KEGG   PATHWAY: oha03013
Entry
oha03013                    Pathway                                
Name
Nucleocytoplasmic transport - Opisthocomus hoazin (hoatzin)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
oha03013  Nucleocytoplasmic transport
oha03013

Other DBs
GO: 0050658
Organism
Opisthocomus hoazin (hoatzin) [GN:oha]
Gene
104326590  NUPL2; nucleoporin-like protein 2 [KO:K14321]
104329965  GLE1; nucleoporin GLE1 [KO:K18723]
104335952  ATP-dependent RNA helicase DDX19A isoform X1 [KO:K18655] [EC:5.6.2.7]
104328792  RAE1; mRNA export factor [KO:K14298]
104336384  NUP98; LOW QUALITY PROTEIN: nuclear pore complex protein Nup98-Nup96 [KO:K14297]
104329723  NUP214; LOW QUALITY PROTEIN: nuclear pore complex protein Nup214 [KO:K14317]
104328672  NUP88; nuclear pore complex protein Nup88 [KO:K14318]
104326933  RANBP2; LOW QUALITY PROTEIN: E3 SUMO-protein ligase RanBP2 [KO:K12172] [EC:2.3.2.-]
104329825  RANGAP1; LOW QUALITY PROTEIN: ran GTPase-activating protein 1 [KO:K14319]
104336151  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
104327616  small ubiquitin-related modifier 3-like [KO:K12160]
104332861  SUMO2; small ubiquitin-related modifier 2 [KO:K12160]
104334236  SUMO1; small ubiquitin-related modifier 1 [KO:K12160]
104330843  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
104332862  NUP85; nuclear pore complex protein Nup85 [KO:K14304]
104334373  SEC13; protein SEC13 homolog [KO:K14004]
104326809  NUP107; nuclear pore complex protein Nup107 [KO:K14301]
104332606  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
104333447  SEH1L; nucleoporin SEH1 [KO:K14299]
104328706  NUP43; nucleoporin Nup43 [KO:K14305]
104338277  NUP37; nucleoporin Nup37 [KO:K14302]
104329566  NUP62CL; nucleoporin-62 C-terminal-like protein [KO:K14306]
104337304  NUPL1; LOW QUALITY PROTEIN: nucleoporin p58/p45 [KO:K14307]
104330293  NUP54; LOW QUALITY PROTEIN: nucleoporin p54 [KO:K14308]
104334532  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
104329882  NUP188; nucleoporin NUP188 homolog [KO:K14311]
104337678  NUP155; LOW QUALITY PROTEIN: nuclear pore complex protein Nup155 [KO:K14312]
104334762  LOW QUALITY PROTEIN: nuclear pore complex protein Nup93-like [KO:K14309]
104338568  NUP35; nucleoporin NUP53 isoform X1 [KO:K14313]
104334158  NDC1; nucleoporin NDC1 [KO:K14315]
104335240  NUP210; nuclear pore membrane glycoprotein 210 [KO:K14314]
104330307  TMEM33; transmembrane protein 33 [KO:K20724]
104326329  TPR; nucleoprotein TPR [KO:K09291]
104334102  NUP50; nuclear pore complex protein Nup50 [KO:K14295]
104333854  NUP153; LOW QUALITY PROTEIN: nuclear pore complex protein Nup153 [KO:K14296]
104335070  SENP2; LOW QUALITY PROTEIN: sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
104327315  KPNA1; importin subunit alpha-5 [KO:K23940]
104332931  KPNA2; importin subunit alpha-1 [KO:K15043]
104335651  KPNA7; importin subunit alpha-8 isoform X1 [KO:K15043]
104334386  KPNA4; importin subunit alpha-3 [KO:K23583]
104336962  KPNA3; importin subunit alpha-4 [KO:K23583]
104326484  KPNA6; importin subunit alpha-7 [KO:K15042]
104338783  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
104336371  KPNB1; importin subunit beta-1 [KO:K14293]
104332756  TNPO1; transportin-1 [KO:K18752]
104338604  IPO5; importin-5 [KO:K20222]
104328425  IPO7; LOW QUALITY PROTEIN: importin-7 [KO:K20223]
104336044  IPO8; importin-8 [KO:K18755]
104327347  IPO9; importin-9 [KO:K20224]
104337723  IPO11; LOW QUALITY PROTEIN: importin-11 [KO:K25201]
104338855  IPO13; importin-13 [KO:K25202]
104336675  XPO1; exportin-1 [KO:K14290]
104328769  CSE1L; exportin-2 isoform X1 [KO:K18423]
104326778  XPOT; exportin-T [KO:K14288]
104337293  XPO4; exportin-4 [KO:K25203]
104329299  XPO5; exportin-5 [KO:K14289]
104336081  XPO6; exportin-6 [KO:K25204]
104336225  XPO7; LOW QUALITY PROTEIN: exportin-7 [KO:K18460]
104334685  RANBP17; ran-binding protein 17 [KO:K24115]
104327558  RAN; GTP-binding nuclear protein Ran [KO:K07936]
104328814  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
104334388  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
104330007  PHAX; phosphorylated adapter RNA export protein [KO:K14291]
104338460  NCBP1; LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 1 [KO:K12882]
104338769  NCBP2; LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 2 [KO:K12883]
104335748  nuclear cap-binding protein subunit 2-like [KO:K12883]
104334442  NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
104334186  MAGOH; protein mago nashi homolog [KO:K12877]
104332230  CASC3; protein CASC3 [KO:K14323]
104326291  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
104337295  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
104333651  RNPS1; RNA-binding protein with serine-rich domain 1 [KO:K14325]
104333923  PNN; pinin [KO:K13114]
104327841  ALYREF; THO complex subunit 4 [KO:K12881]
104327355  UPF1; regulator of nonsense transcripts 1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
104337626  UPF2; regulator of nonsense transcripts 2 [KO:K14327]
104329593  UPF3B; regulator of nonsense transcripts 3B [KO:K14328]
104326889  UPF3A; regulator of nonsense transcripts 3A [KO:K14328]
104339083  NXT2; NTF2-related export protein 2 [KO:K14285]
104326318  SRRM1; LOW QUALITY PROTEIN: serine/arginine repetitive matrix protein 1 [KO:K13171]
104326640  THOC1; THO complex subunit 1 [KO:K12878]
104339098  THOC2; THO complex subunit 2 [KO:K12879]
104331307  THOC5; THO complex subunit 5 homolog [KO:K13174]
104331339  THOC7; THO complex subunit 7 homolog [KO:K13176]
104336766  THOC3; THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
oha03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

DBGET integrated database retrieval system