KEGG PATHWAY: muo00260

PATHWAY: muo00260

Entry

muo00260                    Pathway

Name

Glycine, serine and threonine metabolism - Microcaecilia unicolor

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

muo00260

Glycine, serine and threonine metabolism

Module

muo_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:muo00260]

muo_M00047

Creatine pathway [PATH:muo00260]

muo_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:muo00260]

muo_M00555

Betaine biosynthesis, choline => betaine [PATH:muo00260]

muo_M00621

Glycine cleavage system [PATH:muo00260]

muo_M00974

Betaine metabolism, animals, betaine => glycine [PATH:muo00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Microcaecilia unicolor [GN:muo]

Gene

115473574

probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]

115472586

LOW QUALITY PROTEIN: probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]

115476745

SHMT1; serine hydroxymethyltransferase, cytosolic isoform X1 [KO:K00600] [EC:2.1.2.1]

115465855

SHMT2; serine hydroxymethyltransferase, mitochondrial isoform X1 [KO:K00600] [EC:2.1.2.1]

115478497

AGXT; LOW QUALITY PROTEIN: serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

115463657

glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]

115463658

GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]

115471606

GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]

115469262

PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]

115470027

PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]

115477952

BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]

115474244

LOW QUALITY PROTEIN: D-3-phosphoglycerate dehydrogenase-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]

115474404

D-3-phosphoglycerate dehydrogenase-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]

115478821

PSAT1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

115456572

PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]

115473233

GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]

115467051

L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]

115463492

5-aminolevulinate synthase, erythroid-specific, mitochondrial-like [KO:K00643] [EC:2.3.1.37]

115473308

ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]

115469568

LOW QUALITY PROTEIN: amine oxidase [flavin-containing] B-like [KO:K00274] [EC:1.4.3.4]

115469747

amine oxidase [flavin-containing] A-like [KO:K00274] [EC:1.4.3.4]

115458927

amine oxidase [flavin-containing] A-like [KO:K00274] [EC:1.4.3.4]

115481417

membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]

115463357

GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]

115471735

AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]

115478531

DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]

115470899

GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]

115479103

LOW QUALITY PROTEIN: D-amino-acid oxidase-like [KO:K00273] [EC:1.4.3.3]

115479408

DAO; D-amino-acid oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]

115462930

AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]

115459815

GATM; glycine amidinotransferase, mitochondrial isoform X1 [KO:K00613] [EC:2.1.4.1]

115479445

GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]

115472750

CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]

115463235

ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

115463048

betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]

115463049

DMGDH; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]

115456622

PIPOX; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]

115473063

SARDH; sarcosine dehydrogenase, mitochondrial isoform X1 [KO:K00314] [EC:1.5.8.3]

115465289

GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

115470541

CBS; cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]

115472000

CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]

115480443

L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]

115465980

uncharacterized protein LOC115465980 [KO:K20498] [EC:4.3.1.18]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721