KEGG   PATHWAY: pki04010
Entry
pki04010                    Pathway                                
Name
MAPK signaling pathway - Paramormyrops kingsleyae
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
pki04010  MAPK signaling pathway
pki04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Paramormyrops kingsleyae [GN:pki]
Gene
111832689  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
111832812  [KO:K18497]
111832832  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
111832882  [KO:K04466] [EC:2.7.11.25]
111833172  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111833200  [KO:K04429] [EC:2.7.11.1]
111833208  [KO:K02583]
111833211  [KO:K08018]
111833226  [KO:K04438]
111833289  [KO:K04858]
111833297  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
111833314  [KO:K05460]
111833360  [KO:K18496]
111833375  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
111833382  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
111833410  [KO:K04849]
111833549  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
111833563  [KO:K04364]
111833654  [KO:K05450]
111833700  [KO:K03283]
111833736  [KO:K04468] [EC:2.7.11.24]
111833742  taok2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
111833879  [KO:K04438]
111833901  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
111833932  pdgfd; platelet-derived growth factor D [KO:K05450]
111834017  mecom; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
111834059  [KO:K04358]
111834215  grb2; growth factor receptor-bound protein 2 [KO:K04364]
111834279  cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
111834334  [KO:K03283]
111834362  [KO:K04443] [EC:2.7.11.1]
111834368  [KO:K04857]
111834375  [KO:K05459]
111834408  [KO:K04393]
111834459  [KO:K04370]
111834477  [KO:K04393]
111834485  map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
111834660  [KO:K04358]
111834818  [KO:K04448]
111834820  [KO:K04389]
111835014  [KO:K04407] [EC:2.7.11.1]
111835053  [KO:K05096] [EC:2.7.10.1]
111835194  kitlg; kit ligand [KO:K05461]
111835201  [KO:K13376]
111835238  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
111835263  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
111835361  [KO:K03173] [EC:2.3.2.27]
111835374  [KO:K04393]
111835453  [KO:K05462]
111835519  fgf2; fibroblast growth factor 2 [KO:K18497]
111835682  map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
111835740  [KO:K03099]
111835754  [KO:K04378]
111835825  [KO:K04371] [EC:2.7.11.24]
111835972  [KO:K04867]
111835975  [KO:K04374]
111835987  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
111835993  [KO:K04441] [EC:2.7.11.24]
111836018  [KO:K05099] [EC:2.7.10.1]
111836472  [KO:K04358]
111836645  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111836682  [KO:K04358]
111836730  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
111836737  [KO:K04348] [EC:3.1.3.16]
111836739  [KO:K12361]
111836749  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
111836823  [KO:K04464] [EC:2.7.11.24]
111836837  [KO:K22429]
111836856  [KO:K04406] [EC:2.7.11.1]
111836858  [KO:K04378]
111836871  [KO:K04436]
111836888  rras; ras-related protein R-Ras isoform X1 [KO:K07830]
111836901  [KO:K04432] [EC:2.7.12.2]
111836934  [KO:K03099]
111837306  rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
111837344  [KO:K05450]
111837474  cacnb3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
111837477  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111837508  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
111837545  [KO:K04411]
111837555  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111837588  [KO:K04444] [EC:2.7.11.1]
111837634  [KO:K04421] [EC:2.7.11.25]
111837678  [KO:K05866] [EC:3.1.3.48]
111837750  [KO:K05083] [EC:2.7.10.1]
111837760  [KO:K04872]
111837761  [KO:K05096] [EC:2.7.10.1]
111837820  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
111837851  [KO:K04421] [EC:2.7.11.25]
111837943  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
111838006  [KO:K05096] [EC:2.7.10.1]
111838013  [KO:K13375]
111838048  [KO:K04350]
111838069  [KO:K04439]
111838070  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
111838191  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
111838441  [KO:K03176] [EC:2.7.10.1]
111838521  nf1; neurofibromin [KO:K08052]
111838586  [KO:K04424] [EC:2.7.11.25]
111838634  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
111838854  [KO:K04456] [EC:2.7.11.1]
111838905  max; protein max isoform X1 [KO:K04453]
111838912  rasgrp1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
111838972  [KO:K04674] [EC:2.7.11.30]
111838992  [KO:K03156]
111839117  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
111839168  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
111839208  ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
111839229  [KO:K05462]
111839256  ereg; proepiregulin isoform X1 [KO:K09784]
111839275  [KO:K04402]
111839280  [KO:K04402]
111839282  [KO:K04402]
111839372  [KO:K04440] [EC:2.7.11.24]
111839432  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
111839654  [KO:K04381]
111839862  [KO:K04353]
111839944  fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
111840011  ppm1b; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
111840084  [KO:K16342] [EC:3.1.1.4]
111840085  [KO:K16342] [EC:3.1.1.4]
111840143  [KO:K18018] [EC:3.1.3.48]
111840193  [KO:K04415] [EC:2.7.11.25]
111840275  [KO:K04429] [EC:2.7.11.1]
111840300  [KO:K04366] [EC:2.7.11.1]
111840348  [KO:K04441] [EC:2.7.11.24]
111840358  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111840385  nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
111840455  [KO:K04438]
111840606  [KO:K04444] [EC:2.7.11.1]
111840699  [KO:K02833]
111840707  map3k20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
111840805  map3k2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
111840847  mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
111840853  [KO:K05462]
111840875  efna3; ephrin-A3 isoform X1 [KO:K05462]
111840922  [KO:K05462]
111840961  [KO:K04345] [EC:2.7.11.11]
111841019  [KO:K16342] [EC:3.1.1.4]
111841061  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111841178  [KO:K07830]
111841195  [KO:K04358]
111841200  [KO:K04358]
111841255  [KO:K22603]
111841368  [KO:K03158]
111841410  [KO:K13769]
111841418  [KO:K03175] [EC:2.3.2.27]
111841476  [KO:K13375]
111841509  [KO:K04350]
111841525  [KO:K04439]
111841531  csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
111841598  [KO:K04361] [EC:2.7.10.1]
111841624  [KO:K04377]
111841712  stmn1; stathmin [KO:K04381]
111842012  tek; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
111842069  fgf10; fibroblast growth factor 10 [KO:K04358]
111842106  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111842191  gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
111842196  [KO:K04448]
111842285  [KO:K04437]
111842404  [KO:K07827]
111842446  [KO:K21946] [EC:3.1.3.16 3.1.3.48]
111842452  [KO:K04435]
111842454  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
111842626  [KO:K04409] [EC:2.7.11.1]
111842818  taok1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
111843005  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
111843026  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
111843039  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
111843097  il1rap; interleukin-1 receptor accessory protein [KO:K04723]
111843101  cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
111843125  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
111843189  [KO:K04856]
111843200  [KO:K04869]
111843225  [KO:K02677] [EC:2.7.11.13]
111843226  [KO:K04344]
111843262  [KO:K04355]
111843273  [KO:K04347]
111843291  [KO:K04866]
111843309  [KO:K04359]
111843315  [KO:K07860]
111843522  [KO:K17333]
111843577  [KO:K04349]
111843816  [KO:K04362] [EC:2.7.10.1]
111843993  angpt1; angiopoietin-1 [KO:K05465]
111844168  taok3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
111844188  [KO:K04873]
111844207  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
111844324  [KO:K07836]
111844398  [KO:K04379]
111844437  [KO:K13377]
111844442  [KO:K04457] [EC:3.1.3.16]
111844443  [KO:K04379]
111844528  [KO:K05448]
111844594  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
111844635  cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
111844712  [KO:K04423] [EC:2.7.11.25]
111844715  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
111844750  [KO:K18019] [EC:3.1.3.48]
111844835  [KO:K04457] [EC:3.1.3.16]
111844863  relb; transcription factor RelB isoform X1 [KO:K09253]
111844900  map3k10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
111844970  [KO:K04358]
111845000  igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
111845084  stk3; serine/threonine-protein kinase 3 [KO:K04412]
111845122  dusp3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
111845227  [KO:K25416]
111845249  [KO:K04374]
111845270  [KO:K17386]
111845281  cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
111845370  [KO:K04358]
111845481  [KO:K04346]
111845521  [KO:K19662] [EC:2.7.11.13]
111845539  cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
111845558  cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
111845607  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111845610  map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
111845660  kras; GTPase KRas isoform X1 [KO:K07827]
111845666  [KO:K04441] [EC:2.7.11.24]
111845679  [KO:K04441] [EC:2.7.11.24]
111845734  [KO:K05087] [EC:2.7.10.1]
111845763  vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
111845775  [KO:K04446]
111845778  [KO:K04358]
111845900  [KO:K04361] [EC:2.7.10.1]
111846015  [KO:K25415]
111846144  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
111846155  hgf; hepatocyte growth factor [KO:K05460]
111846161  cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
111846207  [KO:K04377]
111846337  arrb2; beta-arrestin-2 [KO:K04439]
111846342  fgf16; fibroblast growth factor 16 isoform X1 [KO:K04358]
111846386  [KO:K17386]
111846472  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
111846473  [KO:K04347]
111846569  igf1; LOW QUALITY PROTEIN: insulin-like growth factor I [KO:K05459]
111846686  [KO:K04358]
111846987  [KO:K04356]
111847020  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111847396  [KO:K04372] [EC:2.7.11.1]
111847400  [KO:K04410] [EC:2.7.11.1]
111847460  [KO:K03173] [EC:2.3.2.27]
111847550  [KO:K04448]
111847562  [KO:K04527] [EC:2.7.10.1]
111847607  nrtn; neurturin [KO:K25414]
111847625  [KO:K04852]
111847642  [KO:K04345] [EC:2.7.11.11]
111847733  map2k3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
111847734  [KO:K04436]
111847800  cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
111847817  [KO:K04853]
111847950  [KO:K05095] [EC:2.7.10.1]
111848299  cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
111848312  [KO:K04866]
111848341  [KO:K04461] [EC:3.1.3.16]
111848368  [KO:K04440] [EC:2.7.11.24]
111848425  map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
111848451  rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
111848470  [KO:K04469]
111848526  dusp5; dual specificity protein phosphatase 5 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111848546  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
111848567  [KO:K04519]
111848574  fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
111848593  [KO:K03173] [EC:2.3.2.27]
111848649  prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111848699  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111848782  cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
111848885  [KO:K04426] [EC:2.7.11.25]
111848989  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
111849035  rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
111849138  [KO:K04868]
111849218  prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
111849289  [KO:K19662] [EC:2.7.11.13]
111849374  egf; pro-epidermal growth factor isoform X1 [KO:K04357]
111849376  [KO:K04370]
111849456  [KO:K07831]
111849521  [KO:K08053]
111849744  [KO:K04421] [EC:2.7.11.25]
111849849  [KO:K04348] [EC:3.1.3.16]
111849899  [KO:K04455]
111850064  [KO:K04363] [EC:2.7.10.1]
111850065  kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
111850109  map3k8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
111850116  [KO:K05449]
111850117  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
111850307  [KO:K12326]
111850356  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111850420  [KO:K02583]
111850485  [KO:K05090] [EC:2.7.10.1]
111850518  [KO:K04355]
111850582  mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
111850623  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
111850633  [KO:K04456] [EC:2.7.11.1]
111850760  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
111850762  [KO:K04440] [EC:2.7.11.24]
111850821  ins; insulin isoform X1 [KO:K04526]
111851037  [KO:K04457] [EC:3.1.3.16]
111851087  rap1a; ras-related protein Rap-1A [KO:K04353]
111851225  [KO:K04358]
111851234  rap1b; ras-related protein Rap-1b [KO:K07836]
111851387  [KO:K04674] [EC:2.7.11.30]
111851431  [KO:K04360] [EC:2.7.10.1]
111851454  [KO:K04519]
111851484  [KO:K05462]
111851536  ptprr; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
111851553  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
111851556  tgfb2; transforming growth factor beta-2 [KO:K13376]
111851594  [KO:K05085] [EC:2.7.10.1]
111851740  cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
111851762  mras; ras-related protein M-Ras [KO:K07831]
111851785  [KO:K04438]
111851847  fgf3; fibroblast growth factor 3 [KO:K04358]
111851901  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
111851956  [KO:K04358]
111851964  fgf19; fibroblast growth factor 19 [KO:K22603]
111851979  [KO:K04419] [EC:2.7.11.25]
111851985  [KO:K12361]
111851986  [KO:K04735]
111852024  [KO:K04445] [EC:2.7.11.1]
111852228  [KO:K05085] [EC:2.7.10.1]
111852343  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
111852355  akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111852373  [KO:K04379]
111852442  tgfb3; transforming growth factor beta-3 [KO:K13377]
111852514  pgf; placenta growth factor [KO:K16859]
111852518  [KO:K04379]
111852528  [KO:K04860]
111852542  [KO:K04851]
111852554  [KO:K04863]
111852585  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111852799  angpt2; angiopoietin-2 [KO:K05466]
111852832  [KO:K04373] [EC:2.7.11.1]
111852859  [KO:K04421] [EC:2.7.11.25]
111852889  [KO:K02583]
111852918  [KO:K04439]
111853026  [KO:K04348] [EC:3.1.3.16]
111853263  [KO:K04346]
111853291  [KO:K19663] [EC:2.7.11.13]
111853300  [KO:K04872]
111853324  [KO:K04873]
111853326  cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
111853403  [KO:K05103] [EC:2.7.10.1]
111853413  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
111853509  [KO:K03176] [EC:2.7.10.1]
111853530  daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
111853593  casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
111853601  fgf20; fibroblast growth factor 20 [KO:K04358]
111853643  fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
111853849  [KO:K04392]
111853850  [KO:K04392]
111853904  [KO:K04441] [EC:2.7.11.24]
111853914  nras; GTPase NRas [KO:K07828]
111853915  [KO:K05103] [EC:2.7.10.1]
111853948  [KO:K02580]
111853966  [KO:K17534] [EC:2.7.11.25]
111853984  [KO:K04849]
111854004  [KO:K17534] [EC:2.7.11.25]
111854099  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
111854121  [KO:K04386]
111854129  map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
111854164  erbb3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
111854266  [KO:K05466]
111854363  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
111854424  mapkapk2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
111854492  [KO:K04451]
111854694  hspb1; heat shock protein beta-1 [KO:K04455]
111854743  [KO:K04465]
111855164  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
111855173  [KO:K05449]
111855185  [KO:K05090] [EC:2.7.10.1]
111855217  [KO:K04457] [EC:3.1.3.16]
111855250  [KO:K02582]
111855289  [KO:K04373] [EC:2.7.11.1]
111855295  [KO:K07210]
111855422  [KO:K04735]
111855427  map3k11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
111855469  [KO:K04440] [EC:2.7.11.24]
111855496  [KO:K04373] [EC:2.7.11.1]
111855608  mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
111855610  [KO:K04352]
111855675  [KO:K03283]
111855702  [KO:K03283]
111855939  [KO:K04430] [EC:2.7.12.2]
111855959  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
111855960  [KO:K04466] [EC:2.7.11.25]
111856067  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
111856137  [KO:K04375]
111856149  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
111856186  [KO:K04441] [EC:2.7.11.24]
111856245  map3k9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
111856400  nlk; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
111856500  [KO:K05452]
111856689  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
111856750  [KO:K07861]
111856785  mapt; microtubule-associated protein tau isoform X1 [KO:K04380]
111856922  [KO:K04430] [EC:2.7.12.2]
111856976  [KO:K02582]
111856989  [KO:K04437]
111857113  [KO:K04853]
111857200  [KO:K04388] [EC:2.7.11.30]
111857272  [KO:K04373] [EC:2.7.11.1]
111857297  fgf6; fibroblast growth factor 6 [KO:K04358]
111857479  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111857500  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
111857512  [KO:K04362] [EC:2.7.10.1]
111857559  ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
111857581  fgf23; fibroblast growth factor 23 [KO:K22428]
111857699  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
111857710  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
111857802  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111857846  tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
111858190  [KO:K05462]
111858191  [KO:K05462]
111858203  [KO:K05462]
111858263  [KO:K22429]
111858314  map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
111858411  [KO:K04358]
111858519  [KO:K04414] [EC:2.7.11.1]
111858668  traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
111858929  [KO:K04857]
111858989  [KO:K04445] [EC:2.7.11.1]
111859033  [KO:K04356]
111859212  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
111859225  [KO:K04414] [EC:2.7.11.1]
111859334  [KO:K04358]
111859362  [KO:K04349]
111859481  [KO:K13769]
111859493  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111859511  [KO:K03175] [EC:2.3.2.27]
111859517  [KO:K18018] [EC:3.1.3.48]
111859528  hras; GTPase HRas [KO:K02833]
111859649  [KO:K04373] [EC:2.7.11.1]
111859704  [KO:K04455]
111859722  [KO:K04867]
111859727  [KO:K07860]
111859731  [KO:K04856]
111859759  [KO:K04433] [EC:2.7.12.2]
111859769  [KO:K06268]
111859862  [KO:K04358]
111859941  [KO:K04454]
111859979  [KO:K12326]
111860018  [KO:K04859]
111860072  [KO:K04352]
111860179  [KO:K25414]
111860235  [KO:K04527] [EC:2.7.10.1]
111860238  jund; transcription factor jun-D [KO:K04449]
111860273  [KO:K04372] [EC:2.7.11.1]
111860367  [KO:K04369] [EC:2.7.12.2]
111860524  fgf22; fibroblast growth factor 22 [KO:K04358]
111860532  [KO:K04345] [EC:2.7.11.11]
111860586  [KO:K04359]
111860702  [KO:K04386]
111860895  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
111860950  [KO:K21946] [EC:3.1.3.16 3.1.3.48]
111860952  [KO:K05461]
111860965  akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111860999  rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
111861008  [KO:K04456] [EC:2.7.11.1]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
pki04070  Phosphatidylinositol signaling system
pki04110  Cell cycle
pki04115  p53 signaling pathway
pki04210  Apoptosis
pki04310  Wnt signaling pathway
KO pathway
ko04010   

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