KEGG   PATHWAY: tcc04141
Entry
tcc04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Theobroma cacao (cacao)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
tcc04141  Protein processing in endoplasmic reticulum
tcc04141

Other DBs
GO: 0030433 0034976
Organism
Theobroma cacao (cacao) [GN:tcc]
Gene
18589118  preprotein translocase subunit SCY1, chloroplastic [KO:K10956]
18594328  protein transport protein Sec61 subunit alpha [KO:K10956]
18596636  protein transport protein Sec61 subunit alpha [KO:K10956]
18590074  protein transport protein Sec61 subunit beta [KO:K09481]
18614384  protein transport protein Sec61 subunit beta [KO:K09481]
18601536  protein transport protein Sec61 subunit beta [KO:K09481]
18602368  protein transport protein Sec61 subunit beta [KO:K09481]
18605111  protein transport protein Sec61 subunit gamma-1 [KO:K07342]
18601031  protein transport protein Sec61 subunit gamma [KO:K07342]
18589848  translocation protein sec62 [KO:K12275]
18605647  dnaJ protein ERDJ2A [KO:K09540]
18591743  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1A [KO:K12666]
18586410  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1B [KO:K12666]
18613118  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
18606822  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
18610990  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
18608141  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
18588531  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
18587116  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
18597100  probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3B [KO:K19478]
18589457  putative oligosaccharyltransferase complex subunit CG9662 [KO:K26501]
18588394  transmembrane protein 258 [KO:K26502]
18609047  mannosyl-oligosaccharide glucosidase GCS1 [KO:K01228] [EC:3.2.1.106]
18586977  heat shock 70 kDa protein 17 [KO:K09486]
18606752  luminal-binding protein 5 [KO:K09490] [EC:3.6.4.10]
18600465  luminal-binding protein 5 [KO:K09490] [EC:3.6.4.10]
18613669  dnaJ protein ERDJ3B [KO:K09517]
18597931  dnaJ protein P58IPK homolog [KO:K09523]
18610157  heat shock protein 90-5, chloroplastic [KO:K09487]
18612439  heat shock protein 90-6, mitochondrial [KO:K09487]
18591572  endoplasmin homolog [KO:K09487]
18611939  probable glucan 1,3-alpha-glucosidase [KO:K05546] [EC:3.2.1.207]
18589130  glucosidase 2 subunit beta [KO:K08288]
18599909  glucosidase 2 subunit beta [KO:K08288]
18605229  calnexin homolog [KO:K08054]
18602442  calreticulin-3 [KO:K08057]
18600563  calreticulin [KO:K08057]
18599245  calreticulin-3 [KO:K08057]
18589416  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1 [KO:K01230] [EC:3.2.1.113]
18595629  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1 [KO:K01230] [EC:3.2.1.113]
18596509  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS3 [KO:K23741] [EC:3.2.1.209]
18609781  SEC12-like protein 2 [KO:K14003]
18586574  SEC12-like protein 1 [KO:K14003]
18613680  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
18603614  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
18603615  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
18600560  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
18601336  protein transport protein SEC13 homolog B [KO:K14004]
18596002  protein transport protein SEC13 homolog B [KO:K14004]
18614567  protein transport protein SEC31 homolog B [KO:K14005]
18603120  protein transport protein SEC23 [KO:K14006]
18602606  protein transport protein SEC23 [KO:K14006]
18587546  protein transport protein SEC23 [KO:K14006]
18600249  protein transport protein Sec24-like At4g32640 [KO:K14007]
18593362  protein transport protein Sec24-like At3g07100 [KO:K14007]
18592347  protein transport protein Sec24-like At4g32640 [KO:K14007]
18607815  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
18603839  alpha-mannosidase I MNS5 [KO:K10084]
18603112  alpha-mannosidase I MNS4 [KO:K10085]
18590870  protein disulfide isomerase-like 1-4 [KO:K09580] [EC:5.3.4.1]
18595938  protein disulfide isomerase-like 1-6 [KO:K09580] [EC:5.3.4.1]
18592965  protein disulfide-isomerase 5-2 [KO:K09580] [EC:5.3.4.1]
18592962  protein disulfide-isomerase 5-2 [KO:K09580] [EC:5.3.4.1]
18586389  protein disulfide isomerase-like 1-4 [KO:K09580] [EC:5.3.4.1]
18592361  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
18612371  protein disulfide isomerase-like 2-3 [KO:K09584] [EC:5.3.4.1]
18613666  protein disulfide-isomerase like 2-1 [KO:K09584] [EC:5.3.4.1]
18596466  endoplasmic reticulum oxidoreductin-1 [KO:K10950] [EC:1.8.4.-]
18588868  protein OS-9 homolog [KO:K10088]
18607608  translocon-associated protein subunit alpha [KO:K13249]
18601094  translocon-associated protein subunit beta [KO:K13250]
18612747  uncharacterized LOC18612747 [KO:K14009]
18610588  B-cell receptor-associated protein 31 [KO:K14009]
18593469  uncharacterized LOC18593469 [KO:K14009]
18597186  uncharacterized LOC18597186 [KO:K14009]
18605305  derlin-1.1 [KO:K13989]
18588486  derlin-1 [KO:K13989]
18588011  derlin-1 [KO:K13989]
18597127  derlin-2.2 [KO:K13989]
18602699  UBX domain-containing protein 4 [KO:K24348]
18602533  plant UBX domain-containing protein 11 [KO:K24348]
18609857  plant UBX domain-containing protein 2 [KO:K14011]
18612339  plant UBX domain-containing protein 4 [KO:K14012]
18597225  plant UBX domain-containing protein 4 [KO:K14012]
18597993  cell division cycle protein 48 homolog [KO:K13525]
18590940  cell division cycle protein 48 homolog [KO:K13525]
18613451  NPL4-like protein 1 [KO:K14015]
18607683  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
18604096  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
18604109  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
18590662  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
18589003  heat shock 70 kDa protein [KO:K03283]
18590718  heat shock cognate 70 kDa protein 2 [KO:K03283]
18602333  heat shock 70 kDa protein 6, chloroplastic [KO:K03283]
108660436  heat shock 70 kDa protein 6, chloroplastic [KO:K03283]
18590712  heat shock cognate 70 kDa protein 2 [KO:K03283]
18597781  heat shock cognate 70 kDa protein 2 [KO:K03283]
18586117  heat shock cognate 70 kDa protein 2 [KO:K03283]
18586110  heat shock cognate 70 kDa protein 2 [KO:K03283]
18590190  dnaJ protein homolog [KO:K09503]
18614412  dnaJ protein homolog 2 [KO:K09503]
18586851  dnaJ protein homolog [KO:K09503]
18588741  chaperone protein dnaJ 49 [KO:K09518]
18603516  chaperone protein dnaJ 49 [KO:K09518]
18606583  heat shock protein 83 [KO:K04079]
18605634  heat shock protein 83 [KO:K04079]
18593230  heat shock cognate protein 80 [KO:K04079]
18597724  hsp70 nucleotide exchange factor fes1 [KO:K09562]
18612867  hsp70 nucleotide exchange factor FES1 [KO:K09562]
18590579  17.3 kDa class I heat shock protein [KO:K13993]
18590578  18.2 kDa class I heat shock protein [KO:K13993]
18590587  17.3 kDa class I heat shock protein [KO:K13993]
18590586  17.3 kDa class I heat shock protein [KO:K13993]
18588112  17.9 kDa class II heat shock protein [KO:K13993]
18597644  18.1 kDa class I heat shock protein [KO:K13993]
18590707  18.1 kDa class I heat shock protein [KO:K13993]
18597643  class I heat shock protein [KO:K13993]
18606272  heat shock 22 kDa protein, mitochondrial [KO:K13993]
18607751  small heat shock protein, chloroplastic [KO:K13993]
18605848  small heat shock protein, chloroplastic [KO:K13993]
18588113  17.1 kDa class II heat shock protein [KO:K13993]
18601202  15.7 kDa heat shock protein, peroxisomal [KO:K13993]
18590706  17.4 kDa class I heat shock protein [KO:K13993]
18590786  18.5 kDa class I heat shock protein [KO:K13993]
18590582  17.3 kDa class I heat shock protein [KO:K13993]
18590583  17.3 kDa class I heat shock protein [KO:K13993]
18588114  17.6 kDa class II heat shock protein [KO:K13993]
18605356  23.6 kDa heat shock protein, mitochondrial [KO:K13993]
18600899  18.1 kDa class I heat shock protein [KO:K13993]
18595235  22.0 kDa class IV heat shock protein [KO:K13993]
18596287  17.4 kDa class III heat shock protein [KO:K13993]
18595249  26.5 kDa heat shock protein, mitochondrial [KO:K13993]
18597130  15.4 kDa class V heat shock protein [KO:K13993]
18592997  22.0 kDa class IV heat shock protein [KO:K13993]
18585969  18.2 kDa class I heat shock protein [KO:K13993]
18611572  18.5 kDa class IV heat shock protein [KO:K13993]
18593509  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
18608135  phospholipase A-2-activating protein [KO:K14018]
18610499  ubiquitin receptor RAD23c [KO:K10839]
18602065  ubiquitin receptor RAD23d [KO:K10839]
18596343  ubiquitin receptor RAD23b [KO:K10839]
18607401  ubiquitin domain-containing protein DSK2b [KO:K04523]
18610658  ubiquitin domain-containing protein DSK2b [KO:K04523]
18600220  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
18597609  ataxin-3 homolog [KO:K11863] [EC:3.4.22.-]
18601598  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
18606432  eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
18588592  subtilisin-like protease SBT6.1 [KO:K08653] [EC:3.4.21.112]
18600480  membrane-bound transcription factor site-2 protease homolog [KO:K07765] [EC:3.4.24.85]
18610631  serine/threonine-protein kinase/endoribonuclease IRE1a [KO:K08852] [EC:2.7.11.1 3.1.26.-]
18591735  serine/threonine-protein kinase/endoribonuclease IRE1b [KO:K08852] [EC:2.7.11.1 3.1.26.-]
18607965  probable E3 ubiquitin ligase SUD1 [KO:K10661] [EC:2.3.2.27]
18603636  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
18596318  ubiquitin-conjugating enzyme E2 34 [KO:K04554] [EC:2.3.2.23]
18590723  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
18586119  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
18590133  ERAD-associated E3 ubiquitin-protein ligase HRD1B [KO:K10601] [EC:2.3.2.27]
18608699  E3 ubiquitin-protein ligase RMA1H1 [KO:K10666] [EC:2.3.2.27]
18599129  breast cancer type 1 susceptibility protein homolog [KO:K10666] [EC:2.3.2.27]
18596859  E3 ubiquitin-protein ligase RMA1H1 [KO:K10666] [EC:2.3.2.27]
18593925  E3 ubiquitin-protein ligase RMA3 [KO:K10666] [EC:2.3.2.27]
18591332  RING finger protein 5 [KO:K10666] [EC:2.3.2.27]
18610997  E3 ubiquitin-protein ligase RNF185 [KO:K10666] [EC:2.3.2.27]
18604337  ERAD-associated E3 ubiquitin-protein ligase component HRD3A [KO:K14026]
18605361  E3 ubiquitin protein ligase RIN2 [KO:K10636] [EC:2.3.2.36]
18612670  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
18591828  ubiquitin-conjugating enzyme E2 11 [KO:K06689] [EC:2.3.2.23]
18592943  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
18614028  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
18593175  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
18606642  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
18591103  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
18605704  ubiquitin-conjugating enzyme E2 10 [KO:K06689] [EC:2.3.2.23]
18607551  ubiquitin-conjugating enzyme E2 10 [KO:K06689] [EC:2.3.2.23]
18610733  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
18588272  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
18586388  cullin-1 [KO:K03347]
18613499  cullin-1 [KO:K03347]
18603479  cullin-1 [KO:K03347]
18607537  SKP1-like protein 1A [KO:K03094]
18610726  SKP1-like protein 1B [KO:K03094]
18592993  SKP1-like protein 14 [KO:K03094]
18594890  SKP1-like protein 14 [KO:K03094]
18596119  SKP1-like protein 1A [KO:K03094]
18586475  SKP1-like protein 11 [KO:K03094]
18599688  SKP1-like protein 3 [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
tcc00510  N-Glycan biosynthesis
tcc03050  Proteasome
tcc03060  Protein export
KO pathway
ko04141   
LinkDB

DBGET integrated database retrieval system