KEGG   PATHWAY: oda04727
Entry
oda04727                    Pathway                                
Name
GABAergic synapse - Oryx dammah (scimitar-horned oryx)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
Pathway map
oda04727  GABAergic synapse
oda04727

Other DBs
GO: 0051932
Organism
Oryx dammah (scimitar-horned oryx) [GN:oda]
Gene
120861341  sodium-coupled neutral amino acid transporter 1 [KO:K14990]
120857923  sodium-coupled neutral amino acid transporter 1 [KO:K14990]
120861340  sodium-coupled neutral amino acid transporter 2 isoform X1 [KO:K14207]
120857925  sodium-coupled neutral amino acid transporter 2 isoform X1 [KO:K14207]
120854685  GLS; glutaminase kidney isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
120857455  GLS2; glutaminase liver isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
120880876  glutamate decarboxylase 1-like [KO:K01580] [EC:4.1.1.15]
120869304  GAD2; glutamate decarboxylase 2 [KO:K01580] [EC:4.1.1.15]
120854913  GAD1; glutamate decarboxylase 1 [KO:K01580] [EC:4.1.1.15]
120869211  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
120855550  ABAT; 4-aminobutyrate aminotransferase, mitochondrial [KO:K13524] [EC:2.6.1.19 2.6.1.22]
120881794  GABRA3; gamma-aminobutyric acid receptor subunit alpha-3 [KO:K05175]
120875274  GABRA5; gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175]
120862085  GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 isoform X1 [KO:K05175]
120862088  GABRA4; gamma-aminobutyric acid receptor subunit alpha-4 [KO:K05175]
120863342  GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 [KO:K05175]
120863343  GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 [KO:K05175]
120875278  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 [KO:K05181]
120862089  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
120863344  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181]
120875379  GABRG3; gamma-aminobutyric acid receptor subunit gamma-3 [KO:K05186]
120862084  GABRG1; gamma-aminobutyric acid receptor subunit gamma-1 [KO:K05186]
120863341  GABRG2; gamma-aminobutyric acid receptor subunit gamma-2 isoform X1 [KO:K05186]
120880621  GABRD; gamma-aminobutyric acid receptor subunit delta [KO:K05184]
120881793  GABRE; gamma-aminobutyric acid receptor subunit epsilon [KO:K05185]
120881812  GABRQ; gamma-aminobutyric acid receptor subunit theta [KO:K05192]
120879686  gamma-aminobutyric acid receptor subunit pi [KO:K05189]
120864090  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
120856949  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
120868632  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
120866588  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
120876193  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
120871941  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
120867144  HAP1; LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K04647]
120858827  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
120872848  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
120866076  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
120866986  NSF; vesicle-fusing ATPase isoform X1 [KO:K06027] [EC:3.6.4.6]
120854619  TRAK2; trafficking kinesin-binding protein 2 [KO:K15374]
120854654  PLCL1; inactive phospholipase C-like protein 1 [KO:K15375]
120852804  GPHN; gephyrin isoform X1 [KO:K15376] [EC:2.10.1.1 2.7.7.75]
120869125  SLC12A5; solute carrier family 12 member 5 isoform X1 [KO:K23967]
120853031  GABRR3; gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190]
120862726  GABRR2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190]
120862729  GABRR1; gamma-aminobutyric acid receptor subunit rho-1 [KO:K05190]
120864066  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
120852240  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
120857839  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
120868392  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
120881638  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
120880100  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
120862678  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
120870325  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615]
120878127  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
120868293  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
120856729  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
120873213  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
120880626  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
120879254  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
120858736  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
120871461  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
120853003  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
120853103  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
120874576  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
120860493  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
120865418  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
120856943  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
120864776  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
120863079  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
120877950  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
120864061  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
120857016  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
120855448  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
120877949  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
120867306  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
120877473  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
120879368  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
120851596  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
120853482  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
120870754  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
120861292  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
120858160  adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
120872811  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
120878868  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
120874335  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
120880571  G protein-activated inward rectifier potassium channel 2-like [KO:K05000]
120868131  SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
120857860  SLC6A13; sodium- and chloride-dependent GABA transporter 2 isoform X1 [KO:K05046]
120868130  SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
120857859  SLC6A12; sodium- and chloride-dependent betaine transporter isoform X1 [KO:K05045]
120880488  GLUL; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
120865484  glutamine synthetase-like [KO:K01915] [EC:6.3.1.2]
120868292  SLC38A3; sodium-coupled neutral amino acid transporter 3 isoform X1 [KO:K13576]
120860580  SLC38A5; sodium-coupled neutral amino acid transporter 5 [KO:K14992]
Compound
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00042  Succinate
C00064  L-Glutamine
C00076  Calcium cation
C00238  Potassium cation
C00334  4-Aminobutanoate
C00575  3',5'-Cyclic AMP
C00698  Cl-
Reference
  Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
  Title
Neuropsychopharmacology: The fifth generation of progress
  Journal
Lippincott Williams & Wikins (2002)
DOI:10.1002/hup.431
Reference
PMID:17499109
  Authors
Farrant M, Kaila K
  Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
  Journal
Prog Brain Res 160:59-87 (2007)
DOI:10.1016/S0079-6123(06)60005-8
Reference
PMID:9364667
  Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
  Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
  Journal
Trends Neurosci 20:523-9 (1997)
DOI:10.1016/S0166-2236(97)01147-8
Reference
PMID:20655485
  Authors
Pinard A, Seddik R, Bettler B
  Title
GABAB receptors: physiological functions and mechanisms of diversity.
  Journal
Adv Pharmacol 58:231-55 (2010)
DOI:10.1016/S1054-3589(10)58010-4
Reference
PMID:21376567
  Authors
Chalifoux JR, Carter AG
  Title
GABAB receptor modulation of synaptic function.
  Journal
Curr Opin Neurobiol 21:339-44 (2011)
DOI:10.1016/j.conb.2011.02.004
Reference
PMID:20655481
  Authors
Padgett CL, Slesinger PA
  Title
GABAB receptor coupling to G-proteins and ion channels.
  Journal
Adv Pharmacol 58:123-47 (2010)
DOI:10.1016/S1054-3589(10)58006-2
Reference
PMID:17499108
  Authors
Emson PC
  Title
GABA(B) receptors: structure and function.
  Journal
Prog Brain Res 160:43-57 (2007)
DOI:10.1016/S0079-6123(06)60004-6
Reference
PMID:16932937
  Authors
Kornau HC
  Title
GABA(B) receptors and synaptic modulation.
  Journal
Cell Tissue Res 326:517-33 (2006)
DOI:10.1007/s00441-006-0264-7
Reference
PMID:18382465
  Authors
Jacob TC, Moss SJ, Jurd R
  Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
  Journal
Nat Rev Neurosci 9:331-43 (2008)
DOI:10.1038/nrn2370
Reference
PMID:12086709
  Authors
Kneussel M
  Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
  Journal
Brain Res Brain Res Rev 39:74-83 (2002)
DOI:10.1016/S0165-0173(02)00159-5
Reference
PMID:21555068
  Authors
Luscher B, Fuchs T, Kilpatrick CL
  Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
  Journal
Neuron 70:385-409 (2011)
DOI:10.1016/j.neuron.2011.03.024
Reference
PMID:19374920
  Authors
Arancibia-Carcamo IL, Kittler JT
  Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
  Journal
Pharmacol Ther 123:17-31 (2009)
DOI:10.1016/j.pharmthera.2009.03.012
Reference
PMID:16787421
  Authors
Bak LK, Schousboe A, Waagepetersen HS
  Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
  Journal
J Neurochem 98:641-53 (2006)
DOI:10.1111/j.1471-4159.2006.03913.x
Reference
PMID:15210304
  Authors
Conti F, Minelli A, Melone M
  Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
  Journal
Brain Res Brain Res Rev 45:196-212 (2004)
DOI:10.1016/j.brainresrev.2004.03.003
Reference
PMID:12888801
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
Reference
PMID:10780899
  Authors
Chebib M, Johnston GA
  Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
  Journal
J Med Chem 43:1427-47 (2000)
DOI:10.1021/jm9904349
Related
pathway
oda00020  Citrate cycle (TCA cycle)
oda00250  Alanine, aspartate and glutamate metabolism
oda04144  Endocytosis
oda04721  Synaptic vesicle cycle
KO pathway
ko04727   
LinkDB

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