KEGG   PATHWAY: tfs00260
Entry
tfs00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Takifugu flavidus (sansaifugu)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
tfs00260  Glycine, serine and threonine metabolism
tfs00260

Module
tfs_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:tfs00260]
tfs_M00047  Creatine pathway [PATH:tfs00260]
tfs_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:tfs00260]
tfs_M00555  Betaine biosynthesis, choline => betaine [PATH:tfs00260]
tfs_M00621  Glycine cleavage system [PATH:tfs00260]
tfs_M00974  Betaine metabolism, animals, betaine => glycine [PATH:tfs00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Takifugu flavidus (sansaifugu) [GN:tfs]
Gene
130533064  tha1; threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
130514844  shmt1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
130530175  serine hydroxymethyltransferase, mitochondrial-like [KO:K00600] [EC:2.1.2.1]
130524374  shmt2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
130528920  agxta; alanine--glyoxylate and serine--pyruvate aminotransferase a [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
130538450  agxtb; alanine--glyoxylate and serine--pyruvate aminotransferase b isoform X1 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
130527802  grhprb; glyoxylate reductase/hydroxypyruvate reductase b [KO:K00049] [EC:1.1.1.79 1.1.1.81]
130531770  grhpra; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
130524511  glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]
130533524  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
130520634  pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
130527814  pgam1b; phosphoglycerate mutase 1b [KO:K01834] [EC:5.4.2.11]
130535769  bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
130537555  phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
130525664  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
130535066  psph; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
130514714  gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
130513117  tdh2; L-threonine dehydrogenase 2 isoform X1 [KO:K15789] [EC:1.1.1.103]
130516211  tdh; L-threonine dehydrogenase [KO:K15789] [EC:1.1.1.103]
130529842  5-aminolevulinate synthase, non-specific, mitochondrial-like isoform X1 [KO:K00643] [EC:2.3.1.37]
130523933  alas1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
130530625  alas2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
130517669  si:ch211-127i16.2; probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
130526123  mao; amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
130514696  aoc2; retina-specific copper amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
130526129  gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
130530339  amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
130535778  dldh; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
130521461  gcshb; glycine cleavage system protein H (aminomethyl carrier), b [KO:K02437]
130536142  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
130525625  D-amino-acid oxidase-like isoform X1 [KO:K00273] [EC:1.4.3.3]
130517485  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
130521797  gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
130528241  gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
130530557  chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
130528198  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
130517451  bhmt; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
130526444  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
130517445  dmgdh; dimethylglycine dehydrogenase, mitochondrial isoform X1 [KO:K00315] [EC:1.5.8.4]
130534496  pipox; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
130517643  sardh; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
130540187  gnmt; LOW QUALITY PROTEIN: glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
130522675  cbsb; cystathionine beta-synthase b [KO:K01697] [EC:4.2.1.22]
130522797  cbsa; cystathionine beta-synthase a [KO:K01697] [EC:4.2.1.22]
130528857  cth; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
130534231  uncharacterized protein LOC130534231 [KO:K01754] [EC:4.3.1.19]
130540372  sdsl; serine dehydratase-like isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
130539326  zgc:162816; D-serine dehydratase [KO:K20498] [EC:4.3.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
tfs00010  Glycolysis / Gluconeogenesis
tfs00020  Citrate cycle (TCA cycle)
tfs00230  Purine metabolism
tfs00250  Alanine, aspartate and glutamate metabolism
tfs00270  Cysteine and methionine metabolism
tfs00290  Valine, leucine and isoleucine biosynthesis
tfs00330  Arginine and proline metabolism
tfs00470  D-Amino acid metabolism
tfs00564  Glycerophospholipid metabolism
tfs00600  Sphingolipid metabolism
tfs00620  Pyruvate metabolism
tfs00630  Glyoxylate and dicarboxylate metabolism
tfs00640  Propanoate metabolism
tfs00860  Porphyrin metabolism
tfs00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system