KEGG   PATHWAY: salp00260
Entry
salp00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Salvelinus sp. IW2-2015 (Arctic char)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
salp00260  Glycine, serine and threonine metabolism
salp00260

Module
salp_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:salp00260]
salp_M00047  Creatine pathway [PATH:salp00260]
salp_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:salp00260]
salp_M00555  Betaine biosynthesis, choline => betaine [PATH:salp00260]
salp_M00621  Glycine cleavage system [PATH:salp00260]
salp_M00974  Betaine metabolism, animals, betaine => glycine [PATH:salp00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Salvelinus sp. IW2-2015 (Arctic char) [GN:salp]
Gene
111977723  LOW QUALITY PROTEIN: probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]
112069557  LOW QUALITY PROTEIN: serine hydroxymethyltransferase, mitochondrial-like [KO:K00600] [EC:2.1.2.1]
112070392  LOW QUALITY PROTEIN: serine--pyruvate aminotransferase, mitochondrial-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
111956728  serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
111967403  glyoxylate reductase/hydroxypyruvate reductase isoform X1 [KO:K00049] [EC:1.1.1.79 1.1.1.81]
111965623  glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
111969973  glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]
111961670  phosphoglycerate mutase 2 isoform X1 [KO:K01834] [EC:5.4.2.11]
111969290  phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
111977859  phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
111968082  phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
111962766  bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
111952995  bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
111959716  D-3-phosphoglycerate dehydrogenase-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
111974903  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
112071973  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
111959061  phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]
111949658  phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]
111980209  gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
111968809  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
111982268  L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
112077538  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
111966395  5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
112071095  5-aminolevulinate synthase, nonspecific, mitochondrial-like [KO:K00643] [EC:2.3.1.37]
111976613  5-aminolevulinate synthase, nonspecific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
112073439  5-aminolevulinate synthase, nonspecific, mitochondrial-like isoform X1 [KO:K00643] [EC:2.3.1.37]
111980245  LOW QUALITY PROTEIN: amine oxidase [flavin-containing]-like [KO:K00274] [EC:1.4.3.4]
111980559  membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
112070086  membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
111957724  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
111974182  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
111966272  LOW QUALITY PROTEIN: aminomethyltransferase, mitochondrial-like [KO:K00605] [EC:2.1.2.10]
111976930  aminomethyltransferase, mitochondrial isoform X1 [KO:K00605] [EC:2.1.2.10]
111971987  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
111962178  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
111974122  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
111962527  glycine cleavage system H protein, mitochondrial [KO:K02437]
111953054  glycine cleavage system H protein, mitochondrial [KO:K02437]
111969364  glycine cleavage system H protein, mitochondrial isoform X1 [KO:K02437]
111957687  dao; D-amino-acid oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]
111980518  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
112072607  gatm; LOW QUALITY PROTEIN: glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
111952574  guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
111975887  guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
111966268  chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
111961923  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
111963903  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
111961763  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
111961762  dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
111979999  LOW QUALITY PROTEIN: uncharacterized protein LOC111979999 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
111950942  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
111960712  peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
111961266  sardh; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
111969168  gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
111979408  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
111959713  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
111975559  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
111952371  cystathionine gamma-lyase isoform X1 [KO:K01758] [EC:4.4.1.1]
111951755  L-threonine ammonia-lyase-like isoform X1 [KO:K01754] [EC:4.3.1.19]
111977537  L-threonine ammonia-lyase isoform X1 [KO:K01754] [EC:4.3.1.19]
111974151  L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
111957459  L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
111968541  L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
112073463  uncharacterized protein LOC112073463 [KO:K20498] [EC:4.3.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
salp00010  Glycolysis / Gluconeogenesis
salp00020  Citrate cycle (TCA cycle)
salp00230  Purine metabolism
salp00250  Alanine, aspartate and glutamate metabolism
salp00270  Cysteine and methionine metabolism
salp00290  Valine, leucine and isoleucine biosynthesis
salp00330  Arginine and proline metabolism
salp00470  D-Amino acid metabolism
salp00564  Glycerophospholipid metabolism
salp00600  Sphingolipid metabolism
salp00620  Pyruvate metabolism
salp00630  Glyoxylate and dicarboxylate metabolism
salp00640  Propanoate metabolism
salp00860  Porphyrin metabolism
salp00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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