KEGG   PATHWAY: stru00270
Entry
stru00270                   Pathway                                
Name
Cysteine and methionine metabolism - Salmo trutta (river trout)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
stru00270  Cysteine and methionine metabolism
stru00270

Module
stru_M00034  Methionine salvage pathway [PATH:stru00270]
stru_M00035  Methionine degradation [PATH:stru00270]
stru_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:stru00270]
Other DBs
GO: 0006534 0006555
Organism
Salmo trutta (river trout) [GN:stru]
Gene
115158134  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
115151722  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
115158848  kyat3; kynurenine--oxoglutarate transaminase 3 isoform X1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
115159911  kyat1; kynurenine--oxoglutarate transaminase 1 isoform X1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
115180906  cystathionine beta-synthase-like isoform X1 [KO:K01697] [EC:4.2.1.22]
115182132  cystathionine beta-synthase-like isoform X1 [KO:K01697] [EC:4.2.1.22]
115156315  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
115161215  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
115159735  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
115203928  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
115151432  uncharacterized protein LOC115151432 isoform X1 [KO:K00547] [EC:2.1.1.10]
115151436  uncharacterized protein LOC115151436 isoform X1 [KO:K00547] [EC:2.1.1.10]
115190126  methionine synthase-like isoform X1 [KO:K00548] [EC:2.1.1.13]
115190130  methionine synthase-like isoform X1 [KO:K00548] [EC:2.1.1.13]
115193555  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
115153383  S-adenosylmethionine synthase-like [KO:K00789] [EC:2.5.1.6]
115153920  mat2b; methionine adenosyltransferase 2 subunit beta isoform X1 [KO:K00789] [EC:2.5.1.6]
115158965  S-adenosylmethionine synthase-like [KO:K00789] [EC:2.5.1.6]
115159444  S-adenosylmethionine synthase-like [KO:K00789] [EC:2.5.1.6]
115164459  S-adenosylmethionine synthase-like [KO:K00789] [EC:2.5.1.6]
115149311  S-adenosylmethionine synthase-like isoform X1 [KO:K00789] [EC:2.5.1.6]
115204189  S-adenosylmethionine synthase-like [KO:K00789] [EC:2.5.1.6]
115200178  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
115194087  S-adenosylmethionine decarboxylase proenzyme-like isoform X1 [KO:K01611] [EC:4.1.1.50]
115174893  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
115165926  srm; spermidine synthase [KO:K00797] [EC:2.5.1.16]
115154759  spermine synthase-like [KO:K00802] [EC:2.5.1.22]
115204368  spermine synthase-like isoform X1 [KO:K00802] [EC:2.5.1.22]
115191707  S-methyl-5'-thioadenosine phosphorylase [KO:K00772] [EC:2.4.2.28]
115202316  S-methyl-5'-thioadenosine phosphorylase-like isoform X1 [KO:K00772] [EC:2.4.2.28]
115161055  laccase domain-containing protein 1-like [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
115147629  mri1; methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
115166786  methylthioribulose-1-phosphate dehydratase-like isoform X1 [KO:K08964] [EC:4.2.1.109]
115203646  methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]
115159239  enolase-phosphatase E1 [KO:K09880] [EC:3.1.3.77]
115149314  enolase-phosphatase E1-like isoform X1 [KO:K09880] [EC:3.1.3.77]
115162485  adi1; 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase isoform X1 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
115151894  tyrosine aminotransferase-like [KO:K00815] [EC:2.6.1.5]
115196871  tyrosine aminotransferase-like [KO:K00815] [EC:2.6.1.5]
115163246  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
115197037  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
115206184  L-amino-acid oxidase-like isoform X1 [KO:K03334] [EC:1.4.3.2]
115202816  gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
115171244  DNA (cytosine-5)-methyltransferase 1-like isoform X1 [KO:K00558] [EC:2.1.1.37]
115199224  DNA (cytosine-5)-methyltransferase 1-like isoform X1 [KO:K00558] [EC:2.1.1.37]
115162012  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
115180838  DNA (cytosine-5)-methyltransferase 3A-like [KO:K17398] [EC:2.1.1.37]
115172261  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
115168047  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17399] [EC:2.1.1.37]
115168285  DNA (cytosine-5)-methyltransferase 3B-like isoform X1 [KO:K17399] [EC:2.1.1.37]
115168287  uncharacterized protein LOC115168287 isoform X1 [KO:K17399] [EC:2.1.1.37]
115165708  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17399] [EC:2.1.1.37]
115166262  DNA (cytosine-5)-methyltransferase 3B-like [KO:K17399] [EC:2.1.1.37]
115152111  putative adenosylhomocysteinase 3 isoform X1 [KO:K01251] [EC:3.13.2.1]
115180569  putative adenosylhomocysteinase 3 isoform X1 [KO:K01251] [EC:3.13.2.1]
115168684  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
115165332  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
115150611  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
115151129  ahcy; adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
115207796  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
115198716  putative adenosylhomocysteinase 3 isoform X1 [KO:K01251] [EC:3.13.2.1]
115180416  branched-chain-amino-acid aminotransferase, cytosolic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
115171474  branched-chain-amino-acid aminotransferase, cytosolic-like [KO:K00826] [EC:2.6.1.42]
115203019  branched-chain-amino-acid aminotransferase, cytosolic-like [KO:K00826] [EC:2.6.1.42]
115198782  branched-chain-amino-acid aminotransferase, cytosolic-like [KO:K00826] [EC:2.6.1.42]
115149465  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
115153437  glutamate--cysteine ligase catalytic subunit-like isoform X1 [KO:K11204] [EC:6.3.2.2]
115201609  glutamate--cysteine ligase catalytic subunit-like [KO:K11204] [EC:6.3.2.2]
115192507  glutamate--cysteine ligase regulatory subunit-like [KO:K11205]
115158377  glutamate--cysteine ligase regulatory subunit-like isoform X1 [KO:K11205]
115165949  gss; glutathione synthetase isoform X1 [KO:K21456] [EC:6.3.2.3]
115164966  cdo1; cysteine dioxygenase type 1 [KO:K00456] [EC:1.13.11.20]
115199722  cysteine dioxygenase type 1-like [KO:K00456] [EC:1.13.11.20]
115153413  aspartate aminotransferase, cytoplasmic-like [KO:K14454] [EC:2.6.1.1]
115177821  aspartate aminotransferase, cytoplasmic-like [KO:K14454] [EC:2.6.1.1]
115147523  aspartate aminotransferase, cytoplasmic-like [KO:K14454] [EC:2.6.1.1]
115201574  aspartate aminotransferase, cytoplasmic-like [KO:K14454] [EC:2.6.1.1]
115200120  aspartate aminotransferase, cytoplasmic-like [KO:K14454] [EC:2.6.1.1]
115167196  aspartate aminotransferase, mitochondrial-like isoform X1 [KO:K14455] [EC:2.6.1.1]
115151970  aspartate aminotransferase, mitochondrial-like [KO:K14455] [EC:2.6.1.1]
115203136  aspartate aminotransferase, mitochondrial-like [KO:K14455] [EC:2.6.1.1]
115196788  aspartate aminotransferase, mitochondrial-like [KO:K14455] [EC:2.6.1.1]
115170927  3-mercaptopyruvate sulfurtransferase-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
115170928  3-mercaptopyruvate sulfurtransferase-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
115147449  3-mercaptopyruvate sulfurtransferase-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
115152382  L-lactate dehydrogenase B-A chain isoform X1 [KO:K00016] [EC:1.1.1.27]
115152410  L-lactate dehydrogenase A chain-like [KO:K00016] [EC:1.1.1.27]
115180614  L-lactate dehydrogenase B chain [KO:K00016] [EC:1.1.1.27]
115197177  L-lactate dehydrogenase A chain [KO:K00016] [EC:1.1.1.27]
115197636  L-lactate dehydrogenase B-A chain-like isoform X1 [KO:K00016] [EC:1.1.1.27]
115198662  L-lactate dehydrogenase B chain-like [KO:K00016] [EC:1.1.1.27]
115193507  malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
115152771  malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
115177786  malate dehydrogenase, cytoplasmic-like isoform X1 [KO:K00025] [EC:1.1.1.37]
115208568  malate dehydrogenase, cytoplasmic-like isoform X1 [KO:K00025] [EC:1.1.1.37]
115154257  malate dehydrogenase, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
115148790  malate dehydrogenase, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
115172388  L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
115164497  L-serine dehydratase/L-threonine deaminase-like isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
115200144  L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
115156035  D-3-phosphoglycerate dehydrogenase-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
115160744  D-3-phosphoglycerate dehydrogenase-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
115200666  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01102  O-Phospho-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
stru00010  Glycolysis / Gluconeogenesis
stru00250  Alanine, aspartate and glutamate metabolism
stru00260  Glycine, serine and threonine metabolism
stru00290  Valine, leucine and isoleucine biosynthesis
stru00430  Taurine and hypotaurine metabolism
stru00480  Glutathione metabolism
stru00620  Pyruvate metabolism
stru00640  Propanoate metabolism
stru00770  Pantothenate and CoA biosynthesis
stru00900  Terpenoid backbone biosynthesis
stru00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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