KEGG   PATHWAY: nmel04141
Entry
nmel04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Numida meleagris (helmeted guineafowl)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
nmel04141  Protein processing in endoplasmic reticulum
nmel04141

Other DBs
GO: 0030433 0034976
Organism
Numida meleagris (helmeted guineafowl) [GN:nmel]
Gene
110404854  SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956]
110392261  SEC61A2; protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956]
110393669  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
110394438  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
110397782  SEC62; translocation protein SEC62 [KO:K12275]
110395642  SEC63; translocation protein SEC63 homolog [KO:K09540]
110405077  RPN1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
110408175  RPN2; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X1 [KO:K12667]
110391161  DAD1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
110408524  DDOST; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
110387683  STT3A; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
110394818  STT3B; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
110402984  MAGT1; magnesium transporter protein 1 isoform X1 [KO:K19478]
110398061  TUSC3; tumor suppressor candidate 3 [KO:K19478]
110398075  OSTC; oligosaccharyltransferase complex subunit OSTC [KO:K26501]
110400876  TMEM258; transmembrane protein 258 isoform X1 [KO:K26502]
110393674  CKAP4; cytoskeleton-associated protein 4 [KO:K13999]
110397099  RRBP1; ribosome-binding protein 1 isoform X1 [KO:K14000]
110405550  SIL1; nucleotide exchange factor SIL1 isoform X1 [KO:K14001]
110387537  HYOU1; hypoxia up-regulated protein 1 [KO:K09486]
110406904  HSPA5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
110398902  DNAJB11; dnaJ homolog subfamily B member 11 [KO:K09517]
110394193  DNAJC1; dnaJ homolog subfamily C member 1 [KO:K09521]
110408139  DNAJC3; dnaJ homolog subfamily C member 3 [KO:K09523]
110399622  DNAJC10; dnaJ homolog subfamily C member 10 [KO:K09530] [EC:1.8.4.-]
110393845  HSP90B1; endoplasmin [KO:K09487]
110405437  CANX; calnexin [KO:K08054]
110403810  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
110388960  CALR3; calreticulin-3 [KO:K08057]
110391183  CALR; calreticulin [KO:K08057]
110395643  MAN1A1; mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [KO:K01230] [EC:3.2.1.113]
110387421  MAN1C1; mannosyl-oligosaccharide 1,2-alpha-mannosidase IC [KO:K01230] [EC:3.2.1.113]
110398840  MAN1A2; mannosyl-oligosaccharide 1,2-alpha-mannosidase IB [KO:K01230] [EC:3.2.1.113]
110407012  MAN1B1; endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X1 [KO:K23741] [EC:3.2.1.209]
110405284  LMAN2; vesicular integral-membrane protein VIP36 [KO:K10082]
110389844  LMAN1; protein ERGIC-53 [KO:K10080]
110396878  PREB; prolactin regulatory element-binding protein [KO:K14003]
110405349  SAR1B; GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
110400004  SAR1A; GTP-binding protein SAR1a [KO:K07953] [EC:3.6.5.-]
110405040  SEC13; protein SEC13 homolog [KO:K14004]
110399773  SEC31B; protein transport protein Sec31B [KO:K14005]
110398884  SEC31A; protein transport protein Sec31A isoform X1 [KO:K14005]
110396082  SEC23B; protein transport protein Sec23B [KO:K14006]
110400911  SEC23A; protein transport protein Sec23A [KO:K14006]
110398606  SEC24D; protein transport protein Sec24D isoform X1 [KO:K14007]
110405345  SEC24A; protein transport protein Sec24A [KO:K14007]
110398054  SEC24B; protein transport protein Sec24B isoform X1 [KO:K14007]
110399408  SEC24C; protein transport protein Sec24C isoform X1 [KO:K14007]
110408109  UGGT2; UDP-glucose:glycoprotein glucosyltransferase 2 isoform X1 [KO:K11718] [EC:2.4.1.-]
110397909  UGGT1; UDP-glucose:glycoprotein glucosyltransferase 1 isoform X1 [KO:K11718] [EC:2.4.1.-]
110404705  EDEM1; ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
110408248  EDEM2; ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
110402927  EDEM3; ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
110407219  P4HB; protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
110390792  PDIA4; protein disulfide-isomerase A4 isoform X1 [KO:K09582] [EC:5.3.4.1]
110395778  PDIA6; protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
110406634  ERP29; endoplasmic reticulum resident protein 29 [KO:K09586]
110394689  TXNDC5; thioredoxin domain-containing protein 5 isoform X1 [KO:K13984] [EC:5.3.4.1]
110400802  ERO1A; ERO1-like protein alpha isoform X1 [KO:K10950] [EC:1.8.4.-]
110396290  ERO1B; ERO1-like protein beta [KO:K10976] [EC:1.8.4.-]
110396355  ERLEC1; endoplasmic reticulum lectin 1 [KO:K14008]
110393769  SSR1; translocon-associated protein subunit alpha [KO:K13249]
110387857  SSR2; translocon-associated protein subunit beta [KO:K13250]
110397939  SSR3; translocon-associated protein subunit gamma [KO:K13251]
110391538  BCAP31; B-cell receptor-associated protein 31 isoform X1 [KO:K14009]
110393762  TRAM1; translocating chain-associated membrane protein 1 isoform X1 [KO:K14010]
110393450  DERL1; derlin-1 [KO:K11519]
110406373  DERL3; derlin-3 isoform X1 [KO:K13989]
110407863  DERL2; derlin-2 [KO:K13989]
110399357  UBXN4; UBX domain-containing protein 4 isoform X1 [KO:K24348]
110395935  UBXN2A; UBX domain-containing protein 2A [KO:K24349]
110388783  UBXN6; UBX domain-containing protein 6 [KO:K14011]
110408393  NSFL1C; NSFL1 cofactor p47 [KO:K14012]
110401795  SVIP; small VCP/p97-interacting protein [KO:K14014]
110389320  VCP; transitional endoplasmic reticulum ATPase [KO:K13525]
110407137  NPLOC4; nuclear protein localization protein 4 homolog [KO:K14015]
110406394  UFD1; ubiquitin recognition factor in ER-associated degradation protein 1 [KO:K14016]
110387614  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
110389531  DNAJA1; dnaJ homolog subfamily A member 1 [KO:K09502]
110387937  dnaJ homolog subfamily A member 1-like [KO:K09502]
110404234  DNAJA2; dnaJ homolog subfamily A member 2 [KO:K09503]
110399197  DNAJB2; dnaJ homolog subfamily B member 2 isoform X1 [KO:K09508]
110400608  DNAJB12; dnaJ homolog subfamily B member 12 [KO:K09518]
110408168  DNAJC5; dnaJ homolog subfamily C member 5 [KO:K09525]
110394115  DNAJC5B; dnaJ homolog subfamily C member 5B [KO:K09525]
110396284  DNAJC5G; dnaJ homolog subfamily C member 5G [KO:K09525]
110395331  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
110400900  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
110397655  HSPA4L; heat shock 70 kDa protein 4L [KO:K09485]
110388764  HSPH1; heat shock protein 105 kDa isoform X1 [KO:K09485]
110394556  BAG1; BAG family molecular chaperone regulator 1 isoform X1 [KO:K09555]
110396024  BAG2; BAG family molecular chaperone regulator 2 [KO:K09556]
110391344  HSPBP1; hsp70-binding protein 1 [KO:K09562]
110403502  CRYAA; alpha-crystallin A chain isoform X1 [KO:K09541]
110387574  CRYAB; alpha-crystallin B chain isoform X1 [KO:K09542]
110388379  YOD1; ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
110390340  PLAA; phospholipase A-2-activating protein isoform X1 [KO:K14018]
110391185  RAD23A; UV excision repair protein RAD23 homolog A isoform X1 [KO:K10839]
110389315  RAD23B; UV excision repair protein RAD23 homolog B isoform X1 [KO:K10839]
110391958  ubiquilin-1-like [KO:K04523]
110389384  UBQLN1; ubiquilin-1 isoform X1 [KO:K04523]
110387888  UBQLN4; ubiquilin-4 isoform X1 [KO:K04523]
110393878  NGLY1; peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
110402067  ATXN3; ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
110408575  UBE4B; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
110397823  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
110401065  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
110399826  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
110392532  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
110402723  DNA damage-inducible transcript 3 protein-like isoform X1 [KO:K04452]
110395041  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
110402649  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
110397902  WFS1; wolframin [KO:K14020]
110404327  MBTPS1; membrane-bound transcription factor site-1 protease [KO:K08653] [EC:3.4.21.112]
110404550  MBTPS2; membrane-bound transcription factor site-2 protease [KO:K07765] [EC:3.4.24.85]
110406519  XBP1; X-box-binding protein 1 [KO:K09027]
110407264  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
110405607  ERN2; serine/threonine-protein kinase/endoribonuclease IRE2 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
110406784  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
110395802  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
110390478  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
110398630  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110405490  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110399325  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110388215  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
110395367  CAPN11; calpain-11 [KO:K01367] [EC:3.4.22.52]
110395702  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
110393318  MARCH6; E3 ubiquitin-protein ligase MARCH6 isoform X1 [KO:K10661] [EC:2.3.2.27]
110395588  UBE2J1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
110408584  UBE2J2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
110407666  UBE2G1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
110397646  UBE2G2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
110406477  RNF185; E3 ubiquitin-protein ligase RNF185 isoform X1 [KO:K10666] [EC:2.3.2.27]
110403792  SELENOS; selenoprotein S [KO:K14025]
110401100  SEL1L; protein sel-1 homolog 1 isoform X1 [KO:K14026]
110404109  HERPUD1; homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform X1 [KO:K14027]
110404071  AMFR; E3 ubiquitin-protein ligase AMFR isoform X1 [KO:K10636] [EC:2.3.2.36]
110405767  STUB1; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
110405147  UBE2D2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
110398431  UBE2D3; ubiquitin-conjugating enzyme E2 D3 isoform X1 [KO:K06689] [EC:2.3.2.23]
110400646  UBE2D1; ubiquitin-conjugating enzyme E2 D1 isoform X1 [KO:K06689] [EC:2.3.2.23]
110395954  PRKN; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
110392307  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
110390791  CUL1; cullin-1 isoform X1 [KO:K03347]
110405291  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
110387001  F-box only protein 6-like isoform X1 [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
nmel00510  N-Glycan biosynthesis
nmel03050  Proteasome
nmel03060  Protein export
nmel04210  Apoptosis
KO pathway
ko04141   
LinkDB

DBGET integrated database retrieval system