KEGG   PATHWAY: pki04010
Entry
pki04010                    Pathway                                
Name
MAPK signaling pathway - Paramormyrops kingsleyae
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
pki04010  MAPK signaling pathway
pki04010

Other DBs
GO: 0000165
Organism
Paramormyrops kingsleyae [GN:pki]
Gene
111845281  cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
111843226  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
111853984  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
111833410  voltage-dependent N-type calcium channel subunit alpha-1B-like isoform X1 [KO:K04849]
111843125  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
111852542  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
111833375  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
111844635  cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
111847625  voltage-dependent R-type calcium channel subunit alpha-1E-like isoform X1 [KO:K04852]
111857113  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04853]
111847817  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
111856689  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
111845539  cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
111859731  voltage-dependent T-type calcium channel subunit alpha-1I-like isoform X1 [KO:K04856]
111843189  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
111858929  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
111834368  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
111833289  voltage-dependent calcium channel subunit alpha-2/delta-1-like isoform X1 [KO:K04858]
111846161  cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
111848782  cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
111860018  voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859]
111852528  voltage-dependent calcium channel subunit alpha-2/delta-3-like isoform X1 [KO:K04860]
111833382  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
111843101  cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
111855959  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
111834279  cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
111852554  voltage-dependent L-type calcium channel subunit beta-2-like [KO:K04863]
111837474  cacnb3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
111851740  cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
111843291  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
111848312  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
111835972  voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
111859722  voltage-dependent calcium channel gamma-2 subunit-like isoform X1 [KO:K04867]
111845558  cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
111849138  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
111843200  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
111848299  cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
111847800  cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
111853326  cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
111837760  voltage-dependent calcium channel gamma-7 subunit-like isoform X1 [KO:K04872]
111853300  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
111844188  voltage-dependent calcium channel gamma-8 subunit-like [KO:K04873]
111853324  voltage-dependent calcium channel gamma-4 subunit-like isoform X1 [KO:K04873]
111840961  cAMP-dependent protein kinase catalytic subunit alpha-like isoform X1 [KO:K04345] [EC:2.7.11.11]
111847642  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
111849218  prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
111860532  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
111843225  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
111848649  prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111845521  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
111849289  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
111853291  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
111845481  guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
111853263  guanine nucleotide-binding protein subunit alpha-12-like [KO:K04346]
111846473  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
111843273  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like isoform X1 [KO:K04347]
111848699  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111849849  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
111853026  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
111836737  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
111857559  ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
111850760  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
111859769  calcineurin subunit B type 1 isoform X1 [KO:K06268]
111859362  ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349]
111843577  ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
111850307  ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
111859979  ras-specific guanine nucleotide-releasing factor 2-like isoform X1 [KO:K12326]
111838048  RAS guanyl-releasing protein 1-like isoform X1 [KO:K04350]
111838912  rasgrp1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
111841509  RAS guanyl-releasing protein 1-like isoform X1 [KO:K04350]
111851985  LOW QUALITY PROTEIN: RAS guanyl-releasing protein 2-like [KO:K12361]
111836739  RAS guanyl-releasing protein 2-like isoform X1 [KO:K12361]
111849035  rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
111833211  rap guanine nucleotide exchange factor 2-like isoform X1 [KO:K08018]
111837306  rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
111838521  nf1; neurofibromin [KO:K08052]
111860072  ras GTPase-activating protein 1-like isoform X1 [KO:K04352]
111855610  ras GTPase-activating protein 1-like isoform X1 [KO:K04352]
111849521  ras GTPase-activating protein 2-like [KO:K08053]
111839862  ras-related protein Rap-1A-like isoform X1 [KO:K04353]
111851087  rap1a; ras-related protein Rap-1A [KO:K04353]
111844324  ras-related protein Rap-1b-like [KO:K07836]
111851234  rap1b; ras-related protein Rap-1b [KO:K07836]
111849374  egf; pro-epidermal growth factor isoform X1 [KO:K04357]
111848546  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
111839256  ereg; proepiregulin isoform X1 [KO:K09784]
111833360  putative fibroblast growth factor 1 [KO:K18496]
111832812  fibroblast growth factor 2-like [KO:K18497]
111835519  fgf2; fibroblast growth factor 2 [KO:K18497]
111836472  fibroblast growth factor 8-like [KO:K04358]
111841195  fibroblast growth factor 4B-like isoform X1 [KO:K04358]
111841200  fibroblast growth factor 3-like isoform X1 [KO:K04358]
111844970  fibroblast growth factor 7-like [KO:K04358]
111834059  fibroblast growth factor 4A-like [KO:K04358]
111842069  fgf10; fibroblast growth factor 10 [KO:K04358]
111851847  fgf3; fibroblast growth factor 3 [KO:K04358]
111851956  fibroblast growth factor 4B-like [KO:K04358]
111845370  fibroblast growth factor 20-like [KO:K04358]
111845778  fibroblast growth factor 18-like [KO:K04358]
111846686  fibroblast growth factor 7-like [KO:K04358]
111853601  fgf20; fibroblast growth factor 20 [KO:K04358]
111846342  fgf16; fibroblast growth factor 16 isoform X1 [KO:K04358]
111851225  fibroblast growth factor 6-like [KO:K04358]
111834660  fibroblast growth factor 18-like isoform X1 [KO:K04358]
111848574  fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
111836682  fibroblast growth factor 22-like [KO:K04358]
111857297  fgf6; fibroblast growth factor 6 [KO:K04358]
111858411  fibroblast growth factor 8 [KO:K04358]
111860524  fgf22; fibroblast growth factor 22 [KO:K04358]
111857500  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
111859862  fibroblast growth factor 18-like [KO:K04358]
111859334  fibroblast growth factor 18-like isoform X1 [KO:K04358]
111851964  fgf19; fibroblast growth factor 19 [KO:K22603]
111841255  fibroblast growth factor 19-like isoform X1 [KO:K22603]
111836837  fibroblast growth factor 21-like [KO:K22429]
111858263  fibroblast growth factor 21-like isoform X1 [KO:K22429]
111857581  fgf23; fibroblast growth factor 23 [KO:K22428]
111856976  nerve growth factor-like [KO:K02582]
111855250  neurotrophin-7-like isoform X1 [KO:K02582]
111843262  brain-derived neurotrophic factor-like isoform X1 [KO:K04355]
111850518  brain-derived neurotrophic factor-like isoform X1 [KO:K04355]
111846987  neurotrophin-3-like isoform X1 [KO:K04356]
111859033  neurotrophin-3-like isoform X1 [KO:K04356]
111850821  ins; insulin isoform X1 [KO:K04526]
111834375  insulin-like growth factor I [KO:K05459]
111846569  igf1; LOW QUALITY PROTEIN: insulin-like growth factor I [KO:K05459]
111859481  insulin-like growth factor II [KO:K13769]
111841410  insulin-like growth factor II isoform X1 [KO:K13769]
111843309  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
111860586  platelet-derived growth factor subunit A-like [KO:K04359]
111845270  uncharacterized protein LOC111845270 [KO:K17386]
111846386  platelet-derived growth factor subunit B-like isoform X1 [KO:K17386]
111833654  platelet-derived growth factor C-like isoform X1 [KO:K05450]
111833932  pdgfd; platelet-derived growth factor D [KO:K05450]
111837344  platelet-derived growth factor C-like isoform X1 [KO:K05450]
111841531  csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
111835194  kitlg; kit ligand [KO:K05461]
111860952  kit ligand-like [KO:K05461]
111851553  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
111843715  vascular endothelial growth factor A-like isoform X1 [KO:K05448]
111844528  vascular endothelial growth factor A-A-like isoform X1 [KO:K05448]
111852514  pgf; placenta growth factor [KO:K16859]
111845763  vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
111838191  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
111850116  vascular endothelial growth factor C-like isoform X1 [KO:K05449]
111855173  vascular endothelial growth factor C-like isoform X1 [KO:K05449]
111846155  hgf; hepatocyte growth factor [KO:K05460]
111833314  hepatocyte growth factor-like isoform X1 [KO:K05460]
111843993  angpt1; angiopoietin-1 [KO:K05465]
111843632  angiopoietin-1-like [KO:K05465]
111852799  angpt2; angiopoietin-2 [KO:K05466]
111854266  angiopoietin-2-like isoform X1 [KO:K05466]
111839229  ephrin-A5-like isoform X1 [KO:K05462]
111851484  ephrin-A5-like [KO:K05462]
111840853  ephrin-A1-like [KO:K05462]
111840875  efna3; ephrin-A3 isoform X1 [KO:K05462]
111840922  ephrin-A4-like [KO:K05462]
111835453  ephrin-A2-like isoform X1 [KO:K05462]
111858190  ephrin-A3-like isoform X1 [KO:K05462]
111858191  ephrin-A1-like [KO:K05462]
111858203  ephrin-A2-like isoform X1 [KO:K05462]
111842191  gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
111856500  glial cell line-derived neurotrophic factor-like isoform X1 [KO:K05452]
111847607  nrtn; neurturin [KO:K25414]
111860179  neurturin-like [KO:K25414]
111846015  artemin-like [KO:K25415]
111845227  artemin-like [KO:K25416]
111845900  epidermal growth factor receptor-like isoform X1 [KO:K04361] [EC:2.7.10.1]
111841598  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
111854099  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
111837750  receptor tyrosine-protein kinase erbB-2-like [KO:K05083] [EC:2.7.10.1]
111854164  erbb3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
111852228  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
111851594  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
111857512  fibroblast growth factor receptor 1-A-like [KO:K04362] [EC:2.7.10.1]
111843816  fibroblast growth factor receptor 1-A-like isoform X1 [KO:K04362] [EC:2.7.10.1]
111839944  fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
111844207  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
111847950  fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
111860895  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
111852889  tumor necrosis factor receptor superfamily member 16-like isoform X1 [KO:K02583]
111833208  tumor necrosis factor receptor superfamily member 16-like isoform X1 [KO:K02583]
111850420  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
111838441  high affinity nerve growth factor receptor-like [KO:K03176] [EC:2.7.10.1]
111853509  high affinity nerve growth factor receptor-like isoform X1 [KO:K03176] [EC:2.7.10.1]
111851431  BDNF/NT-3 growth factors receptor-like [KO:K04360] [EC:2.7.10.1]
111839208  ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
111847562  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
111860235  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
111845000  igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
111845734  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
111850064  platelet-derived growth factor receptor alpha-like [KO:K04363] [EC:2.7.10.1]
111855164  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
111850485  macrophage colony-stimulating factor 1 receptor-like [KO:K05090] [EC:2.7.10.1]
111855185  macrophage colony-stimulating factor 1 receptor-like isoform X1 [KO:K05090] [EC:2.7.10.1]
111850065  kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
111839117  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
111835053  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
111837761  vascular endothelial growth factor receptor 1-like isoform X1 [KO:K05096] [EC:2.7.10.1]
111838006  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
111857710  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
111850117  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
111842454  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
111836018  hepatocyte growth factor receptor-like isoform X1 [KO:K05099] [EC:2.7.10.1]
111842012  tek; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
111853915  ephrin type-A receptor 2-like isoform X1 [KO:K05103] [EC:2.7.10.1]
111853403  ephrin type-A receptor 2-like isoform X1 [KO:K05103] [EC:2.7.10.1]
111848989  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
111833563  growth factor receptor-bound protein 2-like isoform X1 [KO:K04364]
111834215  grb2; growth factor receptor-bound protein 2 [KO:K04364]
111835740  LOW QUALITY PROTEIN: son of sevenless homolog 1-like [KO:K03099]
111836934  son of sevenless homolog 1-like [KO:K03099]
111840699  GTPase HRas-like [KO:K02833]
111859528  hras; GTPase HRas [KO:K02833]
111842404  GTPase KRas-like [KO:K07827]
111845660  kras; GTPase KRas isoform X1 [KO:K07827]
111853914  nras; GTPase NRas [KO:K07828]
111841178  ras-related protein R-Ras2 isoform X1 [KO:K07830]
111836888  rras; ras-related protein R-Ras isoform X1 [KO:K07830]
111851762  mras; ras-related protein M-Ras [KO:K07831]
111849456  ras-related protein M-Ras-like [KO:K07831]
111844715  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
111836730  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
111837477  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111840300  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
111845607  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111836645  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111860367  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111834459  ragulator complex protein LAMTOR3-like isoform X1 [KO:K04370]
111849376  ragulator complex protein LAMTOR3 [KO:K04370]
111835825  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
111857802  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111847396  MAP kinase-interacting serine/threonine-protein kinase 2-like isoform X1 [KO:K04372] [EC:2.7.11.1]
111860273  MAP kinase-interacting serine/threonine-protein kinase 2-like isoform X1 [KO:K04372] [EC:2.7.11.1]
111857272  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
111855289  ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
111859649  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
111852832  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
111855496  ribosomal protein S6 kinase alpha-6-like isoform X1 [KO:K04373] [EC:2.7.11.1]
111860999  rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
111835975  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
111845249  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
111856137  ETS domain-containing protein Elk-1-like isoform X1 [KO:K04375]
111841624  transcriptional regulator Myc-1-like [KO:K04377]
111846207  transcriptional regulator Myc-2-like [KO:K04377]
111835754  serum response factor-like isoform X1 [KO:K04378]
111836858  serum response factor-like isoform X1 [KO:K04378]
111844398  proto-oncogene c-Fos-like [KO:K04379]
111844443  proto-oncogene c-Fos-like [KO:K04379]
111852373  proto-oncogene c-Fos-like [KO:K04379]
111852518  proto-oncogene c-Fos-like isoform X1 [KO:K04379]
111856785  mapt; microtubule-associated protein tau isoform X1 [KO:K04380]
111839654  stathmin-like [KO:K04381]
111841712  stmn1; stathmin [KO:K04381]
111840084  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
111840085  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
111841019  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
111838992  tumor necrosis factor-like [KO:K03156]
111851454  interleukin-1 beta-like [KO:K04519]
111848567  interleukin-1 beta-like [KO:K04519]
111838013  transforming growth factor beta-1-like [KO:K13375]
111841476  transforming growth factor beta-1-like isoform X1 [KO:K13375]
111835201  transforming growth factor beta-2-like isoform X1 [KO:K13376]
111851556  tgfb2; transforming growth factor beta-2 [KO:K13376]
111844437  transforming growth factor beta-3-like [KO:K13377]
111852442  tgfb3; transforming growth factor beta-3 [KO:K13377]
111841368  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
111854121  interleukin-1 receptor type 1-like [KO:K04386]
111860702  interleukin-1 receptor type 1-like isoform X1 [KO:K04386]
111843097  il1rap; interleukin-1 receptor accessory protein [KO:K04723]
111851387  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
111838972  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
111857200  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
111857846  tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
111834820  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
111853643  fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
111856067  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
111853849  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]
111853850  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
111843315  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
111859727  ras-related C3 botulinum toxin substrate 2-like [KO:K07860]
111848451  rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
111856750  ras-related C3 botulinum toxin substrate 3-like [KO:K07861]
111834408  cell division control protein 42 homolog isoform X1 [KO:K04393]
111834477  cell division control protein 42 homolog isoform X1 [KO:K04393]
111835374  cell division control protein 42 homolog isoform X1 [KO:K04393]
111851901  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
111853593  casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
111847460  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
111848593  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
111835361  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
111858668  traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
111853530  daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
111837820  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
111856149  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
111833297  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
111841418  TNF receptor-associated factor 6-like isoform X1 [KO:K03175] [EC:2.3.2.27]
111859511  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
111844594  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
111839168  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
111839275  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
111839280  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
111839282  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
111846472  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
111835987  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
111843039  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
111859212  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
111836856  mitogen-activated protein kinase kinase kinase kinase 3-like isoform X1 [KO:K04406] [EC:2.7.11.1]
111835682  map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
111854129  map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
111835014  mitogen-activated protein kinase kinase kinase kinase 4-like isoform X1 [KO:K04407] [EC:2.7.11.1]
111833901  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
111842626  serine/threonine-protein kinase PAK 1-like [KO:K04409] [EC:2.7.11.1]
111832832  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
111847400  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
111837545  serine/threonine-protein kinase 4-like [KO:K04411]
111845084  stk3; serine/threonine-protein kinase 3 [KO:K04412]
111859225  mitogen-activated protein kinase kinase kinase kinase 2-like isoform X1 [KO:K04414] [EC:2.7.11.1]
111858519  mitogen-activated protein kinase kinase kinase kinase 2-like [KO:K04414] [EC:2.7.11.1]
111840193  mitogen-activated protein kinase kinase kinase 8-like isoform X1 [KO:K04415] [EC:2.7.11.25]
111850109  map3k8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
111834485  map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
111851979  mitogen-activated protein kinase kinase kinase 11-like [KO:K04419] [EC:2.7.11.25]
111855427  map3k11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
111840805  map3k2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
111849744  mitogen-activated protein kinase kinase kinase 3-like isoform X1 [KO:K04421] [EC:2.7.11.25]
111837634  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
111852859  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
111837851  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
111856245  map3k9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
111844900  map3k10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
111853966  mitogen-activated protein kinase kinase kinase 21-like isoform X1 [KO:K17534] [EC:2.7.11.25]
111854004  mitogen-activated protein kinase kinase kinase 21-like isoform X1 [KO:K17534] [EC:2.7.11.25]
111844712  mitogen-activated protein kinase kinase kinase 12-like [KO:K04423] [EC:2.7.11.25]
111835238  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
111858314  map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
111838586  mitogen-activated protein kinase kinase kinase 20-like [KO:K04424] [EC:2.7.11.25]
111840707  map3k20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
111848885  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
111843026  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
111843005  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
111853413  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
111833200  serine/threonine-protein kinase TAO2-like isoform X1 [KO:K04429] [EC:2.7.11.1]
111833742  taok2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
111840275  serine/threonine-protein kinase TAO1-like [KO:K04429] [EC:2.7.11.1]
111842818  taok1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
111844168  taok3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
111856922  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
111855939  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
111833549  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
111836901  dual specificity mitogen-activated protein kinase kinase 3-like [KO:K04432] [EC:2.7.12.2]
111847733  map2k3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
111848425  map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
111859759  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
111840847  mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
111842452  C-Jun-amino-terminal kinase-interacting protein 2-like [KO:K04435]
111846144  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
111836871  C-Jun-amino-terminal kinase-interacting protein 3-like isoform X1 [KO:K04436]
111847734  C-Jun-amino-terminal kinase-interacting protein 3-like isoform X1 [KO:K04436]
111842285  filamin-A-like isoform X1 [KO:K04437]
111856989  filamin-A-like [KO:K04437]
111840455  adapter molecule crk-like [KO:K04438]
111833226  crk-like protein [KO:K04438]
111851785  crk-like protein [KO:K04438]
111833879  adapter molecule crk-like isoform X1 [KO:K04438]
111838069  beta-arrestin-1-like [KO:K04439]
111852918  arrestin red cell-like [KO:K04439]
111846337  arrb2; beta-arrestin-2 [KO:K04439]
111841525  beta-arrestin-1 [KO:K04439]
111850762  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
111839372  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
111850356  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111848368  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111852585  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111855469  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
111835993  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
111845666  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
111845679  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
111840348  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
111853904  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
111856186  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
111850582  mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
111834362  MAP kinase-activated protein kinase 2-like [KO:K04443] [EC:2.7.11.1]
111854424  mapkapk2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
111837588  MAP kinase-activated protein kinase 2-like [KO:K04444] [EC:2.7.11.1]
111840606  MAP kinase-activated protein kinase 2-like [KO:K04444] [EC:2.7.11.1]
111852024  ribosomal protein S6 kinase alpha-5-like [KO:K04445] [EC:2.7.11.1]
111858989  ribosomal protein S6 kinase alpha-5-like [KO:K04445] [EC:2.7.11.1]
111837678  M-phase inducer phosphatase 1-like [KO:K05866] [EC:3.1.3.48]
111852343  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
111845775  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
111832689  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
111843522  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
111842196  transcription factor AP-1-like [KO:K04448]
111834818  transcription factor AP-1-like [KO:K04448]
111847550  transcription factor AP-1-like [KO:K04448]
111860238  jund; transcription factor jun-D [KO:K04449]
111838634  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
111850623  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
111854492  cellular tumor antigen p53-like isoform X1 [KO:K04451]
111835263  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
111838905  max; protein max isoform X1 [KO:K04453]
111855608  mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
111859941  myocyte-specific enhancer factor 2C-like isoform X1 [KO:K04454]
111849899  heat shock protein beta-1-like [KO:K04455]
111854694  hspb1; heat shock protein beta-1 [KO:K04455]
111859704  heat shock protein beta-1-like [KO:K04455]
111838854  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
111852355  akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111850633  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111860965  akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111861008  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111851037  protein phosphatase 1A-like isoform X1 [KO:K04457] [EC:3.1.3.16]
111844442  protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
111844835  protein phosphatase 1A-like [KO:K04457] [EC:3.1.3.16]
111855217  protein phosphatase 1A-like isoform X1 [KO:K04457] [EC:3.1.3.16]
111851536  ptprr; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
111840143  tyrosine-protein phosphatase non-receptor type 5-like [KO:K18018] [EC:3.1.3.48]
111859517  tyrosine-protein phosphatase non-receptor type 5-like isoform X1 [KO:K18018] [EC:3.1.3.48]
111844750  tyrosine-protein phosphatase non-receptor type 7-like isoform X1 [KO:K18019] [EC:3.1.3.48]
111857699  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
111847020  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111842106  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111837555  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111841061  dual specificity protein phosphatase 8-like isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111840358  dual specificity protein phosphatase 7-like isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111848526  dusp5; dual specificity protein phosphatase 5 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111859493  dual specificity protein phosphatase 8-like isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111857479  dual specificity protein phosphatase 2-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111842446  dual specificity protein phosphatase 6-like [KO:K21946] [EC:3.1.3.16 3.1.3.48]
111860950  dual specificity protein phosphatase 6-like [KO:K21946] [EC:3.1.3.16 3.1.3.48]
111837943  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
111845122  dusp3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
111838070  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
111848341  protein phosphatase 1B-like isoform X1 [KO:K04461] [EC:3.1.3.16]
111840011  ppm1b; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
111855675  heat shock cognate 71 kDa protein-like [KO:K03283]
111834334  heat shock 70 kDa protein [KO:K03283]
111855702  heat shock cognate 71 kDa protein [KO:K03283]
111833700  heat shock cognate 71 kDa protein-like [KO:K03283]
111834017  mecom; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
111845610  map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
111836823  mitogen-activated protein kinase 7-like [KO:K04464] [EC:2.7.11.24]
111840385  nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
111854743  nuclear receptor subfamily 4 group A member 1-like [KO:K04465]
111832882  mitogen-activated protein kinase kinase kinase 14-like [KO:K04466] [EC:2.7.11.25]
111855960  mitogen-activated protein kinase kinase kinase 14-like isoform X1 [KO:K04466] [EC:2.7.11.25]
111836749  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
111854363  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
111837508  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
111855295  NF-kappa-B essential modulator-like [KO:K07210]
111833736  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
111856400  nlk; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
111833172  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111853948  nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
111839432  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
111848470  nuclear factor NF-kappa-B p100 subunit-like [KO:K04469]
111851986  putative transcription factor p65 homolog [KO:K04735]
111855422  putative transcription factor p65 homolog [KO:K04735]
111844863  relb; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
pki04070  Phosphatidylinositol signaling system
pki04110  Cell cycle
pki04115  p53 signaling pathway
pki04210  Apoptosis
pki04310  Wnt signaling pathway
KO pathway
ko04010   
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