KEGG   PATHWAY: ray04142
Entry
ray04142                    Pathway                                
Name
Lysosome - Rousettus aegyptiacus (Egyptian rousette)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
ray04142  Lysosome
ray04142

Other DBs
GO: 0005764
Organism
Rousettus aegyptiacus (Egyptian rousette) [GN:ray]
Gene
107503485  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform 3 [KO:K02154]
107504599  V-type proton ATPase 116 kDa subunit a isoform 2 isoform X1 [KO:K02154]
107519336  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform 4 isoform X1 [KO:K02154]
107513825  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform 1 isoform X1 [KO:K02154]
107514921  ATP6V0D2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146]
107520218  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
107511566  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
107499491  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
107506034  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit isoform X1 [KO:K02155]
107499515  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
107511159  DMXL1; dmX-like protein 1 isoform X1 [KO:K24155]
107519718  DMXL2; dmX-like protein 2 isoform X1 [KO:K24155]
107502180  WDR7; WD repeat-containing protein 7 isoform X1 [KO:K24738]
107519078  NCOA7; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
107514542  CTSA; lysosomal protective protein isoform X1 [KO:K13289] [EC:3.4.16.5]
107507224  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
107514936  CTSC; dipeptidyl peptidase 1 isoform X1 [KO:K01275] [EC:3.4.14.1]
107513216  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
107508871  CTSE; cathepsin E [KO:K01382] [EC:3.4.23.34]
107513867  CTSF; cathepsin F isoform X1 [KO:K01373] [EC:3.4.22.41]
107513514  cathepsin G-like isoform X1 [KO:K01319] [EC:3.4.21.20]
107513515  CTSG; cathepsin G isoform X1 [KO:K01319] [EC:3.4.21.20]
107500384  CTSH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
107498992  CTSK; cathepsin K isoform X1 [KO:K01371] [EC:3.4.22.38]
107500189  CTSV; cathepsin L2 [KO:K01365] [EC:3.4.22.15]
107502729  CTSL; LOW QUALITY PROTEIN: cathepsin L1 [KO:K01365] [EC:3.4.22.15]
107518088  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
107507551  CTSO; cathepsin O isoform X1 [KO:K01374] [EC:3.4.22.42]
107498990  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
107497547  CTSW; cathepsin W isoform X1 [KO:K08569] [EC:3.4.22.-]
107500086  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
107500445  NAPSA; napsin-A [KO:K08565] [EC:3.4.23.-]
107511241  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
107504378  TPP1; tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
107503618  GLA; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
107508775  GLB1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
107510082  GAA; lysosomal alpha-glucosidase [KO:K12316] [EC:3.2.1.20]
107521506  GBA; LOW QUALITY PROTEIN: glucosylceramidase [KO:K01201] [EC:3.2.1.45]
107517976  IDUA; alpha-L-iduronidase [KO:K01217] [EC:3.2.1.76]
107505567  NAGA; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
107513826  NAGLU; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
107499539  GALC; galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
107507443  GUSB; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
107497588  FUCA2; plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
107501012  FUCA1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
107501116  HEXA; beta-hexosaminidase subunit alpha isoform X1 [KO:K12373] [EC:3.2.1.52]
107498722  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
107517912  MANBA; beta-mannosidase isoform X1 [KO:K01192] [EC:3.2.1.25]
107519445  MAN2B1; lysosomal alpha-mannosidase isoform X1 [KO:K12311] [EC:3.2.1.24]
107498467  NEU1; sialidase-1 isoform X1 [KO:K01186] [EC:3.2.1.18]
107513380  HYAL3; LOW QUALITY PROTEIN: hyaluronidase-3 [KO:K01197] [EC:3.2.1.35]
107513383  HYAL2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
107513385  HYAL1; hyaluronidase-1 [KO:K01197] [EC:3.2.1.35]
107500196  SPAM1; hyaluronidase PH-20 [KO:K01197] [EC:3.2.1.35]
107500203  HYAL4; hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
107500279  ARSA; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
107497236  ARSB; arylsulfatase B isoform X1 [KO:K01135] [EC:3.1.6.12]
107510291  ARSG; arylsulfatase G isoform X1 [KO:K12381] [EC:3.1.6.-]
107502355  GALNS; N-acetylgalactosamine-6-sulfatase isoform X1 [KO:K01132] [EC:3.1.6.4]
107508223  GNS; N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
107502397  LOW QUALITY PROTEIN: iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
107502399  IDS; iduronate 2-sulfatase [KO:K01136] [EC:3.1.6.13]
107507961  LOW QUALITY PROTEIN: iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
107506382  uncharacterized protein LOC107506382 [KO:K01136] [EC:3.1.6.13]
107507519  iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
107510086  SGSH; N-sulphoglucosamine sulphohydrolase isoform X1 [KO:K01565] [EC:3.10.1.1]
107502208  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
107520513  PLA2G15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
107519410  DNASE2; deoxyribonuclease-2-alpha isoform X1 [KO:K01158] [EC:3.1.22.1]
107511586  DNASE2B; deoxyribonuclease-2-beta isoform X1 [KO:K01158] [EC:3.1.22.1]
107511854  ACP2; lysosomal acid phosphatase isoform X1 [KO:K14410] [EC:3.1.3.2]
107515122  ACP5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
107504370  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
107502652  ASAH1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
107504302  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase [KO:K01444] [EC:3.5.1.26]
107519509  PSAP; prosaposin isoform X1 [KO:K12382]
107501210  PSAPL1; proactivator polypeptide-like 1 [KO:K12382]
107497177  GM2A; ganglioside GM2 activator [KO:K12383]
107508325  PPT1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
107498454  PPT2; lysosomal thioesterase PPT2 isoform X1 [KO:K01074] [EC:3.1.2.22]
107514339  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
107498693  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
107507025  LAMP3; lysosome-associated membrane glycoprotein 3 isoform X1 [KO:K06562]
107506400  CD68; macrosialin [KO:K06501]
107521263  CD63; CD63 antigen [KO:K06497]
107516360  SCARB2; lysosome membrane protein 2 isoform X1 [KO:K12384]
107520847  NPC1; Niemann-Pick C1 protein isoform X1 [KO:K12385]
107507759  NPC2; epididymal secretory protein E1 [KO:K13443]
107507678  CTNS; cystinosin [KO:K12386]
107509283  SLC17A5; sialin isoform X1 [KO:K12301]
107516777  SLC11A1; natural resistance-associated macrophage protein 1 isoform X1 [KO:K12347]
107509802  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
107503563  LAPTM5; lysosomal-associated transmembrane protein 5 isoform X1 [KO:K12387]
107517283  LAPTM4B; lysosomal-associated transmembrane protein 4B [KO:K12387]
107510836  LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387]
107503077  ABCA2; LOW QUALITY PROTEIN: ATP-binding cassette sub-family A member 2 [KO:K05642]
107515214  ABCB9; LOW QUALITY PROTEIN: ATP-binding cassette sub-family B member 9 [KO:K05656]
107518498  CD164; sialomucin core protein 24 [KO:K06546]
107509207  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
107516137  SORT1; LOW QUALITY PROTEIN: sortilin [KO:K12388]
107515830  CLN3; battenin isoform X1 [KO:K12389]
107513077  CLN5; LOW QUALITY PROTEIN: ceroid-lipofuscinosis neuronal protein 5 [KO:K12390]
107512499  MFSD8; major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307]
107501324  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
107504148  SUMF1; LOW QUALITY PROTEIN: sulfatase-modifying factor 1 [KO:K13444] [EC:1.8.3.7]
107501162  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
107506092  GNPTG; LOW QUALITY PROTEIN: N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087]
107518987  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase isoform X1 [KO:K01125] [EC:3.1.4.45]
107514750  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
107501665  M6PR; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]
107502826  CLTA; clathrin light chain A isoform X1 [KO:K04644]
107517505  CLTB; clathrin light chain B isoform X1 [KO:K04645]
107497861  CLTCL1; LOW QUALITY PROTEIN: clathrin heavy chain 2 [KO:K04646]
107510139  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
107520527  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
107497987  AP1G2; AP-1 complex subunit gamma-like 2 isoform X1 [KO:K12391]
107520481  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
107517242  AP1M1; AP-1 complex subunit mu-1 [KO:K12393]
107515116  AP1M2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
107511773  AP1S1; AP-1 complex subunit sigma-1A isoform X1 [KO:K12394]
107497186  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
107499072  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
107498814  AP3D1; AP-3 complex subunit delta-1 isoform X1 [KO:K12396]
107505329  AP3B2; AP-3 complex subunit beta-2 isoform X1 [KO:K12397]
107497237  AP3B1; AP-3 complex subunit beta-1 [KO:K12397]
107503017  AP3M1; AP-3 complex subunit mu-1 [KO:K12398]
107501342  AP3M2; AP-3 complex subunit mu-2 [KO:K12398]
107514162  AP-3 complex subunit sigma-2 isoform X1 [KO:K12399]
107498160  AP3S1; AP-3 complex subunit sigma-1 isoform X1 [KO:K12399]
107501989  AP-4 complex subunit epsilon-1-like isoform X1 [KO:K12400]
107519735  AP4E1; AP-4 complex subunit epsilon-1 isoform X1 [KO:K12400]
107499837  AP4B1; AP-4 complex subunit beta-1 isoform X1 [KO:K12401]
107499996  AP4M1; AP-4 complex subunit mu-1 isoform X1 [KO:K12402]
107499457  AP4S1; AP-4 complex subunit sigma-1 [KO:K12403]
107516065  GGA2; ADP-ribosylation factor-binding protein GGA2 [KO:K12404]
107503780  GGA3; LOW QUALITY PROTEIN: ADP-ribosylation factor-binding protein GGA3 [KO:K12404]
107519249  GGA1; ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404]
107519913  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
107515368  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
107518197  LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
ray00511  Other glycan degradation
ray00531  Glycosaminoglycan degradation
ray04130  SNARE interactions in vesicular transport
ray04140  Autophagy - animal
ray04144  Endocytosis
KO pathway
ko04142   
LinkDB

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