KEGG PATHWAY: pfri00270

PATHWAY: pfri00270

Entry

pfri00270                   Pathway

Name

Cysteine and methionine metabolism - Peribacillus frigoritolerans

Description

Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].

Class

Metabolism; Amino acid metabolism

Pathway map

pfri00270

Cysteine and methionine metabolism

Module

pfri_M00017

Methionine biosynthesis, aspartate => homoserine => methionine [PATH:pfri00270]

pfri_M00021

Cysteine biosynthesis, serine => cysteine [PATH:pfri00270]

pfri_M00034

Methionine salvage pathway [PATH:pfri00270]

pfri_M00609

Cysteine biosynthesis, methionine => cysteine [PATH:pfri00270]

Other DBs

GO:	0006534 0006555

Organism

Peribacillus frigoritolerans [GN:pfri]

Gene

L8956_00590

cysE; serine O-acetyltransferase [KO:K00640] [EC:2.3.1.30]

L8956_00430

cysK; cysteine synthase A [KO:K01738] [EC:2.5.1.47]

L8956_06005

cysK; cysteine synthase A [KO:K01738] [EC:2.5.1.47]

L8956_17555

bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase [KO:K17217] [EC:4.4.1.1 4.4.1.2]

L8956_05840

metC; cystathionine beta-lyase [KO:K01760] [EC:4.4.1.13]

L8956_24260

PatB family C-S lyase [KO:K14155] [EC:4.4.1.13]

L8956_02070

pyridoxal phosphate-dependent aminotransferase [KO:K14155] [EC:4.4.1.13]

L8956_17560

cysteine synthase family protein [KO:K17216] [EC:2.5.1.134]

L8956_13935

mmuM; homocysteine S-methyltransferase [KO:K00547] [EC:2.1.1.10]

L8956_14550

metH; methionine synthase [KO:K00548] [EC:2.1.1.13]

L8956_14555

bifunctional homocysteine S-methyltransferase/methylenetetrahydrofolate reductase [KO:K24042] [EC:2.1.1.13 1.5.1.54]

L8956_03945

metE; 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase [KO:K00549] [EC:2.1.1.14]

L8956_23505

metK; methionine adenosyltransferase [KO:K00789] [EC:2.5.1.6]

L8956_18725

speD; adenosylmethionine decarboxylase [KO:K01611] [EC:4.1.1.50]

L8956_12940

speD; adenosylmethionine decarboxylase [KO:K01611] [EC:4.1.1.50]

L8956_25835

speE; spermidine synthase [KO:K00797] [EC:2.5.1.16]

L8956_17565

mtnN; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase [KO:K01243] [EC:3.2.2.9]

L8956_20545

5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase [KO:K01243] [EC:3.2.2.9]

L8956_22010

HAD hydrolase-like protein [KO:K01243] [EC:3.2.2.9]

L8956_14725

mtnK; S-methyl-5-thioribose kinase [KO:K00899] [EC:2.7.1.100]

L8956_08005

pgeF; peptidoglycan editing factor PgeF [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]

L8956_21110

amidohydrolase family protein [KO:K12960] [EC:3.5.4.31 3.5.4.28]

L8956_14730

mtnA; S-methyl-5-thioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]

L8956_14700

methylthioribulose 1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]

L8956_14710

mtnW; 2,3-diketo-5-methylthiopentyl-1-phosphate enolase [KO:K08965] [EC:5.3.2.5]

L8956_14705

2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase [KO:K08966] [EC:3.1.3.87]

L8956_14695

cupin domain-containing protein [KO:K08967] [EC:1.13.11.53 1.13.11.54]

L8956_14715

pyridoxal phosphate-dependent aminotransferase [KO:K08969] [EC:2.6.1.117]

L8956_03090

megL; methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]

L8956_19045

GAF domain-containing protein [KO:K08968] [EC:1.8.4.14]

L8956_17570

class I SAM-dependent methyltransferase [KO:K17462] [EC:2.1.1.-]

L8956_23600

S-ribosylhomocysteine lyase [KO:K07173] [EC:4.4.1.21]

L8956_18495

aspartate kinase [KO:K00928] [EC:2.7.2.4]

L8956_02925

aspartate kinase [KO:K00928] [EC:2.7.2.4]

L8956_08540

dapG; aspartate kinase [KO:K00928] [EC:2.7.2.4]

L8956_08535

asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

L8956_24475

homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

L8956_09160

homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

L8956_24465

thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]

L8956_15000

metA; homoserine O-succinyltransferase [KO:K00651] [EC:2.3.1.46 2.3.1.31]

L8956_05845

methionine biosynthesis PLP-dependent protein [KO:K01739] [EC:2.5.1.48]

L8956_09155

cystathionine gamma-synthase family protein [KO:K01739] [EC:2.5.1.48]

L8956_24605

O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase [KO:K01740] [EC:2.5.1.49]

L8956_13340

branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]

L8956_15190

pyridoxal phosphate-dependent aminotransferase [KO:K00812] [EC:2.6.1.1]

L8956_15955

pyridoxal phosphate-dependent aminotransferase [KO:K00812] [EC:2.6.1.1]

L8956_15745

sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]

L8956_09220

L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]

L8956_21870

amino acid racemase [KO:K25316] [EC:5.1.1.10]

L8956_02090

D-cysteine desulfhydrase [KO:K05396] [EC:4.4.1.15]

L8956_11795

D-cysteine desulfhydrase [KO:K05396] [EC:4.4.1.15]

L8956_18775

mdh; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]

L8956_22875

sdaAA; L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha [KO:K01752] [EC:4.3.1.17]

L8956_22880

sdaAB; L-serine ammonia-lyase, iron-sulfur-dependent subunit beta [KO:K01752] [EC:4.3.1.17]

L8956_08205

sdaAB; L-serine ammonia-lyase, iron-sulfur-dependent subunit beta [KO:K01752] [EC:4.3.1.17]

L8956_08210

sdaAA; L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha [KO:K01752] [EC:4.3.1.17]

L8956_15675

hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

L8956_16305

serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

L8956_20835

phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

L8956_13670

C-terminal binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]

L8956_06085

serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]

Compound

C00019

S-Adenosyl-L-methionine

C00021

S-Adenosyl-L-homocysteine

C00022

Pyruvate

C00041

L-Alanine

C00049

L-Aspartate

C00051

Glutathione

C00059

Sulfate

C00065

L-Serine

C00073

L-Methionine

C00094

Sulfite

C00097

L-Cysteine

C00109

2-Oxobutanoate

C00155

L-Homocysteine

C00170

5'-Methylthioadenosine

C00197

3-Phospho-D-glycerate

C00263

L-Homoserine

C00283

Hydrogen sulfide

C00409

Methanethiol

C00441

L-Aspartate 4-semialdehyde

C00491

L-Cystine

C00506

L-Cysteate

C00606

3-Sulfino-L-alanine

C00793

D-Cysteine

C00957

Mercaptopyruvate

C00979

O-Acetyl-L-serine

C01005

O-Phospho-L-serine

C01077

O-Acetyl-L-homoserine

C01102

O-Phospho-L-homoserine

C01118

O-Succinyl-L-homoserine

C01137

S-Adenosylmethioninamine

C01180

4-Methylthio-2-oxobutanoic acid

C01234

1-Aminocyclopropane-1-carboxylate

C01817

L-Homocystine

C01962

Thiocysteine

C02218

Dehydroalanine

C02291

L-Cystathionine

C02356

(S)-2-Aminobutanoate

C02989

L-Methionine S-oxide

C03082

4-Phospho-L-aspartate

C03089

5-Methylthio-D-ribose

C03145

N-Formylmethionine

C03232

3-Phosphonooxypyruvate

C03431

S-Inosyl-L-homocysteine

C03539

S-Ribosyl-L-homocysteine

C04188

S-Methyl-5-thio-D-ribose 1-phosphate

C04582

S-Methyl-5-thio-D-ribulose 1-phosphate

C05324

Nicotianamine

C05524

Aminoacyl-L-methionine

C05526

S-Glutathionyl-L-cysteine

C05527

3-Sulfinylpyruvate

C05528

3-Sulfopyruvate

C05823

3-Mercaptolactate

C05824

S-Sulfo-L-cysteine

C06547

Ethylene

C08276

3-(Methylthio)propanoate

C09306

Sulfur dioxide

C11437

1-Deoxy-D-xylulose 5-phosphate

C11481

HSO3-

C11499

(S)-3-Sulfolactate

C11537

(2R)-3-Sulfolactate

C15606

1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

C15650

2,3-Diketo-5-methylthiopentyl-1-phosphate

C15651

2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate

C18049

N-Acyl-L-homoserine lactone

C19787

5'-S-Methyl-5'-thioinosine

C21015

gamma-L-Glutamyl-L-2-aminobutyrate

C21016

Ophthalmate

C22359

S-Methyl-1-thio-D-xylulose 5-phosphate

Reference

PMID:15102328

Authors

Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A

Title

Bacterial variations on the methionine salvage pathway.

Journal

BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9

Reference

PMID:14551435

Authors

Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.

Title

A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.

Journal

Science 302:286-90 (2003)
DOI:10.1126/science.1086997

Reference

PMID:12022921

Authors

Sekowska A, Danchin A.

Title

The methionine salvage pathway in Bacillus subtilis.

Journal

BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8

Reference

PMID:12670965

Authors

Berger BJ, English S, Chan G, Knodel MH.

Title

Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.

Journal

J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003

Reference

PMID:17169919

Authors

Goyer A, Collakova E, Shachar-Hill Y, Hanson AD

Title

Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.

Journal

Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055

Reference

PMID:17030798

Authors

Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S

Title

Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.

Journal

Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103

Reference

PMID:18625006

Authors

Pirkov I, Norbeck J, Gustafsson L, Albers E

Title

A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.

Journal

FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x

Reference

PMID:18391471

Authors

Ashida H, Saito Y, Kojima C, Yokota A

Title

Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.

Journal

Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651

Reference

PMID:10613873

Authors

Kitabatake M, So MW, Tumbula DL, Soll D

Title

Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?

Journal

J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000

Reference

PMID:12644499

Authors

Mino K, Ishikawa K

Title

Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.

Journal

J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003

Reference

PMID:18520135

Authors

Tanabe S

Title

Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.

Journal

Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:19270684

Authors