Entry
Name
mRNA surveillance pathway - Phasianus colchicus (Ring-necked pheasant)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
Other DBs
Organism
Phasianus colchicus (Ring-necked pheasant) [GN:
pcoc ]
Gene
116225784 PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354 ]
116225912 FIP1L1; pre-mRNA 3'-end-processing factor FIP1 isoform X1 [KO:K14405 ]
116226590 CPSF6; cleavage and polyadenylation specificity factor subunit 6 isoform X1 [KO:K14398 ]
116227574 PABPC1L; polyadenylate-binding protein 1-like isoform X1 [KO:K13126 ]
116227920 MSI2; RNA-binding protein Musashi homolog 2 isoform X1 [KO:K14411 ]
116228077 SMG6; telomerase-binding protein EST1A isoform X1 [KO:K11124 ] [EC:3.1.-.-]
116228420 MSI1; RNA-binding protein Musashi homolog 1 isoform X1 [KO:K14411 ]
116228842 PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584 ]
116228900 CPSF2; cleavage and polyadenylation specificity factor subunit 2 [KO:K14402 ]
116229363 PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583 ]
116229659 CSTF2; cleavage stimulation factor subunit 2 isoform X1 [KO:K14407 ]
116230063 SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171 ]
116230345 PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584 ]
116230794 PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583 ]
116231037 PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583 ]
116231516 PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354 ]
116231967 ETF1; eukaryotic peptide chain release factor subunit 1 [KO:K03265 ]
116232217 PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382 ] [EC:3.1.3.16 ]
116232273 PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354 ]
116235295 PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584 ]
116236376 WDR33; pre-mRNA 3' end processing protein WDR33 isoform X1 [KO:K15542 ]
116236499 UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328 ]
116236797 PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584 ]
116237461 CPSF4; cleavage and polyadenylation specificity factor subunit 4 [KO:K14404 ]
116237579 GSPT1; eukaryotic peptide chain release factor GTP-binding subunit ERF3A [KO:K03267 ]
116238391 PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354 ]
116240406 CPSF3; cleavage and polyadenylation specificity factor subunit 3 isoform X1 [KO:K14403 ] [EC:3.1.27.-]
116241931 PCF11; pre-mRNA cleavage complex 2 protein Pcf11 isoform X1 [KO:K14400 ]
116243028 CPSF7; cleavage and polyadenylation specificity factor subunit 7 [KO:K14398 ]
116243582 NUDT21; cleavage and polyadenylation specificity factor subunit 5 [KO:K14397 ]
Reference
Authors
Maquat LE
Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
Journal
Reference
Authors
Amrani N, Sachs MS, Jacobson A
Title
Early nonsense: mRNA decay solves a translational problem.
Journal
Reference
Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
Title
P bodies: at the crossroads of post-transcriptional pathways.
Journal
Reference
Authors
Mandel CR, Bai Y, Tong L
Title
Protein factors in pre-mRNA 3'-end processing.
Journal
Reference
Authors
Clement SL, Lykke-Andersen J
Title
No mercy for messages that mess with the ribosome.
Journal
Related pathway
KO pathway