101671296  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
101676211  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
101673819  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
101676713  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
101684190  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
101693988  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101680942  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101686119  KCNJ6; G protein-activated inward rectifier potassium channel 2 isoform X1 [KO:K05000]
101684935  SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
101670718  SLC6A13; sodium- and chloride-dependent GABA transporter 2 isoform X2 [KO:K05046]
101684462  SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
101693646  SLC6A12; sodium- and chloride-dependent betaine transporter isoform X1 [KO:K05045]
101678318  GLUL; glutamine synthetase isoform X1 [KO:K01915] [EC:6.3.1.2]
101688397  SLC38A3; sodium-coupled neutral amino acid transporter 3 isoform X2 [KO:K13576]
101692523  SLC38A5; sodium-coupled neutral amino acid transporter 5 isoform X1 [KO:K14992]
Compound
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00042  Succinate
C00064  L-Glutamine
C00076  Calcium cation
C00238  Potassium cation
C00334  4-Aminobutanoate
C00575  3',5'-Cyclic AMP
C00698  Cl-
Reference
  Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
  Title
Neuropsychopharmacology: The fifth generation of progress
  Journal
Lippincott Williams & Wikins (2002)
DOI:10.1002/hup.431
Reference
PMID:17499109
  Authors
Farrant M, Kaila K
  Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
  Journal
Prog Brain Res 160:59-87 (2007)
DOI:10.1016/S0079-6123(06)60005-8
Reference
PMID:9364667
  Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
  Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
  Journal
Trends Neurosci 20:523-9 (1997)
DOI:10.1016/S0166-2236(97)01147-8
Reference
PMID:20655485
  Authors
Pinard A, Seddik R, Bettler B
  Title
GABAB receptors: physiological functions and mechanisms of diversity.
  Journal
Adv Pharmacol 58:231-55 (2010)
DOI:10.1016/S1054-3589(10)58010-4
Reference
PMID:21376567
  Authors
Chalifoux JR, Carter AG
  Title
GABAB receptor modulation of synaptic function.
  Journal
Curr Opin Neurobiol 21:339-44 (2011)
DOI:10.1016/j.conb.2011.02.004
Reference
PMID:20655481
  Authors
Padgett CL, Slesinger PA
  Title
GABAB receptor coupling to G-proteins and ion channels.
  Journal
Adv Pharmacol 58:123-47 (2010)
DOI:10.1016/S1054-3589(10)58006-2
Reference
PMID:17499108
  Authors
Emson PC
  Title
GABA(B) receptors: structure and function.
  Journal
Prog Brain Res 160:43-57 (2007)
DOI:10.1016/S0079-6123(06)60004-6
Reference
PMID:16932937
  Authors
Kornau HC
  Title
GABA(B) receptors and synaptic modulation.
  Journal
Cell Tissue Res 326:517-33 (2006)
DOI:10.1007/s00441-006-0264-7
Reference
PMID:18382465
  Authors
Jacob TC, Moss SJ, Jurd R
  Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
  Journal
Nat Rev Neurosci 9:331-43 (2008)
DOI:10.1038/nrn2370
Reference
PMID:12086709
  Authors
Kneussel M
  Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
  Journal
Brain Res Brain Res Rev 39:74-83 (2002)
DOI:10.1016/S0165-0173(02)00159-5
Reference
PMID:21555068
  Authors
Luscher B, Fuchs T, Kilpatrick CL
  Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
  Journal
Neuron 70:385-409 (2011)
DOI:10.1016/j.neuron.2011.03.024
Reference
PMID:19374920
  Authors
Arancibia-Carcamo IL, Kittler JT
  Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
  Journal
Pharmacol Ther 123:17-31 (2009)
DOI:10.1016/j.pharmthera.2009.03.012
Reference
PMID:16787421
  Authors
Bak LK, Schousboe A, Waagepetersen HS
  Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
  Journal
J Neurochem 98:641-53 (2006)
DOI:10.1111/j.1471-4159.2006.03913.x
Reference
PMID:15210304
  Authors
Conti F, Minelli A, Melone M
  Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
  Journal
Brain Res Brain Res Rev 45:196-212 (2004)
DOI:10.1016/j.brainresrev.2004.03.003
Reference
PMID:12888801
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
Reference
PMID:10780899
  Authors
Chebib M, Johnston GA
  Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
  Journal
J Med Chem 43:1427-47 (2000)
DOI:10.1021/jm9904349
Related
pathway
mpuf00020  Citrate cycle (TCA cycle)
mpuf00250  Alanine, aspartate and glutamate metabolism
mpuf04144  Endocytosis
mpuf04721  Synaptic vesicle cycle
KO pathway
ko04727   
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