KEGG   PATHWAY: mthb04216
Entry
mthb04216                   Pathway                                
Name
Ferroptosis - Macaca thibetana thibetana (Pere David's macaque)
Description
Ferroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compounds (e.g.,erastin, RSL3) or clinical drugs(e.g., sulfasalazine, sorafenib) in cancer cell and certain normal cells. It is involved in multiple physiological and pathological processes, such as cancer cell death, neurodegenerative disease, tissue damage and acute renal failure.
Class
Cellular Processes; Cell growth and death
Pathway map
mthb04216  Ferroptosis
mthb04216

Other DBs
GO: 0097707
Organism
Macaca thibetana thibetana (Pere David's macaque) [GN:mthb]
Gene
126935461  4F2 cell-surface antigen heavy chain isoform X1 [KO:K06519]
126954607  cystine/glutamate transporter [KO:K13869]
126939707  cellular tumor antigen p53 isoform X1 [KO:K04451]
126953682  glutamate--cysteine ligase catalytic subunit [KO:K11204] [EC:6.3.2.2]
126964268  glutamate--cysteine ligase regulatory subunit [KO:K11205]
126964227  glutathione synthetase [KO:K21456] [EC:6.3.2.3]
126955290  long-chain-fatty-acid--CoA ligase 1 isoform X1 [KO:K01897] [EC:6.2.1.3]
126962826  long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
126955976  long-chain-fatty-acid--CoA ligase 6 isoform X1 [KO:K01897] [EC:6.2.1.3]
126932845  fatty acid CoA ligase Acsl3 [KO:K01897] [EC:6.2.1.3]
126946898  long-chain-fatty-acid--CoA ligase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
126930470  lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
126939685  polyunsaturated fatty acid lipoxygenase ALOX15 [KO:K00460] [EC:1.13.11.33]
126939687  polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type-like [KO:K00458] [EC:1.13.11.31]
126939790  thialysine N-epsilon-acetyltransferase [KO:K00657] [EC:2.3.1.57]
126946728  diamine acetyltransferase 1 [KO:K00657] [EC:2.3.1.57]
126948140  serotransferrin [KO:K14736]
126947954  transferrin receptor protein 1 [KO:K06503]
126933146  metalloreductase STEAP3 [KO:K10142] [EC:1.16.1.-]
126931038  natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
126955397  LOW QUALITY PROTEIN: metal cation symporter ZIP8 [KO:K14714]
126961265  metal cation symporter ZIP14 isoform X1 [KO:K14720]
126931118  poly(rC)-binding protein 2 isoform X1 [KO:K13162]
126956424  poly(rC)-binding protein 2-like [KO:K13162]
126932755  solute carrier family 40 member 1 isoform X1 [KO:K14685]
126947498  ceruloplasmin isoform X1 [KO:K13624] [EC:1.16.3.1]
126934047  poly(rC)-binding protein 1 [KO:K12889]
126930080  ferritin heavy chain-like [KO:K00522] [EC:1.16.3.1]
126933717  ferritin heavy chain-like [KO:K00522] [EC:1.16.3.1]
126935523  ferritin heavy chain [KO:K00522] [EC:1.16.3.1]
126961296  ferritin heavy chain [KO:K00522] [EC:1.16.3.1]
126949072  ferritin light chain-like [KO:K13625]
126943604  ferritin light chain [KO:K13625]
126945534  ferritin light chain-like [KO:K13625]
126942985  microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
126938294  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
126944350  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
126964325  microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
126952311  autophagy protein 5 isoform X1 [KO:K08339]
126949053  ubiquitin-like modifier-activating enzyme ATG7 isoform X1 [KO:K08337]
126963212  nuclear receptor coactivator 4 isoform X1 [KO:K09289]
126929129  major prion protein [KO:K05634]
126964018  heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
126962446  voltage-dependent anion-selective channel protein 2 [KO:K15040]
126960768  voltage-dependent anion-selective channel protein 3 [KO:K15041]
126946357  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
126957532  ferritin, mitochondrial [KO:K18495] [EC:1.16.3.1]
Compound
C00010  CoA
C00024  Acetyl-CoA
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00032  Heme
C00051  Glutathione
C00097  L-Cysteine
C00127  Glutathione disulfide
C00129  Isopentenyl diphosphate
C00219  Arachidonate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00418  (R)-Mevalonate
C00491  L-Cystine
C00669  gamma-L-Glutamyl-L-cysteine
C02249  Arachidonyl-CoA
C02477  alpha-Tocopherol
C11378  Ubiquinone-10
C14818  Fe2+
C14819  Fe3+
C16170  (7Z,10Z,13Z,16Z)-Docosatetraenoyl-CoA
C16527  Adrenic acid
C16844  Hydroxyl radical
C21478  Erastin
C21479  RSL3
C21480  1-Octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
C21481  1-Octadecanoyl-2-(7Z,10Z,13Z,16Z-docosatetraenoyl)-sn-glycero-3-phosphoethanolamine
C21482  1-Octadecanoyl-2-(15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
C21483  1-Octadecanoyl-2-(15S-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
C21484  1-Octadecanoyl-sn-glycero-3-phosphoethanolamine
D00448  Sulfasalazine (USP/INN)
D08524  Sorafenib (USAN/INN)
Reference
PMID:26775689
  Authors
Conrad M, Angeli JP, Vandenabeele P, Stockwell BR
  Title
Regulated necrosis: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 15:348-66 (2016)
DOI:10.1038/nrd.2015.6
Reference
PMID:26653790
  Authors
Yang WS, Stockwell BR
  Title
Ferroptosis: Death by Lipid Peroxidation.
  Journal
Trends Cell Biol 26:165-76 (2016)
DOI:10.1016/j.tcb.2015.10.014
Reference
PMID:27842066
  Authors
Kagan VE, Mao G, Qu F, Angeli JP, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA, Ritov VB, Kapralov AA, Amoscato AA, Jiang J, Anthonymuthu T, Mohammadyani D, Yang Q, Proneth B, Klein-Seetharaman J, Watkins S, Bahar I, Greenberger J, Mallampalli RK, Stockwell BR, Tyurina YY, Conrad M, Bayir H
  Title
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis.
  Journal
Nat Chem Biol 13:81-90 (2017)
DOI:10.1038/nchembio.2238
Reference
PMID:27842067
  Authors
D'Herde K, Krysko DV
  Title
Ferroptosis: Oxidized PEs trigger death.
  Journal
Nat Chem Biol 13:4-5 (2017)
DOI:10.1038/nchembio.2261
Reference
PMID:28082232
  Authors
Guiney SJ, Adlard PA, Bush AI, Finkelstein DI, Ayton S
  Title
Ferroptosis and cell death mechanisms in Parkinson's disease.
  Journal
Neurochem Int 104:34-48 (2017)
DOI:10.1016/j.neuint.2017.01.004
Reference
PMID:26725301
  Authors
Bogdan AR, Miyazawa M, Hashimoto K, Tsuji Y
  Title
Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease.
  Journal
Trends Biochem Sci 41:274-86 (2016)
DOI:10.1016/j.tibs.2015.11.012
Reference
PMID:26794443
  Authors
Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X, Kang R, Tang D
  Title
Ferroptosis: process and function.
  Journal
Cell Death Differ 23:369-79 (2016)
DOI:10.1038/cdd.2015.158
Reference
PMID:27791175
  Authors
Murphy ME
  Title
Ironing out how p53 regulates ferroptosis.
  Journal
Proc Natl Acad Sci U S A 113:12350-12352 (2016)
DOI:10.1073/pnas.1615159113
Reference
PMID:28129536
  Authors
Muckenthaler MU, Rivella S, Hentze MW, Galy B
  Title
A Red Carpet for Iron Metabolism.
  Journal
Cell 168:344-361 (2017)
DOI:10.1016/j.cell.2016.12.034
Reference
PMID:27860262
  Authors
Yu H, Guo P, Xie X, Wang Y, Chen G
  Title
Ferroptosis, a new form of cell death, and its relationships with tumourous diseases.
  Journal
J Cell Mol Med 21:648-657 (2017)
DOI:10.1111/jcmm.13008
Reference
PMID:27314071
  Authors
Wang SJ, Ou Y, Jiang L, Gu W
  Title
Ferroptosis: A missing puzzle piece in the p53 blueprint?
  Journal
Mol Cell Oncol 3:e1046581 (2016)
DOI:10.1080/23723556.2015.1046581
Reference
PMID:27048822
  Authors
Cao JY, Dixon SJ
  Title
Mechanisms of ferroptosis.
  Journal
Cell Mol Life Sci 73:2195-209 (2016)
DOI:10.1007/s00018-016-2194-1
Reference
PMID:26436293
  Authors
Mancias JD, Pontano Vaites L, Nissim S, Biancur DE, Kim AJ, Wang X, Liu Y, Goessling W, Kimmelman AC, Harper JW
  Title
Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis.
  Journal
Elife 4:e10308 (2015)
DOI:10.7554/eLife.10308
Reference
PMID:28066232
  Authors
Wang YQ, Chang SY, Wu Q, Gou YJ, Jia L, Cui YM, Yu P, Shi ZH, Wu WS, Gao G, Chang YZ
  Title
The Protective Role of Mitochondrial Ferritin on Erastin-Induced Ferroptosis.
  Journal
Front Aging Neurosci 8:308 (2016)
DOI:10.3389/fnagi.2016.00308
Reference
PMID:26405158
  Authors
Kwon MY, Park E, Lee SJ, Chung SW
  Title
Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death.
  Journal
Oncotarget 6:24393-403 (2015)
DOI:10.18632/oncotarget.5162
Reference
PMID:22632964
  Authors
Reed JC, Pellecchia M
  Title
Ironing out cell death mechanisms.
  Journal
Cell 149:963-5 (2012)
DOI:10.1016/j.cell.2012.05.009
Related
pathway
mthb00480  Glutathione metabolism
mthb00900  Terpenoid backbone biosynthesis
KO pathway
ko04216   
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