KEGG   PATHWAY: tdc03008
Entry
tdc03008                    Pathway                                
Name
Ribosome biogenesis in eukaryotes - Triticum dicoccoides (wild emmer wheat)
Description
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Class
Genetic Information Processing; Translation
Pathway map
tdc03008  Ribosome biogenesis in eukaryotes
tdc03008

Organism
Triticum dicoccoides (wild emmer wheat) [GN:tdc]
Gene
119275544  putative casein kinase II subunit beta-4 [KO:K03115]
119292276  putative casein kinase II subunit beta-4 [KO:K03115]
119365080  casein kinase II subunit beta-1-like [KO:K03115]
119354585  putative casein kinase II subunit beta-4 isoform X1 [KO:K03115]
119355932  casein kinase II subunit beta-1-like [KO:K03115]
119304342  putative casein kinase II subunit beta-4 [KO:K03115]
119339394  putative casein kinase II subunit beta-4 [KO:K03115]
119363885  casein kinase II subunit alpha-2-like isoform X1 [KO:K03097] [EC:2.7.11.1]
119311916  casein kinase II subunit alpha-2-like isoform X1 [KO:K03097] [EC:2.7.11.1]
119311923  casein kinase II subunit alpha-2-like [KO:K03097] [EC:2.7.11.1]
119354734  casein kinase II subunit alpha-2 isoform X1 [KO:K03097] [EC:2.7.11.1]
119284858  casein kinase II subunit alpha-2-like [KO:K03097] [EC:2.7.11.1]
119303243  casein kinase II subunit alpha-2-like [KO:K03097] [EC:2.7.11.1]
119303253  casein kinase II subunit alpha-2-like [KO:K03097] [EC:2.7.11.1]
119291283  casein kinase II subunit alpha-2-like [KO:K03097] [EC:2.7.11.1]
119302337  nucleolar protein 6-like [KO:K14544]
119308184  nucleolar protein 6-like isoform X1 [KO:K14544]
119317739  uncharacterized protein LOC119317739 [KO:K14545]
119322722  uncharacterized protein LOC119322722 isoform X1 [KO:K14545]
119325789  uncharacterized protein LOC119325789 isoform X1 [KO:K14546]
119276400  uncharacterized protein LOC119276400 isoform X1 [KO:K14546]
119296366  uncharacterized protein LOC119296366 [KO:K14546]
119298781  WD repeat-containing protein 43-like [KO:K14546]
119268511  uncharacterized protein LOC119268511 isoform X1 [KO:K14546]
119285453  uncharacterized protein LOC119285453 [KO:K14546]
119307027  WD repeat-containing protein 43-like [KO:K14546]
119294986  WD repeat-containing protein PCN-like [KO:K14548]
119286751  WD repeat-containing protein PCN-like [KO:K14548]
119327910  protein SLOW WALKER 1-like [KO:K14549]
119292646  protein SLOW WALKER 1-like [KO:K14549]
119335377  protein SLOW WALKER 1-like [KO:K14549]
119365319  uncharacterized protein At3g06530-like [KO:K14550]
119356163  uncharacterized protein At3g06530-like isoform X1 [KO:K14550]
119299173  WD repeat-containing protein 75-like [KO:K14552]
119307421  WD repeat-containing protein 75-like [KO:K14552]
119312195  U3 small nucleolar RNA-associated protein 18 homolog [KO:K14553]
119303538  U3 small nucleolar RNA-associated protein 18 homolog [KO:K14553]
119329365  U3 small nucleolar RNA-associated protein 21 homolog [KO:K14554]
119337070  U3 small nucleolar RNA-associated protein 21 homolog [KO:K14554]
119356383  transducin beta-like protein 3 [KO:K14555]
119337544  transducin beta-like protein 3 [KO:K14555]
119291804  WD repeat-containing protein 3-like [KO:K14556]
119287621  WD repeat-containing protein 3-like [KO:K14556]
119343314  U3 small nucleolar RNA-associated protein 6 homolog [KO:K14557]
119363919  U3 small nucleolar RNA-associated protein 6 homolog [KO:K14557]
119354697  U3 small nucleolar RNA-associated protein 6 homolog [KO:K14557]
119349028  periodic tryptophan protein 2-like [KO:K14558]
119287313  periodic tryptophan protein 2-like [KO:K14558]
119300865  U3 small nucleolar ribonucleoprotein protein MPP10-like [KO:K14559]
119308363  U3 small nucleolar ribonucleoprotein protein MPP10-like [KO:K14559]
119365947  U3 small nucleolar ribonucleoprotein protein IMP3-like [KO:K14560]
119356714  U3 small nucleolar ribonucleoprotein protein IMP3-like [KO:K14560]
119330608  U3 small nucleolar ribonucleoprotein protein IMP4-like [KO:K14561]
119338082  U3 small nucleolar ribonucleoprotein protein IMP4-like [KO:K14561]
119329975  rRNA 2'-O-methyltransferase fibrillarin 1-like [KO:K14563] [EC:2.1.1.-]
119318582  rRNA 2'-O-methyltransferase fibrillarin 1-like [KO:K14563] [EC:2.1.1.-]
119321575  rRNA 2'-O-methyltransferase fibrillarin 1-like [KO:K14563] [EC:2.1.1.-]
119321702  rRNA 2'-O-methyltransferase fibrillarin 1-like [KO:K14563] [EC:2.1.1.-]
119338293  rRNA 2'-O-methyltransferase fibrillarin 1-like [KO:K14563] [EC:2.1.1.-]
119289613  alpha carbonic anhydrase 8-like [KO:K14563] [EC:2.1.1.-]
119324863  rRNA 2'-O-methyltransferase fibrillarin 1-like [KO:K14563] [EC:2.1.1.-]
119349414  nucleolar protein 56-like [KO:K14564]
119353443  nucleolar protein 56-like [KO:K14564]
119353448  nucleolar protein 56-like [KO:K14564]
119362589  nucleolar protein 56-like [KO:K14564]
119362591  nucleolar protein 56-like [KO:K14564]
119290749  nucleolar protein 56-like [KO:K14564]
119349245  probable nucleolar protein 5-2 [KO:K14565]
119278741  uncharacterized protein LOC119278741 isoform X1 [KO:K14565]
119368681  probable nucleolar protein 5-1 [KO:K14565]
119279648  uncharacterized protein LOC119279648 [KO:K14565]
119296750  probable nucleolar protein 5-1 [KO:K14565]
119297239  uncharacterized protein LOC119297239 [KO:K14565]
119353394  probable nucleolar protein 5-2 [KO:K14565]
119282182  uncharacterized protein LOC119282182 [KO:K14565]
119282819  probable nucleolar protein 5-1 [KO:K14565]
119336100  uncharacterized protein LOC119336100 [KO:K14565]
119285686  probable nucleolar protein 5-2 [KO:K14565]
119302381  uncharacterized protein LOC119302381 isoform X1 [KO:K14565]
119305518  uncharacterized protein LOC119305518 [KO:K14565]
119271421  probable nucleolar protein 5-1 isoform X1 [KO:K14565]
119362533  probable nucleolar protein 5-2 [KO:K14565]
119341367  uncharacterized protein LOC119341367 [KO:K14565]
119308313  uncharacterized protein LOC119308313 isoform X1 [KO:K14565]
119308475  uncharacterized protein LOC119308475 isoform X1 [KO:K14565]
119308476  uncharacterized protein LOC119308476 isoform X1 [KO:K14565]
119285076  NHP2-like protein 1 [KO:K12845]
119291040  NHP2-like protein 1 [KO:K12845]
119353663  H/ACA ribonucleoprotein complex subunit 4-like [KO:K11131] [EC:5.4.99.-]
119353664  H/ACA ribonucleoprotein complex subunit 4-like [KO:K11131] [EC:5.4.99.-]
119362833  H/ACA ribonucleoprotein complex subunit 4-like [KO:K11131] [EC:5.4.99.-]
119362834  H/ACA ribonucleoprotein complex subunit 4-like [KO:K11131] [EC:5.4.99.-]
119317740  H/ACA ribonucleoprotein complex subunit 2-like protein [KO:K11129]
119322723  H/ACA ribonucleoprotein complex subunit 2-like protein [KO:K11129]
119277165  putative H/ACA ribonucleoprotein complex subunit 1-like protein 1 [KO:K11128]
119295847  putative H/ACA ribonucleoprotein complex subunit 1-like protein 1 [KO:K11128]
119269176  putative H/ACA ribonucleoprotein complex subunit 1-like protein 1 [KO:K11128]
119285871  putative H/ACA ribonucleoprotein complex subunit 1-like protein 1 [KO:K11128]
119317132  H/ACA ribonucleoprotein complex subunit 3-like protein [KO:K11130]
119324288  H/ACA ribonucleoprotein complex subunit 3-like protein [KO:K11130]
119329549  rRNA-processing protein FCF1 homolog [KO:K14566]
119339482  rRNA-processing protein FCF1 homolog [KO:K14566]
119328946  uncharacterized protein C57A7.06-like [KO:K14567]
119336436  U3 small nucleolar RNA-associated protein 14-like [KO:K14567]
119316998  ribosomal RNA small subunit methyltransferase nep-1-like [KO:K14568] [EC:2.1.1.260]
119333589  ribosomal RNA small subunit methyltransferase nep-1-like [KO:K14568] [EC:2.1.1.260]
119338228  ribosomal RNA small subunit methyltransferase nep-1-like [KO:K14568] [EC:2.1.1.260]
119324536  ribosomal RNA small subunit methyltransferase nep-1-like [KO:K14568] [EC:2.1.1.260]
119341921  ribosomal RNA small subunit methyltransferase nep-1-like [KO:K14568] [EC:2.1.1.260]
119296242  ribosome biogenesis protein BMS1 homolog [KO:K14569]
119285618  ribosome biogenesis protein BMS1 homolog isoform X1 [KO:K14569]
119284800  RNA cytidine acetyltransferase 1-like [KO:K14521] [EC:2.3.1.-]
119291380  RNA cytidine acetyltransferase 1-like isoform X1 [KO:K14521] [EC:2.3.1.-]
119312670  probable RNA 3'-terminal phosphate cyclase-like protein isoform X1 [KO:K11108]
119299718  probable RNA 3'-terminal phosphate cyclase-like protein [KO:K11108]
119287562  probable RNA 3'-terminal phosphate cyclase-like protein [KO:K11108]
119307709  probable RNA 3'-terminal phosphate cyclase-like protein [KO:K11108]
119295564  uncharacterized protein C05D11.9-like isoform X1 [KO:K01164] [EC:3.1.26.5]
119286039  uncharacterized protein C05D11.9-like isoform X1 [KO:K01164] [EC:3.1.26.5]
119348661  ribonuclease P protein subunit p29-like isoform X1 [KO:K03538] [EC:3.1.26.5]
119283584  uncharacterized protein LOC119283584 [KO:K03538] [EC:3.1.26.5]
119355750  uncharacterized protein LOC119355750 isoform X1 [KO:K03538] [EC:3.1.26.5]
119363969  probable ribonuclease P/MRP protein subunit POP5 isoform X1 [KO:K03537] [EC:3.1.26.5]
119359446  probable ribonuclease P/MRP protein subunit POP5 isoform X1 [KO:K03537] [EC:3.1.26.5]
119364282  ribonuclease P protein subunit p25-like [KO:K14525] [EC:3.1.26.5]
119355156  ribonuclease P protein subunit p25-like [KO:K14525] [EC:3.1.26.5]
119295682  uncharacterized protein LOC119295682 [KO:K03539] [EC:3.1.26.5]
119286114  uncharacterized protein LOC119286114 isoform X1 [KO:K03539] [EC:3.1.26.5]
119277178  small RNA degrading nuclease 5-like [KO:K14570] [EC:3.1.-.-]
119366058  small RNA degrading nuclease 3-like [KO:K14570] [EC:3.1.-.-]
119356823  small RNA degrading nuclease 1-like [KO:K14570] [EC:3.1.-.-]
119269186  small RNA degrading nuclease 5-like [KO:K14570] [EC:3.1.-.-]
119326783  oligoribonuclease-like [KO:K13288] [EC:3.1.-.-]
119363980  oligoribonuclease-like [KO:K13288] [EC:3.1.-.-]
119354853  oligoribonuclease-like isoform X1 [KO:K13288] [EC:3.1.-.-]
119318601  oligoribonuclease-like isoform X1 [KO:K13288] [EC:3.1.-.-]
119311331  5'-3' exoribonuclease 3-like isoform X1 [KO:K12619] [EC:3.1.13.-]
119277762  5'-3' exoribonuclease 3-like [KO:K12619] [EC:3.1.13.-]
119367112  5'-3' exoribonuclease 3-like [KO:K12619] [EC:3.1.13.-]
119302655  5'-3' exoribonuclease 3-like [KO:K12619] [EC:3.1.13.-]
119269753  5'-3' exoribonuclease 3-like isoform X1 [KO:K12619] [EC:3.1.13.-]
119358824  5'-3' exoribonuclease 3-like [KO:K12619] [EC:3.1.13.-]
119314290  nucleolar GTP-binding protein 1-like [KO:K06943]
119298904  nucleolar GTP-binding protein 1-like [KO:K06943]
119333548  nucleolar GTP-binding protein 1-like [KO:K06943]
119335570  nucleolar GTP-binding protein 1-like [KO:K06943]
119323370  nucleolar GTP-binding protein 1-like [KO:K06943]
119316468  nuclear/nucleolar GTPase 2 [KO:K14537]
119307718  LOW QUALITY PROTEIN: nuclear/nucleolar GTPase 2-like [KO:K14537]
119353208  guanine nucleotide-binding protein-like NSN1 [KO:K14538]
119362331  guanine nucleotide-binding protein-like NSN1 [KO:K14538]
119343716  cell division control protein 48 homolog C-like [KO:K14571]
119346028  cell division control protein 48 homolog C-like [KO:K14571]
119278323  cell division control protein 48 homolog C-like [KO:K14571]
119288223  cell division control protein 48 homolog C-like [KO:K14571]
119272987  cell division control protein 48 homolog C-like [KO:K14571]
119332313  midasin-like isoform X1 [KO:K14572]
119268039  midasin-like isoform X1 [KO:K14572]
119312279  RNA-binding protein 28-like [KO:K14573]
119303616  RNA-binding protein 28-like isoform X1 [KO:K14573]
119315512  RNA-binding protein NOB1-like [KO:K11883]
119322631  RNA-binding protein NOB1-like [KO:K11883]
119293077  GTP-binding nuclear protein Ran-2 [KO:K07936]
119349660  GTP-binding nuclear protein Ran-2 [KO:K07936]
119332122  GTP-binding nuclear protein Ran-3-like [KO:K07936]
119338277  GTP-binding nuclear protein Ran-3 [KO:K07936]
119312998  protein EXPORTIN 1A-like [KO:K14290]
119287268  protein EXPORTIN 1A-like [KO:K14290]
119280183  60S ribosomal export protein NMD3-like [KO:K07562]
119337344  60S ribosomal export protein NMD3-like [KO:K07562]
119273029  60S ribosomal export protein NMD3-like [KO:K07562]
119273157  60S ribosomal export protein NMD3-like [KO:K07562]
119353629  eukaryotic translation initiation factor 6-2 [KO:K03264]
119362794  eukaryotic translation initiation factor 6-2-like [KO:K03264]
119365393  ribosome maturation protein SBDS-like [KO:K14574]
119356225  ribosome maturation protein SBDS-like [KO:K14574]
119323869  uncharacterized protein LOC119323869 isoform X1 [KO:K14574]
119311663  elongation factor-like GTPase 1 [KO:K14536] [EC:3.6.5.-]
119350125  elongation factor-like GTPase 1 [KO:K14536] [EC:3.6.5.-]
119350130  elongation factor-like GTPase 1 [KO:K14536] [EC:3.6.5.-]
119350690  elongation factor 2-like [KO:K14536] [EC:3.6.5.-]
119302988  elongation factor-like GTPase 1 [KO:K14536] [EC:3.6.5.-]
119311682  GTPase LSG1-2-like [KO:K14539] [EC:3.6.1.-]
119298902  GTPase LSG1-1-like [KO:K14539] [EC:3.6.1.-]
119303007  GTPase LSG1-2-like [KO:K14539] [EC:3.6.1.-]
119307194  GTPase LSG1-1-like [KO:K14539] [EC:3.6.1.-]
119314633  adenylate kinase isoenzyme 6 homolog [KO:K18532] [EC:2.7.4.3]
119322708  adenylate kinase isoenzyme 6 homolog [KO:K18532] [EC:2.7.4.3]
119275469  serine/threonine-protein kinase RIO1-like [KO:K07178] [EC:2.7.11.1]
119330226  serine/threonine-protein kinase RIO1-like [KO:K07178] [EC:2.7.11.1]
119367670  serine/threonine-protein kinase RIO1-like isoform X1 [KO:K07178] [EC:2.7.11.1]
119267592  serine/threonine-protein kinase RIO1-like [KO:K07178] [EC:2.7.11.1]
119335951  serine/threonine-protein kinase RIO1-like [KO:K07178] [EC:2.7.11.1]
119359310  serine/threonine-protein kinase RIO1-like [KO:K07178] [EC:2.7.11.1]
119340418  serine/threonine-protein kinase RIO1-like [KO:K07178] [EC:2.7.11.1]
119277929  serine/threonine-protein kinase rio2-like [KO:K07179] [EC:2.7.11.1]
119269918  serine/threonine-protein kinase rio2-like [KO:K07179] [EC:2.7.11.1]
119344429  18S ribosomal RNA [KO:K01979]
119344842  18S ribosomal RNA [KO:K01979]
119344838  18S ribosomal RNA [KO:K01979]
119345954  18S ribosomal RNA [KO:K01979]
119346797  18S ribosomal RNA [KO:K01979]
119346494  28S ribosomal RNA [KO:K01982]
119346134  28S ribosomal RNA [KO:K01982]
119347432  28S ribosomal RNA [KO:K01982]
119346135  28S ribosomal RNA [KO:K01982]
119344422  28S ribosomal RNA [KO:K01982]
119345962  28S ribosomal RNA [KO:K01982]
119344423  28S ribosomal RNA [KO:K01982]
119334965  small nucleolar RNA U3 [KO:K14483]
119327169  small nucleolar RNA U3 [KO:K14483]
119290408  small nucleolar RNA U3 [KO:K14483]
Reference
PMID:20174677
  Authors
Freed EF, Bleichert F, Dutca LM, Baserga SJ
  Title
When ribosomes go bad: diseases of ribosome biogenesis.
  Journal
Mol Biosyst 6:481-93 (2010)
DOI:10.1039/b919670f
Reference
PMID:17515605
  Authors
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
  Title
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
  Journal
Mol Cell Biol 27:5414-29 (2007)
DOI:10.1128/MCB.00380-07
Reference
PMID:19850913
  Authors
Strunk BS, Karbstein K
  Title
Powering through ribosome assembly.
  Journal
RNA 15:2083-104 (2009)
DOI:10.1261/rna.1792109
Reference
PMID:15120992
  Authors
Granneman S, Baserga SJ
  Title
Ribosome biogenesis: of knobs and RNA processing.
  Journal
Exp Cell Res 296:43-50 (2004)
DOI:10.1016/j.yexcr.2004.03.016
Reference
PMID:19879902
  Authors
Kressler D, Hurt E, Bassler J
  Title
Driving ribosome assembly.
  Journal
Biochim Biophys Acta 1803:673-83 (2010)
DOI:10.1016/j.bbamcr.2009.10.009
Related
pathway
tdc03010  Ribosome
KO pathway
ko03008   
LinkDB

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