KEGG   PATHWAY: tng04912
Entry
tng04912                    Pathway                                
Name
GnRH signaling pathway - Tetraodon nigroviridis (spotted green pufferfish)
Description
Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnRHR is coupled to Gq/11 proteins to activate phospholipase C which transmits its signal to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG activates the intracellular protein kinase C (PKC) pathway and IP3 stimulates release of intracellular calcium. In addition to the classical Gq/11, coupling of Gs is occasionally observed in a cell-specific fashion. Signaling downstream of protein kinase C (PKC) leads to transactivation of the epidermal growth factor (EGF) receptor and activation of mitogen-activated protein kinases (MAPKs), including extracellular-signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 MAPK. Active MAPKs translocate to the nucleus, resulting in activation of transcription factors and rapid induction of early genes.
Class
Organismal Systems; Endocrine system
Pathway map
tng04912  GnRH signaling pathway
tng04912

Organism
Tetraodon nigroviridis (spotted green pufferfish) [GN:tng]
Gene
GSTEN00024957G001  unnamed protein product [KO:K05252]
GSTEN00002046G001  unnamed protein product [KO:K04280]
GSTEN00022369G001  unnamed protein product [KO:K04280]
GSTEN00035626G001  unnamed protein product [KO:K04280]
GSTEN00019368G001  unnamed protein product [KO:K04280]
GSTEN00008791G001  unnamed protein product [KO:K04280]
GSTEN00007847G001  unnamed protein product [KO:K04280]
GSTEN00013542G001  unnamed protein product [KO:K04632]
GSTEN00022571G001  unnamed protein product [KO:K04632]
GSTEN00012275G001  unnamed protein product [KO:K08041] [EC:4.6.1.1]
GSTEN00004784G001  unnamed protein product [KO:K08041] [EC:4.6.1.1]
GSTEN00017582G001  unnamed protein product [KO:K08042] [EC:4.6.1.1]
GSTEN00007551G001  unnamed protein product [KO:K08042] [EC:4.6.1.1]
GSTEN00021989G001  unnamed protein product [KO:K08043] [EC:4.6.1.1]
GSTEN00029196G001  unnamed protein product [KO:K08045] [EC:4.6.1.1]
GSTEN00028124G001  unnamed protein product [KO:K08046] [EC:4.6.1.1]
GSTEN00030377G001  unnamed protein product [KO:K08048] [EC:4.6.1.1]
GSTEN00015280G001  unnamed protein product [KO:K08048] [EC:4.6.1.1]
GSTEN00012568G001  unnamed protein product [KO:K08048] [EC:4.6.1.1]
GSTEN00026314G001  unnamed protein product [KO:K08049] [EC:4.6.1.1]
GSTEN00026315G001  unnamed protein product [KO:K08049] [EC:4.6.1.1]
GSTEN00019760G001  unnamed protein product [KO:K04345] [EC:2.7.11.11]
GSTEN00026232G001  unnamed protein product [KO:K04345] [EC:2.7.11.11]
GSTEN00022860G001  unnamed protein product [KO:K04345] [EC:2.7.11.11]
GSTEN00016205G001  unnamed protein product [KO:K04345] [EC:2.7.11.11]
GSTEN00021675G001  unnamed protein product [KO:K04374]
GSTEN00003142G001  unnamed protein product [KO:K04634]
GSTEN00029406G001  unnamed protein product [KO:K04634]
GSTEN00014468G001  unnamed protein product [KO:K04634]
GSTEN00031920G001  unnamed protein product [KO:K04634]
GSTEN00031921G001  unnamed protein product [KO:K04635]
GSTEN00028786G001  unnamed protein product [KO:K04635]
GSTEN00003549G001  unnamed protein product [KO:K05858] [EC:3.1.4.11]
GSTEN00020281G001  unnamed protein product [KO:K05858] [EC:3.1.4.11]
GSTEN00032419G001  unnamed protein product [KO:K05858] [EC:3.1.4.11]
GSTEN00018741G001  unnamed protein product [KO:K05858] [EC:3.1.4.11]
GSTEN00014091G001  unnamed protein product [KO:K04958]
GSTEN00022806G001  unnamed protein product [KO:K04959]
GSTEN00005900G001  unnamed protein product [KO:K04960]
GSTEN00018131G001  unnamed protein product [KO:K02183]
GSTEN00031732G001  unnamed protein product [KO:K02183]
GSTEN00014816G001  unnamed protein product [KO:K02183]
GSTEN00018439G001  unnamed protein product [KO:K02183]
GSTEN00006151G001  unnamed protein product [KO:K02183]
GSTEN00009461G001  unnamed protein product [KO:K04515] [EC:2.7.11.17]
GSTEN00029080G001  unnamed protein product [KO:K04515] [EC:2.7.11.17]
GSTEN00014312G001  unnamed protein product [KO:K04515] [EC:2.7.11.17]
GSTEN00033048G001  unnamed protein product [KO:K04515] [EC:2.7.11.17]
GSTEN00025360G001  unnamed protein product [KO:K04515] [EC:2.7.11.17]
GSTEN00014562G001  unnamed protein product [KO:K04515] [EC:2.7.11.17]
GSTEN00009847G001  unnamed protein product [KO:K19662] [EC:2.7.11.13]
GSTEN00021867G001  unnamed protein product [KO:K19662] [EC:2.7.11.13]
GSTEN00004810G001  unnamed protein product [KO:K06068] [EC:2.7.11.13]
GSTEN00027270G001  unnamed protein product [KO:K06068] [EC:2.7.11.13]
GSTEN00022583G001  unnamed protein product [KO:K04851]
GSTEN00027380G001  unnamed protein product [KO:K04851]
GSTEN00026488G001  unnamed protein product [KO:K04853]
GSTEN00023513G001  unnamed protein product [KO:K04853]
GSTEN00028107G001  unnamed protein product [KO:K04857]
GSTEN00015785G001  unnamed protein product [KO:K04857]
GSTEN00003091G001  unnamed protein product [KO:K04420] [EC:2.7.11.25]
GSTEN00031843G001  unnamed protein product [KO:K04420] [EC:2.7.11.25]
GSTEN00023918G001  unnamed protein product [KO:K04421] [EC:2.7.11.25]
GSTEN00027814G001  unnamed protein product [KO:K04421] [EC:2.7.11.25]
GSTEN00030726G001  unnamed protein product [KO:K04428] [EC:2.7.11.25]
GSTEN00018597G001  unnamed protein product [KO:K04433] [EC:2.7.12.2]
GSTEN00001777G001  unnamed protein product [KO:K04441] [EC:2.7.11.24]
GSTEN00015915G001  unnamed protein product [KO:K04441] [EC:2.7.11.24]
GSTEN00028159G001  unnamed protein product [KO:K04441] [EC:2.7.11.24]
GSTEN00020585G001  unnamed protein product [KO:K04441] [EC:2.7.11.24]
GSTEN00006610G001  unnamed protein product [KO:K04441] [EC:2.7.11.24]
GSTEN00013269G001  unnamed protein product [KO:K04441] [EC:2.7.11.24]
GSTEN00013270G001  unnamed protein product [KO:K04441] [EC:2.7.11.24]
GSTEN00028301G001  unnamed protein product [KO:K04464] [EC:2.7.11.24]
GSTEN00033633G001  unnamed protein product [KO:K16342] [EC:3.1.1.4]
GSTEN00007932G001  unnamed protein product [KO:K01115] [EC:3.1.4.4]
GSTEN00012719G001  unnamed protein product [KO:K01115] [EC:3.1.4.4]
GSTEN00022141G001  unnamed protein product [KO:K01115] [EC:3.1.4.4]
GSTEN00033858G001  unnamed protein product [KO:K05704] [EC:2.7.10.2]
GSTEN00036856G001  unnamed protein product [KO:K05704] [EC:2.7.10.2]
GSTEN00023599G001  unnamed protein product [KO:K04393]
GSTEN00004992G001  unnamed protein product [KO:K04393]
GSTEN00014160G001  unnamed protein product [KO:K04393]
GSTEN00021736G001  unnamed protein product [KO:K04430] [EC:2.7.12.2]
GSTEN00021246G001  unnamed protein product [KO:K04430] [EC:2.7.12.2]
GSTEN00026353G001  unnamed protein product [KO:K04431] [EC:2.7.12.2]
GSTEN00019882G001  unnamed protein product [KO:K04440] [EC:2.7.11.24]
GSTEN00014434G001  unnamed protein product [KO:K04440] [EC:2.7.11.24]
GSTEN00030625G001  unnamed protein product [KO:K04440] [EC:2.7.11.24]
GSTEN00020512G001  unnamed protein product [KO:K04448]
GSTEN00015028G001  unnamed protein product [KO:K04448]
GSTEN00013845G001  unnamed protein product [KO:K04448]
GSTEN00018755G001  unnamed protein product [KO:K08521]
GSTEN00032138G001  unnamed protein product [KO:K08522]
GSTEN00030312G001  unnamed protein product [KO:K05871] [EC:2.7.10.2]
GSTEN00027121G001  unnamed protein product [KO:K05871] [EC:2.7.10.2]
GSTEN00012583G001  unnamed protein product [KO:K01398] [EC:3.4.24.24]
GSTEN00025878G001  unnamed protein product [KO:K07763] [EC:3.4.24.80]
GSTEN00015140G001  unnamed protein product [KO:K07763] [EC:3.4.24.80]
GSTEN00017128G001  unnamed protein product [KO:K08523]
GSTEN00029620G001  unnamed protein product [KO:K08523]
GSTEN00025328G001  unnamed protein product [KO:K04361] [EC:2.7.10.1]
GSTEN00025331G001  unnamed protein product [KO:K04361] [EC:2.7.10.1]
GSTEN00027642G001  unnamed protein product [KO:K04361] [EC:2.7.10.1]
GSTEN00006471G001  unnamed protein product [KO:K04364]
GSTEN00018287G001  unnamed protein product [KO:K03099]
GSTEN00035791G001  unnamed protein product [KO:K03099]
GSTEN00008944G001  unnamed protein product [KO:K03099]
GSTEN00003165G001  unnamed protein product [KO:K02833]
GSTEN00021499G001  unnamed protein product [KO:K02833]
GSTEN00022812G001  unnamed protein product [KO:K07827]
GSTEN00023725G001  unnamed protein product [KO:K04366] [EC:2.7.11.1]
GSTEN00016020G001  unnamed protein product [KO:K04368] [EC:2.7.12.2]
GSTEN00004843G001  unnamed protein product [KO:K04369] [EC:2.7.12.2]
GSTEN00028566G001  unnamed protein product [KO:K04371] [EC:2.7.11.24]
GSTEN00021811G001  unnamed protein product [KO:K04371] [EC:2.7.11.24]
GSTEN00003483G001  unnamed protein product [KO:K04375]
GSTEN00014544G001  unnamed protein product [KO:K09203]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00416  Phosphatidate
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:15350605
  Authors
Ruf F, Sealfon SC.
  Title
Genomics view of gonadotrope signaling circuits.
  Journal
Trends Endocrinol Metab 15:331-8 (2004)
DOI:10.1016/j.tem.2004.07.008
Reference
PMID:15613448
  Authors
Harrison GS, Wierman ME, Nett TM, Glode LM.
  Title
Gonadotropin-releasing hormone and its receptor in normal and malignant cells.
  Journal
Endocr Relat Cancer 11:725-48 (2004)
DOI:10.1677/erc.1.00777
Reference
PMID:15982836
  Authors
Pawson AJ, McNeilly AS.
  Title
The pituitary effects of GnRH.
  Journal
Anim Reprod Sci 88:75-94 (2005)
DOI:10.1016/j.anireprosci.2005.05.010
Reference
  Authors
DeGroot LJ, Jameson JL (ed).
  Title
Endocrinology (Fifth edition)
  Journal
Elsevier Saunders (2006)
Reference
PMID:10707049
  Authors
Naor Z, Benard O, Seger R.
  Title
Activation of MAPK cascades by G-protein-coupled receptors: the case of gonadotropin-releasing hormone receptor.
  Journal
Trends Endocrinol Metab 11:91-9 (2000)
DOI:10.1016/S1043-2760(99)00232-5
Reference
PMID:14596811
  Authors
Ruf F, Fink MY, Sealfon SC.
  Title
Structure of the GnRH receptor-stimulated signaling network: insights from genomics.
  Journal
Front Neuroendocrinol 24:181-99 (2003)
DOI:10.1016/S0091-3022(03)00027-X
Reference
PMID:12943720
  Authors
Farshori PQ, Shah BH, Arora KK, Martinez-Fuentes A, Catt KJ.
  Title
Activation and nuclear translocation of PKCdelta, Pyk2 and ERK1/2 by gonadotropin releasing hormone in HEK293 cells.
  Journal
J Steroid Biochem Mol Biol 85:337-47 (2003)
DOI:10.1016/S0960-0760(03)00226-7
Reference
PMID:15080147
  Authors
Shah BH, Catt KJ.
  Title
Matrix metalloproteinases in reproductive endocrinology.
  Journal
Trends Endocrinol Metab 15:47-9 (2004)
DOI:10.1016/j.tem.2004.01.004
Reference
PMID:12963732
  Authors
Roelle S, Grosse R, Aigner A, Krell HW, Czubayko F, Gudermann T.
  Title
Matrix metalloproteinases 2 and 9 mediate epidermal growth factor receptor transactivation by gonadotropin-releasing hormone.
  Journal
J Biol Chem 278:47307-18 (2003)
DOI:10.1074/jbc.M304377200
Reference
PMID:18708085
  Authors
Naor Z
  Title
Signaling by G-protein-coupled receptor (GPCR): studies on the GnRH receptor.
  Journal
Front Neuroendocrinol 30:10-29 (2009)
DOI:10.1016/j.yfrne.2008.07.001
Related
pathway
tng04010  MAPK signaling pathway
tng04020  Calcium signaling pathway
tng04060  Cytokine-cytokine receptor interaction
tng04080  Neuroactive ligand-receptor interaction
KO pathway
ko04912   
LinkDB

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