KEGG   PATHWAY: sgh04010
Entry
sgh04010                    Pathway                                
Name
MAPK signaling pathway - Sinocyclocheilus grahami (golden-line barbel)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
sgh04010  MAPK signaling pathway
sgh04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Sinocyclocheilus grahami (golden-line barbel) [GN:sgh]
Gene
107548248  [KO:K04853]
107548350  [KO:K08018]
107548527  [KO:K04442] [EC:2.7.11.1]
107548624  [KO:K04457] [EC:3.1.3.16]
107548633  [KO:K04440] [EC:2.7.11.24]
107548678  [KO:K04866]
107548710  [KO:K04869]
107548771  [KO:K04849]
107548920  [KO:K17333]
107548987  [KO:K12326]
107549046  [KO:K04465]
107549084  max; protein max isoform X1 [KO:K04453]
107549277  [KO:K07827]
107549289  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107549293  [KO:K04443] [EC:2.7.11.1]
107549410  [KO:K04415] [EC:2.7.11.25]
107549470  [KO:K19663] [EC:2.7.11.13]
107549472  [KO:K04872]
107549473  [KO:K04873]
107549474  [KO:K04871]
107549565  [KO:K04851]
107549680  [KO:K04852]
107549841  [KO:K02308]
107549945  [KO:K04853]
107549963  [KO:K04441] [EC:2.7.11.24]
107549991  [KO:K04372] [EC:2.7.11.1]
107550052  [KO:K04461] [EC:3.1.3.16]
107550115  [KO:K04853]
107550175  [KO:K12361]
107550328  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
107550415  [KO:K04379]
107550416  [KO:K04379]
107550462  [KO:K04857]
107550532  [KO:K04456] [EC:2.7.11.1]
107550773  [KO:K05096] [EC:2.7.10.1]
107550806  [KO:K03158]
107550950  [KO:K04443] [EC:2.7.11.1]
107550972  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107550990  [KO:K05097] [EC:2.7.10.1]
107551139  [KO:K04867]
107551144  [KO:K04856]
107551145  [KO:K22429]
107551172  [KO:K07860]
107551196  [KO:K04388] [EC:2.7.11.30]
107551248  [KO:K13375]
107551308  [KO:K04460] [EC:3.1.3.16]
107551382  [KO:K04378]
107551448  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
107551519  [KO:K04441] [EC:2.7.11.24]
107551583  [KO:K05091] [EC:2.7.10.1]
107551712  [KO:K04402]
107551713  [KO:K04347]
107551717  [KO:K25415]
107551779  [KO:K04444] [EC:2.7.11.1]
107551822  taok3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
107551856  [KO:K04723]
107551889  [KO:K05084] [EC:2.7.10.1]
107551895  [KO:K04424] [EC:2.7.11.25]
107551943  [KO:K07831]
107552015  [KO:K05449]
107552074  [KO:K04358]
107552214  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
107552439  [KO:K04419] [EC:2.7.11.25]
107552451  [KO:K04436]
107552492  [KO:K04862]
107552672  [KO:K04369] [EC:2.7.12.2]
107552678  [KO:K04449]
107552726  [KO:K25414]
107552769  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
107552774  [KO:K04854]
107552852  [KO:K04393]
107552954  [KO:K17534] [EC:2.7.11.25]
107553138  [KO:K16342] [EC:3.1.1.4]
107553150  ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
107553151  [KO:K16342] [EC:3.1.1.4]
107553171  [KO:K04362] [EC:2.7.10.1]
107553172  [KO:K04428] [EC:2.7.11.25]
107553182  [KO:K16342] [EC:3.1.1.4]
107553203  [KO:K04417] [EC:2.7.11.25]
107553213  [KO:K03099]
107553408  rasgrp3; ras guanyl-releasing protein 3 [KO:K12362]
107553522  nrtn; neurturin [KO:K25414]
107553537  [KO:K04402]
107553709  [KO:K04348] [EC:3.1.3.16]
107553852  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107553858  [KO:K13769]
107553873  [KO:K04860]
107553881  rap1b; ras-related protein Rap-1b [KO:K07836]
107553916  [KO:K04454]
107553923  [KO:K04352]
107553980  [KO:K04441] [EC:2.7.11.24]
107554068  [KO:K04390]
107554105  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107554112  [KO:K07830]
107554113  [KO:K04526]
107554152  [KO:K04426] [EC:2.7.11.25]
107554201  [KO:K02582]
107554210  [KO:K02582]
107554269  [KO:K09253]
107554314  arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
107554345  [KO:K02308]
107554387  [KO:K04358]
107554416  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107554498  [KO:K04418] [EC:2.7.11.25]
107554524  [KO:K04519]
107554596  [KO:K18018] [EC:3.1.3.48]
107554607  [KO:K04466] [EC:2.7.11.25]
107554712  [KO:K18496]
107554783  tgfb3; transforming growth factor beta-3 [KO:K13377]
107554784  fos; proto-oncogene c-Fos [KO:K04379]
107554803  [KO:K04361] [EC:2.7.10.1]
107554888  [KO:K25415]
107554894  [KO:K04355]
107555091  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
107555104  [KO:K04867]
107555372  [KO:K04402]
107555383  [KO:K04347]
107555492  rasgrf2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
107555722  [KO:K17333]
107555780  [KO:K04366] [EC:2.7.11.1]
107555909  [KO:K05085] [EC:2.7.10.1]
107555918  cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
107555932  [KO:K04388] [EC:2.7.11.30]
107555973  [KO:K05103] [EC:2.7.10.1]
107555982  [KO:K04406] [EC:2.7.11.1]
107555985  [KO:K04441] [EC:2.7.11.24]
107556043  [KO:K04442] [EC:2.7.11.1]
107556089  [KO:K04426] [EC:2.7.11.25]
107556197  [KO:K05085] [EC:2.7.10.1]
107556199  [KO:K04856]
107556266  [KO:K05085] [EC:2.7.10.1]
107556305  [KO:K04344]
107556321  [KO:K04353]
107556381  [KO:K04412]
107556455  [KO:K05449]
107556463  [KO:K04430] [EC:2.7.12.2]
107556610  [KO:K02677] [EC:2.7.11.13]
107556612  [KO:K04870]
107556616  [KO:K04392]
107556843  [KO:K02187] [EC:3.4.22.56]
107556903  [KO:K04370]
107556909  [KO:K05453]
107556915  [KO:K05094] [EC:2.7.10.1]
107557026  [KO:K04348] [EC:3.1.3.16]
107557050  [KO:K12361]
107557293  [KO:K05460]
107557297  [KO:K04410] [EC:2.7.11.1]
107557316  [KO:K05085] [EC:2.7.10.1]
107557341  [KO:K04464] [EC:2.7.11.24]
107557372  [KO:K04380]
107557428  mef2c; myocyte-specific enhancer factor 2C [KO:K04454]
107557440  rasa1; ras GTPase-activating protein 1 [KO:K04352]
107557572  [KO:K03173] [EC:2.3.2.27]
107557841  rasa2; ras GTPase-activating protein 2 [KO:K08053]
107557843  [KO:K04456] [EC:2.7.11.1]
107557907  [KO:K04353]
107558038  [KO:K05097] [EC:2.7.10.1]
107558048  [KO:K21278] [EC:3.1.3.16 3.1.3.48]
107558058  [KO:K05121] [EC:2.7.10.1]
107558158  [KO:K04863]
107558201  casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
107558205  [KO:K06268]
107558252  [KO:K04416] [EC:2.7.11.25]
107558272  [KO:K04859]
107558311  [KO:K02833]
107558335  [KO:K04377]
107558386  [KO:K04386]
107558389  [KO:K04422] [EC:2.7.11.25]
107558448  [KO:K04405]
107558456  [KO:K18496]
107558510  [KO:K04867]
107558512  [KO:K04856]
107558783  [KO:K05449]
107558844  [KO:K04527] [EC:2.7.10.1]
107558968  [KO:K04404]
107559057  [KO:K05448]
107559060  [KO:K04348] [EC:3.1.3.16]
107559105  [KO:K20216] [EC:3.1.3.16 3.1.3.48]
107559165  [KO:K04402]
107559262  [KO:K13376]
107559267  [KO:K04348] [EC:3.1.3.16]
107559274  [KO:K04358]
107559325  [KO:K04467] [EC:2.7.11.10]
107559333  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
107559452  [KO:K04362] [EC:2.7.10.1]
107559453  [KO:K04362] [EC:2.7.10.1]
107559548  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107559552  [KO:K17386]
107559596  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
107559624  fgf1; fibroblast growth factor 1 [KO:K18497]
107559839  [KO:K05460]
107559841  [KO:K04858]
107559857  [KO:K04441] [EC:2.7.11.24]
107559864  [KO:K04435]
107559882  [KO:K16859]
107559955  [KO:K04863]
107560135  rasgrp1; RAS guanyl-releasing protein 1 [KO:K04350]
107560156  [KO:K04418] [EC:2.7.11.25]
107560222  [KO:K04849]
107560229  [KO:K03173] [EC:2.3.2.27]
107560378  [KO:K04457] [EC:3.1.3.16]
107560413  map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
107560415  [KO:K04345] [EC:2.7.11.11]
107560426  [KO:K04353]
107560555  [KO:K05083] [EC:2.7.10.1]
107560558  [KO:K02583]
107560656  [KO:K12361]
107560707  [KO:K04365] [EC:2.7.11.1]
107560753  [KO:K07827]
107560825  [KO:K05452]
107560832  [KO:K05450]
107560912  [KO:K07210]
107560941  [KO:K04437]
107560995  [KO:K05103] [EC:2.7.10.1]
107561023  [KO:K04364]
107561230  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107561246  [KO:K05096] [EC:2.7.10.1]
107561280  [KO:K04526]
107561340  [KO:K04856]
107561353  [KO:K07860]
107561356  [KO:K04867]
107561365  [KO:K22429]
107561798  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107561815  [KO:K04433] [EC:2.7.12.2]
107561939  [KO:K04439]
107561948  [KO:K04674] [EC:2.7.11.30]
107561987  ppp3r1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
107562015  [KO:K04429] [EC:2.7.11.1]
107562137  [KO:K04458] [EC:3.1.3.48]
107562165  [KO:K05090] [EC:2.7.10.1]
107562193  [KO:K04455]
107562423  tgfb2; transforming growth factor beta-2 [KO:K13376]
107562470  [KO:K07210]
107562482  [KO:K03099]
107562518  [KO:K13769]
107562521  [KO:K03175] [EC:2.3.2.27]
107562658  [KO:K04360] [EC:2.7.10.1]
107562747  [KO:K02187] [EC:3.4.22.56]
107562835  [KO:K02833]
107562853  [KO:K04852]
107562862  [KO:K04345] [EC:2.7.11.11]
107562923  [KO:K04358]
107563053  [KO:K04469]
107563229  [KO:K04359]
107563389  [KO:K04448]
107563393  [KO:K05121] [EC:2.7.10.1]
107563411  cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
107563412  [KO:K05460]
107563421  [KO:K16342] [EC:3.1.1.4]
107563437  [KO:K16342] [EC:3.1.1.4]
107563438  [KO:K16342] [EC:3.1.1.4]
107563458  [KO:K17333]
107563477  map2k5; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
107563708  [KO:K04446]
107564028  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107564200  [KO:K04373] [EC:2.7.11.1]
107564278  raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
107564316  [KO:K16859]
107564390  [KO:K25415]
107564436  [KO:K04347]
107564442  [KO:K04402]
107564496  [KO:K05466]
107564512  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
107564527  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
107564711  [KO:K04372] [EC:2.7.11.1]
107564744  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
107564847  [KO:K04854]
107564851  [KO:K04854]
107565051  [KO:K05466]
107565186  [KO:K04359]
107565289  [KO:K05085] [EC:2.7.10.1]
107565387  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
107565462  [KO:K04456] [EC:2.7.11.1]
107565520  [KO:K04852]
107565536  [KO:K04456] [EC:2.7.11.1]
107565565  cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
107565608  [KO:K04359]
107565612  [KO:K04347]
107565709  [KO:K04358]
107565734  [KO:K04393]
107565829  [KO:K03158]
107565857  [KO:K04866]
107565862  [KO:K04869]
107566059  [KO:K04373] [EC:2.7.11.1]
107566067  [KO:K02582]
107566132  [KO:K04434]
107566165  [KO:K04674] [EC:2.7.11.30]
107566195  [KO:K02583]
107566214  [KO:K04440] [EC:2.7.11.24]
107566268  [KO:K17333]
107566410  ddit3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
107566457  [KO:K04361] [EC:2.7.10.1]
107566682  [KO:K08053]
107566698  [KO:K08018]
107566792  [KO:K04865]
107566814  [KO:K07828]
107566897  [KO:K05450]
107567271  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
107567276  [KO:K04457] [EC:3.1.3.16]
107567284  [KO:K16510] [EC:2.7.11.1]
107567406  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
107567423  [KO:K04386]
107567433  [KO:K04386]
107567516  [KO:K07827]
107567568  [KO:K04439]
107567653  [KO:K04358]
107567702  [KO:K03173] [EC:2.3.2.27]
107567712  [KO:K04422] [EC:2.7.11.25]
107567791  [KO:K04371] [EC:2.7.11.24]
107567797  map2k7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
107567856  [KO:K05866] [EC:3.1.3.48]
107568096  [KO:K05462]
107568129  [KO:K05090] [EC:2.7.10.1]
107568132  [KO:K05089] [EC:2.7.10.1]
107568177  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
107568217  [KO:K20216] [EC:3.1.3.16 3.1.3.48]
107568266  [KO:K04378]
107568392  atf4; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
107568444  [KO:K02583]
107568529  [KO:K04381]
107568661  [KO:K18497]
107568726  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107568749  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
107568785  [KO:K04358]
107568911  angpt2; angiopoietin-2 [KO:K05466]
107568990  [KO:K04358]
107569030  [KO:K04423] [EC:2.7.11.25]
107569044  [KO:K04358]
107569131  [KO:K25416]
107569132  pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
107569139  [KO:K04388] [EC:2.7.11.30]
107569160  efna5; ephrin-A5 [KO:K05462]
107569188  [KO:K04392]
107569198  [KO:K02583]
107569323  [KO:K05449]
107569368  [KO:K05452]
107569457  [KO:K04866]
107569462  [KO:K02677] [EC:2.7.11.13]
107569463  [KO:K04870]
107569479  [KO:K04439]
107569731  [KO:K04429] [EC:2.7.11.1]
107569836  [KO:K04357]
107569869  [KO:K04381]
107569904  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107569930  [KO:K04358]
107570115  ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
107570227  [KO:K04864]
107570276  [KO:K04437]
107570444  [KO:K04406] [EC:2.7.11.1]
107570516  [KO:K04426] [EC:2.7.11.25]
107570719  [KO:K04430] [EC:2.7.12.2]
107570739  [KO:K04378]
107570753  [KO:K04421] [EC:2.7.11.25]
107570979  [KO:K04344]
107570980  [KO:K04441] [EC:2.7.11.24]
107571174  [KO:K02677] [EC:2.7.11.13]
107571175  [KO:K04870]
107571214  [KO:K04366] [EC:2.7.11.1]
107571265  [KO:K04440] [EC:2.7.11.24]
107571502  [KO:K04344]
107571507  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107571514  [KO:K16510] [EC:2.7.11.1]
107571543  [KO:K04348] [EC:3.1.3.16]
107571767  [KO:K07861]
107571768  [KO:K04429] [EC:2.7.11.1]
107571995  [KO:K03099]
107572026  [KO:K04373] [EC:2.7.11.1]
107572332  [KO:K04373] [EC:2.7.11.1]
107572342  [KO:K04374]
107572408  [KO:K04358]
107572552  [KO:K04857]
107572728  [KO:K04456] [EC:2.7.11.1]
107572734  [KO:K04456] [EC:2.7.11.1]
107572787  [KO:K04465]
107572879  [KO:K13769]
107572933  [KO:K05461]
107572940  [KO:K04372] [EC:2.7.11.1]
107572944  [KO:K21946] [EC:3.1.3.16 3.1.3.48]
107572995  [KO:K04434]
107573058  [KO:K13375]
107573300  [KO:K04376]
107573314  [KO:K22428]
107573419  [KO:K05083] [EC:2.7.10.1]
107573530  [KO:K04364]
107573599  [KO:K04345] [EC:2.7.11.11]
107573921  [KO:K04735]
107574004  [KO:K05099] [EC:2.7.10.1]
107574010  rela; transcription factor p65 isoform X1 [KO:K04735]
107574045  [KO:K04358]
107574346  [KO:K04457] [EC:3.1.3.16]
107574590  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
107574657  [KO:K04861]
107574675  [KO:K04414] [EC:2.7.11.1]
107574676  [KO:K04444] [EC:2.7.11.1]
107574814  [KO:K05099] [EC:2.7.10.1]
107574886  [KO:K21946] [EC:3.1.3.16 3.1.3.48]
107574894  [KO:K05461]
107575101  [KO:K04358]
107575154  [KO:K04419] [EC:2.7.11.25]
107575219  [KO:K04358]
107575298  [KO:K16859]
107575628  [KO:K04430] [EC:2.7.12.2]
107575734  [KO:K04373] [EC:2.7.11.1]
107575785  [KO:K04369] [EC:2.7.12.2]
107576554  [KO:K04443] [EC:2.7.11.1]
107577029  [KO:K06268]
107577128  [KO:K03283]
107577187  [KO:K21278] [EC:3.1.3.16 3.1.3.48]
107577463  [KO:K04869]
107577967  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107578398  [KO:K08052]
107578769  [KO:K04402]
107578828  [KO:K04866]
107578914  [KO:K22603]
107579303  [KO:K04412]
107579544  [KO:K04441] [EC:2.7.11.24]
107579565  [KO:K04441] [EC:2.7.11.24]
107579734  [KO:K04356]
107579742  [KO:K22428]
107579754  [KO:K05448]
107579852  [KO:K04358]
107580157  [KO:K04393]
107580740  [KO:K04358]
107580747  [KO:K05461]
107581079  [KO:K04519]
107581346  [KO:K04420] [EC:2.7.11.25]
107581391  [KO:K04424] [EC:2.7.11.25]
107581402  [KO:K05084] [EC:2.7.10.1]
107581481  [KO:K04448]
107581522  [KO:K04389]
107581538  [KO:K02583]
107581709  gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
107581769  [KO:K04855]
107581790  [KO:K04860]
107581799  [KO:K04851]
107581961  [KO:K05095] [EC:2.7.10.1]
107581987  [KO:K04414] [EC:2.7.11.1]
107582013  [KO:K18496]
107582070  [KO:K05462]
107582071  [KO:K05462]
107582164  [KO:K05462]
107582226  [KO:K04462] [EC:2.1.1.367]
107582348  artn; artemin [KO:K25415]
107582378  [KO:K04860]
107582393  [KO:K04376]
107582398  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
107582429  [KO:K04851]
107582534  [KO:K05866] [EC:3.1.3.48]
107582584  [KO:K04373] [EC:2.7.11.1]
107582588  [KO:K09253]
107582617  [KO:K03283]
107582744  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
107582773  [KO:K04461] [EC:3.1.3.16]
107582857  [KO:K04429] [EC:2.7.11.1]
107582859  [KO:K04468] [EC:2.7.11.24]
107582897  [KO:K04374]
107582898  [KO:K04359]
107582903  [KO:K04445] [EC:2.7.11.1]
107582916  [KO:K04380]
107582970  [KO:K04344]
107583016  [KO:K07830]
107583042  [KO:K04421] [EC:2.7.11.25]
107583200  [KO:K06268]
107583254  [KO:K04364]
107583548  [KO:K04390]
107583642  [KO:K16342] [EC:3.1.1.4]
107583647  [KO:K12362]
107583658  [KO:K04406] [EC:2.7.11.1]
107583702  [KO:K16342] [EC:3.1.1.4]
107583745  [KO:K05087] [EC:2.7.10.1]
107583767  [KO:K04368] [EC:2.7.12.2]
107583837  [KO:K04441] [EC:2.7.11.24]
107583896  [KO:K04441] [EC:2.7.11.24]
107583972  [KO:K04441] [EC:2.7.11.24]
107583986  [KO:K22428]
107583988  [KO:K04358]
107584016  [KO:K04377]
107584056  [KO:K04356]
107584066  [KO:K05467]
107584407  [KO:K04415] [EC:2.7.11.25]
107584639  [KO:K04440] [EC:2.7.11.24]
107584740  [KO:K22603]
107584753  [KO:K04358]
107584755  [KO:K04358]
107584801  [KO:K04420] [EC:2.7.11.25]
107584867  [KO:K05462]
107584885  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
107584912  [KO:K04730] [EC:2.7.11.1]
107584943  [KO:K04729]
107584944  [KO:K04421] [EC:2.7.11.25]
107584975  [KO:K05092] [EC:2.7.10.1]
107584976  [KO:K05096] [EC:2.7.10.1]
107585031  [KO:K04359]
107585034  [KO:K04374]
107585060  [KO:K04380]
107585233  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
107585253  [KO:K04461] [EC:3.1.3.16]
107585257  [KO:K04674] [EC:2.7.11.30]
107585263  [KO:K05094] [EC:2.7.10.1]
107585271  [KO:K04456] [EC:2.7.11.1]
107585369  [KO:K04358]
107585454  [KO:K05093] [EC:2.7.10.1]
107585573  [KO:K04438]
107585593  [KO:K04429] [EC:2.7.11.1]
107585770  [KO:K03283]
107585877  [KO:K04372] [EC:2.7.11.1]
107585947  rras2; ras-related protein R-Ras2 [KO:K07830]
107585960  [KO:K03171]
107586120  [KO:K04348] [EC:3.1.3.16]
107586162  [KO:K04439]
107586178  [KO:K04358]
107586338  [KO:K02677] [EC:2.7.11.13]
107586339  [KO:K04870]
107586374  [KO:K04866]
107586376  [KO:K04869]
107586388  [KO:K04369] [EC:2.7.12.2]
107586903  [KO:K16859]
107586934  [KO:K04527] [EC:2.7.10.1]
107587007  [KO:K07831]
107587053  [KO:K02580]
107587200  [KO:K05095] [EC:2.7.10.1]
107587237  [KO:K04414] [EC:2.7.11.1]
107587303  [KO:K18496]
107587320  [KO:K03173] [EC:2.3.2.27]
107587387  [KO:K04455]
107587417  [KO:K04348] [EC:3.1.3.16]
107587427  [KO:K04849]
107587450  [KO:K04429] [EC:2.7.11.1]
107587539  [KO:K12326]
107587574  [KO:K04859]
107587743  [KO:K04381]
107587753  igf1; insulin-like growth factor I [KO:K05459]
107587798  [KO:K04462] [EC:2.1.1.367]
107587842  akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107587863  [KO:K04393]
107588115  [KO:K04468] [EC:2.7.11.24]
107588248  [KO:K04424] [EC:2.7.11.25]
107588320  [KO:K05090] [EC:2.7.10.1]
107588322  [KO:K05089] [EC:2.7.10.1]
107588396  [KO:K04358]
107588462  [KO:K04378]
107588497  [KO:K04426] [EC:2.7.11.25]
107588586  [KO:K03283]
107588600  [KO:K04457] [EC:3.1.3.16]
107588610  [KO:K04440] [EC:2.7.11.24]
107588741  [KO:K04358]
107588969  [KO:K04454]
107588970  [KO:K04352]
107588986  [KO:K04362] [EC:2.7.10.1]
107589025  [KO:K04519]
107589041  [KO:K04850]
107589071  [KO:K04457] [EC:3.1.3.16]
107589094  [KO:K04348] [EC:3.1.3.16]
107589121  [KO:K02187] [EC:3.4.22.56]
107589132  [KO:K04358]
107589143  [KO:K13376]
107589201  mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
107589229  [KO:K04438]
107589246  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107589251  [KO:K05462]
107589264  ppm1n; probable protein phosphatase 1N [KO:K04457] [EC:3.1.3.16]
107589284  [KO:K04358]
107589289  [KO:K04402]
107589304  [KO:K13375]
107589386  [KO:K04873]
107589388  [KO:K04872]
107589389  [KO:K04871]
107589415  [KO:K05462]
107589416  efna3; ephrin-A3 [KO:K05462]
107589809  [KO:K04674] [EC:2.7.11.30]
107589858  [KO:K04372] [EC:2.7.11.1]
107589895  [KO:K16342] [EC:3.1.1.4]
107589955  [KO:K04377]
107590058  [KO:K04440] [EC:2.7.11.24]
107590124  [KO:K05459]
107590153  [KO:K04443] [EC:2.7.11.1]
107590208  [KO:K04373] [EC:2.7.11.1]
107590367  [KO:K04466] [EC:2.7.11.25]
107590403  [KO:K04868]
107590404  [KO:K19662] [EC:2.7.11.13]
107590411  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
107590440  [KO:K04858]
107590454  [KO:K07861]
107590568  [KO:K04371] [EC:2.7.11.24]
107590584  [KO:K04850]
107590690  [KO:K05085] [EC:2.7.10.1]
107590741  [KO:K19662] [EC:2.7.11.13]
107590766  [KO:K04868]
107590788  [KO:K04429] [EC:2.7.11.1]
107590835  [KO:K04861]
107590844  [KO:K04468] [EC:2.7.11.24]
107590932  [KO:K04373] [EC:2.7.11.1]
107590990  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
107591033  [KO:K04353]
107591085  [KO:K05103] [EC:2.7.10.1]
107591101  [KO:K04861]
107591118  [KO:K05084] [EC:2.7.10.1]
107591220  [KO:K05096] [EC:2.7.10.1]
107591262  [KO:K05096] [EC:2.7.10.1]
107591272  [KO:K04421] [EC:2.7.11.25]
107591276  [KO:K05092] [EC:2.7.10.1]
107591285  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
107591310  [KO:K05460]
107591323  [KO:K04410] [EC:2.7.11.1]
107591352  [KO:K04527] [EC:2.7.10.1]
107591447  [KO:K04402]
107591457  [KO:K16342] [EC:3.1.1.4]
107591466  [KO:K04455]
107591493  [KO:K16342] [EC:3.1.1.4]
107591521  [KO:K03173] [EC:2.3.2.27]
107591536  [KO:K05091] [EC:2.7.10.1]
107591577  [KO:K08018]
107591703  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107591716  [KO:K04438]
107591720  [KO:K04457] [EC:3.1.3.16]
107591728  [KO:K05462]
107591738  [KO:K04402]
107591746  [KO:K04358]
107591792  [KO:K04857]
107591834  [KO:K04441] [EC:2.7.11.24]
107591881  [KO:K04407] [EC:2.7.11.1]
107591972  angpt1; angiopoietin-1 [KO:K05465]
107592032  [KO:K04446]
107592146  [KO:K03176] [EC:2.7.10.1]
107592284  [KO:K04373] [EC:2.7.11.1]
107592291  [KO:K04451]
107592338  [KO:K08845] [EC:2.7.11.1]
107592392  [KO:K04855]
107592455  [KO:K03176] [EC:2.7.10.1]
107592501  [KO:K04346]
107592575  [KO:K04441] [EC:2.7.11.24]
107592581  [KO:K04345] [EC:2.7.11.11]
107592606  [KO:K04438]
107592626  [KO:K04429] [EC:2.7.11.1]
107592924  [KO:K04468] [EC:2.7.11.24]
107592975  [KO:K05465]
107593037  [KO:K07831]
107593049  [KO:K04527] [EC:2.7.10.1]
107593260  [KO:K04379]
107593301  [KO:K04379]
107593814  [KO:K04439]
107593907  [KO:K05084] [EC:2.7.10.1]
107593930  [KO:K05103] [EC:2.7.10.1]
107594271  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
107594274  [KO:K07830]
107594289  [KO:K04456] [EC:2.7.11.1]
107594309  [KO:K04345] [EC:2.7.11.11]
107594372  pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
107594412  [KO:K06268]
107594466  [KO:K04864]
107594496  [KO:K22603]
107594497  [KO:K04358]
107594498  [KO:K04358]
107594522  [KO:K04353]
107594590  [KO:K05452]
107594591  [KO:K04358]
107594616  [KO:K03171]
107594671  [KO:K16342] [EC:3.1.1.4]
107594738  [KO:K05087] [EC:2.7.10.1]
107594895  [KO:K08018]
107594982  [KO:K04851]
107595001  [KO:K05462]
107595004  [KO:K08845] [EC:2.7.11.1]
107595011  [KO:K05462]
107595030  [KO:K04348] [EC:3.1.3.16]
107595107  [KO:K04355]
107595236  [KO:K07827]
107595354  [KO:K04358]
107595439  [KO:K04859]
107595449  [KO:K05465]
107595700  [KO:K04849]
107595780  [KO:K02580]
107595988  [KO:K03173] [EC:2.3.2.27]
107596017  [KO:K04360] [EC:2.7.10.1]
107596078  [KO:K04388] [EC:2.7.11.30]
107596082  [KO:K04865]
107596147  [KO:K05462]
107596207  [KO:K04526]
107596254  jund; transcription factor jun-D [KO:K04449]
107596307  [KO:K04865]
107596396  [KO:K04358]
107596425  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
107596428  [KO:K03175] [EC:2.3.2.27]
107596433  [KO:K13769]
107596435  [KO:K02833]
107596579  [KO:K04392]
107596698  [KO:K05465]
107596732  [KO:K03158]
107596749  [KO:K02583]
107596860  [KO:K02582]
107596877  [KO:K04369] [EC:2.7.12.2]
107596887  [KO:K04350]
107596941  [KO:K05087] [EC:2.7.10.1]
107596971  [KO:K04368] [EC:2.7.12.2]
107597104  [KO:K04381]
107597151  [KO:K04402]
107597152  [KO:K25414]
107597437  [KO:K05091] [EC:2.7.10.1]
107597438  [KO:K04363] [EC:2.7.10.1]
107597453  [KO:K03156]
107597461  [KO:K04427] [EC:2.7.11.25]
107597532  [KO:K03283]
107597642  fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
107597804  [KO:K04448]
107597819  [KO:K04389]
107597823  [KO:K04433] [EC:2.7.12.2]
107597876  [KO:K04414] [EC:2.7.11.1]
107597881  [KO:K04405]
107598017  [KO:K04429] [EC:2.7.11.1]
107598307  [KO:K04455]
107598392  [KO:K04873]
107598394  [KO:K04872]
107598398  [KO:K04871]
107598407  [KO:K19663] [EC:2.7.11.13]
107598536  [KO:K04456] [EC:2.7.11.1]
107598564  [KO:K13375]
107598565  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
107598589  [KO:K04380]
107598937  [KO:K13376]
107598961  [KO:K04441] [EC:2.7.11.24]
107598969  [KO:K07828]
107598996  [KO:K05459]
107599003  [KO:K04852]
107599091  [KO:K16342] [EC:3.1.1.4]
107599100  [KO:K04410] [EC:2.7.11.1]
107599134  [KO:K04371] [EC:2.7.11.24]
107599194  [KO:K04358]
107599231  [KO:K04526]
107599301  [KO:K04345] [EC:2.7.11.11]
107599423  [KO:K05103] [EC:2.7.10.1]
107599526  [KO:K04871]
107599529  [KO:K04873]
107599530  [KO:K04872]
107599554  [KO:K16342] [EC:3.1.1.4]
107599562  [KO:K05462]
107599610  [KO:K04371] [EC:2.7.11.24]
107599721  [KO:K04361] [EC:2.7.10.1]
107599747  [KO:K04466] [EC:2.7.11.25]
107599770  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107599899  [KO:K04435]
107599945  [KO:K04451]
107599949  [KO:K04373] [EC:2.7.11.1]
107600042  [KO:K04402]
107600181  [KO:K04526]
107600310  [KO:K04345] [EC:2.7.11.11]
107600440  [KO:K07831]
107600445  [KO:K02833]
107600517  [KO:K04388] [EC:2.7.11.30]
107600581  [KO:K04360] [EC:2.7.10.1]
107600703  [KO:K04450]
107600726  [KO:K04424] [EC:2.7.11.25]
107600813  [KO:K04723]
107600856  [KO:K04445] [EC:2.7.11.1]
107601146  [KO:K04863]
107601176  [KO:K12361]
107601253  [KO:K19662] [EC:2.7.11.13]
107601254  [KO:K04868]
107601271  [KO:K07861]
107601304  [KO:K04466] [EC:2.7.11.25]
107601341  [KO:K04864]
107601595  [KO:K04430] [EC:2.7.12.2]
107601626  [KO:K04378]
107601801  [KO:K05126] [EC:2.7.10.1]
107601822  [KO:K04469]
107601877  [KO:K04467] [EC:2.7.11.10]
107601905  [KO:K04363] [EC:2.7.10.1]
107601906  [KO:K05091] [EC:2.7.10.1]
107601907  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
107601937  [KO:K04427] [EC:2.7.11.25]
107602014  [KO:K04358]
107602050  [KO:K04453]
107602069  [KO:K04362] [EC:2.7.10.1]
107602079  [KO:K04352]
107602081  [KO:K04454]
107602219  [KO:K12326]
107602286  [KO:K04364]
107602297  [KO:K04424] [EC:2.7.11.25]
107602505  [KO:K04461] [EC:3.1.3.16]
107602547  [KO:K05462]
107602582  pdgfc; platelet-derived growth factor C [KO:K05450]
107602591  [KO:K04357]
107602651  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107602672  [KO:K17386]
107602709  [KO:K04345] [EC:2.7.11.11]
107602739  [KO:K04358]
107602795  [KO:K04372] [EC:2.7.11.1]
107602810  [KO:K05462]
107602833  [KO:K04402]
107602945  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
107602953  [KO:K04417] [EC:2.7.11.25]
107602966  [KO:K03099]
107602992  [KO:K04431] [EC:2.7.12.2]
107603155  [KO:K04393]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
sgh04070  Phosphatidylinositol signaling system
sgh04110  Cell cycle
sgh04115  p53 signaling pathway
sgh04210  Apoptosis
sgh04310  Wnt signaling pathway
KO pathway
ko04010   

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