KEGG PATHWAY: ptg00260

PATHWAY: ptg00260

Entry

ptg00260                    Pathway

Name

Glycine, serine and threonine metabolism - Panthera tigris altaica (Amur tiger)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

ptg00260

Glycine, serine and threonine metabolism

Module

ptg_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:ptg00260]

ptg_M00047

Creatine pathway [PATH:ptg00260]

ptg_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:ptg00260]

ptg_M00555

Betaine biosynthesis, choline => betaine [PATH:ptg00260]

ptg_M00621

Glycine cleavage system [PATH:ptg00260]

ptg_M00974

Betaine metabolism, animals, betaine => glycine [PATH:ptg00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Panthera tigris altaica (Amur tiger) [GN:ptg]

Gene

102951123

probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]

102955890

SHMT1; serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]

102950765

SHMT2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]

102960731

AGXT; alanine-glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

102967428

GRHPR; glyoxylate and hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]

102967881

GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]

102959146

PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]

102952431

PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]

102952979

BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]

102957848

PHGDH; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

102954995

PSAT1; phosphoserine aminotransferase 1 [KO:K00831] [EC:2.6.1.52]

102966336

PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]

102969935

GCAT; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]

102967009

L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]

102969461

ALAS1; 5'-aminolevulinate synthase 1 [KO:K00643] [EC:2.3.1.37]

102969114

ALAS2; 5'-aminolevulinate synthase 2 [KO:K00643] [EC:2.3.1.37]

102961494

MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]

102961954

MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]

102950796

membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]

102951108

membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]

102963389

AOC2; retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]

102960715

GLDC; glycine decarboxylase [KO:K00281] [EC:1.4.4.2]

102953327

AMT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]

102956479

DLD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]

102960524

GCSH; glycine cleavage system protein H [KO:K02437]

102965053

DAO; D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]

102966139

AGXT2; alanine--glyoxylate aminotransferase 2 [KO:K00827] [EC:2.6.1.44 2.6.1.40]

102969260

GATM; glycine amidinotransferase [KO:K00613] [EC:2.1.4.1]

102972234

GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]

102958076

CHDH; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]

102951788

ALDH7A1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

102955687

BHMT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]

102963363

DMGDH; dimethylglycine dehydrogenase [KO:K00315] [EC:1.5.8.4]

102957447

PIPOX; pipecolic acid and sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]

102959524

SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]

102965502

GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

102966178

CBS; cystathionine-beta-synthase [KO:K01697] [EC:4.2.1.22]

102949336

CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]

102954530

SDS; serine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]

102959658

SDSL; serine dehydratase like [KO:K17989] [EC:4.3.1.17 4.3.1.19]

102953178

SRR; serine racemase [KO:K12235] [EC:5.1.1.18]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721