KEGG   PATHWAY: pvt00260
Entry
pvt00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Pogona vitticeps (central bearded dragon)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pvt00260  Glycine, serine and threonine metabolism
pvt00260

Module
pvt_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pvt00260]
pvt_M00047  Creatine pathway [PATH:pvt00260]
pvt_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:pvt00260]
pvt_M00555  Betaine biosynthesis, choline => betaine [PATH:pvt00260]
pvt_M00621  Glycine cleavage system [PATH:pvt00260]
pvt_M00974  Betaine metabolism, animals, betaine => glycine [PATH:pvt00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pogona vitticeps (central bearded dragon) [GN:pvt]
Gene
110090439  probable low-specificity L-threonine aldolase 2 isoform X1 [KO:K01620] [EC:4.1.2.48]
110090795  SHMT1; serine hydroxymethyltransferase, cytosolic isoform X1 [KO:K00600] [EC:2.1.2.1]
110070945  SHMT2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
110075840  AGXT; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
110077846  GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
110084481  GLYCTK; glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]
110089164  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
110084343  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
110088825  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
110089840  PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
110076006  PSAT1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
110084527  PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
110075957  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
110071093  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
110078642  ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
110080626  ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
110074057  amine oxidase [flavin-containing] A-like [KO:K00274] [EC:1.4.3.4]
110074070  amine oxidase [flavin-containing] B-like [KO:K00274] [EC:1.4.3.4]
110080289  AOC3; membrane primary amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
110080305  membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
110080308  membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
110088214  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
110076999  AMT; aminomethyltransferase, mitochondrial isoform X1 [KO:K00605] [EC:2.1.2.10]
110070348  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
110085501  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
110083399  DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
110080093  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
110077278  GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
110072519  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
110084508  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
110077534  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
110073962  BHMT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
110073960  DMGDH; dimethylglycine dehydrogenase, mitochondrial isoform X1 [KO:K00315] [EC:1.5.8.4]
110084318  PIPOX; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
110089290  SARDH; sarcosine dehydrogenase, mitochondrial isoform X1 [KO:K00314] [EC:1.5.8.3]
110087012  GNMT; glycine N-methyltransferase isoform X1 [KO:K00552] [EC:2.1.1.20]
110074069  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
110074034  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
110079859  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
110079862  cystathionine gamma-lyase-like isoform X1 [KO:K01758] [EC:4.4.1.1]
110083788  LOW QUALITY PROTEIN: uncharacterized protein LOC110083788 [KO:K01754] [EC:4.3.1.19]
110086277  SDSL; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
110086281  L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
110071404  L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
110091501  uncharacterized protein LOC110091501 [KO:K20498] [EC:4.3.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pvt00010  Glycolysis / Gluconeogenesis
pvt00020  Citrate cycle (TCA cycle)
pvt00230  Purine metabolism
pvt00250  Alanine, aspartate and glutamate metabolism
pvt00270  Cysteine and methionine metabolism
pvt00290  Valine, leucine and isoleucine biosynthesis
pvt00330  Arginine and proline metabolism
pvt00470  D-Amino acid metabolism
pvt00564  Glycerophospholipid metabolism
pvt00600  Sphingolipid metabolism
pvt00620  Pyruvate metabolism
pvt00630  Glyoxylate and dicarboxylate metabolism
pvt00640  Propanoate metabolism
pvt00860  Porphyrin metabolism
pvt00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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