KEGG   PATHWAY: pcoc03013
Entry
pcoc03013                   Pathway                                
Name
Nucleocytoplasmic transport - Phasianus colchicus (Ring-necked pheasant)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
pcoc03013  Nucleocytoplasmic transport
pcoc03013

Other DBs
GO: 0050658
Organism
Phasianus colchicus (Ring-necked pheasant) [GN:pcoc]
Gene
116234937  AAAS; aladin isoform X1 [KO:K14320]
116227036  NUP42; nucleoporin NUP42 [KO:K14321]
116234210  GLE1; nucleoporin GLE1 [KO:K18723]
116242731  ATP-dependent RNA helicase DDX19B isoform X1 [KO:K18655] [EC:5.6.2.7]
116244651  RAE1; mRNA export factor isoform X1 [KO:K14298]
116232709  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
116234256  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
116228171  NUP88; nuclear pore complex protein Nup88 [KO:K14318]
116236505  RGPD4; ranBP2-like and GRIP domain-containing protein 4 isoform X1 [KO:K12172] [EC:2.3.2.-]
116233386  RANGAP1; ran GTPase-activating protein 1 isoform X1 [KO:K14319]
116237356  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
116230969  small ubiquitin-related modifier 3 [KO:K12160]
116232367  SUMO2; small ubiquitin-related modifier 2 isoform X1 [KO:K12160]
116237850  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
116232354  NUP85; nuclear pore complex protein Nup85 [KO:K14304]
116236562  SEC13; protein SEC13 homolog [KO:K14004]
116226599  NUP107; nuclear pore complex protein Nup107 [KO:K14301]
116242785  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
116226222  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
116241438  NUP43; nucleoporin Nup43 isoform X1 [KO:K14305]
116226784  NUP37; nucleoporin Nup37 [KO:K14302]
116228783  AHCTF1; protein ELYS [KO:K25129]
116229552  NUP62CL; nucleoporin-62 C-terminal-like protein isoform X1 [KO:K14306]
116244264  NUP58; nucleoporin p58/p45 isoform X1 [KO:K14307]
116231167  NUP54; nucleoporin p54 isoform X1 [KO:K14308]
116233465  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
116234225  NUP188; nucleoporin NUP188 homolog isoform X1 [KO:K14311]
116229806  NUP155; nuclear pore complex protein Nup155 isoform X1 [KO:K14312]
116243945  NUP93; nuclear pore complex protein Nup93 [KO:K14309]
116235925  NUP35; nucleoporin NUP35 [KO:K14313]
116234977  NDC1; LOW QUALITY PROTEIN: nucleoporin NDC1 [KO:K14315]
116237311  NUP210L; nuclear pore membrane glycoprotein 210-like isoform X1 [KO:K14314]
116238814  NUP210; nuclear pore membrane glycoprotein 210 [KO:K14314]
116227873  nuclear envelope pore membrane protein POM 121-like [KO:K14316]
116225878  TMEM33; transmembrane protein 33 [KO:K20724]
116238675  TPR; nucleoprotein TPR isoform X1 [KO:K09291]
116231453  NUP50; nuclear pore complex protein Nup50 [KO:K14295]
116226467  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
116231010  SENP2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
116240001  KPNA1; importin subunit alpha-5 [KO:K23940]
116237494  KPNA7; importin subunit alpha-8 [KO:K15043]
116232454  KPNA2; importin subunit alpha-1 [KO:K15043]
116244291  KPNA3; importin subunit alpha-4 [KO:K23583]
116235494  KPNA4; importin subunit alpha-3 [KO:K23583]
116240384  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
116229961  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
116233639  KPNB1; importin subunit beta-1 [KO:K14293]
116234820  TNPO1; transportin-1 [KO:K18752]
116243080  TNPO2; LOW QUALITY PROTEIN: transportin-2 [KO:K18727]
116236437  TNPO3; transportin-3 isoform X1 [KO:K15436]
116240270  IPO5; importin-5 [KO:K20222]
116243047  IPO7; importin-7 [KO:K20223]
116226845  IPO8; importin-8 isoform X1 [KO:K18755]
116238716  IPO9; importin-9 [KO:K20224]
116238503  IPO11; importin-11 [KO:K25201]
116233853  IPO13; importin-13 isoform X1 [KO:K25202]
116244564  SNUPN; snurportin-1 isoform X1 [KO:K13151]
116230191  XPO1; exportin-1 [KO:K14290]
116227285  CSE1L; exportin-2 [KO:K18423]
116226618  XPOT; exportin-T [KO:K14288]
116244256  XPO4; exportin-4 [KO:K25203]
116229209  XPO5; exportin-5 isoform X1 [KO:K14289]
116230266  XPO6; exportin-6 isoform X1 [KO:K25204]
116234558  XPO7; exportin-7 isoform X1 [KO:K18460]
116228672  RAN; GTP-binding nuclear protein Ran [KO:K07936]
116227862  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
116240445  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
116238186  PHAX; phosphorylated adapter RNA export protein [KO:K14291]
116239466  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
116230870  LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 2-like [KO:K12883]
116229604  nuclear cap-binding protein subunit 2 [KO:K12883]
116235501  NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
116241275  RBM8A; RNA-binding protein 8A [KO:K12876]
116234886  MAGOH; protein mago nashi homolog [KO:K12877]
116233641  CASC3; protein CASC3 isoform X1 [KO:K14323]
116231462  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
116244180  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
116230318  RNPS1; RNA-binding protein with serine-rich domain 1 [KO:K14325]
116229379  PNN; pinin [KO:K13114]
116232560  ALYREF; THO complex subunit 4 [KO:K12881]
116235731  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
116237875  UPF2; regulator of nonsense transcripts 2 [KO:K14327]
116236499  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
116234889  UPF3B; regulator of nonsense transcripts 3B [KO:K14328]
116229781  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
116230063  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
116239270  PYM1; partner of Y14 and mago [KO:K14294]
116242276  THOC1; THO complex subunit 1 isoform X1 [KO:K12878]
116234901  THOC2; THO complex subunit 2 [KO:K12879]
116228348  THOC5; THO complex subunit 5 homolog isoform X1 [KO:K13174]
116237244  THOC7; THO complex subunit 7 homolog [KO:K13176]
116232092  THOC3; THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
pcoc03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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