KEGG   PATHWAY: sgh04350
Entry
sgh04350                    Pathway                                
Name
TGF-beta signaling pathway - Sinocyclocheilus grahami (golden-line barbel)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
sgh04350  TGF-beta signaling pathway
sgh04350

Other DBs
GO: 0007179
Organism
Sinocyclocheilus grahami (golden-line barbel) [GN:sgh]
Gene
107568886  chrd; chordin [KO:K04657]
107570268  chordin-like [KO:K04657]
107567560  noggin-1 [KO:K04658]
107581671  noggin-3-like [KO:K04658]
107553387  noggin-2-like [KO:K04658]
107553390  noggin-2-like [KO:K04658]
107580985  noggin-2-like [KO:K04658]
107556646  noggin-2 [KO:K04658]
107566874  noggin-3 [KO:K04658]
107601571  noggin-1-like [KO:K04658]
107573770  neuroblastoma suppressor of tumorigenicity 1-like [KO:K19558]
107549097  gremlin-1-like [KO:K23318]
107553877  gremlin-2-like [KO:K23318]
107569817  gremlin-1-like [KO:K23318]
107570400  gremlin-2-like [KO:K23318]
107574503  gremlin-2-like [KO:K23318]
107583498  gremlin-2-like [KO:K23318]
107601908  gremlin-1-like [KO:K23318]
107567351  thbs1; thrombospondin-1 [KO:K16857]
107568499  thrombospondin-1-like [KO:K16857]
107601983  thrombospondin-1-like [KO:K16857]
107549089  thrombospondin-1-like [KO:K16857]
107585689  decorin-like [KO:K04660]
107565639  decorin-like [KO:K04660]
107556092  fibromodulin-like [KO:K08121]
107575999  fibromodulin-like [KO:K08121]
107599070  left-right determination factor 2-like [KO:K04668]
107553491  left-right determination factor 2-like [KO:K04668]
107586666  left-right determination factor 2-like [KO:K04668]
107589597  left-right determination factor 2-like [KO:K04668]
107595577  follistatin-A-like isoform X1 [KO:K04661]
107599173  follistatin-A isoform X1 [KO:K04661]
107597631  follistatin-A-like isoform X1 [KO:K04661]
107573477  follistatin-A-like [KO:K04661]
107602023  follistatin-A-like isoform X1 [KO:K04661]
107552890  bone morphogenetic protein 2-like [KO:K21283]
107575557  bone morphogenetic protein 2-like [KO:K21283]
107566293  bone morphogenetic protein 2-like [KO:K21283]
107577119  bone morphogenetic protein 2-like [KO:K21283]
107580644  bone morphogenetic protein 2-like [KO:K21283]
107594089  bmp2; bone morphogenetic protein 2 [KO:K21283]
107593250  bone morphogenetic protein 2-like [KO:K21283]
107552681  bone morphogenetic protein 2-like [KO:K21283]
107596296  bone morphogenetic protein 2-like [KO:K21283]
107565000  bone morphogenetic protein 4-like [KO:K04662]
107565007  bone morphogenetic protein 4-like [KO:K04662]
107577028  bone morphogenetic protein 4-like [KO:K04662]
107557245  bone morphogenetic protein 7-like isoform X1 [KO:K16620]
107550027  bmp6; bone morphogenetic protein 6 isoform X1 [KO:K16620]
107552402  inhibin beta B chain-like [KO:K22687]
107575493  inhibin beta B chain-like [KO:K22687]
107596060  inhibin beta B chain-like isoform X1 [KO:K22687]
107597480  inhibin beta B chain-like isoform X1 [KO:K22687]
107558161  inhibin beta B chain-like [KO:K22687]
107558356  inhibin beta B chain-like [KO:K22687]
107558372  inhibin beta B chain-like [KO:K22687]
107553258  serotransferrin-1-like [KO:K14736]
107565057  bone morphogenetic protein 5-like [KO:K04663]
107597730  bmp5; bone morphogenetic protein 5 [KO:K04663]
107565994  bone morphogenetic protein 7-like [KO:K16621]
107601355  bone morphogenetic protein 7-like isoform X1 [KO:K16621]
107592570  bone morphogenetic protein 7-like [KO:K16621]
107601320  bone morphogenetic protein 7-like [KO:K16621]
107568055  bone morphogenetic protein 7-like [KO:K16621]
107556408  bone morphogenetic protein 8A-like [KO:K16622]
107574712  bone morphogenetic protein 8A-like [KO:K16622]
107564489  bone morphogenetic protein 8A-like [KO:K16622]
107595463  growth/differentiation factor 5-like [KO:K04664]
107587642  growth/differentiation factor 5-like [KO:K04664]
107563717  growth/differentiation factor 6-B-like [KO:K20012]
107551190  growth/differentiation factor 6-A-like [KO:K20012]
107592104  growth/differentiation factor 6-B [KO:K20012]
107600621  growth/differentiation factor 6-A [KO:K20012]
107594862  growth/differentiation factor 6-A-like [KO:K20013]
107563371  growth/differentiation factor 6-A-like [KO:K20013]
107593309  muellerian-inhibiting factor-like isoform X1 [KO:K04665]
107586395  muellerian-inhibiting factor-like isoform X1 [KO:K04665]
107597453  tumor necrosis factor-like [KO:K03156]
107568158  thsd4; thrombospondin type-1 domain-containing protein 4 [KO:K23377]
107570220  thrombospondin type-1 domain-containing protein 4-like [KO:K23377]
107595388  fibrillin-2-like [KO:K06825]
107553384  latent-transforming growth factor beta-binding protein 1-like isoform X1 [KO:K19559]
107583538  latent-transforming growth factor beta-binding protein 1-like isoform X1 [KO:K19559]
107573058  transforming growth factor beta-1 [KO:K13375]
107589304  transforming growth factor beta-1-like [KO:K13375]
107551248  transforming growth factor beta-1-like [KO:K13375]
107598564  transforming growth factor beta-1-like [KO:K13375]
107589143  transforming growth factor beta-2-like [KO:K13376]
107598937  transforming growth factor beta-2-like [KO:K13376]
107559262  transforming growth factor beta-2-like [KO:K13376]
107562423  tgfb2; transforming growth factor beta-2 [KO:K13376]
107554783  tgfb3; transforming growth factor beta-3 [KO:K13377]
107600138  inhibin beta A chain-like [KO:K04667]
107589832  inhibin beta A chain-like [KO:K04667]
107593113  inhibin beta A chain-like [KO:K04667]
107589292  nodal homolog 2-A-like [KO:K04666]
107548501  nodal homolog [KO:K04666]
107597771  nodal homolog [KO:K04666]
107556015  nodal homolog 2-B-like [KO:K04666]
107591687  nodal homolog [KO:K04666]
107595201  nodal homolog 2-A-like [KO:K04666]
107582766  bone morphogenetic protein receptor type-1A-like [KO:K04673] [EC:2.7.11.30]
107550060  bone morphogenetic protein receptor type-1A-like [KO:K04673] [EC:2.7.11.30]
107563048  bone morphogenetic protein receptor type-1A-like isoform X1 [KO:K04673] [EC:2.7.11.30]
107601818  bone morphogenetic protein receptor type-1A-like [KO:K04673] [EC:2.7.11.30]
107594551  bone morphogenetic protein receptor type-1B-like [KO:K13578] [EC:2.7.11.30]
107558980  bone morphogenetic protein receptor type-1B-like [KO:K13578] [EC:2.7.11.30]
107560828  bone morphogenetic protein receptor type-1B-like [KO:K13578] [EC:2.7.11.30]
107564364  bone morphogenetic protein receptor type-1B-like [KO:K13578] [EC:2.7.11.30]
107602619  activin receptor type-1-like [KO:K04675] [EC:2.7.11.30]
107567977  activin receptor type-1-like isoform X1 [KO:K04675] [EC:2.7.11.30]
107588871  activin receptor type-1-like isoform X1 [KO:K04675] [EC:2.7.11.30]
107548806  activin receptor type-1-like [KO:K04675] [EC:2.7.11.30]
107563639  activin receptor type-1-like [KO:K04675] [EC:2.7.11.30]
107570535  activin receptor type-1-like isoform X1 [KO:K04675] [EC:2.7.11.30]
107584759  bone morphogenetic protein receptor type-2-like [KO:K04671] [EC:2.7.11.30]
107593012  bone morphogenetic protein receptor type-2-like [KO:K04671] [EC:2.7.11.30]
107555441  bone morphogenetic protein receptor type-2-like isoform X1 [KO:K04671] [EC:2.7.11.30]
107596525  bmpr2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
107601072  activin receptor type-2A-like isoform X1 [KO:K04670] [EC:2.7.11.30]
107572302  activin receptor type-2A-like isoform X1 [KO:K04670] [EC:2.7.11.30]
107582301  activin receptor type-2A-like isoform X1 [KO:K04670] [EC:2.7.11.30]
107555835  activin receptor type-2A-like [KO:K04670] [EC:2.7.11.30]
107592496  hfe2; hemojuvelin [KO:K23100]
107592274  LOW QUALITY PROTEIN: hemojuvelin-like [KO:K23100]
107559439  neo1; neogenin [KO:K06766]
107549579  neogenin-like [KO:K06766]
107594493  neogenin-like [KO:K06766]
107567111  transferrin receptor protein 2-like [KO:K23910]
107590232  transferrin receptor protein 1-like isoform X1 [KO:K06503]
107550442  transferrin receptor protein 1-like [KO:K06503]
107564243  transferrin receptor protein 1-like [KO:K06503]
107586743  transferrin receptor protein 1-like isoform X1 [KO:K06503]
107601649  rgma; repulsive guidance molecule A [KO:K23096]
107596905  RGM domain family member B-like [KO:K23096]
107576054  RGM domain family member B-like [KO:K23096]
107587502  RGM domain family member B-like [KO:K06847]
107555502  RGM domain family member B-like [KO:K06847]
107566165  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
107585257  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
107589809  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
107561948  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
107596078  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
107555932  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
107551196  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
107569139  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
107600517  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
107582472  epithelial membrane protein 3-like [KO:K26257]
107592909  epithelial membrane protein 3-like [KO:K26257]
107560919  epithelial membrane protein 3-like [KO:K26257]
107562456  epithelial membrane protein 3-like [KO:K26257]
107575466  leucine-rich repeat-containing protein 32-like [KO:K26316]
107565546  leucine-rich repeat-containing protein 32-like isoform X1 [KO:K26316]
107558542  negative regulator of reactive oxygen species-like isoform X1 [KO:K26317]
107590262  negative regulator of reactive oxygen species-like [KO:K26317]
107554883  activin receptor type-1B-like [KO:K13567] [EC:2.7.11.30]
107582342  activin receptor type-1B-like [KO:K13567] [EC:2.7.11.30]
107563637  activin receptor type-1B-like isoform X1 [KO:K13567] [EC:2.7.11.30]
107570552  activin receptor type-1B-like [KO:K13567] [EC:2.7.11.30]
107558294  activin receptor type-2B-like [KO:K13596] [EC:2.7.11.30]
107554365  acvr2b; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
107560362  activin receptor type-2B-like [KO:K13596] [EC:2.7.11.30]
107600193  activin receptor type-2B-like [KO:K13596] [EC:2.7.11.30]
107567976  activin receptor type-1C-like isoform X1 [KO:K13568] [EC:2.7.11.30]
107548804  activin receptor type-1C-like isoform X1 [KO:K13568] [EC:2.7.11.30]
107549411  BMP and activin membrane-bound inhibitor homolog [KO:K10162]
107580862  BMP and activin membrane-bound inhibitor homolog [KO:K10162]
107566715  BMP and activin membrane-bound inhibitor homolog [KO:K10162]
107584374  BMP and activin membrane-bound inhibitor homolog [KO:K10162]
107551956  mothers against decapentaplegic homolog 1 [KO:K04676]
107598763  mothers against decapentaplegic homolog 1-like [KO:K04676]
107598346  mothers against decapentaplegic homolog 1-like [KO:K16790]
107563595  mothers against decapentaplegic homolog 5 isoform X1 [KO:K16790]
107589102  smad9; mothers against decapentaplegic homolog 9 [KO:K16791]
107577799  mothers against decapentaplegic homolog 9-like isoform X1 [KO:K16791]
107558710  smad2; mothers against decapentaplegic homolog 2 [KO:K04500]
107583760  mothers against decapentaplegic homolog 3-like [KO:K23605]
107553101  mothers against decapentaplegic homolog 3 [KO:K23605]
107563442  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
107570722  mothers against decapentaplegic homolog 4-like [KO:K04501]
107594567  mothers against decapentaplegic homolog 4-like [KO:K04501]
107597968  mothers against decapentaplegic homolog 4-like [KO:K04501]
107563920  mothers against decapentaplegic homolog 4-like [KO:K04501]
107549232  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
107559658  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
107557579  mothers against decapentaplegic homolog 4-like [KO:K04501]
107550085  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
107583766  mothers against decapentaplegic homolog 6-like [KO:K04677]
107596967  mothers against decapentaplegic homolog 6-like [KO:K04677]
107577436  mothers against decapentaplegic homolog 6-like [KO:K04677]
107563445  smad6; mothers against decapentaplegic homolog 6 [KO:K04677]
107553098  mothers against decapentaplegic homolog 6-like isoform X1 [KO:K04677]
107585687  smad7; mothers against decapentaplegic homolog 7 [KO:K19631]
107585655  mothers against decapentaplegic homolog 7-like [KO:K19631]
107599400  mothers against decapentaplegic homolog 7-like [KO:K19631]
107581717  E3 ubiquitin-protein ligase SMURF1-like isoform X1 [KO:K04678] [EC:2.3.2.26]
107602340  smurf2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
107583299  E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:2.3.2.26]
107591759  E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
107602218  zinc finger FYVE domain-containing protein 16-like [KO:K04679]
107548968  zinc finger FYVE domain-containing protein 16-like [KO:K04679]
107553256  zinc finger FYVE domain-containing protein 9-like isoform X1 [KO:K04679]
107563295  zinc finger FYVE domain-containing protein 9-like [KO:K04679]
107562066  zinc finger FYVE domain-containing protein 9-like [KO:K04679]
107602767  zinc finger FYVE domain-containing protein 9-like [KO:K04679]
107602336  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
107580054  RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
107549182  cullin-1-like [KO:K03347]
107595130  cullin-1-like [KO:K03347]
107599244  cullin-1 [KO:K03347]
107600214  cullin-1-like [KO:K03347]
107603266  skp1; S-phase kinase-associated protein 1 isoform X1 [KO:K03094]
107590568  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107599610  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107599134  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107567791  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107579050  transforming protein RhoA-like [KO:K04513]
107549297  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
107562777  rho-related GTP-binding protein RhoA-D-like isoform X1 [KO:K04513]
107569805  rho-related GTP-binding protein RhoA-D [KO:K04513]
107599000  rho-related GTP-binding protein RhoA-A-like [KO:K04513]
107603137  rho-related GTP-binding protein RhoA-A [KO:K04513]
107558917  rho-related GTP-binding protein RhoA-C [KO:K04513]
107571578  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
107556503  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
107591763  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
107591788  rho-related GTP-binding protein RhoA-B [KO:K04513]
107593752  rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
107567877  rho-associated protein kinase 1-like [KO:K04514] [EC:2.7.11.1]
107603174  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
107586237  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform-like [KO:K03456]
107601716  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
107600790  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
107564119  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like [KO:K04382] [EC:3.1.3.16]
107573265  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
107594878  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
107562914  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
107594920  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
107603261  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
107576702  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
107582630  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
107548877  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
107597508  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
107552513  hepcidin-1-like isoform X1 [KO:K23106]
107568867  hepcidin-1-like isoform X1 [KO:K23106]
107590169  DNA-binding protein inhibitor ID-1-like [KO:K04680]
107556485  DNA-binding protein inhibitor ID-1-like [KO:K04680]
107579075  DNA-binding protein inhibitor ID-2-like [KO:K17693]
107602869  DNA-binding protein inhibitor ID-2-like [KO:K17693]
107549107  DNA-binding protein inhibitor ID-2-like [KO:K17693]
107553286  DNA-binding protein inhibitor ID-2-like [KO:K17693]
107590890  DNA-binding protein inhibitor ID-3-like [KO:K17694]
107590891  DNA-binding protein inhibitor ID-3-like [KO:K17694]
107583515  DNA-binding protein inhibitor ID-3-like [KO:K17694]
107564867  DNA-binding protein inhibitor ID-4-like [KO:K17695]
107596695  DNA-binding protein inhibitor ID-4-like [KO:K17695]
107596834  retinoblastoma-like protein 1 [KO:K04681]
107584070  retinoblastoma-like protein 1 isoform X1 [KO:K04681]
107558188  transcription factor E2F5-like [KO:K04682]
107584115  transcription factor E2F5-like [KO:K04682]
107576162  transcription factor E2F4-like [KO:K04682]
107572751  transcription factor E2F4-like [KO:K04682]
107597491  transcription factor Dp-1-like [KO:K04683]
107595816  transcription factor Dp-1-like [KO:K04683]
107573442  transcription factor Dp-1-like [KO:K04683]
107566050  CREB-binding protein-like [KO:K04498] [EC:2.3.1.48]
107602282  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
107553628  CREB-binding protein-like [KO:K04498] [EC:2.3.1.48]
107554018  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
107566670  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
107584175  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
107583302  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
107601576  CREB-binding protein-like [KO:K04498] [EC:2.3.1.48]
107575074  transcription factor Sp1-like isoform X1 [KO:K04684]
107590240  skil; ski-like protein [KO:K18499]
107591339  ski-like protein isoform X1 [KO:K18499]
107557528  ski-like protein [KO:K18499]
107599811  ski oncogene-like [KO:K26503]
107597161  ski oncogene-like [KO:K26503]
107548407  ski oncogene-like [KO:K26503]
107565209  ski oncogene-like isoform X1 [KO:K26503]
107562276  paired amphipathic helix protein Sin3a-like [KO:K11644]
107560009  paired amphipathic helix protein Sin3a-like isoform X1 [KO:K11644]
107596483  paired amphipathic helix protein Sin3a-like [KO:K11644]
107562523  paired amphipathic helix protein Sin3a-like [KO:K11644]
107562876  probable histone deacetylase 1-B isoform X1 [KO:K06067] [EC:3.5.1.98]
107584281  probable histone deacetylase 1-B isoform X1 [KO:K06067] [EC:3.5.1.98]
107576062  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
107552540  nuclear receptor corepressor 1-like [KO:K04650]
107553567  nuclear receptor corepressor 1-like [KO:K04650]
107558340  homeobox protein TGIF1-like isoform X1 [KO:K19383]
107589945  homeobox protein TGIF1-like isoform X1 [KO:K19383]
107554859  homeobox protein TGIF2-like [KO:K19553]
107582308  homeobox protein TGIF1-like isoform X1 [KO:K19553]
107584016  transcriptional regulator Myc-B isoform X1 [KO:K04377]
107558335  transcriptional regulator Myc-1 [KO:K04377]
107589955  transcriptional regulator Myc-2 [KO:K04377]
107598259  cyclin-dependent kinase 4 inhibitor B-like [KO:K04685]
107595098  cyclin-dependent kinase inhibitor 2A-like [KO:K04685]
107602588  pitx2; pituitary homeobox 2 isoform X1 [KO:K04686]
107569829  pituitary homeobox 2 [KO:K04686]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Related
pathway
sgh04010  MAPK signaling pathway
sgh04110  Cell cycle
sgh04120  Ubiquitin mediated proteolysis
sgh04210  Apoptosis
KO pathway
ko04350   
LinkDB

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