Entry Name Progesterone-mediated oocyte maturation - Paramormyrops kingsleyae
Description Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class Organismal Systems; Endocrine systemBRITE hierarchy
Pathway map pki04914 Progesterone-mediated oocyte maturation
Ortholog table Other DBs Organism Paramormyrops kingsleyae [GN:
pki ]
Gene 111835615 pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
111834821 pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
111847640 phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649 ]
111860386 pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
111856594 phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649 ]
111836364 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
111860453 pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
111860909 pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
111853393 pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
111847017 guanine nucleotide-binding protein G(i) subunit alpha-1-like [KO:K04630 ]
111843401 guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
111840552 guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
111834337 guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630 ]
111839819 guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630 ]
111836020 cytoplasmic polyadenylation element-binding protein 4-like isoform X1 [KO:K02602 ]
111850357 cpeb3; cytoplasmic polyadenylation element-binding protein 3 isoform X1 [KO:K02602 ]
111850165 cpeb2; cytoplasmic polyadenylation element-binding protein 2 isoform X1 [KO:K02602 ]
111857408 cpeb1; cytoplasmic polyadenylation element-binding protein 1 isoform X1 [KO:K02602 ]
111859593 cytoplasmic polyadenylation element-binding protein 4-like isoform X1 [KO:K02602 ]
111833119 pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633 ] [EC:2.7.11.1 ]
111846569 igf1; LOW QUALITY PROTEIN: insulin-like growth factor I [KO:K05459 ]
111845484 mad1l1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679 ]
111850972 mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537 ]
111834307 mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728 ]
111852351 anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348 ]
111839268 anapc5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11554 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference Authors Schmitt A, Nebreda AR.
Title Signalling pathways in oocyte meiotic maturation.
Journal J Cell Sci 115:2457-9 (2002)
Reference Authors Cato AC, Nestl A, Mink S.
Title Rapid actions of steroid receptors in cellular signaling pathways.
Journal Reference Authors Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
Title The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
Journal Reference Authors Nebreda AR, Ferby I.
Title Regulation of the meiotic cell cycle in oocytes.
Journal Reference Authors Ferrell JE Jr.
Title Xenopus oocyte maturation: new lessons from a good egg.
Journal Reference Authors Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
Title Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
Journal Reference Authors Duckworth BC, Weaver JS, Ruderman JV.
Title G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
Journal Reference Authors Abrieu A, Doree M, Fisher D.
Title The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
Journal J Cell Sci 114:257-67 (2001)
Related KO pathway LinkDB All DBs
