KEGG   PATHWAY: tge00982
Entry
tge00982                    Pathway                                
Name
Drug metabolism - cytochrome P450 - Theropithecus gelada (gelada)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
tge00982  Drug metabolism - cytochrome P450
tge00982

Organism
Theropithecus gelada (gelada) [GN:tge]
Gene
112632623  cytochrome P450 2D17 isoform X1 [KO:K17712] [EC:1.14.14.1]
112632624  LOW QUALITY PROTEIN: cytochrome P450 2D17-like [KO:K17712] [EC:1.14.14.1]
112631549  cytochrome P450 2C9-like isoform X1 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
112631550  cytochrome P450 2C9 isoform X1 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
112621193  cytochrome P450 3A8 isoform X1 [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
112631006  putative dimethylaniline monooxygenase [N-oxide-forming] 6 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
112631498  FMO3; dimethylaniline monooxygenase [N-oxide-forming] 3 isoform X1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
112631629  FMO2; LOW QUALITY PROTEIN: dimethylaniline monooxygenase [N-oxide-forming] 2 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
112631669  FMO4; LOW QUALITY PROTEIN: dimethylaniline monooxygenase [N-oxide-forming] 4 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
112631807  dimethylaniline monooxygenase [N-oxide-forming] 3-like [KO:K00485] [EC:1.14.13.8 1.8.1.-]
112618427  FMO5; dimethylaniline monooxygenase [N-oxide-forming] 5 isoform X1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
112633660  dimethylaniline monooxygenase [N-oxide-forming] 1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
112617245  cytochrome P450 2B6 [KO:K17709] [EC:1.14.14.-]
112617418  cytochrome P450 2B6-like [KO:K17709] [EC:1.14.14.-]
112621194  cytochrome P450 3A5 isoform X1 [KO:K17690] [EC:1.14.14.1]
112620616  glutathione S-transferase Mu 5-like [KO:K00799] [EC:2.5.1.18]
112621167  GSTM3; glutathione S-transferase Mu 3 isoform X1 [KO:K00799] [EC:2.5.1.18]
112621171  GSTM2; glutathione S-transferase Mu 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
112621181  LOW QUALITY PROTEIN: glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
112622506  glutathione S-transferase A5 [KO:K00799] [EC:2.5.1.18]
112622507  glutathione S-transferase A3 isoform X1 [KO:K00799] [EC:2.5.1.18]
112622508  glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
112622509  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
112608193  MGST3; microsomal glutathione S-transferase 3 isoform X1 [KO:K00799] [EC:2.5.1.18]
112608562  LOW QUALITY PROTEIN: glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
112623241  GSTA4; glutathione S-transferase A4 isoform X1 [KO:K00799] [EC:2.5.1.18]
112615486  glutathione S-transferase omega-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
112631543  GSTO2; glutathione S-transferase omega-2 isoform X1 [KO:K00799] [EC:2.5.1.18]
112624568  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
112631835  GSTO1; glutathione S-transferase omega-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
112617555  glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
112633149  glutathione S-transferase theta-2B isoform X1 [KO:K00799] [EC:2.5.1.18]
112633539  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
112633995  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
112632541  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
112633418  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
112606114  GSTP1; glutathione S-transferase P isoform X1 [KO:K23790] [EC:2.5.1.18]
112620448  GSTK1; glutathione S-transferase kappa 1 isoform X1 [KO:K13299] [EC:2.5.1.18]
112624964  HPGDS; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
112624674  ADH7; alcohol dehydrogenase class 4 mu/sigma chain isoform X1 [KO:K13951] [EC:1.1.1.1]
112625323  alcohol dehydrogenase 1B isoform X1 [KO:K13951] [EC:1.1.1.1]
112625324  alcohol dehydrogenase 1A [KO:K13951] [EC:1.1.1.1]
112625325  LOW QUALITY PROTEIN: alcohol dehydrogenase 1A-like [KO:K13951] [EC:1.1.1.1]
112624428  ADH4; alcohol dehydrogenase 4 isoform X1 [KO:K13980] [EC:1.1.1.1]
112624429  ADH5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
112624743  ADH6; alcohol dehydrogenase 6 [KO:K13952] [EC:1.1.1.1]
112606703  ALDH3B1; aldehyde dehydrogenase family 3 member B1 isoform X1 [KO:K00129] [EC:1.2.1.5]
112609398  ALDH3A1; aldehyde dehydrogenase, dimeric NADP-preferring isoform X1 [KO:K00129] [EC:1.2.1.5]
112606143  ALDH3B2; aldehyde dehydrogenase family 3 member B2 isoform X1 [KO:K00129] [EC:1.2.1.5]
112615444  MAOA; amine oxidase [flavin-containing] A isoform X1 [KO:K00274] [EC:1.4.3.4]
112616093  MAOB; amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
112635867  aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
112636354  AOX1; aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
112636356  LOW QUALITY PROTEIN: aldehyde oxidase 4-like [KO:K00157] [EC:1.2.3.1]
112636116  UDP-glucuronosyltransferase 1-5 isoform X1 [KO:K00699] [EC:2.4.1.17]
112614480  UDP-glucuronosyltransferase 1-3-like [KO:K00699] [EC:2.4.1.17]
112614481  UDP-glucuronosyltransferase 1-3-like [KO:K00699] [EC:2.4.1.17]
112615319  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
112624278  UDP-glucuronosyltransferase 2B9 isoform X1 [KO:K00699] [EC:2.4.1.17]
112624279  UDP-glucuronosyltransferase 2B9-like isoform X1 [KO:K00699] [EC:2.4.1.17]
112624280  UDP-glucuronosyltransferase 2B33 isoform X1 [KO:K00699] [EC:2.4.1.17]
112624281  UDP-glucuronosyltransferase 2B23 isoform X1 [KO:K00699] [EC:2.4.1.17]
112624282  UDP-glucuronosyltransferase 2B19 isoform X1 [KO:K00699] [EC:2.4.1.17]
112624284  UDP-glucuronosyltransferase 2B30 isoform X1 [KO:K00699] [EC:2.4.1.17]
112624285  UGT2A3; UDP-glucuronosyltransferase 2A3 [KO:K00699] [EC:2.4.1.17]
112624646  UDP-glucuronosyltransferase 2A1 isoform X1 [KO:K00699] [EC:2.4.1.17]
112624786  UDP-glucuronosyltransferase 2B20 isoform X1 [KO:K00699] [EC:2.4.1.17]
112624823  UDP-glucuronosyltransferase 2B18 isoform X1 [KO:K00699] [EC:2.4.1.17]
112627775  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
112631352  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
112631637  cytochrome P450 2E1-like [KO:K07415] [EC:1.14.14.-]
112631270  cytochrome P450 2C20 isoform X1 [KO:K17718] [EC:1.14.14.1]
112631271  cytochrome P450 2C20-like isoform X1 [KO:K17718] [EC:1.14.14.1]
112611969  LOW QUALITY PROTEIN: cytochrome P450 2A13-like [KO:K17683] [EC:1.14.14.-]
Compound
C01471  Acrolein
C01516  Morphine
C05011  Hydroxytamoxifen
C06174  Codeine
C06754  Chloroacetaldehyde
C06868  Carbamazepine
C07047  Ifosfamide
C07073  Lidocaine
C07108  Tamoxifen
C07163  Methadone
C07185  Valproic acid
C07492  Oxcarbazepine
C07493  10-Hydroxycarbazepine
C07495  Dihydroxycarbazepine
C07496  Carbamazepine-10,11-epoxide
C07501  Felbamate
C07572  Citalopram
C07643  4-Hydroxycyclophosphamide
C07644  4-Ketocyclophosphamide
C07645  Aldophosphamide
C07646  Carboxyphosphamide
C07647  Phosphoramide mustard
C07888  Cyclophosphamide
C08012  Levomethadyl acetate
C11004  2,6-Dimethylaniline
C11583  4-Glutathionyl cyclophosphamide
C11785  Normorphine
C16544  alpha-Hydroxytamoxifen
C16545  Tamoxifen N-oxide
C16546  N-Desmethyltamoxifen
C16547  Endoxifen
C16548  N,N-Didesmethyltamoxifen
C16549  alpha-Hydroxy-N-desmethyltamoxifen
C16550  Dechloroethylcyclophosphamide
C16551  Alcophosphamide
C16552  Nornitrogen mustard
C16553  4-Hydroxyifosfamide
C16554  4-Ketoifosfamide
C16555  2-Dechloroethylifosfamide
C16556  Aldoifosfamide
C16557  Carboxyifosfamide
C16558  Alcoifosfamide
C16559  Isophosphoramide mustard
C16560  3-Hydroxylidocaine
C16561  Monoethylglycinexylidide
C16569  Glycinexylidide
C16570  4-Hydroxy-2,6-dimethylaniline
C16571  2-Amino-3-methylbenzoate
C16572  3-Hydroxymonoethylglycinexylidide
C16576  Norcodeine
C16577  Codeine-6-glucuronide
C16578  Morphine-6-glucuronide
C16582  2-Hydroxyfelbamate
C16584  p-Hydroxyfelbamate
C16586  2-Phenyl-1,3-propanediol monocarbamate
C16587  3-Carbamoyl-2-phenylpropionaldehyde
C16591  3-Carbamoyl-2-phenylpropionic acid
C16592  Atropaldehyde
C16595  4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one
C16596  5-Phenyl-1,3-oxazinane-2,4-dione
C16601  2-Hydroxycarbamazepine
C16602  3-Hydroxycarbamazepine
C16603  2,3-Dihydroxycarbamazepine
C16604  2-Hydroxyiminostilbene
C16605  2H-Dibenz[b,f]azepin-2-one
C16606  Carbamazepine-o-quinone
C16607  Citalopram N-oxide
C16608  Demethylcitalopram
C16609  Didemethylcitalopram
C16610  Citalopram propionic acid
C16612  Citalopram aldehyde
C16643  Morphine-3-glucuronide
C16648  2-n-Propyl-4-pentenoic acid
C16649  4-Hydroxyvalproic acid
C16650  5-Hydroxyvalproic acid
C16651  3-Hydroxyvalproic acid
C16652  3-Oxovalproic acid
C16653  2-n-Propyl-2-pentenoic acid
C16654  2-n-Propyl-3-pentenoic acid
C16655  2-n-Propyl-4-oxopentanoic acid
C16656  2-Propyl-2,4-pentadienoic acid
C16657  2-Propylsuccinic acid
C16658  2-Propylglutaric acid
C16659  2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
C16660  2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
C16661  L-alpha-Acetyl-N-normethadol
C16662  L-alpha-Acetyl-N,N-dinormethadol
D00195  Codeine (USP)
D00252  Carbamazepine (JP18/USP/INN)
D00343  Ifosfamide (JAN/USP/INN)
D00358  Lidocaine (JP18/USP/INN)
D00399  Valproic acid (USP)
D00533  Oxcarbazepine (JAN/USP/INN)
D00536  Felbamate (USPINN)
D04716  Levomethadyl acetate (USAN)
D07704  Citalopram (USP/INN)
D07760  Cyclophosphamide (INN)
D08195  Methadone (BAN)
D08233  Morphine (BAN)
D08559  Tamoxifen (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Gjerde J, Kisanga ER, Hauglid M, Holm PI, Mellgren G, Lien EA.
  Title
Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry.
  Journal
J Chromatogr A 1082:6-14 (2005)
DOI:10.1016/j.chroma.2005.01.004
Reference
  Authors
Buck MB, Coller JK, Murdter TE, Eichelbaum M, Knabbe C.
  Title
TGFbeta2 and TbetaRII are valid molecular biomarkers for the antiproliferative effects of tamoxifen and tamoxifen metabolites in breast cancer cells.
  Journal
Breast Cancer Res Treat 107:15-24 (2008)
DOI:10.1007/s10549-007-9526-7
Reference
  Authors
Rodriguez-Antona C, Ingelman-Sundberg M.
  Title
Cytochrome P450 pharmacogenetics and cancer.
  Journal
Oncogene 25:1679-91 (2006)
DOI:10.1038/sj.onc.1209377
Reference
  Authors
Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, Duan W, Zhu YZ.
  Title
Metabolism and transport of oxazaphosphorines and the clinical implications.
  Journal
Drug Metab Rev 37:611-703 (2005)
DOI:10.1080/03602530500364023
Reference
  Authors
Kosel M, Amey M, Aubert AC, Baumann P.
  Title
In vitro metabolism of citalopram by monoamine oxidase B in human blood.
  Journal
Eur Neuropsychopharmacol 11:75-8 (2001)
DOI:10.1016/S0924-977X(00)00128-0
Reference
  Authors
Olesen OV, Linnet K.
  Title
Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes.
  Journal
Pharmacology 59:298-309 (1999)
DOI:10.1159/000028333
Reference
PMID:9698084
  Authors
Rochat B, Kosel M, Boss G, Testa B, Gillet M, Baumann P.
  Title
Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver.
  Journal
Biochem Pharmacol 56:15-23 (1998)
DOI:10.1016/S0006-2952(98)00008-2
Reference
  Authors
David AW, Thomas LL, William OF.
  Title
Foye's Principles of Medicinal Chemistry (5th ed)
  Journal
Lippincott Williams & Wilkins (2002)
Reference
  Authors
Oda Y, Kharasch ED.
  Title
Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.
  Journal
J Pharmacol Exp Ther 298:1021-32 (2001)
Reference
  Authors
Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT.
  Title
Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.
  Journal
Drug Metab Dispos 28:959-65 (2000)
Reference
  Authors
Dieckhaus CM, Thompson CD, Roller SG, Macdonald TL.
  Title
Mechanisms of idiosyncratic drug reactions: the case of felbamate.
  Journal
Chem Biol Interact 142:99-117 (2002)
DOI:10.1016/S0009-2797(02)00057-1
Reference
  Authors
Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS
  Title
Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
  Journal
Drug Metab Dispos 36:1637-49 (2008)
DOI:10.1124/dmd.107.019562
Reference
  Authors
Pearce RE, Vakkalagadda GR, Leeder JS.
  Title
Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
  Journal
Drug Metab Dispos 30:1170-9 (2002)
DOI:10.1124/dmd.30.11.1170
Reference
  Authors
Kumar S, Wong H, Yeung SA, Riggs KW, Abbott FS, Rurak DW.
  Title
Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.
  Journal
Drug Metab Dispos 28:857-64 (2000)
Reference
  Authors
Bernad T, Joachim M.
  Title
Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology
  Journal
Wiley-VCH (2003)
KO pathway
ko00982   
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