KEGG   PATHWAY: rphi04146
Entry
rphi04146                   Pathway                                
Name
Peroxisome - Ruditapes philippinarum (Manila clam)
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
rphi04146  Peroxisome
rphi04146

Other DBs
GO: 0005777
Organism
Ruditapes philippinarum (Manila clam) [GN:rphi]
Gene
132722316  peroxisomal membrane protein PEX16-like [KO:K13335]
132758377  peroxisomal membrane protein PEX16-like [KO:K13335]
132740877  peroxisomal biogenesis factor 3-like [KO:K13336]
132745511  peroxisomal biogenesis factor 19-like [KO:K13337]
132753613  LOW QUALITY PROTEIN: ATP-binding cassette sub-family D member 3-like [KO:K05677] [EC:7.6.2.4]
132716771  peroxisomal ATPase PEX1-like [KO:K13338]
132743558  peroxisome assembly protein 26-like [KO:K13340]
132719227  peroxisomal targeting signal 2 receptor-like [KO:K13341]
132722514  peroxisomal targeting signal 1 receptor-like isoform X1 [KO:K13342]
132760510  peroxisomal targeting signal 1 receptor-like [KO:K13342]
132736719  peroxisomal membrane protein PEX14-like [KO:K13343]
132757670  peroxisomal membrane protein PEX13-like [KO:K13344]
132754829  peroxisome assembly protein 12-like [KO:K13345]
132721230  peroxisome biogenesis factor 10-like [KO:K13346]
132735748  peroxisome biogenesis factor 2-like [KO:K06664]
132735270  peroxisomal membrane protein 2-like [KO:K13347]
132753944  peroxisomal membrane protein 2-like [KO:K13347]
132737674  mpv17-like protein 2 [KO:K13348]
132724714  mpv17-like protein 2 [KO:K13348]
132714652  protein Mpv17-like isoform X1 [KO:K13348]
132759144  mpv17-like protein 2 [KO:K13348]
132751278  mpv17-like protein [KO:K13349]
132746674  mpv17-like protein [KO:K13349]
132716535  peroxisomal membrane protein 4-like [KO:K13350]
132715174  peroxisomal membrane protein 11B-like [KO:K13352]
132715261  peroxisomal membrane protein 11B-like [KO:K13352]
132725222  peroxisomal membrane protein 11C-like [KO:K13353]
132718836  peroxisomal membrane protein 11C-like [KO:K13353]
132721397  peroxisomal membrane protein PMP34-like [KO:K13354]
132760561  2-hydroxyacyl-CoA lyase 1-like [KO:K12261] [EC:4.1.2.63]
132748970  alpha-methylacyl-CoA racemase-like [KO:K01796] [EC:5.1.99.4]
132728155  alpha-methylacyl-CoA racemase-like [KO:K01796] [EC:5.1.99.4]
132754947  phytanoyl-CoA dioxygenase, peroxisomal-like [KO:K00477] [EC:1.14.11.18]
132720360  peroxisomal acyl-coenzyme A oxidase 3-like [KO:K00232] [EC:1.3.3.6]
132734147  peroxisomal acyl-coenzyme A oxidase 1-like [KO:K00232] [EC:1.3.3.6]
132721384  peroxisomal acyl-coenzyme A oxidase 1-like [KO:K00232] [EC:1.3.3.6]
132722212  peroxisomal acyl-coenzyme A oxidase 1-like [KO:K00232] [EC:1.3.3.6]
132756802  peroxisomal acyl-coenzyme A oxidase 1-like [KO:K00232] [EC:1.3.3.6]
132760661  peroxisomal acyl-coenzyme A oxidase 1-like [KO:K00232] [EC:1.3.3.6]
132750164  peroxisomal multifunctional enzyme type 2-like isoform X1 [KO:K12405] [EC:1.1.1.- 4.2.1.107 4.2.1.119]
132748206  sterol carrier protein 2-like [KO:K08764] [EC:2.3.1.176]
132748431  sterol carrier protein 2-like [KO:K08764] [EC:2.3.1.176]
132726396  sterol carrier protein 2-like [KO:K08764] [EC:2.3.1.176]
132744866  sterol carrier protein 2-like [KO:K08764] [EC:2.3.1.176]
132733646  acyl-coenzyme A amino acid N-acyltransferase 1-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
132733647  acyl-coenzyme A thioesterase 1-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
132737676  bile acid-CoA:amino acid N-acyltransferase-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
132751977  peroxisomal bifunctional enzyme-like [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
132720965  3-ketoacyl-CoA thiolase A, peroxisomal-like [KO:K07513] [EC:2.3.1.16]
132737925  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]-like [KO:K13237] [EC:1.3.1.124]
132733852  delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial-like [KO:K12663] [EC:5.3.3.21]
132750867  ATP-binding cassette sub-family D member 2-like [KO:K05676] [EC:7.6.2.4]
132741079  lysosomal cobalamin transporter ABCD4-like isoform X1 [KO:K05678] [EC:7.6.2.8]
132734556  long-chain fatty acid transport protein 2-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
132734570  long-chain fatty acid transport protein 2-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
132716988  long-chain fatty acid transport protein 2-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
132716989  long-chain fatty acid transport protein 2-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
132719795  long-chain-fatty-acid--CoA ligase 1-like isoform X1 [KO:K01897] [EC:6.2.1.3]
132733041  long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]
132721924  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
132727033  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
132743773  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
132743774  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
132718275  long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]
132718126  peroxisomal trans-2-enoyl-CoA reductase-like [KO:K07753] [EC:1.3.1.38]
132752879  enoyl-CoA delta isomerase 2-like [KO:K13239] [EC:5.3.3.8]
132759993  uncharacterized Nudix hydrolase NudL-like [KO:K17879] [EC:3.6.1.77]
132727699  NAD-capped RNA hydrolase NUDT12-like [KO:K03426] [EC:3.6.1.22]
132741376  acyl-coenzyme A diphosphatase NUDT19-like [KO:K13355] [EC:3.6.1.77]
132741378  LOW QUALITY PROTEIN: acyl-coenzyme A diphosphatase NUDT19-like [KO:K13355] [EC:3.6.1.77]
132747938  acyl-coenzyme A thioesterase 8-like isoform X1 [KO:K11992] [EC:3.1.2.27]
132713755  acyl-coenzyme A thioesterase 8-like isoform X1 [KO:K11992] [EC:3.1.2.27]
132723993  carnitine O-acetyltransferase-like isoform X1 [KO:K00624] [EC:2.3.1.7]
132744273  LOW QUALITY PROTEIN: carnitine O-acetyltransferase-like [KO:K00624] [EC:2.3.1.7]
132712915  peroxisomal carnitine O-octanoyltransferase-like isoform X1 [KO:K05940] [EC:2.3.1.137]
132756042  malonyl-CoA decarboxylase, mitochondrial-like [KO:K01578] [EC:4.1.1.9]
132759181  dihydroxyacetone phosphate acyltransferase-like [KO:K00649] [EC:2.3.1.42]
132714962  alkyldihydroxyacetonephosphate synthase, peroxisomal-like [KO:K00803] [EC:2.5.1.26]
132754435  fatty acyl-CoA reductase 1-like [KO:K13356] [EC:1.2.1.84]
132717623  fatty acyl-CoA reductase 1-like [KO:K13356] [EC:1.2.1.84]
132735902  mevalonate kinase-like [KO:K00869] [EC:2.7.1.36]
132736225  mevalonate kinase-like [KO:K00869] [EC:2.7.1.36]
132713382  phosphomevalonate kinase-like isoform X1 [KO:K13273] [EC:2.7.4.2]
132748887  alanine--glyoxylate aminotransferase-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
132721618  D-aspartate oxidase-like [KO:K00272] [EC:1.4.3.1]
132723299  D-aspartate oxidase-like isoform X1 [KO:K00272] [EC:1.4.3.1]
132725194  D-aspartate oxidase-like [KO:K00272] [EC:1.4.3.1]
132717161  D-aspartate oxidase-like [KO:K00272] [EC:1.4.3.1]
132734268  isocitrate dehydrogenase [NADP] cytoplasmic-like [KO:K00031] [EC:1.1.1.42]
132722469  isocitrate dehydrogenase [NADP], mitochondrial-like [KO:K00031] [EC:1.1.1.42]
132751580  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
132751587  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
132749767  hydroxymethylglutaryl-CoA lyase, mitochondrial-like [KO:K01640] [EC:4.1.3.4]
132724793  hydroxymethylglutaryl-CoA lyase, mitochondrial-like [KO:K01640] [EC:4.1.3.4]
132727126  catalase-like isoform X1 [KO:K03781] [EC:1.11.1.6]
132729302  peroxiredoxin-5, mitochondrial-like [KO:K11187] [EC:1.11.1.24]
132729334  peroxiredoxin-5, mitochondrial-like [KO:K11187] [EC:1.11.1.24]
132749066  uncharacterized protein LOC132749066 [KO:K04565] [EC:1.15.1.1]
132735455  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
132735761  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
132737865  uncharacterized protein LOC132737865 [KO:K04565] [EC:1.15.1.1]
132740731  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
132756296  uncharacterized protein LOC132756296 [KO:K04565] [EC:1.15.1.1]
132745263  uncharacterized protein LOC132745263 [KO:K04565] [EC:1.15.1.1]
132743261  superoxide dismutase [Mn], mitochondrial-like [KO:K04564] [EC:1.15.1.1]
132714136  peroxiredoxin-2-like isoform X1 [KO:K13279] [EC:1.11.1.24]
132721786  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
132752622  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
132752826  uncharacterized protein LOC132752826 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
132740917  LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
132756187  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
132741753  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
132715800  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
132730649  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
132758938  uncharacterized protein LOC132758938 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
132759647  uncharacterized protein LOC132759647 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
132717420  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
132733025  dehydrogenase/reductase SDR family member 4-like [KO:K11147] [EC:1.1.-.-]
132733026  dehydrogenase/reductase SDR family member 4-like [KO:K11147] [EC:1.1.-.-]
132733027  dehydrogenase/reductase SDR family member 4-like [KO:K11147] [EC:1.1.-.-]
132714634  dehydrogenase/reductase SDR family member 4-like [KO:K11147] [EC:1.1.-.-]
Reference
PMID:17055078
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
PMID:17055079
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
PMID:17010456
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
PMID:16631601
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
rphi00071  Fatty acid degradation
rphi00230  Purine metabolism
rphi00564  Glycerophospholipid metabolism
rphi00565  Ether lipid metabolism
rphi00830  Retinol metabolism
rphi00900  Terpenoid backbone biosynthesis
KO pathway
ko04146   
LinkDB

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