KEGG   PATHWAY: oga00260
Entry
oga00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Otolemur garnettii (small-eared galago)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
oga00260  Glycine, serine and threonine metabolism
oga00260

Module
oga_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:oga00260]
oga_M00047  Creatine pathway [PATH:oga00260]
oga_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:oga00260]
oga_M00555  Betaine biosynthesis, choline => betaine [PATH:oga00260]
oga_M00621  Glycine cleavage system [PATH:oga00260]
oga_M00974  Betaine metabolism, animals, betaine => glycine [PATH:oga00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Otolemur garnettii (small-eared galago) [GN:oga]
Gene
100951242  SHMT2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
100960593  SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
100943592  AGXT; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
100944904  GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
100946826  GLYCTK; glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]
100965676  LOW QUALITY PROTEIN: phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
100953071  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
100942456  phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
100956918  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
100966151  PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
100947718  PSAT1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
100954108  PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
100953728  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial isoform X1 [KO:K00639] [EC:2.3.1.29]
100954012  L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
100962763  ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
100961107  ALAS1; LOW QUALITY PROTEIN: 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
100966845  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
100944892  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
100950894  membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
111721718  membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
100951534  AOC2; retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
100943493  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
100955394  AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
100947397  DLD; LOW QUALITY PROTEIN: dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
100961661  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
100960595  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
100957840  DAO; LOW QUALITY PROTEIN: D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
100940834  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X2 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
100952301  GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
100965714  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
100954819  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
100961474  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
100945871  BHMT; betaine--homocysteine S-methyltransferase 1 isoform X1 [KO:K00544] [EC:2.1.1.5]
100945232  DMGDH; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
100946238  PIPOX; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
100950320  SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
100950716  GNMT; glycine N-methyltransferase isoform X2 [KO:K00552] [EC:2.1.1.20]
100948655  CBS; cystathionine beta-synthase isoform X5 [KO:K01697] [EC:4.2.1.22]
100963157  CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
105888269  LOW QUALITY PROTEIN: cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
100949132  SDSL; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
100951869  SDS; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
100953083  SRR; serine racemase [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
oga00010  Glycolysis / Gluconeogenesis
oga00020  Citrate cycle (TCA cycle)
oga00230  Purine metabolism
oga00250  Alanine, aspartate and glutamate metabolism
oga00270  Cysteine and methionine metabolism
oga00290  Valine, leucine and isoleucine biosynthesis
oga00330  Arginine and proline metabolism
oga00470  D-Amino acid metabolism
oga00564  Glycerophospholipid metabolism
oga00600  Sphingolipid metabolism
oga00620  Pyruvate metabolism
oga00630  Glyoxylate and dicarboxylate metabolism
oga00640  Propanoate metabolism
oga00860  Porphyrin metabolism
oga00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system