KEGG   PATHWAY: niq03040
Entry
niq03040                    Pathway                                
Name
Spliceosome - Nymphalis io (European peacock)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
niq03040  Spliceosome
niq03040

Other DBs
GO: 0005681
Organism
Nymphalis io (European peacock) [GN:niq]
Gene
126776630  U1 spliceosomal RNA [KO:K14276]
126777738  U1 spliceosomal RNA [KO:K14276]
126779352  U1 spliceosomal RNA [KO:K14276]
126778006  U1 spliceosomal RNA [KO:K14276]
126774070  U1 spliceosomal RNA [KO:K14276]
126779314  U2 spliceosomal RNA [KO:K14277]
126778958  U2 spliceosomal RNA [KO:K14277]
126781510  U4 spliceosomal RNA [KO:K14278]
126776631  U4 spliceosomal RNA [KO:K14278]
126769315  U4 spliceosomal RNA [KO:K14278]
126780067  U4 spliceosomal RNA [KO:K14278]
126769800  U5 spliceosomal RNA [KO:K14279]
126769801  U5 spliceosomal RNA [KO:K14279]
126773094  U5 spliceosomal RNA [KO:K14279]
126772597  U6 spliceosomal RNA [KO:K14280]
126779321  U6 spliceosomal RNA [KO:K14280]
126779325  U6 spliceosomal RNA [KO:K14280]
126771911  probable ATP-dependent RNA helicase DDX46 [KO:K12811] [EC:5.6.2.7]
126775223  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:5.6.2.7]
126780904  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
126774448  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 isoform X1 [KO:K12815] [EC:5.6.2.6]
126768918  pre-mRNA-processing factor 17 [KO:K12816]
126772846  pre-mRNA-splicing factor 18 [KO:K12817]
126769940  ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
126772193  pre-mRNA-splicing factor Slu7 [KO:K12819]
126779469  putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 [KO:K12820] [EC:5.6.2.6]
126781417  small nuclear ribonucleoprotein-associated protein B [KO:K11086]
126779685  probable small nuclear ribonucleoprotein Sm D1 [KO:K11087]
126778320  probable small nuclear ribonucleoprotein Sm D2 [KO:K11096]
126775378  small nuclear ribonucleoprotein Sm D3 [KO:K11088]
126774107  probable small nuclear ribonucleoprotein E [KO:K11097]
126774500  small nuclear ribonucleoprotein F [KO:K11098]
126777934  probable small nuclear ribonucleoprotein G [KO:K11099]
126780038  U1 small nuclear ribonucleoprotein 70 kDa [KO:K11093]
126769049  U1 small nuclear ribonucleoprotein C [KO:K11095]
126771108  pre-mRNA-processing factor 40 homolog B isoform X1 [KO:K12821]
126774294  uncharacterized protein LOC126774294 isoform X1 [KO:K12823] [EC:5.6.2.7]
126774392  ATP-dependent RNA helicase p62 [KO:K12823] [EC:5.6.2.7]
126774399  ATP-dependent RNA helicase p62-like [KO:K12823] [EC:5.6.2.7]
126774542  uncharacterized protein LOC126774542 isoform X1 [KO:K12823] [EC:5.6.2.7]
126768560  U2 small nuclear ribonucleoprotein A' isoform X1 [KO:K11092]
126774495  U1 small nuclear ribonucleoprotein A [KO:K11094]
126772661  splicing factor 3A subunit 1 [KO:K12825]
126781784  splicing factor 3A subunit 2 [KO:K12826]
126772815  splicing factor 3A subunit 3 [KO:K12827]
126770341  splicing factor 3B subunit 1 [KO:K12828]
126776199  splicing factor 3B subunit 2 [KO:K12829]
126774380  splicing factor 3B subunit 3 isoform X1 [KO:K12830]
126773845  splicing factor 3B subunit 4 [KO:K12831]
126777291  splicing factor 3B subunit 5 [KO:K12832]
126769614  splicing factor 3B subunit 6 [KO:K12833]
126773728  PHD finger-like domain-containing protein 5A [KO:K12834]
126774045  ATP-dependent RNA helicase DDX42 [KO:K12835] [EC:5.6.2.7]
126771065  splicing factor U2af 38 kDa subunit [KO:K12836]
126770578  splicing factor U2AF 50 kDa subunit [KO:K12837]
126773349  poly(U)-binding-splicing factor half pint isoform X1 [KO:K12838]
126772182  survival of motor neuron-related-splicing factor 30 [KO:K12839]
126771984  splicing factor 45 [KO:K12840]
126768627  calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841]
126769948  U2 snRNP-associated SURP motif-containing protein [KO:K12842]
126778944  U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
126771988  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
126780146  U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
126770684  U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
126777715  U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
126771980  U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
126772884  U6 snRNA-associated Sm-like protein LSm8 [KO:K12627]
126779474  U4/U6 small nuclear ribonucleoprotein Prp3 [KO:K12843]
126779515  U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
126770321  peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
126770012  U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
126774355  NHP2-like protein 1 [KO:K12845]
126779669  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
126776955  U4/U6.U5 tri-snRNP-associated protein 2 isoform X1 [KO:K12847]
126771245  U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
126768768  zinc finger matrin-type protein 2 [KO:K12848]
126777689  pre-mRNA-splicing factor 38 [KO:K12849]
126777535  pre-mRNA-splicing factor 38B-like isoform X1 [KO:K12850]
126777974  116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
126779435  putative U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
126771916  pre-mRNA-processing factor 6 [KO:K12855]
126773661  pre-mRNA-processing-splicing factor 8 [KO:K12856]
126771633  U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
126776463  probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
126776926  thioredoxin-like protein 4A [KO:K12859]
126770015  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
126769265  cell division cycle 5-like protein [KO:K12860]
126771485  pre-mRNA-splicing factor SPF27 [KO:K12861]
126772358  pleiotropic regulator 1 [KO:K12862]
126780456  protein CWC15 homolog [KO:K12863]
126773168  beta-catenin-like protein 1 [KO:K12864]
126777858  major heat shock 70 kDa protein Ba-like isoform X1 [KO:K03283]
126777867  heat shock protein 68-like [KO:K03283]
126779967  heat shock protein 68-like [KO:K03283]
126769125  heat shock 70 kDa protein cognate 4 [KO:K03283]
126772802  heat shock protein 68-like [KO:K03283]
126775529  heat shock protein 68-like [KO:K03283]
126775869  polyglutamine-binding protein 1 [KO:K12865]
126774393  WW domain-binding protein 11 [KO:K12866]
126778479  puff-specific protein Bx42 [KO:K06063]
126781185  pre-mRNA-splicing factor syf1 homolog [KO:K12867]
126771782  pre-mRNA-splicing factor Syf2 [KO:K12868]
126769455  protein crooked neck [KO:K12869]
126768403  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
126780797  peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
126773477  peptidyl-prolyl cis-trans isomerase [KO:K09564] [EC:5.2.1.8]
126769050  coiled-coil domain-containing protein 12 [KO:K12871]
126773382  pre-mRNA-splicing factor RBM22 [KO:K12872]
126770674  protein BUD31 homolog [KO:K12873]
126775790  RNA helicase aquarius [KO:K12874]
126776213  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
126779018  RNA-binding protein 8A-like [KO:K12876]
126779019  RNA-binding protein 8A-like [KO:K12876]
126779022  RNA-binding protein 8A-like [KO:K12876]
126779023  RNA-binding protein 8A-like [KO:K12876]
126779146  RNA-binding protein 8A-like isoform X1 [KO:K12876]
126773966  protein mago nashi homolog [KO:K12877]
126774459  THO complex subunit 1 [KO:K12878]
126781800  THO complex subunit 2 isoform X1 [KO:K12879]
126778238  THO complex subunit 3 [KO:K12880]
126773971  THO complex subunit 4 isoform X1 [KO:K12881]
126773209  nuclear cap-binding protein subunit 1 [KO:K12882]
126775494  nuclear cap-binding protein subunit 2 [KO:K12883]
126772709  heterogeneous nuclear ribonucleoprotein 87F-like [KO:K12741]
126772710  heterogeneous nuclear ribonucleoprotein A1-like isoform X1 [KO:K12741]
126775062  heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
126775506  serine/arginine-rich splicing factor 1B [KO:K12890]
126770866  serine/arginine-rich splicing factor 2 isoform X1 [KO:K12891]
126776370  serine-arginine protein 55 isoform X1 [KO:K12893]
126777752  RNA-binding protein 1 isoform X1 [KO:K12896]
126771365  serine/arginine-rich splicing factor 7-like isoform X1 [KO:K12896]
126773727  transformer-2 protein homolog alpha isoform X1 [KO:K12897]
Reference
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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